diff --git a/pkg/sql/alter_table.go b/pkg/sql/alter_table.go
index 8f59047dd1bc..10cb850f01b5 100644
--- a/pkg/sql/alter_table.go
+++ b/pkg/sql/alter_table.go
@@ -1104,6 +1104,9 @@ func sanitizeColumnExpression(
 		return nil, "", pgerror.WithCandidateCode(err, pgcode.DatatypeMismatch)
 	}
 
+	if err := funcdesc.MaybeFailOnUDFUsage(typedExpr, context, p.EvalContext().Settings.Version.ActiveVersionOrEmpty(p.ctx)); err != nil {
+		return nil, "", err
+	}
 	s := tree.Serialize(typedExpr)
 	return typedExpr, s, nil
 }
diff --git a/pkg/sql/logictest/testdata/logic_test/udf b/pkg/sql/logictest/testdata/logic_test/udf
index b72789945a2e..0d74816297af 100644
--- a/pkg/sql/logictest/testdata/logic_test/udf
+++ b/pkg/sql/logictest/testdata/logic_test/udf
@@ -583,6 +583,12 @@ ALTER TABLE test_tbl_t ADD COLUMN c int DEFAULT (test_tbl_f());
 statement error pq: unimplemented: usage of user-defined function from relations not supported
 ALTER TABLE test_tbl_t ADD COLUMN c int ON UPDATE (test_tbl_f());
 
+statement error pq: unimplemented: usage of user-defined function from relations not supported
+ALTER TABLE test_tbl_t ALTER COLUMN b SET DEFAULT (test_tbl_f());
+
+statement error pq: unimplemented: usage of user-defined function from relations not supported
+ALTER TABLE test_tbl_t ALTER COLUMN b SET ON UPDATE (test_tbl_f());
+
 subtest disallow_udf_in_views_and_udf
 
 statement ok