diff --git a/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap b/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
index 8f56202c3fa7..e5300d832539 100644
--- a/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
+++ b/packages/react/__tests__/__snapshots__/PublicAPI-test.js.snap
@@ -4038,6 +4038,9 @@ Map {
       "defaultOpen": Object {
         "type": "bool",
       },
+      "disabled": Object {
+        "type": "bool",
+      },
       "enterDelayMs": Object {
         "type": "number",
       },
diff --git a/packages/react/src/components/DataTable/__tests__/__snapshots__/DataTable-test.js.snap b/packages/react/src/components/DataTable/__tests__/__snapshots__/DataTable-test.js.snap
index 6064206bfa3f..51ccc84c448e 100644
--- a/packages/react/src/components/DataTable/__tests__/__snapshots__/DataTable-test.js.snap
+++ b/packages/react/src/components/DataTable/__tests__/__snapshots__/DataTable-test.js.snap
@@ -546,34 +546,38 @@ exports[`DataTable behaves as expected selection should render and match snapsho
           <span
             class="cds--popover-container cds--popover--caret cds--popover--high-contrast cds--popover--top cds--tooltip cds--icon-tooltip"
           >
-            <button
-              aria-expanded="false"
-              aria-haspopup="true"
-              aria-labelledby="tooltip-73"
-              class="cds--btn--icon-only cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
-              title="Settings"
-              type="button"
+            <div
+              class="cds--tooltip-trigger__wrapper"
             >
-              <svg
-                aria-label="Settings"
-                class="cds--overflow-menu__icon"
-                fill="currentColor"
-                focusable="false"
-                height="16"
-                preserveAspectRatio="xMidYMid meet"
-                role="img"
-                viewBox="0 0 16 16"
-                width="16"
-                xmlns="http://www.w3.org/2000/svg"
+              <button
+                aria-expanded="false"
+                aria-haspopup="true"
+                aria-labelledby="tooltip-73"
+                class="cds--btn--icon-only cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
+                title="Settings"
+                type="button"
               >
-                <path
-                  d="M13.5,8.4c0-0.1,0-0.3,0-0.4c0-0.1,0-0.3,0-0.4l1-0.8c0.4-0.3,0.4-0.9,0.2-1.3l-1.2-2C13.3,3.2,13,3,12.6,3 c-0.1,0-0.2,0-0.3,0.1l-1.2,0.4c-0.2-0.1-0.4-0.3-0.7-0.4l-0.3-1.3C10.1,1.3,9.7,1,9.2,1H6.8c-0.5,0-0.9,0.3-1,0.8L5.6,3.1 C5.3,3.2,5.1,3.3,4.9,3.4L3.7,3C3.6,3,3.5,3,3.4,3C3,3,2.7,3.2,2.5,3.5l-1.2,2C1.1,5.9,1.2,6.4,1.6,6.8l0.9,0.9c0,0.1,0,0.3,0,0.4 c0,0.1,0,0.3,0,0.4L1.6,9.2c-0.4,0.3-0.5,0.9-0.2,1.3l1.2,2C2.7,12.8,3,13,3.4,13c0.1,0,0.2,0,0.3-0.1l1.2-0.4 c0.2,0.1,0.4,0.3,0.7,0.4l0.3,1.3c0.1,0.5,0.5,0.8,1,0.8h2.4c0.5,0,0.9-0.3,1-0.8l0.3-1.3c0.2-0.1,0.4-0.2,0.7-0.4l1.2,0.4 c0.1,0,0.2,0.1,0.3,0.1c0.4,0,0.7-0.2,0.9-0.5l1.1-2c0.2-0.4,0.2-0.9-0.2-1.3L13.5,8.4z M12.6,12l-1.7-0.6c-0.4,0.3-0.9,0.6-1.4,0.8 L9.2,14H6.8l-0.4-1.8c-0.5-0.2-0.9-0.5-1.4-0.8L3.4,12l-1.2-2l1.4-1.2c-0.1-0.5-0.1-1.1,0-1.6L2.2,6l1.2-2l1.7,0.6 C5.5,4.2,6,4,6.5,3.8L6.8,2h2.4l0.4,1.8c0.5,0.2,0.9,0.5,1.4,0.8L12.6,4l1.2,2l-1.4,1.2c0.1,0.5,0.1,1.1,0,1.6l1.4,1.2L12.6,12z"
-                />
-                <path
-                  d="M8,11c-1.7,0-3-1.3-3-3s1.3-3,3-3s3,1.3,3,3C11,9.6,9.7,11,8,11C8,11,8,11,8,11z M8,6C6.9,6,6,6.8,6,7.9C6,7.9,6,8,6,8 c0,1.1,0.8,2,1.9,2c0,0,0.1,0,0.1,0c1.1,0,2-0.8,2-1.9c0,0,0-0.1,0-0.1C10,6.9,9.2,6,8,6C8.1,6,8,6,8,6z"
-                />
-              </svg>
-            </button>
+                <svg
+                  aria-label="Settings"
+                  class="cds--overflow-menu__icon"
+                  fill="currentColor"
+                  focusable="false"
+                  height="16"
+                  preserveAspectRatio="xMidYMid meet"
+                  role="img"
+                  viewBox="0 0 16 16"
+                  width="16"
+                  xmlns="http://www.w3.org/2000/svg"
+                >
+                  <path
+                    d="M13.5,8.4c0-0.1,0-0.3,0-0.4c0-0.1,0-0.3,0-0.4l1-0.8c0.4-0.3,0.4-0.9,0.2-1.3l-1.2-2C13.3,3.2,13,3,12.6,3 c-0.1,0-0.2,0-0.3,0.1l-1.2,0.4c-0.2-0.1-0.4-0.3-0.7-0.4l-0.3-1.3C10.1,1.3,9.7,1,9.2,1H6.8c-0.5,0-0.9,0.3-1,0.8L5.6,3.1 C5.3,3.2,5.1,3.3,4.9,3.4L3.7,3C3.6,3,3.5,3,3.4,3C3,3,2.7,3.2,2.5,3.5l-1.2,2C1.1,5.9,1.2,6.4,1.6,6.8l0.9,0.9c0,0.1,0,0.3,0,0.4 c0,0.1,0,0.3,0,0.4L1.6,9.2c-0.4,0.3-0.5,0.9-0.2,1.3l1.2,2C2.7,12.8,3,13,3.4,13c0.1,0,0.2,0,0.3-0.1l1.2-0.4 c0.2,0.1,0.4,0.3,0.7,0.4l0.3,1.3c0.1,0.5,0.5,0.8,1,0.8h2.4c0.5,0,0.9-0.3,1-0.8l0.3-1.3c0.2-0.1,0.4-0.2,0.7-0.4l1.2,0.4 c0.1,0,0.2,0.1,0.3,0.1c0.4,0,0.7-0.2,0.9-0.5l1.1-2c0.2-0.4,0.2-0.9-0.2-1.3L13.5,8.4z M12.6,12l-1.7-0.6c-0.4,0.3-0.9,0.6-1.4,0.8 L9.2,14H6.8l-0.4-1.8c-0.5-0.2-0.9-0.5-1.4-0.8L3.4,12l-1.2-2l1.4-1.2c-0.1-0.5-0.1-1.1,0-1.6L2.2,6l1.2-2l1.7,0.6 C5.5,4.2,6,4,6.5,3.8L6.8,2h2.4l0.4,1.8c0.5,0.2,0.9,0.5,1.4,0.8L12.6,4l1.2,2l-1.4,1.2c0.1,0.5,0.1,1.1,0,1.6l1.4,1.2L12.6,12z"
+                  />
+                  <path
+                    d="M8,11c-1.7,0-3-1.3-3-3s1.3-3,3-3s3,1.3,3,3C11,9.6,9.7,11,8,11C8,11,8,11,8,11z M8,6C6.9,6,6,6.8,6,7.9C6,7.9,6,8,6,8 c0,1.1,0.8,2,1.9,2c0,0,0.1,0,0.1,0c1.1,0,2-0.8,2-1.9c0,0,0-0.1,0-0.1C10,6.9,9.2,6,8,6C8.1,6,8,6,8,6z"
+                  />
+                </svg>
+              </button>
+            </div>
             <span
               aria-hidden="true"
               class="cds--popover"
@@ -948,34 +952,38 @@ exports[`DataTable renders as expected - Component API should render and match s
           <span
             class="cds--popover-container cds--popover--caret cds--popover--high-contrast cds--popover--top cds--tooltip cds--icon-tooltip"
           >
-            <button
-              aria-expanded="false"
-              aria-haspopup="true"
-              aria-labelledby="tooltip-18"
-              class="cds--btn--icon-only cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
-              title="Settings"
-              type="button"
+            <div
+              class="cds--tooltip-trigger__wrapper"
             >
-              <svg
-                aria-label="Settings"
-                class="cds--overflow-menu__icon"
-                fill="currentColor"
-                focusable="false"
-                height="16"
-                preserveAspectRatio="xMidYMid meet"
-                role="img"
-                viewBox="0 0 16 16"
-                width="16"
-                xmlns="http://www.w3.org/2000/svg"
+              <button
+                aria-expanded="false"
+                aria-haspopup="true"
+                aria-labelledby="tooltip-18"
+                class="cds--btn--icon-only cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
+                title="Settings"
+                type="button"
               >
-                <path
-                  d="M13.5,8.4c0-0.1,0-0.3,0-0.4c0-0.1,0-0.3,0-0.4l1-0.8c0.4-0.3,0.4-0.9,0.2-1.3l-1.2-2C13.3,3.2,13,3,12.6,3 c-0.1,0-0.2,0-0.3,0.1l-1.2,0.4c-0.2-0.1-0.4-0.3-0.7-0.4l-0.3-1.3C10.1,1.3,9.7,1,9.2,1H6.8c-0.5,0-0.9,0.3-1,0.8L5.6,3.1 C5.3,3.2,5.1,3.3,4.9,3.4L3.7,3C3.6,3,3.5,3,3.4,3C3,3,2.7,3.2,2.5,3.5l-1.2,2C1.1,5.9,1.2,6.4,1.6,6.8l0.9,0.9c0,0.1,0,0.3,0,0.4 c0,0.1,0,0.3,0,0.4L1.6,9.2c-0.4,0.3-0.5,0.9-0.2,1.3l1.2,2C2.7,12.8,3,13,3.4,13c0.1,0,0.2,0,0.3-0.1l1.2-0.4 c0.2,0.1,0.4,0.3,0.7,0.4l0.3,1.3c0.1,0.5,0.5,0.8,1,0.8h2.4c0.5,0,0.9-0.3,1-0.8l0.3-1.3c0.2-0.1,0.4-0.2,0.7-0.4l1.2,0.4 c0.1,0,0.2,0.1,0.3,0.1c0.4,0,0.7-0.2,0.9-0.5l1.1-2c0.2-0.4,0.2-0.9-0.2-1.3L13.5,8.4z M12.6,12l-1.7-0.6c-0.4,0.3-0.9,0.6-1.4,0.8 L9.2,14H6.8l-0.4-1.8c-0.5-0.2-0.9-0.5-1.4-0.8L3.4,12l-1.2-2l1.4-1.2c-0.1-0.5-0.1-1.1,0-1.6L2.2,6l1.2-2l1.7,0.6 C5.5,4.2,6,4,6.5,3.8L6.8,2h2.4l0.4,1.8c0.5,0.2,0.9,0.5,1.4,0.8L12.6,4l1.2,2l-1.4,1.2c0.1,0.5,0.1,1.1,0,1.6l1.4,1.2L12.6,12z"
-                />
-                <path
-                  d="M8,11c-1.7,0-3-1.3-3-3s1.3-3,3-3s3,1.3,3,3C11,9.6,9.7,11,8,11C8,11,8,11,8,11z M8,6C6.9,6,6,6.8,6,7.9C6,7.9,6,8,6,8 c0,1.1,0.8,2,1.9,2c0,0,0.1,0,0.1,0c1.1,0,2-0.8,2-1.9c0,0,0-0.1,0-0.1C10,6.9,9.2,6,8,6C8.1,6,8,6,8,6z"
-                />
-              </svg>
-            </button>
+                <svg
+                  aria-label="Settings"
+                  class="cds--overflow-menu__icon"
+                  fill="currentColor"
+                  focusable="false"
+                  height="16"
+                  preserveAspectRatio="xMidYMid meet"
+                  role="img"
+                  viewBox="0 0 16 16"
+                  width="16"
+                  xmlns="http://www.w3.org/2000/svg"
+                >
+                  <path
+                    d="M13.5,8.4c0-0.1,0-0.3,0-0.4c0-0.1,0-0.3,0-0.4l1-0.8c0.4-0.3,0.4-0.9,0.2-1.3l-1.2-2C13.3,3.2,13,3,12.6,3 c-0.1,0-0.2,0-0.3,0.1l-1.2,0.4c-0.2-0.1-0.4-0.3-0.7-0.4l-0.3-1.3C10.1,1.3,9.7,1,9.2,1H6.8c-0.5,0-0.9,0.3-1,0.8L5.6,3.1 C5.3,3.2,5.1,3.3,4.9,3.4L3.7,3C3.6,3,3.5,3,3.4,3C3,3,2.7,3.2,2.5,3.5l-1.2,2C1.1,5.9,1.2,6.4,1.6,6.8l0.9,0.9c0,0.1,0,0.3,0,0.4 c0,0.1,0,0.3,0,0.4L1.6,9.2c-0.4,0.3-0.5,0.9-0.2,1.3l1.2,2C2.7,12.8,3,13,3.4,13c0.1,0,0.2,0,0.3-0.1l1.2-0.4 c0.2,0.1,0.4,0.3,0.7,0.4l0.3,1.3c0.1,0.5,0.5,0.8,1,0.8h2.4c0.5,0,0.9-0.3,1-0.8l0.3-1.3c0.2-0.1,0.4-0.2,0.7-0.4l1.2,0.4 c0.1,0,0.2,0.1,0.3,0.1c0.4,0,0.7-0.2,0.9-0.5l1.1-2c0.2-0.4,0.2-0.9-0.2-1.3L13.5,8.4z M12.6,12l-1.7-0.6c-0.4,0.3-0.9,0.6-1.4,0.8 L9.2,14H6.8l-0.4-1.8c-0.5-0.2-0.9-0.5-1.4-0.8L3.4,12l-1.2-2l1.4-1.2c-0.1-0.5-0.1-1.1,0-1.6L2.2,6l1.2-2l1.7,0.6 C5.5,4.2,6,4,6.5,3.8L6.8,2h2.4l0.4,1.8c0.5,0.2,0.9,0.5,1.4,0.8L12.6,4l1.2,2l-1.4,1.2c0.1,0.5,0.1,1.1,0,1.6l1.4,1.2L12.6,12z"
+                  />
+                  <path
+                    d="M8,11c-1.7,0-3-1.3-3-3s1.3-3,3-3s3,1.3,3,3C11,9.6,9.7,11,8,11C8,11,8,11,8,11z M8,6C6.9,6,6,6.8,6,7.9C6,7.9,6,8,6,8 c0,1.1,0.8,2,1.9,2c0,0,0.1,0,0.1,0c1.1,0,2-0.8,2-1.9c0,0,0-0.1,0-0.1C10,6.9,9.2,6,8,6C8.1,6,8,6,8,6z"
+                  />
+                </svg>
+              </button>
+            </div>
             <span
               aria-hidden="true"
               class="cds--popover"
diff --git a/packages/react/src/components/DataTable/__tests__/__snapshots__/TableToolbarMenu-test.js.snap b/packages/react/src/components/DataTable/__tests__/__snapshots__/TableToolbarMenu-test.js.snap
index 86e495ca02a5..063b05def8a3 100644
--- a/packages/react/src/components/DataTable/__tests__/__snapshots__/TableToolbarMenu-test.js.snap
+++ b/packages/react/src/components/DataTable/__tests__/__snapshots__/TableToolbarMenu-test.js.snap
@@ -8,31 +8,35 @@ exports[`TableToolbarMenu renders as expected - Component API should render 1`]
     <span
       class="cds--popover-container cds--popover--caret cds--popover--high-contrast cds--popover--top cds--tooltip cds--icon-tooltip"
     >
-      <button
-        aria-expanded="false"
-        aria-haspopup="true"
-        aria-labelledby="tooltip-2"
-        class="cds--btn--icon-only custom-class cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
-        title="Add"
-        type="button"
+      <div
+        class="cds--tooltip-trigger__wrapper"
       >
-        <svg
-          aria-label="Add"
-          class="cds--overflow-menu__icon"
-          fill="currentColor"
-          focusable="false"
-          height="16"
-          preserveAspectRatio="xMidYMid meet"
-          role="img"
-          viewBox="0 0 16 16"
-          width="16"
-          xmlns="http://www.w3.org/2000/svg"
+        <button
+          aria-expanded="false"
+          aria-haspopup="true"
+          aria-labelledby="tooltip-2"
+          class="cds--btn--icon-only custom-class cds--toolbar-action cds--overflow-menu cds--overflow-menu cds--overflow-menu--md cds--btn cds--btn--md cds--layout--size-md cds--btn--primary"
+          title="Add"
+          type="button"
         >
-          <path
-            d="M13 7L12.3 6.3 8.5 10.1 8.5 1 7.5 1 7.5 10.1 3.7 6.3 3 7 8 12zM13 12v2H3v-2H2v2l0 0c0 .6.4 1 1 1h10c.6 0 1-.4 1-1l0 0v-2H13z"
-          />
-        </svg>
-      </button>
+          <svg
+            aria-label="Add"
+            class="cds--overflow-menu__icon"
+            fill="currentColor"
+            focusable="false"
+            height="16"
+            preserveAspectRatio="xMidYMid meet"
+            role="img"
+            viewBox="0 0 16 16"
+            width="16"
+            xmlns="http://www.w3.org/2000/svg"
+          >
+            <path
+              d="M13 7L12.3 6.3 8.5 10.1 8.5 1 7.5 1 7.5 10.1 3.7 6.3 3 7 8 12zM13 12v2H3v-2H2v2l0 0c0 .6.4 1 1 1h10c.6 0 1-.4 1-1l0 0v-2H13z"
+            />
+          </svg>
+        </button>
+      </div>
       <span
         aria-hidden="true"
         class="cds--popover"
diff --git a/packages/react/src/components/IconButton/index.js b/packages/react/src/components/IconButton/index.js
index 06d54a47cc69..d2ea8fd506a2 100644
--- a/packages/react/src/components/IconButton/index.js
+++ b/packages/react/src/components/IconButton/index.js
@@ -20,6 +20,7 @@ const IconButton = React.forwardRef(function IconButton(props, ref) {
     className,
     closeOnActivation = true,
     defaultOpen = false,
+    disabled,
     enterDelayMs,
     kind,
     label,
@@ -30,7 +31,9 @@ const IconButton = React.forwardRef(function IconButton(props, ref) {
   } = props;
   const prefix = usePrefix();
 
-  const tooltipClasses = classNames(wrapperClasses, `${prefix}--icon-tooltip`);
+  const tooltipClasses = classNames(wrapperClasses, `${prefix}--icon-tooltip`, {
+    [`${prefix}--icon-tooltip--disabled`]: disabled,
+  });
 
   return (
     <Tooltip
@@ -43,6 +46,7 @@ const IconButton = React.forwardRef(function IconButton(props, ref) {
       leaveDelayMs={leaveDelayMs}>
       <Button
         {...rest}
+        disabled={disabled}
         kind={kind}
         ref={ref}
         size={size}
@@ -88,6 +92,11 @@ IconButton.propTypes = {
    */
   defaultOpen: PropTypes.bool,
 
+  /**
+   * Specify whether the Button should be disabled, or not
+   */
+  disabled: PropTypes.bool,
+
   /**
    * Specify the duration in milliseconds to delay before displaying the tooltip
    */
diff --git a/packages/react/src/components/Tooltip/Tooltip.tsx b/packages/react/src/components/Tooltip/Tooltip.tsx
index b6b2033860c5..064b6cc33300 100644
--- a/packages/react/src/components/Tooltip/Tooltip.tsx
+++ b/packages/react/src/components/Tooltip/Tooltip.tsx
@@ -186,12 +186,14 @@ function Tooltip<T extends React.ElementType>({
       onMouseLeave={onMouseLeave}
       open={open}
       ref={containerRef}>
-      {child !== undefined
-        ? React.cloneElement(child, {
-            ...triggerProps,
-            ...getChildEventHandlers(child.props),
-          })
-        : null}
+      <div className={`${prefix}--tooltip-trigger__wrapper`}>
+        {child !== undefined
+          ? React.cloneElement(child, {
+              ...triggerProps,
+              ...getChildEventHandlers(child.props),
+            })
+          : null}
+      </div>
       <PopoverContent
         aria-hidden="true"
         className={`${prefix}--tooltip-content`}
diff --git a/packages/styles/scss/components/button/_button.scss b/packages/styles/scss/components/button/_button.scss
index 574cfc8a831d..0bf002e13a38 100644
--- a/packages/styles/scss/components/button/_button.scss
+++ b/packages/styles/scss/components/button/_button.scss
@@ -198,6 +198,16 @@
     cursor: not-allowed;
   }
 
+  // Workaround to ensure onMouseEnter events fire when moving
+  // from a disabled button to a non-disabled button (#13815)
+  .#{$prefix}--icon-tooltip--disabled .#{$prefix}--tooltip-trigger__wrapper {
+    cursor: not-allowed;
+  }
+
+  .#{$prefix}--icon-tooltip--disabled .#{$prefix}--btn--icon-only[disabled] {
+    pointer-events: none;
+  }
+
   .#{$prefix}--btn--danger {
     @include button-theme(
       $button-danger-primary,