diff --git a/src/Orleans.Core/Hosting/GenericHostExtensions.cs b/src/Orleans.Core/Hosting/OrleansClientGenericHostExtensions.cs
similarity index 59%
rename from src/Orleans.Core/Hosting/GenericHostExtensions.cs
rename to src/Orleans.Core/Hosting/OrleansClientGenericHostExtensions.cs
index 90c5bc2164..55a0432467 100644
--- a/src/Orleans.Core/Hosting/GenericHostExtensions.cs
+++ b/src/Orleans.Core/Hosting/OrleansClientGenericHostExtensions.cs
@@ -1,4 +1,5 @@
 using System;
+using System.Linq;
 using Microsoft.Extensions.DependencyInjection;
 using Orleans.Hosting;
 using Orleans.Runtime;
@@ -10,6 +11,32 @@ namespace Microsoft.Extensions.Hosting
     /// </summary>
     public static class OrleansClientGenericHostExtensions
     {
+        private static readonly Type MarkerType = typeof(OrleansBuilderMarker);
+
+        /// <summary>
+        /// Configures the host app builder to host an Orleans client.
+        /// </summary>
+        /// <param name="hostAppBuilder">The host app builder.</param>
+        /// <param name="configureDelegate">The delegate used to configure the client.</param>
+        /// <returns>The host builder.</returns>
+        /// <remarks>
+        /// Calling this method multiple times on the same <see cref="IClientBuilder"/> instance will result in one client being configured.
+        /// However, the effects of <paramref name="configureDelegate"/> will be applied once for each call.
+        /// Note that this method shouldn't be used in conjunction with HostApplicationBuilder.UseOrleans, since UseOrleans includes a client automatically.
+        /// </remarks>
+        /// <exception cref="ArgumentNullException"><paramref name="hostAppBuilder"/> was null or <paramref name="configureDelegate"/> was null.</exception>
+        public static HostApplicationBuilder UseOrleansClient(
+            this HostApplicationBuilder hostAppBuilder,
+            Action<IClientBuilder> configureDelegate)
+        {
+            ArgumentNullException.ThrowIfNull(hostAppBuilder);
+            ArgumentNullException.ThrowIfNull(configureDelegate);
+
+            hostAppBuilder.Services.AddOrleansClient(configureDelegate);
+
+            return hostAppBuilder;
+        }
+
         /// <summary>
         /// Configures the host builder to host an Orleans client.
         /// </summary>
@@ -22,8 +49,8 @@ public static class OrleansClientGenericHostExtensions
         /// Note that this method should not be used in conjunction with IHostBuilder.UseOrleans, since UseOrleans includes a client automatically.
         /// </remarks>
         /// <exception cref="ArgumentNullException"><paramref name="hostBuilder"/> was null or <paramref name="configureDelegate"/> was null.</exception>
-        public static IHostBuilder UseOrleansClient(this IHostBuilder hostBuilder, Action<IClientBuilder> configureDelegate)
-            => hostBuilder.UseOrleansClient((_, clientBuilder) => configureDelegate(clientBuilder));
+        public static IHostBuilder UseOrleansClient(this IHostBuilder hostBuilder, Action<IClientBuilder> configureDelegate) =>
+            hostBuilder.UseOrleansClient((_, clientBuilder) => configureDelegate(clientBuilder));
 
         /// <summary>
         /// Configures the host builder to host an Orleans client.
@@ -39,14 +66,16 @@ public static IHostBuilder UseOrleansClient(this IHostBuilder hostBuilder, Actio
         /// <exception cref="ArgumentNullException"><paramref name="hostBuilder"/> was null or <paramref name="configureDelegate"/> was null.</exception>
         public static IHostBuilder UseOrleansClient(this IHostBuilder hostBuilder, Action<HostBuilderContext, IClientBuilder> configureDelegate)
         {
-            if (hostBuilder == null) throw new ArgumentNullException(nameof(hostBuilder));
-            if (configureDelegate == null) throw new ArgumentNullException(nameof(configureDelegate));
+            ArgumentNullException.ThrowIfNull(hostBuilder);
+            ArgumentNullException.ThrowIfNull(configureDelegate);
+
             if (hostBuilder.Properties.ContainsKey("HasOrleansSiloBuilder"))
             {
                 throw GetOrleansSiloAddedException();
             }
 
             hostBuilder.Properties["HasOrleansClientBuilder"] = "true";
+
             return hostBuilder.ConfigureServices((ctx, services) => configureDelegate(ctx, AddOrleansClient(services)));
         }
 
@@ -64,8 +93,10 @@ public static IHostBuilder UseOrleansClient(this IHostBuilder hostBuilder, Actio
         /// <exception cref="ArgumentNullException"><paramref name="services"/> was null or <paramref name="configureDelegate"/> was null.</exception>
         public static IServiceCollection AddOrleansClient(this IServiceCollection services, Action<IClientBuilder> configureDelegate)
         {
-            if (configureDelegate == null) throw new ArgumentNullException(nameof(configureDelegate));
+            ArgumentNullException.ThrowIfNull(configureDelegate);
+
             var clientBuilder = AddOrleansClient(services);
+
             configureDelegate(clientBuilder);
             return services;
         }
@@ -73,45 +104,43 @@ public static IServiceCollection AddOrleansClient(this IServiceCollection servic
         private static IClientBuilder AddOrleansClient(IServiceCollection services)
         {
             IClientBuilder clientBuilder = default;
-            foreach (var descriptor in services)
+            foreach (var descriptor in services.Where(d => d.ServiceType.Equals(MarkerType)))
             {
-                if (descriptor.ServiceType.Equals(typeof(OrleansBuilderMarker)))
+                var instance = (OrleansBuilderMarker)descriptor.ImplementationInstance;
+                clientBuilder = instance.BuilderInstance switch
                 {
-                    var instance = (OrleansBuilderMarker)descriptor.ImplementationInstance;
-                    clientBuilder = instance.Instance switch
-                    {
-                        IClientBuilder existingBuilder => existingBuilder,
-                        _ => throw GetOrleansSiloAddedException()
-                    };
-                }
+                    IClientBuilder existingBuilder => existingBuilder,
+                    _ => throw GetOrleansSiloAddedException()
+                };
             }
 
             if (clientBuilder is null)
             {
                 clientBuilder = new ClientBuilder(services);
-                services.Add(new(typeof(OrleansBuilderMarker), new OrleansBuilderMarker(clientBuilder)));
+                services.AddSingleton(new OrleansBuilderMarker(clientBuilder));
             }
 
             return clientBuilder;
         }
 
-        private static OrleansConfigurationException GetOrleansSiloAddedException() => new("Do not use UseOrleans with UseOrleansClient. If you want a client and server in the same process, only UseOrleans is necessary and the UseOrleansClient call can be removed.");
+        private static OrleansConfigurationException GetOrleansSiloAddedException() =>
+            new("Do not use UseOrleans with UseOrleansClient. If you want a client and server in the same process, only UseOrleans is necessary and the UseOrleansClient call can be removed.");
+    }
 
+    /// <summary>
+    /// Marker type used for storing a builder in a service collection.
+    /// </summary>
+    internal sealed class OrleansBuilderMarker
+    {
         /// <summary>
-        /// Marker type used for storing a client builder in a service collection.
+        /// Initializes a new instance of the <see cref="OrleansBuilderMarker"/> class.
         /// </summary>
-        internal class OrleansBuilderMarker
-        {
-            /// <summary>
-            /// Initializes a new instance of the <see cref="OrleansBuilderMarker"/> class.
-            /// </summary>
-            /// <param name="builderInstance">The builder instance.</param>
-            public OrleansBuilderMarker(object builderInstance) => Instance = builderInstance;
-
-            /// <summary>
-            /// Gets the builder instance.
-            /// </summary>
-            public object Instance { get; }
-        }
+        /// <param name="builderInstance">The builder instance.</param>
+        public OrleansBuilderMarker(object builderInstance) => BuilderInstance = builderInstance;
+
+        /// <summary>
+        /// Gets the builder instance.
+        /// </summary>
+        public object BuilderInstance { get; }
     }
 }
diff --git a/src/Orleans.Core/Orleans.Core.csproj b/src/Orleans.Core/Orleans.Core.csproj
index 30f3c10dfe..e8b8e5e560 100644
--- a/src/Orleans.Core/Orleans.Core.csproj
+++ b/src/Orleans.Core/Orleans.Core.csproj
@@ -24,7 +24,7 @@
     <PackageReference Include="Microsoft.Extensions.ObjectPool" />
     <PackageReference Include="Microsoft.Extensions.Options.ConfigurationExtensions" />
     <PackageReference Include="Microsoft.Extensions.Logging" />
-    <PackageReference Include="Microsoft.Extensions.Hosting.Abstractions" />
+    <PackageReference Include="Microsoft.Extensions.Hosting" />
     <PackageReference Include="Newtonsoft.Json" />
     <PackageReference Include="System.Memory.Data" />
   </ItemGroup>
diff --git a/src/Orleans.Runtime/Hosting/GenericHostExtensions.cs b/src/Orleans.Runtime/Hosting/OrleansSiloGenericHostExtensions.cs
similarity index 58%
rename from src/Orleans.Runtime/Hosting/GenericHostExtensions.cs
rename to src/Orleans.Runtime/Hosting/OrleansSiloGenericHostExtensions.cs
index acb6c728b2..e951a2991c 100644
--- a/src/Orleans.Runtime/Hosting/GenericHostExtensions.cs
+++ b/src/Orleans.Runtime/Hosting/OrleansSiloGenericHostExtensions.cs
@@ -1,17 +1,49 @@
 using System;
+using System.Linq;
 using Microsoft.Extensions.DependencyInjection;
-using Orleans;
 using Orleans.Hosting;
 using Orleans.Runtime;
-using static Microsoft.Extensions.Hosting.OrleansClientGenericHostExtensions;
 
 namespace Microsoft.Extensions.Hosting
 {
     /// <summary>
     /// Extension methods for <see cref="IHostBuilder"/>.
     /// </summary>
-    public static class GenericHostExtensions
+    public static class OrleansSiloGenericHostExtensions
     {
+        private static readonly Type MarkerType = typeof(OrleansBuilderMarker);
+
+        /// <summary>
+        /// Configures the host app builder to host an Orleans silo.
+        /// </summary>
+        /// <param name="hostAppBuilder">The host app builder.</param>
+        /// <returns>The host builder.</returns>
+        public static HostApplicationBuilder UseOrleans(
+            this HostApplicationBuilder hostAppBuilder) =>
+            hostAppBuilder.UseOrleans(_ => { });
+
+        /// <summary>
+        /// Configures the host builder to host an Orleans silo.
+        /// </summary>
+        /// <param name="hostAppBuilder">The host app builder.</param>
+        /// <param name="configureDelegate">The delegate used to configure the silo.</param>
+        /// <returns>The host builder.</returns>
+        /// <remarks>
+        /// Calling this method multiple times on the same <see cref="HostApplicationBuilder"/> instance will result in one silo being configured.
+        /// However, the effects of <paramref name="configureDelegate"/> will be applied once for each call.
+        /// </remarks>
+        public static HostApplicationBuilder UseOrleans(
+            this HostApplicationBuilder hostAppBuilder,
+            Action<ISiloBuilder> configureDelegate)
+        {
+            ArgumentNullException.ThrowIfNull(hostAppBuilder);
+            ArgumentNullException.ThrowIfNull(configureDelegate);
+
+            hostAppBuilder.Services.AddOrleans(configureDelegate);
+
+            return hostAppBuilder;
+        }
+
         /// <summary>
         /// Configures the host builder to host an Orleans silo.
         /// </summary>
@@ -40,8 +72,8 @@ public static IHostBuilder UseOrleans(
             this IHostBuilder hostBuilder,
             Action<HostBuilderContext, ISiloBuilder> configureDelegate)
         {
-            if (hostBuilder is null) throw new ArgumentNullException(nameof(hostBuilder));
-            if (configureDelegate == null) throw new ArgumentNullException(nameof(configureDelegate));
+            ArgumentNullException.ThrowIfNull(hostBuilder);
+            ArgumentNullException.ThrowIfNull(configureDelegate);
 
             if (hostBuilder.Properties.ContainsKey("HasOrleansClientBuilder"))
             {
@@ -67,39 +99,39 @@ public static IServiceCollection AddOrleans(
             this IServiceCollection services,
             Action<ISiloBuilder> configureDelegate)
         {
-            if (configureDelegate == null) throw new ArgumentNullException(nameof(configureDelegate));
+            ArgumentNullException.ThrowIfNull(configureDelegate);
+
             var builder = AddOrleans(services);
 
             configureDelegate(builder);
+
             return services;
         }
 
         private static ISiloBuilder AddOrleans(IServiceCollection services)
         {
             ISiloBuilder builder = default;
-            foreach (var descriptor in services)
+            foreach (var descriptor in services.Where(d => d.ServiceType.Equals(MarkerType)))
             {
-                if (descriptor.ServiceType.Equals(typeof(OrleansBuilderMarker)))
+                var marker = (OrleansBuilderMarker)descriptor.ImplementationInstance;
+                builder = marker.BuilderInstance switch
                 {
-                    var instance = (OrleansBuilderMarker)descriptor.ImplementationInstance;
-                    builder = instance.Instance switch
-                    {
-
-                        ISiloBuilder existingBuilder => existingBuilder,
-                        _ => throw GetOrleansClientAddedException()
-                    };
-                }
+
+                    ISiloBuilder existingBuilder => existingBuilder,
+                    _ => throw GetOrleansClientAddedException()
+                };
             }
 
             if (builder is null)
             {
                 builder = new SiloBuilder(services);
-                services.Add(new(typeof(OrleansBuilderMarker), new OrleansBuilderMarker(builder)));
+                services.AddSingleton(new OrleansBuilderMarker(builder));
             }
 
             return builder;
         }
 
-        private static OrleansConfigurationException GetOrleansClientAddedException() => new("Do not call both UseOrleansClient/AddOrleansClient with UseOrleans/AddOrleans. If you want a client and server in the same process, only UseOrleans/AddOrleans is necessary and the UseOrleansClient/AddOrleansClient call can be removed.");
+        private static OrleansConfigurationException GetOrleansClientAddedException() =>
+            new("Do not call both UseOrleansClient/AddOrleansClient with UseOrleans/AddOrleans. If you want a client and server in the same process, only UseOrleans/AddOrleans is necessary and the UseOrleansClient/AddOrleansClient call can be removed.");
     }
 }
\ No newline at end of file
diff --git a/test/DefaultCluster.Tests/HostedClientTests.cs b/test/DefaultCluster.Tests/HostedClientTests.cs
index 2589109439..24cde25268 100644
--- a/test/DefaultCluster.Tests/HostedClientTests.cs
+++ b/test/DefaultCluster.Tests/HostedClientTests.cs
@@ -1,14 +1,9 @@
-using System;
-using System.Collections.Generic;
 using System.Diagnostics;
-using System.Threading.Tasks;
 using Microsoft.Extensions.DependencyInjection;
 using Microsoft.Extensions.Hosting;
 using Microsoft.Extensions.Logging;
-using Orleans;
 using Orleans.Concurrency;
 using Orleans.Configuration;
-using Orleans.Hosting;
 using Orleans.Providers;
 using Orleans.Runtime;
 using Orleans.Streams;
@@ -39,8 +34,8 @@ public Fixture()
             public async Task InitializeAsync()
             {
                 var (siloPort, gatewayPort) = portAllocator.AllocateConsecutivePortPairs(1);
-                Host = new HostBuilder()
-                    .UseOrleans((ctx, siloBuilder) =>
+                Host = Microsoft.Extensions.Hosting.Host.CreateApplicationBuilder()
+                    .UseOrleans(siloBuilder =>
                     {
                         siloBuilder
                             .UseLocalhostClustering(siloPort, gatewayPort)
diff --git a/test/NonSilo.Tests/ClientBuilderTests.cs b/test/NonSilo.Tests/ClientBuilderTests.cs
index 46c76a1581..d2ac437b07 100644
--- a/test/NonSilo.Tests/ClientBuilderTests.cs
+++ b/test/NonSilo.Tests/ClientBuilderTests.cs
@@ -174,7 +174,7 @@ public void ClientBuilder_ServiceProviderTest()
             Assert.Throws<ArgumentNullException>(() => hostBuilder.ConfigureServices(null));
 
             var registeredFirst = new int[1];
-            
+
             var one = new MyService { Id = 1 };
             hostBuilder.ConfigureServices(
                 services =>
@@ -196,7 +196,7 @@ public void ClientBuilder_ServiceProviderTest()
             var client = host.Services.GetRequiredService<IClusterClient>();
             var services = client.ServiceProvider.GetServices<MyService>()?.ToList();
             Assert.NotNull(services);
-            
+
             // Both services should be registered.
             Assert.Equal(2, services.Count);
             Assert.NotNull(services.FirstOrDefault(svc => svc.Id == 1));
@@ -226,6 +226,23 @@ public void ClientBuilderThrowsDuringStartupIfSiloBuildersAdded()
             });
         }
 
+        [Fact]
+        public void ClientBuilderWithHotApplicationBuilderThrowsDuringStartupIfSiloBuildersAdded()
+        {
+            Assert.Throws<OrleansConfigurationException>(() =>
+            {
+                _ = Host.CreateApplicationBuilder()
+                    .UseOrleans(siloBuilder =>
+                    {
+                        siloBuilder.UseLocalhostClustering();
+                    })
+                    .UseOrleansClient(clientBuilder =>
+                    {
+                        clientBuilder.UseLocalhostClustering();
+                    });
+            });
+        }
+
         private static void RemoveConfigValidators(IServiceCollection services)
         {
             var validators = services.Where(descriptor => descriptor.ServiceType == typeof(IConfigurationValidator)).ToList();
diff --git a/test/NonSilo.Tests/SiloBuilderTests.cs b/test/NonSilo.Tests/SiloBuilderTests.cs
index 7a748b8a8d..b874de3810 100644
--- a/test/NonSilo.Tests/SiloBuilderTests.cs
+++ b/test/NonSilo.Tests/SiloBuilderTests.cs
@@ -201,6 +201,23 @@ public void SiloBuilderThrowsDuringStartupIfClientBuildersAdded()
             });
         }
 
+        [Fact]
+        public void SiloBuilderWithHotApplicationBuilderThrowsDuringStartupIfClientBuildersAdded()
+        {
+            Assert.Throws<OrleansConfigurationException>(() =>
+            {
+                _ = Host.CreateApplicationBuilder()
+                    .UseOrleansClient(clientBuilder =>
+                    {
+                        clientBuilder.UseLocalhostClustering();
+                    })
+                    .UseOrleans(siloBuilder =>
+                    {
+                        siloBuilder.UseLocalhostClustering();
+                    });
+            });
+        }
+
         private class FakeHostEnvironmentStatistics : IHostEnvironmentStatistics
         {
             public long? TotalPhysicalMemory => 0;