diff --git a/pkg/apis/provisioning/v1alpha5/requirements.go b/pkg/apis/provisioning/v1alpha5/requirements.go
index e0c384c121e4..064eb09994df 100644
--- a/pkg/apis/provisioning/v1alpha5/requirements.go
+++ b/pkg/apis/provisioning/v1alpha5/requirements.go
@@ -52,6 +52,7 @@ var (
 	// WellKnownLabels supported by karpenter
 	WellKnownLabels = sets.NewString(
 		v1.LabelTopologyZone,
+		v1.LabelTopologyRegion,
 		v1.LabelInstanceTypeStable,
 		v1.LabelArchStable,
 		v1.LabelOSStable,
@@ -63,10 +64,11 @@ var (
 	// however, Provisioner labels are still restricted to WellKnownLabels.
 	// Additional labels may be injected by cloud providers.
 	NormalizedLabels = map[string]string{
-		v1.LabelFailureDomainBetaZone: v1.LabelTopologyZone,
-		"beta.kubernetes.io/arch":     v1.LabelArchStable,
-		"beta.kubernetes.io/os":       v1.LabelOSStable,
-		v1.LabelInstanceType:          v1.LabelInstanceTypeStable,
+		v1.LabelFailureDomainBetaZone:   v1.LabelTopologyZone,
+		v1.LabelFailureDomainBetaRegion: v1.LabelTopologyRegion,
+		"beta.kubernetes.io/arch":       v1.LabelArchStable,
+		"beta.kubernetes.io/os":         v1.LabelOSStable,
+		v1.LabelInstanceType:            v1.LabelInstanceTypeStable,
 	}
 )
 
@@ -77,6 +79,10 @@ func (r Requirements) Zones() sets.String {
 	return r.Requirement(v1.LabelTopologyZone)
 }
 
+func (r Requirements) Regions() sets.String {
+	return r.Requirement(v1.LabelTopologyRegion)
+}
+
 func (r Requirements) InstanceTypes() sets.String {
 	return r.Requirement(v1.LabelInstanceTypeStable)
 }
diff --git a/pkg/cloudprovider/aws/instance.go b/pkg/cloudprovider/aws/instance.go
index bd2f3202cd31..b6d115ef6847 100644
--- a/pkg/cloudprovider/aws/instance.go
+++ b/pkg/cloudprovider/aws/instance.go
@@ -249,17 +249,19 @@ func (p *InstanceProvider) instanceToNode(ctx context.Context, instance *ec2.Ins
 			if injection.GetOptions(ctx).GetAWSNodeNameConvention() == options.ResourceName {
 				nodeName = aws.StringValue(instance.InstanceId)
 			}
+			zone := aws.StringValue(instance.Placement.AvailabilityZone)
 			return &v1.Node{
 				ObjectMeta: metav1.ObjectMeta{
 					Name: nodeName,
 					Labels: map[string]string{
-						v1.LabelTopologyZone:       aws.StringValue(instance.Placement.AvailabilityZone),
+						v1.LabelTopologyZone:       zone,
+						v1.LabelTopologyRegion:     zone[:len(zone)-1],
 						v1.LabelInstanceTypeStable: aws.StringValue(instance.InstanceType),
 						v1alpha5.LabelCapacityType: getCapacityType(instance),
 					},
 				},
 				Spec: v1.NodeSpec{
-					ProviderID: fmt.Sprintf("aws:///%s/%s", aws.StringValue(instance.Placement.AvailabilityZone), aws.StringValue(instance.InstanceId)),
+					ProviderID: fmt.Sprintf("aws:///%s/%s", zone, aws.StringValue(instance.InstanceId)),
 				},
 				Status: v1.NodeStatus{
 					Allocatable: v1.ResourceList{
diff --git a/pkg/cloudprovider/aws/instancetypes.go b/pkg/cloudprovider/aws/instancetypes.go
index 8de27a15da5b..05a0c534f359 100644
--- a/pkg/cloudprovider/aws/instancetypes.go
+++ b/pkg/cloudprovider/aws/instancetypes.go
@@ -17,9 +17,10 @@ package aws
 import (
 	"context"
 	"fmt"
+	"time"
+
 	"github.com/aws/karpenter/pkg/utils/injection"
 	"knative.dev/pkg/ptr"
-	"time"
 
 	"github.com/aws/aws-sdk-go/aws"
 	"github.com/aws/aws-sdk-go/service/ec2"