diff --git a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
index 71edaaa3c4067..47c538af8077f 100644
--- a/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
+++ b/src/libraries/System.Diagnostics.Process/tests/ProcessTests.cs
@@ -2096,6 +2096,7 @@ public void TestLongProcessIsWorking()
         [ActiveIssue("https://github.com/dotnet/runtime/issues/29330", TestPlatforms.OSX)]
         [Fact]
         [ActiveIssue("https://github.com/dotnet/runtime/issues/52852", TestPlatforms.MacCatalyst)]
+        [ActiveIssue("https://github.com/dotnet/runtime/issues/53095", TestPlatforms.Android)]
         public void LongProcessNamesAreSupported()
         {
             string sleepPath;
diff --git a/src/libraries/System.Net.Security/tests/FunctionalTests/SslStreamStreamToStreamTest.cs b/src/libraries/System.Net.Security/tests/FunctionalTests/SslStreamStreamToStreamTest.cs
index f7ca5892fc052..3ecfbc4e92493 100644
--- a/src/libraries/System.Net.Security/tests/FunctionalTests/SslStreamStreamToStreamTest.cs
+++ b/src/libraries/System.Net.Security/tests/FunctionalTests/SslStreamStreamToStreamTest.cs
@@ -68,6 +68,7 @@ public static IEnumerable<object[]> SslStream_StreamToStream_Authentication_Succ
 
         [Theory]
         [MemberData(nameof(SslStream_StreamToStream_Authentication_Success_MemberData))]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "X509 certificate store is not supported on iOS or tvOS.")]
         public async Task SslStream_StreamToStream_Authentication_Success(X509Certificate serverCert = null, X509Certificate clientCert = null)
         {
             (Stream stream1, Stream stream2) = TestHelper.GetConnectedStreams();
@@ -126,6 +127,7 @@ await TestConfiguration.WhenAllOrAnyFailedWithTimeout(client.AuthenticateAsClien
         }
 
         [Fact]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "X509 certificate store is not supported on iOS or tvOS.")]
         public async Task Read_CorrectlyUnlocksAfterFailure()
         {
             (Stream stream1, Stream stream2) = TestHelper.GetConnectedStreams();
@@ -153,6 +155,7 @@ public async Task Read_CorrectlyUnlocksAfterFailure()
         }
 
         [Fact]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "X509 certificate store is not supported on iOS or tvOS.")]
         public async Task Write_CorrectlyUnlocksAfterFailure()
         {
             (Stream stream1, Stream stream2) = TestHelper.GetConnectedStreams();
@@ -201,6 +204,7 @@ public async Task Read_InvokedSynchronously()
         }
 
         [Fact]
+        [SkipOnPlatform(TestPlatforms.iOS | TestPlatforms.tvOS, "X509 certificate store is not supported on iOS or tvOS.")]
         public async Task Write_InvokedSynchronously()
         {
             (Stream stream1, Stream stream2) = TestHelper.GetConnectedStreams();
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 020c562cdde8c..e62cabe7ba503 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -106,9 +106,12 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.NetworkInformation/tests/FunctionalTests/System.Net.NetworkInformation.Functional.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Primitives/tests/FunctionalTests/System.Net.Primitives.Functional.Tests.csproj" />
 
+    <!-- Crashes on CI (possibly flakey) -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/Misc/System.Xml.Misc.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Dynamic.Runtime/tests/System.Dynamic.Runtime.Tests.csproj"/>
   </ItemGroup>
 
-  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'arm64'">
+  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'arm64' and '$(RunDisabledAndroidTests)' != 'true'">
     <!-- Execution may be compromised https://github.com/dotnet/runtime/issues/51017 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Configuration.Xml\tests\Microsoft.Extensions.Configuration.Xml.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Hosting\tests\FunctionalTests\Microsoft.Extensions.Hosting.Functional.Tests.csproj" />
@@ -118,14 +121,49 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Resources.ResourceManager\tests\System.Resources.ResourceManager.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Loader\tests\System.Runtime.Loader.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Serialization.Json\tests\System.Runtime.Serialization.Json.Tests.csproj" />
+
+    <!-- Crashes on CI (possibly flakey) https://github.com/dotnet/runtime/issues/52615 -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Configuration/tests/FunctionalTests/Microsoft.Extensions.Configuration.Functional.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Configuration.Binder/tests/Microsoft.Extensions.Configuration.Binder.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.FileProviders.Physical/tests/Microsoft.Extensions.FileProviders.Physical.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Win32.Primitives/tests/Microsoft.Win32.Primitives.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Collections.Concurrent/tests/System.Collections.Concurrent.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Collections.Specialized/tests/System.Collections.Specialized.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.ComponentModel.Annotations/tests/System.ComponentModel.Annotations.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Composition.Hosting/tests/System.Composition.Hosting.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.FileSystem.Primitives/tests/System.IO.FileSystem.Primitives.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Memory/tests/System.Memory.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Mail/tests/Functional/System.Net.Mail.Functional.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.NameResolution/tests/PalTests/System.Net.NameResolution.Pal.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Security/tests/UnitTests/System.Net.Security.Unit.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.WebClient/tests/System.Net.WebClient.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Numerics.Tensors/tests/System.Numerics.Tensors.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XmlReader/Tests/System.Xml.RW.XmlReader.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XPath/XPathDocument/System.Xml.XPath.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Uri/tests/ExtendedFunctionalTests/System.Private.Uri.ExtendedFunctional.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Reflection.DispatchProxy/tests/System.Reflection.DispatchProxy.Tests.csproj" />
+
+    <!-- JSON parsing exception https://github.com/dotnet/runtime/issues/53097 -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Pipes/tests/System.IO.Pipes.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Numerics.Vectors/tests/System.Numerics.Vectors.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/Misc/System.Xml.Misc.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XmlNodeReader/System.Xml.XmlNodeReader.Tests/System.Xml.XmlNodeReader.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XmlSerializer/System.Xml.XmlSerializer.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Reflection.Emit/tests/System.Reflection.Emit.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Claims/tests/System.Security.Claims.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.Primitives/tests/System.Security.Cryptography.Primitives.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Text.RegularExpressions/tests/System.Text.RegularExpressions.Tests.csproj" />
   </ItemGroup>
 
-  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'x64'">
+  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'x64' and '$(RunDisabledAndroidTests)' != 'true'">
     <!-- Test flakiness on x64 https://github.com/dotnet/runtime/issues/49937 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading\tests\System.Threading.Tests.csproj" />
+
+    <!-- Crashes on CI but passes locally https://github.com/dotnet/runtime/issues/52615 -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Security/tests/UnitTests/System.Net.Security.Unit.Tests.csproj" />
   </ItemGroup>
 
-  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'x86'">
+  <ItemGroup Condition="'$(TargetOS)' == 'Android' and '$(TargetArchitecture)' == 'x86' and '$(RunDisabledAndroidTests)' != 'true'">
     <!-- Crashes only on x86 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Primitives\tests\Microsoft.Extensions.Primitives.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Runtime.Extensions\tests\System.Runtime.Extensions.Tests.csproj" />
@@ -153,12 +191,17 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Net.Security/tests/FunctionalTests/System.Net.Security.Tests.csproj" />
 
     <!-- Crashes on CI but passes locally https://github.com/dotnet/runtime/issues/52615 -->
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Http/tests/Microsoft.Extensions.Http.Tests/Microsoft.Extensions.Http.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)Microsoft.Extensions.Logging/tests/Common/Microsoft.Extensions.Logging.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression/tests/System.IO.Compression.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks.Dataflow/tests/System.Threading.Tasks.Dataflow.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.FileSystem/tests/System.IO.FileSystem.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks/tests/System.Threading.Tasks.Tests.csproj" />
-    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XmlResolver/System.Xml.XmlResolver.Tests/System.Xml.XmlResolver.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Packaging/tests/System.IO.Packaging.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Uri/tests/UnitTests/System.Private.Uri.Unit.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Private.Xml/tests/XmlResolver/System.Xml.XmlResolver.Tests/System.Xml.XmlResolver.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Security.Cryptography.Csp/tests/System.Security.Cryptography.Csp.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks.Dataflow/tests/System.Threading.Tasks.Dataflow.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks/tests/System.Threading.Tasks.Tests.csproj" />
   </ItemGroup>
 
   <ItemGroup Condition="('$(TargetOS)' == 'tvOS' or '$(TargetOS)' == 'tvOSSimulator') and '$(RunDisablediOSTests)' != 'true'">
@@ -167,6 +210,7 @@
 
     <!-- Crashes on CI but passes locally https://github.com/dotnet/runtime/issues/52615 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Diagnostics.Process/tests/System.Diagnostics.Process.Tests.csproj" />
+    <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression.Brotli/tests/System.IO.Compression.Brotli.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.IO.Compression.ZipFile/tests/System.IO.Compression.ZipFile.Tests.csproj" />
   </ItemGroup>
 
@@ -174,6 +218,10 @@
     <!-- Crashes randomly during test runs https://github.com/dotnet/runtime/issues/52460 -->
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks\tests\System.Threading.Tasks.Tests.csproj" />
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Threading.Tasks.Dataflow\tests\System.Threading.Tasks.Dataflow.Tests.csproj" />
+
+    <!-- Crashes on CI but passes locally https://github.com/dotnet/runtime/issues/52615 -->
+    <ProjectExclusions Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\Interpreter\iOS.Simulator.Interpreter.Test.csproj" />
+    <ProjectExclusions Include="$(RepoRoot)\src\tests\FunctionalTests\iOS\Simulator\InvariantCultureOnlyMode\iOS.Simulator.InvariantCultureOnlyMode.Test.csproj" />
   </ItemGroup>
 
   <ItemGroup Condition="'$(TargetOS)' == 'Browser' and '$(RunDisabledWasmTests)' != 'true'">