diff --git a/src/libraries/System.IO.IsolatedStorage/tests/System/IO/IsolatedStorage/HelperTests.cs b/src/libraries/System.IO.IsolatedStorage/tests/System/IO/IsolatedStorage/HelperTests.cs
index 217f4c14de9dc..e1a035c456e26 100644
--- a/src/libraries/System.IO.IsolatedStorage/tests/System/IO/IsolatedStorage/HelperTests.cs
+++ b/src/libraries/System.IO.IsolatedStorage/tests/System/IO/IsolatedStorage/HelperTests.cs
@@ -41,7 +41,8 @@ public void GetDataDirectory(IsolatedStorageScope scope)
         {
             // Machine scope is behind a policy that isn't enabled by default
             // https://github.com/dotnet/runtime/issues/21742
-            if (scope == IsolatedStorageScope.Machine && PlatformDetection.IsInAppContainer)
+            // It's also disabled on Android, see https://github.com/dotnet/runtime/issues/55693
+            if (scope == IsolatedStorageScope.Machine && (PlatformDetection.IsInAppContainer || PlatformDetection.IsAndroid)) 
                 return;
 
             string path = Helper.GetDataDirectory(scope);