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<!doctype html>
<html>
<head>
<meta name="viewport" content="width=device-width, initial-scale=1">
<title>5: Know Your Body Buddies</title>
<meta name="description" content="">
<meta name="keywords" content="">
<link rel="stylesheet" href="style.css">
<link rel="icon" type="image/x-icon" href="img/favicon.svg">
<link href="https://fonts.googleapis.com/css2?family=Cutive&display=swap" rel="stylesheet">
<link href="https://fonts.googleapis.com/css2?family=Inter:wght@500;700;800&display=swap" rel="stylesheet">
<!-- Google tag (gtag.js) -->
<script async src="https://www.googletagmanager.com/gtag/js?id=G-E1811WRJJD"></script>
<script>
window.dataLayer = window.dataLayer || [];
function gtag() {
dataLayer.push(arguments);
}
gtag('js', new Date());
gtag('config', 'G-E1811WRJJD');
</script>
</head>
<body id="two" class="story5section2">
<!-- section top -->
<section class="scrollynav">
<a href="index.html"><img draggable="false" src="img/UI Assets/navlogo.svg" class="navlogo"></a>
<div class="dropdown">
<button class="dropbtn"><img draggable="false" src="img/UI Assets/navhamburger.svg" class="navmenu">
<i class="fa fa-caret-down"></i>
</button>
<div class="dropdown-content">
<a href="story1.html"><img src="img/UI Assets/count1.svg" style="vertical-align:middle"> What
Is An HRA?</a>
<a href="story2.html"><img src="img/UI Assets/count2.svg"
style="vertical-align:middle"> Squiggy's Identity Crisis!</a>
<a href="story3.html"> <img src="img/UI Assets/count3.svg"
style="vertical-align:middle"> Something's NOT Registering!</a>
<hr>
<a href="https://humanatlas.io/" target="_blank"><img src="img/UI Assets/nav_logo.svg"
style="vertical-align:middle"> Human Reference Atlas</a>
<a href="https://apps.humanatlas.io/" target="_blank"><img src="img/UI Assets/nav_apps.svg"
style="vertical-align:middle"> App Library</a>
</div>
</div>
</section>
<!-- section header/intro -->
<section class="intro" id="intro" style="background-color:white;">
<h3 class="overtext" id="introTypeLine"></h3>
<div class="fadeimage">
<img src="img/2-bodyintro1.png">
<img src="img/2-bodyintro2.png" class="picture2 imagepart">
<img src="img/telescope.svg" class="picture3 imagepart" style="width:140px;">
</div>
</section>
<section class="section1">
<div class="container" style="left:20px;">
This is the story of two of them: Squiggy and CeCe.
</div>
</section>
<section class="section1">
<div class="container2 introline" style="left:20px;">
<p>On this week's episode: </p>
<h1 style="font-size: 1.6em;">Know Your Body Buddies</h1>
<p class="descriptionsection">In which our heroes vanquish social anxiety, gain an extra dimension, and
learn that it takes all types of cells to make a body!
</p>
<div class="popupsection">
<img class="introlineimg introcharcece" src="img/popup5left.svg" style="width:12%;">
<img class="introlineimg introcharsquiggy" src="img/popup5right.svg" style="width:10%;">
</div>
</div>
</section>
<section class="section2">
<div class="scene5-1">
<img src="img/5sign.svg" id="sign" class="imageparts">
<img src="img/5move1.svg" id="move1" class="imageparts">
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> You know, CeCe, I don't usually like to travel, but I do like our
visits to the kidneys to see our new friend Mac.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> You said it, Squig old buddy! And I love it that Mac decided to finally
get to know his local community by throwing a tissue block party.
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5 "><b>Squiggy:</b> I'm just so happy he's finally gotten over his shyness and is out
meeting new cells!
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-2"></div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Not so fast, Squig. Something tells me that Mac might not quite be over
his social anxiety yet!
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5 "><b>Squiggy:</b> Uh, Mac, is that you?
</div>
</div>
<div class="talkbubble">
<div class="mactalk"><b>Mac:</b> Oh, drat! I've been discovered!
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Mac, why are you in that ridiculous disguise? Aren't you supposed to be
hosting a tissue block party?
</div>
</div>
<div class="talkbubble">
<div class="mactalk "><b>Mac:</b> But that's the problem! I had just started getting ready when I was hit by
a number of disturbing questions.
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-3">
<img src="img/5bubble1.svg" id="bubble1" class="imageparts"
style="width:40%; left: 32%;top:10%;max-width: 500px;min-width: 100px;">
</div>
<div class="talkbubble" id="showbubble1">
<div class="mactalk2 "><b>Mac:</b> Who were these cells that all lived on my tissue block? What did they do?
What were they like? What could we talk about?
</div>
</div>
<div class="talkbubble">
<div class="mactalk2 "><b>Mac:</b> In short, my friends, I suddenly realized I did not know who lives around
me.
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-35"></div>
<div class="talkbubble">
<div class="squiggytalk6" id="showbubble2"><b>Squiggy:</b> That's not a problem, Mac. How about the three of
us go door-to-door and meet everyone one at a time?
</div>
</div>
<div class="talkbubble">
<div class="cecetalk6"><b>CeCe:</b> No can do, Squiggy. Depending upon the size of Mac's tissue block and
its location in the kidney, there could be millions of cells!
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-4"></div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Aargh! That's way too much walking!
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Don't lose your ribosomes, Squiggy. I think I know something that will
help us out.
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Oooh, I bet it has something to do with the Human Reference Atlas.
</div>
</div>
<div class="talkbubble">
<div class="mactalk"><b>Mac:</b> What makes you say that, Squiggy?
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Exploring the HRA is kind of our thing, Mac.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Right you are, Squig! We're going to use the HRA to help Mac get to know
his community.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Follow me!
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-5"></div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> We just have to jump down here!
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Let's go!
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-6">
<img src="img/5falling.svg" class="falling5">
</div>
<div class="talkbubble" id="scrollupto1">
<div style="top: -30%;position: relative;">And so down they went...
</div>
</div>
<div class="talkbubble">
</div>
<div class="talkbubble">
</div>
<div class="scene5-7" id="scrollto0">
<div class="vid">
<img src="img/uparrowbutton.svg" class="toparrowbutton" id="toparrow1" onclick="scrollup1()">
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<div class="scene5-8"></div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Hey, I remember this place from the time we rescued that lost
tissue block! Isn't this the RUI?
</div>
<div id="scrollto1"></div>
</div>
<div style="height: 20vh;background-color: black;"></div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> That's right, and this RUI, or Registration User Interface, is where our
story begins.
</div>
</div>
<div class="talkbubble">
<div class="mactalk"><b>Mac:</b> That's the kidney! That's where I live!
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5" id="scrollupto2"><b>CeCe:</b> And if I'm not mistaken, your tissue block is right
here.
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-9" id="scrollto2">
<div class="vid">
<img src="img/uparrowbutton.svg" class="toparrowbutton" id="toparrow2" onclick="scrollup2()">
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<div class="talkbubble">
<div class="mactalk"><b>Mac:</b> Exactly!</div>
</div>
<div style="height: 20vh;background-color: black;"></div>
<div id="scrollto3"></div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Alright, let's place Mac's tissue block in the correct location on the
3D reference organ.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5" id="scrollupto3"><b>CeCe:</b> When we do that, we'll see a list of the anatomical
structures within
the kidney that the tissue block collides with.
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-11" id="scrollto4">
<div class="vid">
<img src="img/uparrowbutton.svg" class="toparrowbutton" id="toparrow3" onclick="scrollup3()">
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<div class="scene5-12"></div>
<div class="talkbubble">
<div class="mactalk2" style="top:18%;"><b>Mac:</b> Are you saying that the tissue block where I live
intersects all of those
anatomical structures?
</div>
</div>
<div style="height:20vh;background-color: black;"></div>
<div id="scrollto5"></div>
<div class="talkbubble">
<div class="cecetalk5" style="top:18%;"><b>CeCe:</b> That's exactly what I'm saying. So it's a good idea
to
learn a bit more
about them.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5" style="top:18%;"><b>CeCe:</b> The HRA has already collected quite a bit of
information about these
anatomical structures from experimental datasets.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5" style="top:18%;"><b>CeCe:</b> Experimental datasets are tissue data from healthy
donors for which
it
is possible to derive cell counts.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5" id="scrollupto4" style="top:18%;"><b>CeCe:</b> These datasets are typically found in
scholarly
papers
or in online
collections of data, which are called portals.
</div>
</div>
<div class="talkbubble">
</div>
<div class="scene5-13" id="scrollto6">
<div class="vid">
<img src="img/uparrowbutton.svg" class="toparrowbutton" id="toparrow4" onclick="scrollup4()">
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<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Now, if you add all that data to the spatial data collected when
researchers register tissue samples using the RUI, then we get a pretty good sense of which cell
types
appear in a given organ.
</div>
</div>
<div style="height: 20vh;background-color: black;"></div>
<div id="scrollto7"></div>
<div class="talkbubble">
<div class="cecetalk5" id="scrollupto5"><b>CeCe:</b> We can even get an estimation of where in the organ
they appear. And
that estimation gets more accurate the more data is collected from studies and tissue registration.
</div>
</div>
<div class="talkbubble">
</div>
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</div>
<div class="scene5-16"></div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> For instance, Mac, we see that in your area of the kidney—which
researchers call the “renal pyramid”—these cell types make up the general population.
</div>
</div>
<div class="talkbubble">
<div class="mactalk2"><b>Mac:</b> Wow, that's so many cell types to learn about! I'm overwhelmed!
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> I can't believe I'm the one saying this, Mac, but you really
need
to relax.
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Just pick a cell type with a high population and start from
there.
It looks like there are quite a few inner medullary collecting duct cells.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> Squiggy's right, Mac. Why don't you start with those and work your
way
through all the large populations.
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> You can learn about a cell type's structure, its function, its
relation
to other cells…all that cool stuff.
</div>
</div>
<div class="talkbubble">
<div class="mactalk2"><b>Mac:</b> Yes, that does sound interesting. But for the purposes of my block
party,
I
just want to know which cell types play pickleball and which prefer badminton!
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5"><b>Squiggy:</b> Don't worry Mac, we'll help you learn all about cell types AND
help you set up for your party. Let's get started!
</div>
</div>
<div class="talkbubble">
<div class="cecetalk5"><b>CeCe:</b> OK, but let's say "goodbye" to our readers.
</div>
</div>
<div class="talkbubble">
<div class="squiggytalk5" id="scrollupto6"><b>Squiggy:</b> Bye, everyone! See you next time!
</div>
</div>
<div class="talkbubble">
</div>
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