diff --git a/src/tests/issues.targets b/src/tests/issues.targets
index 9f8c49da4dfdc..b59a656853bbd 100644
--- a/src/tests/issues.targets
+++ b/src/tests/issues.targets
@@ -922,13 +922,6 @@
         </ExcludeList>
     </ItemGroup>
 
-    <!-- All OSX targets on NativeAOT -->
-    <ItemGroup Condition="'$(XunitTestBinBase)' != '' and '$(TargetsOSX)' == 'true' and '$(TestBuildMode)' == 'nativeaot' and '$(RuntimeFlavor)' == 'coreclr' ">
-        <ExcludeList Include="$(XunitTestBinBase)/nativeaot/SmokeTests/DynamicGenerics/DynamicGenerics/*">
-            <Issue>https://github.com/dotnet/runtime/issues/73299</Issue>
-        </ExcludeList>
-    </ItemGroup>
-
     <!-- NativeAOT specific -->
     <ItemGroup Condition="'$(XunitTestBinBase)' != '' and '$(TestBuildMode)' == 'nativeaot' and '$(RuntimeFlavor)' == 'coreclr'">
         <ExcludeList Include="$(XunitTestBinBase)/Loader/classloader/StaticVirtualMethods/NegativeTestCases/**">