diff --git a/src/shared/components/query/gene_lists.ts b/src/shared/components/query/gene_lists.ts index 4b994ed3fdb..587d5469ddb 100644 --- a/src/shared/components/query/gene_lists.ts +++ b/src/shared/components/query/gene_lists.ts @@ -163,6 +163,217 @@ const gene_lists = [ 'PEG3', ], }, + { + id: 'General: Cell Cycle - TCGA PanCan Pathways', + genes: [ + 'CDKN1A', + 'CDKN1B', + 'CDKN2A', + 'CDKN2B', + 'CDKN2C', + 'CCND1', + 'CCND2', + 'CCND3', + 'CCNE1', + 'CDK2', + 'CDK4', + 'CDK6', + 'RB1', + 'E2F1', + 'E2F3', + ], + }, + { + id: 'General: HIPPO - TCGA PanCan Pathways', + genes: [ + 'STK4', + 'STK3', + 'SAV1', + 'LATS1', + 'LATS2', + 'MOB1A', + 'MOB1B', + 'YAP1', + 'TEAD2', + 'PTPN14', + 'NF2', + 'WWC1', + 'TAOK1', + 'TAOK2', + 'TAOK3', + 'CRB1', + 'CRB2', + 'CRB3', + 'FAT1', + 'FAT2', + 'FAT3', + 'FAT4', + 'DCHS1', + 'DCHS2', + 'CSNK1E', + 'CSNK1D', + ], + }, + { + id: 'General: MYC - TCGA PanCan Pathways', + genes: ['MAX', 'MGA', 'MLX', 'MNT', 'MXI1', 'MYC', 'MYCN'], + }, + { + id: 'General: NOTCH - TCGA PanCan Pathways', + genes: [ + 'ARRDC1', + 'CNTN6', + 'CREBBP', + 'EP300', + 'HES1', + 'HES2', + 'HES3', + 'HES4', + 'HES5', + 'HEY1', + 'HEY2', + 'HEYL', + 'KAT2B', + 'KDM5A', + 'NOTCH1', + 'NOTCH2', + 'NOTCH3', + 'NOTCH4', + 'NOV', + 'PSEN2', + 'SPEN', + 'FBXW7', + 'THBS2', + 'CUL1', + 'NCOR1', + 'NCOR2', + 'HDAC1', + 'JAG2', + 'MAML3', + 'DNER', + ], + }, + { + id: 'General: NRF2 - TCGA PanCan Pathways', + genes: ['NFE2L2', 'KEAP1', 'CUL3'], + }, + { + id: 'General: PI3K - TCGA PanCan Pathways', + genes: [ + 'AKT1', + 'AKT2', + 'AKT3', + 'INPP4B', + 'MLST8', + 'MTOR', + 'NPRL2', + 'NPRL3', + 'PIK3CA', + 'PIK3CB', + 'PIK3R1', + 'PIK3R2', + 'PIK3R3', + 'PPP2R1A', + 'PTEN', + 'RHEB', + 'RICTOR', + 'RPTOR', + 'RPS6KB1', + 'STK11', + 'TSC1', + 'TSC2', + ], + }, + { + id: 'General: TGF-Beta - TCGA PanCan Pathways', + genes: [ + 'TGFBR1', + 'TGFBR2', + 'ACVR2A', + 'ACVR1B', + 'SMAD2', + 'SMAD3', + 'SMAD4', + ], + }, + { + id: 'General: RTK-RAS - TCGA PanCan Pathways', + genes: [ + 'ABL1', + 'EGFR', + 'ERBB2', + 'ERBB3', + 'ERBB4', + 'PDGFRA', + 'MET', + 'FGFR1', + 'FGFR2', + 'FGFR3', + 'FGFR4', + 'FLT3', + 'ALK', + 'RET', + 'ROS1', + 'KIT', + 'IGF1R', + 'NTRK1', + 'NTRK2', + 'NTRK3', + 'SOS1', + 'GRB2', + 'PTPN11', + 'KRAS', + 'HRAS', + 'NRAS', + 'RIT1', + 'ARAF', + 'BRAF', + 'RAF1', + 'RAC1', + 'MAP2K1', + 'MAP2K2', + 'MAPK1', + 'NF1', + 'RASA1', + 'CBL', + 'ERRFI1', + 'JAK2', + ], + }, + { + id: 'General: TP53 - TCGA PanCan Pathways', + genes: ['TP53', 'MDM2', 'MDM4', 'ATM', 'CHEK2', 'RPS6KA3'], + }, + { + id: 'General: WNT - TCGA PanCan Pathways', + genes: [ + 'SFRP1', + 'SFRP2', + 'SFRP4', + 'SFRP5', + 'SOST', + 'TCF7L1', + 'TLE1', + 'TLE2', + 'TLE3', + 'TLE4', + 'WIF1', + 'ZNRF3', + 'CTNNB1', + 'AMER1', + 'APC', + 'AXIN1', + 'AXIN2', + 'DKK1', + 'DKK2', + 'DKK3', + 'DKK4', + 'GSK3B', + 'RNF43', + 'TCF7', + 'TCF7L2', + ], + }, { id: 'General: Cell Cycle Control', genes: [