diff --git a/.github/workflows/create-release.yml b/.github/workflows/create-release.yml
new file mode 100644
index 00000000..21b3c03e
--- /dev/null
+++ b/.github/workflows/create-release.yml
@@ -0,0 +1,55 @@
+name: Create release
+
+on:
+  push:
+    tags:
+    - "v*"
+  workflow_dispatch:
+
+permissions:
+  contents: read
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.head_ref || github.run_id }}
+  cancel-in-progress: true
+
+env:
+  FORCE_COLOR: "1"
+  UV_SYSTEM_PYTHON: "1"  # make uv do global installs
+
+jobs:
+  publish-pypi:
+    runs-on: ubuntu-latest
+    name: PyPI Release
+    environment: release
+    if: github.repository_owner == 'breathe-doc'
+    permissions:
+      id-token: write  # for PyPI trusted publishing
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          persist-credentials: false
+
+      - name: Set up Python
+        uses: actions/setup-python@v5
+        with:
+          python-version: "3"
+
+      - name: Install uv
+        uses: astral-sh/setup-uv@v5
+        with:
+          version: latest
+          enable-cache: false
+
+      - name: Install build dependencies (pypa/build, twine)
+        run: uv pip install build "twine>=5.1"
+
+      - name: Build distribution
+        run: python -m build
+
+      - name: Check distribution
+        run: |
+          twine check --strict dist/*
+
+      - name: Upload to PyPI
+        uses: pypa/gh-action-pypi-publish@release/v1
diff --git a/README.rst b/README.rst
index 66ab5e45..e98ca023 100644
--- a/README.rst
+++ b/README.rst
@@ -128,13 +128,11 @@ Examples of projects that use Breathe:
 Release
 -------
 
-See the ``mkrelease`` utility in the root of the repository.
-
-Useful vim command for changelog conversion to the git tag format:
-
-.. code:: vim
-
-   %s/\v`(#[0-9]+) \<[^`]*`__/\1/g
+1. Update `CHANGELOG.rst` and create the git tag (`vX.Y.Z`).
+2. Push the tag to GitHub.
+3. The `create-release.yml` workflow will publish the release to PyPI.
+4. Go to https://github.com/breathe-doc/breathe/tags, select the new tag,
+   and click the "Create release from tag" button to publish a GitHub release.
 
 Maintainers
 -----------
diff --git a/mkrelease b/mkrelease
deleted file mode 100755
index 2aab9cc9..00000000
--- a/mkrelease
+++ /dev/null
@@ -1,122 +0,0 @@
-#!/bin/sh
-
-set -eu
-
-hash cd
-hash git
-hash gpg
-hash mkdir
-hash printf
-hash python3
-hash rm
-hash tar
-hash twine
-
-# Melvin Vermeeren <vermeeren@vermwa.re>
-PGP_KEY='8AED 5802 1FEA CDD5 F27B  A0E6 A72F 6277 16EA 9D96'
-
-REPO_WWW='https://github.com/breathe-doc/breathe/'
-
-help()
-{
-	printf 'Usage: %s pack\n' "$0"
-	printf 'Usage: %s sign\n' "$0"
-	printf 'Usage: %s upload\n' "$0"
-	printf 'Usage: %s clean\n' "$0"
-	return 0
-}
-
-pack()
-(
-	mkdir -- mkrelease_tmp
-
-	git archive \
-		--format=tar.gz \
-		--prefix="breathe-$version/" \
-		-o "mkrelease_tmp/breathe-$version.tar.gz" \
-		-- "v$version" \
-
-	cd -- mkrelease_tmp
-	tar -xf "breathe-$version.tar.gz"
-
-	cd -- "breathe-$version"
-	python3 -m build
-	mv -- dist ..
-
-	cd -- ..
-	rm -r -- "breathe-$version"
-
-	exit 0
-)
-
-sign()
-(
-	cd -- mkrelease_tmp
-
-	gpg -bu "$PGP_KEY" -- "breathe-$version.tar.gz"
-
-	for file in dist/*; do
-		gpg -bau "$PGP_KEY" -- "$file"
-	done
-
-	exit 0
-)
-
-upload()
-(
-	cd -- mkrelease_tmp
-
-	twine check --strict dist/*
-	twine upload -- dist/*
-
-	{
-	printf 'Note: Source tarball signature must be uploaded manually.\n'
-	printf '\tCreate a new release on GitHub for version: %s\n' "$version"
-	printf '\tThe source tarball itself must not be uploaded.\n'
-	printf '\t%s\n' "$REPO_WWW/releases/new?tag=v$version"
-	} >&2
-
-	exit 0
-)
-
-clean()
-(
-	if [ -d mkrelease_tmp ]; then
-		rm -r -- mkrelease_tmp
-	fi
-
-	exit 0
-)
-
-if [ "$#" -eq 0 ]; then
-	help >&2
-	exit 1
-fi
-
-if [ ! -d .git ]; then
-	printf 'Error: Not executed from repository root\n' >&2
-	exit 1
-fi
-
-if ! version="$(git describe --tags --exact)"; then
-	printf 'Error: Cannot retrieve version from git.\n' >&2
-	exit 1
-fi
-version="${version#v}"
-
-command="$1"
-
-case "$command" in
-pack|sign|upload|clean)
-	"$command"
-	;;
-*)
-	{
-	printf 'Error: Unknown command: %s\n' "$command"
-	printf '\n'
-	help
-	} >&2
-	exit 1
-esac
-
-exit 0