diff --git a/DataFormats/SoATemplate/interface/SoALayout.h b/DataFormats/SoATemplate/interface/SoALayout.h
index 3e5a53cd83097..97e7fa3dc2979 100644
--- a/DataFormats/SoATemplate/interface/SoALayout.h
+++ b/DataFormats/SoATemplate/interface/SoALayout.h
@@ -493,10 +493,17 @@
       _ITERATE_ON_ALL(_DEFINE_METADATA_MEMBERS, ~, __VA_ARGS__)                                                        \
                                                                                                                        \
       struct value_element {                                                                                           \
-        SOA_HOST_DEVICE SOA_INLINE value_element(                                                                      \
-          _ITERATE_ON_ALL_COMMA(_VALUE_ELEMENT_CTOR_ARGS, ~, __VA_ARGS__)                                              \
-        ) :                                                                                                            \
-          _ITERATE_ON_ALL_COMMA(_VALUE_ELEMENT_INITIALIZERS, ~, __VA_ARGS__)                                           \
+        SOA_HOST_DEVICE SOA_INLINE value_element                                                                       \
+          BOOST_PP_IF(                                                                                                 \
+            BOOST_PP_SEQ_SIZE(_ITERATE_ON_ALL(_VALUE_ELEMENT_CTOR_ARGS, ~, __VA_ARGS__) ),                             \
+            (_ITERATE_ON_ALL_COMMA(_VALUE_ELEMENT_CTOR_ARGS, ~, __VA_ARGS__)):,                                        \
+            ())                                                                                                        \
+          BOOST_PP_TUPLE_ENUM(BOOST_PP_IF(                                                                             \
+            BOOST_PP_SEQ_SIZE(_ITERATE_ON_ALL(_VALUE_ELEMENT_CTOR_ARGS, ~, __VA_ARGS__)),                              \
+            BOOST_PP_SEQ_TO_TUPLE(_ITERATE_ON_ALL(_VALUE_ELEMENT_INITIALIZERS, ~, __VA_ARGS__)),                       \
+            ()                                                                                                         \
+          )                                                                                                            \
+        )                                                                                                              \
         {}                                                                                                             \
                                                                                                                        \
         _ITERATE_ON_ALL(_DEFINE_VALUE_ELEMENT_MEMBERS, ~, __VA_ARGS__)                                                 \
diff --git a/DataFormats/SoATemplate/test/SoALayoutAndView_t.cu b/DataFormats/SoATemplate/test/SoALayoutAndView_t.cu
index 34dda3bd7a803..d8a92a56bf37a 100644
--- a/DataFormats/SoATemplate/test/SoALayoutAndView_t.cu
+++ b/DataFormats/SoATemplate/test/SoALayoutAndView_t.cu
@@ -67,6 +67,11 @@ GENERATE_SOA_VIEW(SoAFullDeviceConstViewTemplate,
 using SoAFullDeviceView =
     SoAFullDeviceViewTemplate<cms::soa::CacheLineSize::NvidiaGPU, cms::soa::AlignmentEnforcement::enforced>;
 
+// These SoAs validate that the generating macros do not get confused in the special case where there are
+// no columns and only scalar elements in the SoA.
+GENERATE_SOA_LAYOUT(TestSoALayoutNoColumn, SOA_SCALAR(double, r))
+GENERATE_SOA_LAYOUT(TestSoALayoutNoColumn2, SOA_SCALAR(double, r), SOA_SCALAR(double, r2))
+
 // Eigen cross product kernel (on store)
 __global__ void crossProduct(SoAHostDeviceView soa, const unsigned int numElements) {
   int i = blockIdx.x * blockDim.x + threadIdx.x;
diff --git a/DataFormats/SoATemplate/test/SoALayoutAndView_t.hip.cc b/DataFormats/SoATemplate/test/SoALayoutAndView_t.hip.cc
index a70b9fb1d933b..a1cadfd0bd6c2 100644
--- a/DataFormats/SoATemplate/test/SoALayoutAndView_t.hip.cc
+++ b/DataFormats/SoATemplate/test/SoALayoutAndView_t.hip.cc
@@ -69,6 +69,12 @@ GENERATE_SOA_VIEW(SoAFullDeviceConstViewTemplate,
 using SoAFullDeviceView =
     SoAFullDeviceViewTemplate<cms::soa::CacheLineSize::NvidiaGPU, cms::soa::AlignmentEnforcement::enforced>;
 
+
+// These SoAs validate that the generating macros do not get confused in the special case where there are
+// no columns and only scalar elements in the SoA.
+GENERATE_SOA_LAYOUT(TestSoALayoutNoColumn, SOA_SCALAR(double, r))
+GENERATE_SOA_LAYOUT(TestSoALayoutNoColumn2, SOA_SCALAR(double, r), SOA_SCALAR(double, r2))
+
 // Eigen cross product kernel (on store)
 __global__ void crossProduct(SoAHostDeviceView soa, const int numElements) {
   int i = blockIdx.x * blockDim.x + threadIdx.x;