diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index f60775a0c3b35d..58690bd30b6376 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -673,6 +673,13 @@
             <Issue>https://github.com/dotnet/runtime/issues/85663</Issue>
         </ExcludeList>
     </ItemGroup>
+    
+    <!-- Crossgen2 win-arm64 specific excludes -->
+    <ItemGroup Condition="'$(XunitTestBinBase)' != '' and ('$(TestBuildMode)' == 'crossgen2' or '$(TestBuildMode)' == 'crossgen') and '$(RuntimeFlavor)' == 'coreclr' and '$(TargetArchitecture)' == 'arm64' and '$(TargetOS)' == 'windows'">
+        <ExcludeList Include="$(XunitTestBinBase)/JIT/opt/Devirtualization/Comparer_get_Default/*">
+            <Issue>https://github.com/dotnet/runtime/issues/104927</Issue>
+        </ExcludeList>
+    </ItemGroup>
 
     <!-- NativeAOT specific -->
     <ItemGroup Condition="'$(XunitTestBinBase)' != '' and '$(TestBuildMode)' == 'nativeaot' and '$(RuntimeFlavor)' == 'coreclr'">