diff --git a/setup.py b/setup.py
index d5925360e..c18313fe6 100755
--- a/setup.py
+++ b/setup.py
@@ -298,18 +298,8 @@ def initialize_options(self) -> None:
       },
       install_requires=[
           'timeout_decorator',
-          # awscli pins PyYAML. We have seen issues at
-          # run-time if we don't constrain things here as well. So
-          # this tracks the awscli req for python >= 3.6 which is
-          # what we support
-          #
-          # https://github.com/aws/aws-cli/blob/develop/setup.py
-          # #### NEW UNFORTUNATE CONSTRAINTS #####
-          # https://github.com/yaml/pyyaml/issues/724
-          'PyYAML>=3.10,<=5.3.1',
-          # Not sure how/if interface will change in db-facts, so
-          # let's be conservative about what we're specifying for now.
-          'db-facts>=4,<5',
+          'PyYAML>=3.10',
+          'db-facts>=4',
           # Version 4.0.0 is not yet compatible with requests, and pip
           # 20.3 is not smart enough to pay attention to that,
           # resulting in runtime complaints.  Can be removed once 20.4