diff --git a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI-docs.json b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI-docs.json
index a88b7a9ab2e..491e0aff186 100644
--- a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI-docs.json
+++ b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI-docs.json
@@ -2506,6 +2506,26 @@
         }
       }
     },
+    "IntergenicConsequenceSummary": {
+      "type": "object",
+      "properties": {
+        "consequenceTerms": {
+          "type": "array",
+          "items": {
+            "type": "string"
+          }
+        },
+        "impact": {
+          "type": "string"
+        },
+        "variantAllele": {
+          "type": "string"
+        },
+        "variantClassification": {
+          "type": "string"
+        }
+      }
+    },
     "IntergenicConsequences": {
       "type": "object",
       "required": [
@@ -2554,124 +2574,32 @@
     },
     "MutationAssessor": {
       "type": "object",
-      "required": [
-        "input"
-      ],
       "properties": {
-        "codonStartPosition": {
-          "type": "string",
-          "description": "Codon start position"
-        },
-        "cosmicCount": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Number of mutations in COSMIC for this protein"
-        },
-        "functionalImpact": {
-          "type": "string",
-          "description": "Functional impact"
+        "functionalImpactPrediction": {
+          "type": "string"
         },
         "functionalImpactScore": {
           "type": "number",
           "format": "double",
           "description": "Functional impact score"
         },
-        "hgvs": {
+        "hgvspShort": {
           "type": "string"
         },
-        "hugoSymbol": {
-          "type": "string",
-          "description": "Hugo gene symbol"
-        },
-        "input": {
-          "type": "string",
-          "description": "User-input variants"
-        },
-        "mappingIssue": {
-          "type": "string",
-          "description": "Mapping issue info"
-        },
-        "msaGaps": {
-          "type": "number",
-          "format": "double",
-          "description": "Portion of gaps in variant position in multiple sequence alignment"
-        },
-        "msaHeight": {
+        "mav": {
           "type": "integer",
-          "format": "int32",
-          "description": "Number of diverse sequences in multiple sequence alignment (identical or highly similar sequences filtered out)"
-        },
-        "msaLink": {
-          "type": "string",
-          "description": "Link to multiple sequence alignment"
-        },
-        "pdbLink": {
-          "type": "string",
-          "description": "Link to 3d structure browser"
-        },
-        "referenceGenomeVariant": {
-          "type": "string",
-          "description": "Reference genome variant"
-        },
-        "referenceGenomeVariantType": {
-          "type": "string",
-          "description": "Reference genome variant type"
-        },
-        "refseqId": {
-          "type": "string",
-          "description": "Refseq protein ID"
-        },
-        "refseqPosition": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Variant position in Refseq protein, can be different from the one in Uniprot"
+          "format": "int32"
         },
-        "refseqResidue": {
-          "type": "string",
-          "description": "Reference residue in Refseq protein, can be different from the one in Uniprot"
+        "msa": {
+          "type": "string"
         },
-        "snpCount": {
+        "sv": {
           "type": "integer",
-          "format": "int32",
-          "description": "Number of SNPs in dbSNP for this protein"
+          "format": "int32"
         },
         "uniprotId": {
           "type": "string",
           "description": "Uniprot protein accession ID"
-        },
-        "uniprotPosition": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Variant position in Uniprot protein, can be different from the one in Refseq"
-        },
-        "uniprotResidue": {
-          "type": "string",
-          "description": "Reference residue in Uniprot protein, can be different from the one in Refseq"
-        },
-        "variant": {
-          "type": "string",
-          "description": "Amino acid substitution"
-        },
-        "variantConservationScore": {
-          "type": "number",
-          "format": "double",
-          "description": "Variant conservation score"
-        },
-        "variantSpecificityScore": {
-          "type": "number",
-          "format": "double",
-          "description": "Variant specificity score"
-        }
-      }
-    },
-    "MutationAssessorAnnotation": {
-      "type": "object",
-      "properties": {
-        "annotation": {
-          "$ref": "#/definitions/MutationAssessor"
-        },
-        "license": {
-          "type": "string"
         }
       }
     },
@@ -3676,8 +3604,8 @@
           "description": "Most severe consequence"
         },
         "mutation_assessor": {
-          "description": "Mutation Assessor Annotation",
-          "$ref": "#/definitions/MutationAssessorAnnotation"
+          "description": "Mutation Assessor",
+          "$ref": "#/definitions/MutationAssessor"
         },
         "my_variant_info": {
           "description": "My Variant Info Annotation",
@@ -3758,6 +3686,12 @@
           "description": "Genomic location",
           "$ref": "#/definitions/GenomicLocation"
         },
+        "intergenicConsequenceSummaries": {
+          "type": "array",
+          "items": {
+            "$ref": "#/definitions/IntergenicConsequenceSummary"
+          }
+        },
         "strandSign": {
           "type": "string",
           "description": "Strand (- or +)"
diff --git a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI.ts b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI.ts
index 44367862cc5..bf182857798 100644
--- a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI.ts
+++ b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPI.ts
@@ -483,6 +483,16 @@ export type IntegerRange = {
 
         'start': number
 
+};
+export type IntergenicConsequenceSummary = {
+    'consequenceTerms': Array < string >
+
+        'impact': string
+
+        'variantAllele': string
+
+        'variantClassification': string
+
 };
 export type IntergenicConsequences = {
     'impact': string
@@ -501,60 +511,20 @@ export type MainType = {
 
 };
 export type MutationAssessor = {
-    'codonStartPosition': string
-
-        'cosmicCount': number
-
-        'functionalImpact': string
+    'functionalImpactPrediction': string
 
         'functionalImpactScore': number
 
-        'hgvs': string
-
-        'hugoSymbol': string
-
-        'input': string
-
-        'mappingIssue': string
-
-        'msaGaps': number
-
-        'msaHeight': number
-
-        'msaLink': string
-
-        'pdbLink': string
-
-        'referenceGenomeVariant': string
-
-        'referenceGenomeVariantType': string
-
-        'refseqId': string
+        'hgvspShort': string
 
-        'refseqPosition': number
+        'mav': number
 
-        'refseqResidue': string
+        'msa': string
 
-        'snpCount': number
+        'sv': number
 
         'uniprotId': string
 
-        'uniprotPosition': number
-
-        'uniprotResidue': string
-
-        'variant': string
-
-        'variantConservationScore': number
-
-        'variantSpecificityScore': number
-
-};
-export type MutationAssessorAnnotation = {
-    'annotation': MutationAssessor
-
-        'license': string
-
 };
 export type MutationEffectResp = {
     'citations': Citations
@@ -1008,7 +978,7 @@ export type VariantAnnotation = {
 
         'most_severe_consequence': string
 
-        'mutation_assessor': MutationAssessorAnnotation
+        'mutation_assessor': MutationAssessor
 
         'my_variant_info': MyVariantInfoAnnotation
 
@@ -1044,6 +1014,8 @@ export type VariantAnnotationSummary = {
 
         'genomicLocation': GenomicLocation
 
+        'intergenicConsequenceSummaries': Array < IntergenicConsequenceSummary >
+
         'strandSign': string
 
         'transcriptConsequenceSummaries': Array < TranscriptConsequenceSummary >
diff --git a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal-docs.json b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal-docs.json
index 01071225578..59a139f7e9e 100644
--- a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal-docs.json
+++ b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal-docs.json
@@ -469,7 +469,7 @@
           "mutation-assessor-controller"
         ],
         "summary": "Retrieves mutation assessor information for the provided list of variants",
-        "operationId": "postMutationAssessorAnnotation",
+        "operationId": "postMutationAssessor",
         "consumes": [
           "application/json"
         ],
@@ -509,7 +509,7 @@
           "mutation-assessor-controller"
         ],
         "summary": "Retrieves mutation assessor information for the provided list of variants",
-        "operationId": "fetchMutationAssessorAnnotationGET",
+        "operationId": "fetchMutationAssessorGET",
         "consumes": [
           "application/json"
         ],
@@ -1650,115 +1650,54 @@
         }
       }
     },
-    "MutationAssessor": {
+    "IntergenicConsequenceSummary": {
       "type": "object",
-      "required": [
-        "input"
-      ],
       "properties": {
-        "codonStartPosition": {
-          "type": "string",
-          "description": "Codon start position"
+        "consequenceTerms": {
+          "type": "array",
+          "items": {
+            "type": "string"
+          }
         },
-        "cosmicCount": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Number of mutations in COSMIC for this protein"
+        "impact": {
+          "type": "string"
         },
-        "functionalImpact": {
-          "type": "string",
-          "description": "Functional impact"
+        "variantAllele": {
+          "type": "string"
+        },
+        "variantClassification": {
+          "type": "string"
+        }
+      }
+    },
+    "MutationAssessor": {
+      "type": "object",
+      "properties": {
+        "functionalImpactPrediction": {
+          "type": "string"
         },
         "functionalImpactScore": {
           "type": "number",
           "format": "double",
           "description": "Functional impact score"
         },
-        "hgvs": {
+        "hgvspShort": {
           "type": "string"
         },
-        "hugoSymbol": {
-          "type": "string",
-          "description": "Hugo gene symbol"
-        },
-        "input": {
-          "type": "string",
-          "description": "User-input variants"
-        },
-        "mappingIssue": {
-          "type": "string",
-          "description": "Mapping issue info"
-        },
-        "msaGaps": {
-          "type": "number",
-          "format": "double",
-          "description": "Portion of gaps in variant position in multiple sequence alignment"
-        },
-        "msaHeight": {
+        "mav": {
           "type": "integer",
-          "format": "int32",
-          "description": "Number of diverse sequences in multiple sequence alignment (identical or highly similar sequences filtered out)"
-        },
-        "msaLink": {
-          "type": "string",
-          "description": "Link to multiple sequence alignment"
-        },
-        "pdbLink": {
-          "type": "string",
-          "description": "Link to 3d structure browser"
-        },
-        "referenceGenomeVariant": {
-          "type": "string",
-          "description": "Reference genome variant"
-        },
-        "referenceGenomeVariantType": {
-          "type": "string",
-          "description": "Reference genome variant type"
-        },
-        "refseqId": {
-          "type": "string",
-          "description": "Refseq protein ID"
-        },
-        "refseqPosition": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Variant position in Refseq protein, can be different from the one in Uniprot"
+          "format": "int32"
         },
-        "refseqResidue": {
-          "type": "string",
-          "description": "Reference residue in Refseq protein, can be different from the one in Uniprot"
+        "msa": {
+          "type": "string"
         },
-        "snpCount": {
+        "sv": {
           "type": "integer",
-          "format": "int32",
-          "description": "Number of SNPs in dbSNP for this protein"
+          "format": "int32"
         },
         "uniprotId": {
           "type": "string",
           "description": "Uniprot protein accession ID"
-        },
-        "uniprotPosition": {
-          "type": "integer",
-          "format": "int32",
-          "description": "Variant position in Uniprot protein, can be different from the one in Refseq"
-        },
-        "uniprotResidue": {
-          "type": "string",
-          "description": "Reference residue in Uniprot protein, can be different from the one in Refseq"
-        },
-        "variant": {
-          "type": "string",
-          "description": "Amino acid substitution"
-        },
-        "variantConservationScore": {
-          "type": "number",
-          "format": "double",
-          "description": "Variant conservation score"
-        },
-        "variantSpecificityScore": {
-          "type": "number",
-          "format": "double",
-          "description": "Variant specificity score"
         }
       }
     },
@@ -2336,6 +2275,12 @@
           "description": "Genomic location",
           "$ref": "#/definitions/GenomicLocation"
         },
+        "intergenicConsequenceSummaries": {
+          "type": "array",
+          "items": {
+            "$ref": "#/definitions/IntergenicConsequenceSummary"
+          }
+        },
         "strandSign": {
           "type": "string",
           "description": "Strand (- or +)"
diff --git a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal.ts b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal.ts
index ca2ac86b0e0..1617b9c1883 100644
--- a/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal.ts
+++ b/packages/genome-nexus-ts-api-client/src/generated/GenomeNexusAPIInternal.ts
@@ -303,55 +303,31 @@ export type IntegerRange = {
         'start': number
 
 };
-export type MutationAssessor = {
-    'codonStartPosition': string
-
-        'cosmicCount': number
+export type IntergenicConsequenceSummary = {
+    'consequenceTerms': Array < string >
 
-        'functionalImpact': string
-
-        'functionalImpactScore': number
+        'impact': string
 
-        'hgvs': string
-
-        'hugoSymbol': string
-
-        'input': string
-
-        'mappingIssue': string
-
-        'msaGaps': number
-
-        'msaHeight': number
-
-        'msaLink': string
+        'variantAllele': string
 
-        'pdbLink': string
+        'variantClassification': string
 
-        'referenceGenomeVariant': string
+};
+export type MutationAssessor = {
+    'functionalImpactPrediction': string
 
-        'referenceGenomeVariantType': string
+        'functionalImpactScore': number
 
-        'refseqId': string
+        'hgvspShort': string
 
-        'refseqPosition': number
+        'mav': number
 
-        'refseqResidue': string
+        'msa': string
 
-        'snpCount': number
+        'sv': number
 
         'uniprotId': string
 
-        'uniprotPosition': number
-
-        'uniprotResidue': string
-
-        'variant': string
-
-        'variantConservationScore': number
-
-        'variantSpecificityScore': number
-
 };
 export type Mutdb = {
     'alt': string
@@ -602,6 +578,8 @@ export type VariantAnnotationSummary = {
 
         'genomicLocation': GenomicLocation
 
+        'intergenicConsequenceSummaries': Array < IntergenicConsequenceSummary >
+
         'strandSign': string
 
         'transcriptConsequenceSummaries': Array < TranscriptConsequenceSummary >
@@ -1543,7 +1521,7 @@ export default class GenomeNexusAPIInternal {
             return response.body;
         });
     };
-    postMutationAssessorAnnotationURL(parameters: {
+    postMutationAssessorURL(parameters: {
         'variants': Array < string > ,
         $queryParameters ? : any
     }): string {
@@ -1563,10 +1541,10 @@ export default class GenomeNexusAPIInternal {
     /**
      * Retrieves mutation assessor information for the provided list of variants
      * @method
-     * @name GenomeNexusAPIInternal#postMutationAssessorAnnotation
+     * @name GenomeNexusAPIInternal#postMutationAssessor
      * @param {} variants - List of variants. For example ["7:g.140453136A>T","12:g.25398285C>A"]
      */
-    postMutationAssessorAnnotationWithHttpInfo(parameters: {
+    postMutationAssessorWithHttpInfo(parameters: {
         'variants': Array < string > ,
         $queryParameters ? : any,
         $domain ? : string
@@ -1607,20 +1585,20 @@ export default class GenomeNexusAPIInternal {
     /**
      * Retrieves mutation assessor information for the provided list of variants
      * @method
-     * @name GenomeNexusAPIInternal#postMutationAssessorAnnotation
+     * @name GenomeNexusAPIInternal#postMutationAssessor
      * @param {} variants - List of variants. For example ["7:g.140453136A>T","12:g.25398285C>A"]
      */
-    postMutationAssessorAnnotation(parameters: {
+    postMutationAssessor(parameters: {
             'variants': Array < string > ,
             $queryParameters ? : any,
             $domain ? : string
         }): Promise < Array < MutationAssessor >
         > {
-            return this.postMutationAssessorAnnotationWithHttpInfo(parameters).then(function(response: request.Response) {
+            return this.postMutationAssessorWithHttpInfo(parameters).then(function(response: request.Response) {
                 return response.body;
             });
         };
-    fetchMutationAssessorAnnotationGETURL(parameters: {
+    fetchMutationAssessorGETURL(parameters: {
         'variant': string,
         $queryParameters ? : any
     }): string {
@@ -1642,10 +1620,10 @@ export default class GenomeNexusAPIInternal {
     /**
      * Retrieves mutation assessor information for the provided list of variants
      * @method
-     * @name GenomeNexusAPIInternal#fetchMutationAssessorAnnotationGET
+     * @name GenomeNexusAPIInternal#fetchMutationAssessorGET
      * @param {string} variant - A variant. For example 7:g.140453136A>T
      */
-    fetchMutationAssessorAnnotationGETWithHttpInfo(parameters: {
+    fetchMutationAssessorGETWithHttpInfo(parameters: {
         'variant': string,
         $queryParameters ? : any,
         $domain ? : string
@@ -1684,15 +1662,15 @@ export default class GenomeNexusAPIInternal {
     /**
      * Retrieves mutation assessor information for the provided list of variants
      * @method
-     * @name GenomeNexusAPIInternal#fetchMutationAssessorAnnotationGET
+     * @name GenomeNexusAPIInternal#fetchMutationAssessorGET
      * @param {string} variant - A variant. For example 7:g.140453136A>T
      */
-    fetchMutationAssessorAnnotationGET(parameters: {
+    fetchMutationAssessorGET(parameters: {
         'variant': string,
         $queryParameters ? : any,
         $domain ? : string
     }): Promise < MutationAssessor > {
-        return this.fetchMutationAssessorAnnotationGETWithHttpInfo(parameters).then(function(response: request.Response) {
+        return this.fetchMutationAssessorGETWithHttpInfo(parameters).then(function(response: request.Response) {
             return response.body;
         });
     };
diff --git a/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx b/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
index 342a982c845..63fe6274dca 100644
--- a/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
+++ b/packages/react-variant-view/src/component/functionalPrediction/FunctionalPrediction.tsx
@@ -30,10 +30,7 @@ class FunctionalPrediction extends React.Component<IFunctionalPredictionProps> {
     public getData(
         genomeNexusData: VariantAnnotation | undefined
     ): IFunctionalImpactData {
-        const mutationAssessor =
-            genomeNexusData &&
-            genomeNexusData.mutation_assessor &&
-            genomeNexusData.mutation_assessor.annotation;
+        const mutationAssessor = genomeNexusData?.mutation_assessor;
         const siftScore =
             genomeNexusData &&
             genomeNexusData.transcript_consequences &&
diff --git a/packages/react-variant-view/src/component/functionalPrediction/MutationAssessor.tsx b/packages/react-variant-view/src/component/functionalPrediction/MutationAssessor.tsx
index f66039d6e2d..9f97b7c656c 100644
--- a/packages/react-variant-view/src/component/functionalPrediction/MutationAssessor.tsx
+++ b/packages/react-variant-view/src/component/functionalPrediction/MutationAssessor.tsx
@@ -27,25 +27,32 @@ export default class MutationAssessor extends React.Component<
     IMutationAssessorProps,
     {}
 > {
-    private static MUTATION_ASSESSOR_URL: string =
-        'http://mutationassessor.org/r3/';
+    // TODO Change to new url when manuscript is available
+    // New url will need to be added in tooltip, discrption, "Please refer to the score range here." and "Go to Mutation Assessor"
+    // private static MUTATION_ASSESSOR_URL: string = 'http://mutationassessor.org/r3/';
 
     private static mutationAssessorText() {
         return (
-            <div style={{ width: 450, height: 110 }}>
-                <a
-                    href={MutationAssessor.MUTATION_ASSESSOR_URL}
-                    target="_blank"
-                    rel="noopener noreferrer"
-                >
-                    Mutation Assessor
-                </a>{' '}
-                predicts the functional impact of amino-acid substitutions in
-                proteins, such as mutations discovered in cancer or missense
-                polymorphisms. The functional impact is assessed based on
-                evolutionary conservation of the affected amino acid in protein
-                homologs. The method has been validated on a large set (60k) of
-                disease associated (OMIM) and polymorphic variants.
+            <div style={{ width: 450, height: 130 }}>
+                Mutation Assessor predicts the functional impact of amino-acid
+                substitutions in proteins, such as mutations discovered in
+                cancer or missense polymorphisms. The functional impact is
+                assessed based on evolutionary conservation of the affected
+                amino acid in protein homologs. The method has been validated on
+                a large set of disease associated and polymorphic variants (
+                <a href="https://www.ncbi.nlm.nih.gov/clinvar/" target="_blank">
+                    ClinVar
+                </a>
+                ).
+                <br />
+                <b>
+                    Mutation Assessor V4 data is now available in the portal!
+                </b>{' '}
+                New manuscript is in progress. Click{` `}
+                <a href="http://mutationassessor.org/r3/" target="_blank">
+                    here
+                </a>
+                {` `} to see information about V3 data.
             </div>
         );
     }
@@ -143,24 +150,6 @@ export default class MutationAssessor extends React.Component<
         );
     }
 
-    // This is mostly to make the legacy MA links work
-    private static maLink(link: string | undefined) {
-        let url = null;
-
-        // ignore invalid links ("", "NA", "Not Available")
-        if (link) {
-            // getma.org is the legacy link, need to replace it with the actual value
-            url = link.replace('getma.org', 'mutationassessor.org/r3');
-
-            // prepend "http://" if needed
-            if (url.indexOf('http://') !== 0) {
-                url = `http://${url}`;
-            }
-        }
-
-        return url;
-    }
-
     constructor(props: IMutationAssessorProps) {
         super(props);
 
@@ -169,21 +158,13 @@ export default class MutationAssessor extends React.Component<
 
     public render() {
         let maContent: JSX.Element = <span />;
-        const dataSource = (
-            <>
-                Mutation Assessor&nbsp;
-                <i className="fas fa-external-link-alt" />
-                {!this.props.isCanonicalTranscriptSelected && <span> *</span>}
-            </>
-        );
-
         if (
             this.props.mutationAssessor &&
-            this.props.mutationAssessor.functionalImpact != null &&
-            this.props.mutationAssessor.functionalImpact !== ''
+            this.props.mutationAssessor.functionalImpactPrediction != null &&
+            this.props.mutationAssessor.functionalImpactPrediction !== ''
         ) {
             const maData = this.props.mutationAssessor;
-            maContent = <span>{maData.functionalImpact}</span>;
+            maContent = <span>{maData.functionalImpactPrediction}</span>;
         } else {
             maContent = <span>N/A</span>;
         }
@@ -192,25 +173,19 @@ export default class MutationAssessor extends React.Component<
             <div className={featureTableStyle['feature-table-layout']}>
                 <div className={featureTableStyle['data-source']}>
                     {this.mutationAssessorTooltip(
-                        <a
-                            href={MutationAssessor.MUTATION_ASSESSOR_URL}
-                            target="_blank"
-                            rel="noopener noreferrer"
-                        >
-                            {dataSource}
-                        </a>
+                        <>
+                            Mutation Assessor&nbsp;
+                            <i className="fas fa-external-link-alt" />
+                            {!this.props.isCanonicalTranscriptSelected && (
+                                <span> *</span>
+                            )}
+                        </>
                     )}
                 </div>
                 <div>
                     {this.mutationAssessorTooltip(
                         <span className={featureTableStyle['data-with-link']}>
-                            <a
-                                href={MutationAssessor.MUTATION_ASSESSOR_URL}
-                                target="_blank"
-                                rel="noopener noreferrer"
-                            >
-                                {maContent}
-                            </a>
+                            {maContent}
                         </span>
                     )}
                 </div>
@@ -221,12 +196,7 @@ export default class MutationAssessor extends React.Component<
     private mutationAssessorData() {
         if (this.props.mutationAssessor) {
             const maData = this.props.mutationAssessor;
-            const xVarLink = MutationAssessor.maLink(
-                `http://mutationassessor.org/r3/?cm=var&p=${maData.uniprotId}&var=${maData.variant}`
-            );
-            const msaLink = MutationAssessor.maLink(maData.msaLink);
-            const pdbLink = MutationAssessor.maLink(maData.pdbLink);
-            const impact = maData.functionalImpact ? (
+            const impact = maData.functionalImpactPrediction ? (
                 <div>
                     <table className={tooltipStyles['ma-tooltip-table']}>
                         {(maData.functionalImpactScore ||
@@ -245,86 +215,12 @@ export default class MutationAssessor extends React.Component<
                             </tbody>
                         )}
                     </table>
-                    <span>
-                        Please refer to the score range{' '}
-                        <a
-                            href="http://mutationassessor.org/r3/"
-                            target="_blank"
-                            rel="noopener noreferrer"
-                        >
-                            here
-                        </a>
-                        .
-                    </span>
                 </div>
             ) : null;
 
-            const xVar =
-                xVarLink &&
-                maData.uniprotId.length !== 0 &&
-                maData.variant.length !== 0 ? (
-                    <div className={tooltipStyles['mutation-assessor-link']}>
-                        <a
-                            href={xVarLink}
-                            target="_blank"
-                            rel="noopener noreferrer"
-                        >
-                            <img
-                                height="15"
-                                width="19"
-                                src={mutationAssessorLogo}
-                                className={
-                                    tooltipStyles['mutation-assessor-main-img']
-                                }
-                                alt="Mutation Assessor"
-                            />
-                            Go to Mutation Assessor
-                        </a>
-                    </div>
-                ) : null;
-
-            const msa =
-                msaLink && maData.msaLink.length !== 0 ? (
-                    <div className={tooltipStyles['mutation-assessor-link']}>
-                        <a
-                            href={msaLink}
-                            target="_blank"
-                            rel="noopener noreferrer"
-                        >
-                            <span
-                                className={`${tooltipStyles['ma-icon']} ${tooltipStyles['ma-msa-icon']}`}
-                            >
-                                msa
-                            </span>
-                            Multiple Sequence Alignment
-                        </a>
-                    </div>
-                ) : null;
-
-            const pdb =
-                pdbLink && maData.pdbLink.length !== 0 ? (
-                    <div className={tooltipStyles['mutation-assessor-link']}>
-                        <a
-                            href={pdbLink}
-                            target="_blank"
-                            rel="noopener noreferrer"
-                        >
-                            <span
-                                className={`${tooltipStyles['ma-icon']} ${tooltipStyles['ma-3d-icon']}`}
-                            >
-                                3D
-                            </span>
-                            Mutation Assessor 3D View
-                        </a>
-                    </div>
-                ) : null;
-
             return (
                 <div>
                     {impact}
-                    {msa}
-                    {pdb}
-                    {xVar}
                     <br />
                 </div>
             );
diff --git a/src/shared/components/annotation/genomeNexus/MutationAssessor.tsx b/src/shared/components/annotation/genomeNexus/MutationAssessor.tsx
index 4665e3f3e37..d9749083751 100644
--- a/src/shared/components/annotation/genomeNexus/MutationAssessor.tsx
+++ b/src/shared/components/annotation/genomeNexus/MutationAssessor.tsx
@@ -19,7 +19,8 @@ export default class MutationAssessor extends React.Component<
     IMutationAssessorProps,
     {}
 > {
-    static MUTATION_ASSESSOR_URL: string = 'http://mutationassessor.org/r3/';
+    // TODO Replace to new url when manuscript is available
+    // static MUTATION_ASSESSOR_URL: string = 'http://mutationassessor.org/r3/';
 
     constructor(props: IMutationAssessorProps) {
         super(props);
@@ -31,7 +32,7 @@ export default class MutationAssessor extends React.Component<
         mutationAssessorData: MutationAssessorData | undefined
     ): string {
         if (mutationAssessorData) {
-            return `impact: ${mutationAssessorData.functionalImpact}, score: ${mutationAssessorData.functionalImpactScore}`;
+            return `impact: ${mutationAssessorData.functionalImpactPrediction}, score: ${mutationAssessorData.functionalImpactScore}`;
         } else {
             return 'NA';
         }
@@ -44,7 +45,7 @@ export default class MutationAssessor extends React.Component<
 
         if (
             this.props.mutationAssessor &&
-            this.props.mutationAssessor.functionalImpact !== null
+            this.props.mutationAssessor.functionalImpactPrediction !== null
         ) {
             const maData = this.props.mutationAssessor;
             maContent = (
@@ -52,7 +53,7 @@ export default class MutationAssessor extends React.Component<
                     className={classNames(
                         annotationStyles['annotation-item-text'],
                         (mutationAssessorColumn as any)[
-                            `ma-${maData.functionalImpact}`
+                            `ma-${maData.functionalImpactPrediction}`
                         ]
                     )}
                 >
@@ -80,15 +81,14 @@ export default class MutationAssessor extends React.Component<
     private tooltipContent() {
         if (this.props.mutationAssessor) {
             const maData = this.props.mutationAssessor;
-            const impact = maData.functionalImpact ? (
+            const impact = maData.functionalImpactPrediction ? (
                 <div>
                     <table className={tooltipStyles['ma-tooltip-table']}>
                         <tr>
                             <td>Source</td>
                             <td>
-                                <a href="http://mutationassessor.org/r3">
-                                    MutationAssessor
-                                </a>
+                                {/* TODO Add link when manuscript is available */}
+                                Mutation Assessor
                             </td>
                         </tr>
                         <tr>
@@ -97,11 +97,11 @@ export default class MutationAssessor extends React.Component<
                                 <span
                                     className={
                                         (mutationAssessorColumn as any)[
-                                            `ma-${maData.functionalImpact}`
+                                            `ma-${maData.functionalImpactPrediction}`
                                         ]
                                     }
                                 >
-                                    {maData.functionalImpact}
+                                    {maData.functionalImpactPrediction}
                                 </span>
                             </td>
                         </tr>
diff --git a/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx b/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
index c3f418ae07f..1dad21853fc 100644
--- a/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
+++ b/src/shared/components/mutationTable/column/FunctionalImpactColumnFormatter.tsx
@@ -305,19 +305,26 @@ class FunctionalImpactColumnTooltip extends React.Component<
 
     public static mutationAssessorText() {
         return (
-            <div style={{ width: 450, height: 100 }}>
-                <a
-                    href={MutationAssessor.MUTATION_ASSESSOR_URL}
-                    target="_blank"
-                >
-                    Mutation Assessor
-                </a>{' '}
-                predicts the functional impact of amino-acid substitutions in
-                proteins, such as mutations discovered in cancer or missense
-                polymorphisms. The functional impact is assessed based on
-                evolutionary conservation of the affected amino acid in protein
-                homologs. The method has been validated on a large set (60k) of
-                disease associated (OMIM) and polymorphic variants.
+            <div style={{ width: 450, height: 130 }}>
+                Mutation Assessor predicts the functional impact of amino-acid
+                substitutions in proteins, such as mutations discovered in
+                cancer or missense polymorphisms. The functional impact is
+                assessed based on evolutionary conservation of the affected
+                amino acid in protein homologs. The method has been validated on
+                a large set of disease associated and polymorphic variants (
+                <a href="https://www.ncbi.nlm.nih.gov/clinvar/" target="_blank">
+                    ClinVar
+                </a>
+                ).
+                <br />
+                <b>
+                    Mutation Assessor V4 data is now available in the portal!
+                </b>{' '}
+                New manuscript is in progress. Click{` `}
+                <a href="http://mutationassessor.org/r3/" target="_blank">
+                    here
+                </a>
+                {` `} to see information about V3 data.
             </div>
         );
     }
@@ -531,13 +538,7 @@ export default class FunctionalImpactColumnFormatter {
     public static getMutationAssessorData(
         mutationAssessorDataCache: VariantAnnotation | null
     ): MutationAssessorData | undefined {
-        if (!mutationAssessorDataCache) {
-            return undefined;
-        } else {
-            return mutationAssessorDataCache.mutation_assessor
-                ? mutationAssessorDataCache.mutation_assessor.annotation
-                : undefined;
-        }
+        return mutationAssessorDataCache?.mutation_assessor;
     }
 
     public static renderFunction(