diff --git a/lib/galaxy/webapps/base/api.py b/lib/galaxy/webapps/base/api.py
index 22793c85550b..3da3ba3d3900 100644
--- a/lib/galaxy/webapps/base/api.py
+++ b/lib/galaxy/webapps/base/api.py
@@ -201,7 +201,8 @@ async def message_exception_middleware(request: Request, exc: MessageException)
         # Intentionally not logging traceback here as the full context will be
         # dispatched to Sentry if configured.  This just makes logs less opaque
         # when one sees a 500.
-        log.info(f"MessageException: {exc}")
+        if exc.status_code >= 500:
+            log.info(f"MessageException: {exc}")
         return get_error_response_for_request(request, exc)