diff --git a/enginetest/queries/information_schema_queries.go b/enginetest/queries/information_schema_queries.go
index 70a5258f8a..4b9f3aedc9 100644
--- a/enginetest/queries/information_schema_queries.go
+++ b/enginetest/queries/information_schema_queries.go
@@ -1775,6 +1775,26 @@ from information_schema.routines where routine_schema = 'mydb' and routine_type
 			},
 		},
 	},
+	{
+		Name: "information_schema.columns in expression uses info schema collation",
+		SetUpScript: []string{
+			"create table TEST (COL int);",
+		},
+		Assertions: []ScriptTestAssertion{
+			{
+				Query: "select table_schema, table_name, column_name table_comment from information_schema.columns where (table_name, column_name) in (('TEST', 'COL'));",
+				Expected: []sql.Row{
+					{"mydb", "TEST", "COL"},
+				},
+			},
+			{
+				Query: "select table_schema, table_name, column_name table_comment from information_schema.columns where (table_name, column_name) in (('test', 'col'));",
+				Expected: []sql.Row{
+					{"mydb", "TEST", "COL"},
+				},
+			},
+		},
+	},
 }
 
 var SkippedInfoSchemaScripts = []ScriptTest{
diff --git a/enginetest/queries/script_queries.go b/enginetest/queries/script_queries.go
index 682ae79fd8..476ebcbfad 100644
--- a/enginetest/queries/script_queries.go
+++ b/enginetest/queries/script_queries.go
@@ -7143,7 +7143,6 @@ where
 			},
 		},
 	},
-
 	{
 		Name: "unix_timestamp script tests",
 		SetUpScript: []string{
@@ -7174,7 +7173,6 @@ where
 			},
 		},
 	},
-
 	{
 		Name: "name_const queries",
 		SetUpScript: []string{
@@ -7258,6 +7256,31 @@ where
 			},
 		},
 	},
+	{
+		Name: "mismatched collation using hash in tuples",
+		SetUpScript: []string{
+			"create table t (t1 text collate utf8mb4_0900_bin, t2 text collate utf8mb4_0900_ai_ci)",
+			"insert into t values ('ABC', 'DEF')",
+		},
+		Assertions: []ScriptTestAssertion{
+			{
+				Query: "select * from t where (t1, t2) in (('ABC', 'DEF'));",
+				Expected: []sql.Row{
+					{"ABC", "DEF"},
+				},
+			},
+			{
+				Query: "select * from t where (t1, t2) in (('ABC', 'def'));",
+				Expected: []sql.Row{
+					{"ABC", "DEF"},
+				},
+			},
+			{
+				Query:    "select * from t where (t1, t2) in (('abc', 'DEF'));",
+				Expected: []sql.Row{},
+			},
+		},
+	},
 }
 
 var SpatialScriptTests = []ScriptTest{
diff --git a/sql/expression/in.go b/sql/expression/in.go
index d9c695fa42..f648f9816f 100644
--- a/sql/expression/in.go
+++ b/sql/expression/in.go
@@ -253,7 +253,19 @@ func hashOfSimple(ctx *sql.Context, i interface{}, t sql.Type) (uint64, error) {
 
 	var str string
 	coll := sql.Collation_Default
-	if types.IsTextOnly(t) {
+	if types.IsTuple(t) {
+		tup := i.([]interface{})
+		tupType := t.(types.TupleType)
+		hashes := make([]uint64, len(tup))
+		for idx, v := range tup {
+			h, err := hashOfSimple(ctx, v, tupType[idx])
+			if err != nil {
+				return 0, err
+			}
+			hashes[idx] = h
+		}
+		str = fmt.Sprintf("%v", hashes)
+	} else if types.IsTextOnly(t) {
 		coll = t.(sql.StringType).Collation()
 		if s, ok := i.(string); ok {
 			str = s
diff --git a/sql/expression/in_test.go b/sql/expression/in_test.go
index 3f1267e72e..af3bef9592 100644
--- a/sql/expression/in_test.go
+++ b/sql/expression/in_test.go
@@ -414,6 +414,23 @@ func TestHashInTuple(t *testing.T) {
 			nil,
 			nil,
 		},
+		{
+			"heterogeneous collations with nested",
+			expression.NewTuple(
+				expression.NewLiteral("ABC", types.MustCreateString(sqltypes.VarChar, 20, sql.Collation_Default)),
+				expression.NewLiteral("def", types.MustCreateString(sqltypes.VarChar, 20, sql.Collation_utf8mb4_0900_ai_ci)),
+			),
+			expression.NewTuple(
+				expression.NewTuple(
+					expression.NewLiteral("ABC", types.MustCreateString(sqltypes.VarChar, 20, sql.Collation_Default)),
+					expression.NewLiteral("DEF", types.MustCreateString(sqltypes.VarChar, 20, sql.Collation_Default)),
+				),
+			),
+			nil,
+			true,
+			nil,
+			nil,
+		},
 		{
 			"left get field tuple is in right",
 			expression.NewTuple(