the timed task will be to: iterate over each row in a VCF, extract a value from the INFO field (an integer), add it to a vector and report the mean at the end. The exact task is useless, but it gives an idea of relative performance.
Individual runs are below. rust-htslib was compiled with --release and hts-nim was compiled with -d:danger and uses libdeflate. C htslib uses libdeflate and is compiled with -O2.
zig was compiled with -Drelease-fast.
Note that tools using libdeflate are substantially faster
| Tool | Time | File |
|---|---|---|
| cyvcf2 | 8.15s | BCF |
| cyvcf2 (libdeflate) | 3.9s | BCF |
| pysam | 3.8s | BCF |
| rust-htslib | 5.8s | BCF |
| rust-htslib (libdeflate) | 3.5s | BCF |
| rust-noodles (libdeflate) | 3.6s | BCF |
| d-htslib (libdeflate) | 4.6s | BCF |
| hts-nim | 3.5s | BCF |
| crystal-htslib | 3.6s | BCF |
| hts-zig | 3.5s | BCF |
| C htslib | 3.5s | BCF |
(note that these times can be improved to nearly match the BCF speeds above using bcf_hdr_set_samples when possible).
| Tool | Time | File |
|---|---|---|
| pyvcf | 16m49s | VCF |
| cyvcf2 | 29s | VCF |
| cyvcf2 (libdeflate) | 20s | VCF |
| js-gmodvcf | 24s | VCF |
| go-vcfgo | 19s | VCF |
| pysam | 28s | VCF |
| rust-htslib | 19s | VCF |
| d-htslib | 19s | VCF |
| hts-nim | 18s | VCF |
| crystal-htslib | 19s | BCF |
| hts-zig | 18s | BCF |
| C htslib | 18s | VCF |
wget -O - http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/data_collections/1000G_2504_high_coverage/working/20201028_3202_raw_GT_with_annot/20201028_CCDG_14151_B01_GRM_WGS_2020-08-05_chr1.recalibrated_variants.vcf.gz \
| zcat - \
| head -30000 \
| bgzip -c > 1kg.chr1.subset.vcf.gz
$ time python python-pyvcf/read.py 1kg.chr1.subset.vcf.gz
5992.641098163443
real 16m49.068s
user 16m44.487s
sys 0m0.924s
$ time python python-cyvcf2/read.py 1kg.chr1.subset.bcf
5992.64
real 0m8.154s
user 0m8.168s
sys 0m0.268s
$ time python python-cyvcf2/read.py 1kg.chr1.subset.vcf.gz
5992.64
real 0m29.703s
user 0m29.715s
sys 0m0.260s
$ time python python-cyvcf2/read.py 1kg.chr1.subset.vcf.gz
5992.64
real 0m9.927s
user 0m9.938s
$ time rust-htslib/target/release/rust-rhtslib ./1kg.chr1.subset.bcf
sum: 158906864, avg:5992
real 0m5.888s
user 0m5.799s
sys 0m0.088s
$ time rust-htslib/target/release/rust-rhtslib ./1kg.chr1.subset.vcf.gz
sum: 158906864, avg:5992
real 0m22.122s
user 0m22.002s
sys 0m0.116s
$ time ./rust-noodles/target/release/rust-noodles 1kg.chr1.subset.bcf
5992.641098163443
real 0m3.685s
user 0m3.608s
sys 0m0.073s
$ time ./nim-hts-nim/read ./1kg.chr1.subset.bcf
5992.641098163443
real 0m3.579s
user 0m3.482s
sys 0m0.097s
$ time ./nim-hts-nim/read ./1kg.chr1.subset.vcf.gz
5992.641098163443
real 0m18.346s
user 0m18.276s
sys 0m0.068s
$ time ./c-htslib/read 1kg.chr1.subset.bcf
5992.64
real 0m3.528s
user 0m3.463s
sys 0m0.064s
$ time ./c-htslib/read 1kg.chr1.subset.vcf.gz
5992.64
real 0m18.103s
user 0m18.022s
sys 0m0.076s
$ time ./zig-out/bin/hts-zig ../1kg.chr1.subset.bcf
mean:5.992641098163443e+03
real 0m3.546s
user 0m3.465s
sys 0m0.080s
$ time ./zig-out/bin/hts-zig ../1kg.chr1.subset.vcf.gz
mean:5.992641098163443e+03
real 0m18.091s
user 0m18.011s
sys 0m0.077s
$ time python python-pysam/read.py 1kg.chr1.subset.bcf
[E::idx_find_and_load] Could not retrieve index file for '1kg.chr1.subset.bcf'
5992.641098163443
real 0m3.866s
user 0m3.726s
sys 0m0.137s
$ time python python-pysam/read.py 1kg.chr1.subset.vcf.gz
[E::idx_find_and_load] Could not retrieve index file for '1kg.chr1.subset.vcf.gz'
5992.641098163443
real 0m28.743s
user 0m28.570s
sys 0m0.166s
$ time ./go-vcfgo/go-vcfgo 1kg.chr1.subset.vcf.gz
5992.641
real 0m12.890s
user 0m19.456s
sys 0m0.787s
(node v16)
$ time node js-vcf-js/index.js 1kg.chr1.subset.vcf.gz
5992.641098163443
real 0m23.122s
user 0m24.848s
sys 0m3.151s
$ time ./d-dhtslib/read 1kg.chr1.subset.bcf
sum: 158906864, avg: 5992.641098
real 0m4.670s
user 0m6.014s
sys 0m0.662s
$ time ./d-dhtslib/read 1kg.chr1.subset.vcf.gz
sum: 158906864, avg: 5992.641098
real 0m19.095s
user 0m23.688s
sys 0m0.570s
$ time crystal-htslibcr/read 1kg.chr1.subset.bcf
sum: 158906864, avg: 5992.641098163443
real 0m3.691s
user 0m3.597s
sys 0m0.093s
$ time crystal-htslibcr/read 1kg.chr1.subset.vcf.gz
sum: 158906864, avg: 5992.641098163443
real 0m18.756s
user 0m18.638s
sys 0m0.112s