diff --git a/nix/default-s390x.nix b/nix/default-s390x.nix
index dc80f08688..3be20a055d 100644
--- a/nix/default-s390x.nix
+++ b/nix/default-s390x.nix
@@ -1,6 +1,9 @@
 (import ./nixpkgs.nix {
   crossSystem = {
-    config = "s390x-unknown-linux-gnu";
+    # TODO: Switch back to glibc when
+    # https://github.com/NixOS/nixpkgs/issues/306473
+    # is resolved.
+    config = "s390x-unknown-linux-musl";
   };
   overlays = [ (import ./overlay.nix) ];
 }).callPackage ./derivation.nix
diff --git a/nix/derivation.nix b/nix/derivation.nix
index a77993f29a..0b8aa0dd02 100644
--- a/nix/derivation.nix
+++ b/nix/derivation.nix
@@ -7,7 +7,7 @@ with pkgs; rustPlatform.buildRustPackage {
     capnproto
     protobuf
   ];
-  buildInputs = [
+  buildInputs = lib.optionals (!stdenv.hostPlatform.isMusl) [
     glibc
     glibc.static
   ];