diff --git a/Libraries/Text/RCTTextAttributes.m b/Libraries/Text/RCTTextAttributes.m
index 01131cfb20e2fb..2bf3816b852c19 100644
--- a/Libraries/Text/RCTTextAttributes.m
+++ b/Libraries/Text/RCTTextAttributes.m
@@ -192,14 +192,52 @@ - (NSParagraphStyle *)effectiveParagraphStyle
 
 - (UIFont *)effectiveFont
 {
-  // FIXME: RCTFont has thread-safety issues and must be rewritten.
-  return [RCTFont updateFont:nil
-                  withFamily:_fontFamily
-                        size:@(isnan(_fontSize) ? 0 : _fontSize)
-                      weight:_fontWeight
-                       style:_fontStyle
-                     variant:_fontVariant
-             scaleMultiplier:self.effectiveFontSizeMultiplier];
+  NSArray *rawFontFamilies = [_fontFamily componentsSeparatedByString:@","];
+
+  // If _fontFamily is nil or has a single fontFamily, then use the original RN logic.
+  if (rawFontFamilies.count <= 1) {
+    // FIXME: RCTFont has thread-safety issues and must be rewritten.
+    return [RCTFont updateFont:nil
+                    withFamily:_fontFamily
+                          size:@(isnan(_fontSize) ? 0 : _fontSize)
+                        weight:_fontWeight
+                         style:_fontStyle
+                       variant:_fontVariant
+               scaleMultiplier:self.effectiveFontSizeMultiplier];
+  }
+
+  NSMutableArray *fonts = [NSMutableArray new];
+  for (NSString *rawFontFamily in rawFontFamilies) {
+    NSString *fontFamily = [rawFontFamily stringByTrimmingCharactersInSet:[NSCharacterSet whitespaceCharacterSet]];
+    if (fontFamily.length == 0) {
+      continue;
+    }
+
+    UIFont *font = [RCTFont updateFont:nil
+                            withFamily:fontFamily
+                                  size:@(isnan(_fontSize) ? 0 : _fontSize)
+                                weight:_fontWeight
+                                 style:_fontStyle
+                               variant:_fontVariant
+                       scaleMultiplier:self.effectiveFontSizeMultiplier];
+
+    if (font) {
+      [fonts addObject:font];
+    }
+  }
+
+  UIFont *primaryFont = fonts[0];
+
+  NSMutableArray *fontDescriptors = [NSMutableArray new];
+  for (NSUInteger i = 1; i < fonts.count; i++) {
+    UIFont *font = fonts[i];
+    [fontDescriptors addObject:font.fontDescriptor];
+  }
+
+  UIFontDescriptor *fontDescriptor = [primaryFont.fontDescriptor fontDescriptorByAddingAttributes:
+                                      @{UIFontDescriptorCascadeListAttribute: fontDescriptors}];
+
+  return [UIFont fontWithDescriptor:fontDescriptor size:primaryFont.pointSize];
 }
 
 - (CGFloat)effectiveFontSizeMultiplier
diff --git a/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java b/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
index 02800eeda895b8..0ea17b3b52cda6 100644
--- a/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
+++ b/ReactAndroid/src/main/java/com/facebook/react/modules/accessibilityinfo/AccessibilityInfoModule.java
@@ -108,9 +108,10 @@ public String getName() {
 
   @TargetApi(Build.VERSION_CODES.LOLLIPOP)
   private boolean getIsReduceMotionEnabledValue() {
-    float defaultAnimationScale = Float.parseFloat(Settings.Global.TRANSITION_ANIMATION_SCALE);
-    float animationScale = Settings.Global.getFloat(mContentResolver, defaultAnimationScale);
-    return animationScale == 0f;
+    String value =
+        Settings.Global.getString(mContentResolver, Settings.Global.TRANSITION_ANIMATION_SCALE);
+
+    return value != null && value.equals("0.0");
   }
 
   @Override
diff --git a/ReactAndroid/src/main/java/com/facebook/react/views/text/ReactFontManager.java b/ReactAndroid/src/main/java/com/facebook/react/views/text/ReactFontManager.java
index d81490fd82cb25..35d8c41fda8207 100644
--- a/ReactAndroid/src/main/java/com/facebook/react/views/text/ReactFontManager.java
+++ b/ReactAndroid/src/main/java/com/facebook/react/views/text/ReactFontManager.java
@@ -10,11 +10,19 @@
 import android.content.Context;
 import android.content.res.AssetManager;
 import android.graphics.Typeface;
+import android.graphics.fonts.Font;
+import android.graphics.fonts.FontFamily;
+import android.os.Build;
 import android.util.SparseArray;
 import androidx.annotation.Nullable;
+import androidx.annotation.RequiresApi;
 import androidx.core.content.res.ResourcesCompat;
 import com.facebook.infer.annotation.Nullsafe;
+
+import java.io.IOException;
+import java.util.ArrayList;
 import java.util.HashMap;
+import java.util.List;
 import java.util.Map;
 
 /**
@@ -132,6 +140,28 @@ public void setTypeface(String fontFamilyName, int style, Typeface typeface) {
 
   private static Typeface createAssetTypeface(
       String fontFamilyName, int style, AssetManager assetManager) {
+    // This logic attempts to safely check if the frontend code is attempting to use
+    // fallback fonts, and if it is, to use the fallback typeface creation logic.
+    String[] fontFamilyNames = fontFamilyName != null ? fontFamilyName.split(",") : null;
+    if (fontFamilyNames != null) {
+      for (int i = 0; i < fontFamilyNames.length; i++) {
+        fontFamilyNames[i] = fontFamilyNames[i].trim();
+      }
+    }
+
+    // If there are multiple font family names:
+    //   For newer versions of Android, construct a Typeface with fallbacks
+    //   For older versions of Android, ignore all the fallbacks and just use the first font family
+    if (fontFamilyNames != null && fontFamilyNames.length > 1) {
+      if (Build.VERSION.SDK_INT >= Build.VERSION_CODES.Q) {
+        return createAssetTypefaceWithFallbacks(fontFamilyNames, style, assetManager);
+      } else {
+        fontFamilyName = fontFamilyNames[0];
+      }
+    }
+
+    // Lastly, after all those checks above, this is the original RN logic for
+    // getting the typeface.
     String extension = EXTENSIONS[style];
     for (String fileExtension : FILE_EXTENSIONS) {
       String fileName =
@@ -151,6 +181,44 @@ private static Typeface createAssetTypeface(
     return Typeface.create(fontFamilyName, style);
   }
 
+  @RequiresApi(api = Build.VERSION_CODES.Q)
+  private static Typeface createAssetTypefaceWithFallbacks(
+    String[] fontFamilyNames, int style, AssetManager assetManager) {
+    List<FontFamily> fontFamilies = new ArrayList<>();
+
+    // Iterate over the list of fontFamilyNames, constructing new FontFamily objects
+    // for use in the CustomFallbackBuilder below.
+    for (String fontFamilyName : fontFamilyNames) {
+      String extension = EXTENSIONS[style];
+      for (String fileExtension : FILE_EXTENSIONS) {
+        String fileName =
+          new StringBuilder()
+            .append(FONTS_ASSET_PATH)
+            .append(fontFamilyName)
+            .append(extension)
+            .append(fileExtension)
+            .toString();
+        try {
+          Font font = new Font.Builder(assetManager, fileName).build();
+          FontFamily family = new FontFamily.Builder(font).build();
+          fontFamilies.add(family);
+        } catch (RuntimeException e) {
+          // If the typeface asset does not exist, try another extension.
+          continue;
+        } catch (IOException e) {
+          // If the font asset does not exist, try another extension.
+          continue;
+        }
+      }
+    }
+
+    Typeface.CustomFallbackBuilder fallbackBuilder = new Typeface.CustomFallbackBuilder(fontFamilies.get(0));
+    for (int i = 1; i < fontFamilies.size(); i++) {
+      fallbackBuilder.addCustomFallback(fontFamilies.get(i));
+    }
+    return fallbackBuilder.build();
+  }
+
   /** Responsible for caching typefaces for each custom font family. */
   private static class AssetFontFamily {