diff --git a/chrome/browser/extensions/api/chrome_extensions_api_client.cc b/chrome/browser/extensions/api/chrome_extensions_api_client.cc
index ff81674b20edc7..7e22c3cc313f89 100644
--- a/chrome/browser/extensions/api/chrome_extensions_api_client.cc
+++ b/chrome/browser/extensions/api/chrome_extensions_api_client.cc
@@ -324,12 +324,9 @@ ChromeExtensionsAPIClient::CreateDevicePermissionsPrompt(
   return std::make_unique<ChromeDevicePermissionsPrompt>(web_contents);
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 bool ChromeExtensionsAPIClient::ShouldAllowDetachingUsb(int vid,
                                                         int pid) const {
-  // TOOD(huangs): Figure out how to do the following in Lacros, which does not
-  // have access to ash::CrosSettings (https://crbug.com/1219329).
-#if BUILDFLAG(IS_CHROMEOS_ASH)
   const base::ListValue* policy_list;
   if (ash::CrosSettings::Get()->GetList(chromeos::kUsbDetachableAllowlist,
                                         &policy_list)) {
@@ -340,10 +337,10 @@ bool ChromeExtensionsAPIClient::ShouldAllowDetachingUsb(int vid,
       }
     }
   }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
+
   return false;
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 std::unique_ptr<VirtualKeyboardDelegate>
 ChromeExtensionsAPIClient::CreateVirtualKeyboardDelegate(
diff --git a/chrome/browser/extensions/api/chrome_extensions_api_client.h b/chrome/browser/extensions/api/chrome_extensions_api_client.h
index f9cab008394806..3aecf42019d3ae 100644
--- a/chrome/browser/extensions/api/chrome_extensions_api_client.h
+++ b/chrome/browser/extensions/api/chrome_extensions_api_client.h
@@ -65,9 +65,9 @@ class ChromeExtensionsAPIClient : public ExtensionsAPIClient {
       RulesCacheDelegate* cache_delegate) const override;
   std::unique_ptr<DevicePermissionsPrompt> CreateDevicePermissionsPrompt(
       content::WebContents* web_contents) const override;
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   bool ShouldAllowDetachingUsb(int vid, int pid) const override;
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
   std::unique_ptr<VirtualKeyboardDelegate> CreateVirtualKeyboardDelegate(
       content::BrowserContext* browser_context) const override;
   ManagementAPIDelegate* CreateManagementAPIDelegate() const override;
diff --git a/chrome/browser/ui/webui/settings/site_settings_handler_unittest.cc b/chrome/browser/ui/webui/settings/site_settings_handler_unittest.cc
index 888a8f4ebd8137..c67757252e3c6c 100644
--- a/chrome/browser/ui/webui/settings/site_settings_handler_unittest.cc
+++ b/chrome/browser/ui/webui/settings/site_settings_handler_unittest.cc
@@ -70,7 +70,7 @@
 #include "ui/base/text/bytes_formatting.h"
 #include "ui/webui/webui_allowlist.h"
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 #include "chrome/browser/ash/login/users/mock_user_manager.h"
 #include "components/user_manager/scoped_user_manager.h"
 #endif
diff --git a/chromeos/dbus/permission_broker/BUILD.gn b/chromeos/dbus/permission_broker/BUILD.gn
index 56756df3462842..9bcda0647e3a6c 100644
--- a/chromeos/dbus/permission_broker/BUILD.gn
+++ b/chromeos/dbus/permission_broker/BUILD.gn
@@ -4,8 +4,7 @@
 
 import("//third_party/protobuf/proto_library.gni")
 
-assert(is_chromeos_ash || is_chromeos_lacros,
-       "Non-Chrome-OS or Lacros builds must not depend on //chromeos")
+assert(is_chromeos, "Non-ChromeOS builds cannot depend on //chromeos")
 
 component("permission_broker") {
   defines = [ "IS_PERMISSION_BROKER_IMPL" ]
diff --git a/device/gamepad/gamepad_device_linux.cc b/device/gamepad/gamepad_device_linux.cc
index 8592b4863968b2..891eaf1667a2b0 100644
--- a/device/gamepad/gamepad_device_linux.cc
+++ b/device/gamepad/gamepad_device_linux.cc
@@ -27,7 +27,7 @@
 #include "device/udev_linux/udev.h"
 
 #if BUILDFLAG(IS_CHROMEOS_ASH)
-#include "chromeos/dbus/permission_broker/permission_broker_client.h"  // nogncheck
+#include "chromeos/dbus/permission_broker/permission_broker_client.h"
 #endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 namespace device {
diff --git a/extensions/browser/api/BUILD.gn b/extensions/browser/api/BUILD.gn
index 5f5fa931f3ad57..3845583da83a74 100644
--- a/extensions/browser/api/BUILD.gn
+++ b/extensions/browser/api/BUILD.gn
@@ -72,7 +72,6 @@ source_set("api") {
       "clipboard/clipboard_api.h",
     ]
     deps += [
-      "//chromeos/dbus/permission_broker",
       "//components/prefs:prefs",
       "//ui/base/clipboard",
     ]
@@ -104,6 +103,7 @@ source_set("api") {
       "//chromeos/dbus",
       "//chromeos/dbus/media_analytics",
       "//chromeos/dbus/media_analytics:media_perception_proto",
+      "//chromeos/dbus/permission_broker",
       "//chromeos/dbus/upstart",
       "//chromeos/login/login_state",
       "//chromeos/services/media_perception/public/mojom",
diff --git a/extensions/browser/api/device_permissions_prompt.cc b/extensions/browser/api/device_permissions_prompt.cc
index d546818556d97d..8642c2316a1e0b 100644
--- a/extensions/browser/api/device_permissions_prompt.cc
+++ b/extensions/browser/api/device_permissions_prompt.cc
@@ -29,9 +29,9 @@
 #include "services/device/public/mojom/usb_enumeration_options.mojom.h"
 #include "ui/base/l10n/l10n_util.h"
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
-#include "chromeos/dbus/permission_broker/permission_broker_client.h"  // nogncheck
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
+#include "chromeos/dbus/permission_broker/permission_broker_client.h"
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 using device::HidDeviceFilter;
 using device::mojom::UsbDeviceFilterPtr;
@@ -149,7 +149,7 @@ class UsbDevicePermissionsPrompt : public DevicePermissionsPrompt::Prompt,
       remaining_initial_devices_++;
 
     auto device_info = std::make_unique<UsbDeviceInfo>(device.Clone());
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
     auto* device_manager = UsbDeviceManager::Get(browser_context());
     DCHECK(device_manager);
     device_manager->CheckAccess(
@@ -159,7 +159,7 @@ class UsbDevicePermissionsPrompt : public DevicePermissionsPrompt::Prompt,
 #else
     AddCheckedDevice(std::move(device_info), initial_enumeration,
                      /*allowed=*/true);
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
   }
 
   void AddCheckedDevice(std::unique_ptr<UsbDeviceInfo> device_info,
@@ -335,7 +335,6 @@ class HidDevicePermissionsPrompt : public DevicePermissionsPrompt::Prompt,
       remaining_initial_devices_++;
 
     auto device_info = std::make_unique<HidDeviceInfo>(std::move(device));
-    // TODO(huangs): Enable this for Lacros (crbug.com/1217124).
 #if BUILDFLAG(IS_CHROMEOS_ASH)
     chromeos::PermissionBrokerClient::Get()->CheckPathAccess(
         device_info.get()->device()->device_node,
diff --git a/extensions/browser/api/extensions_api_client.cc b/extensions/browser/api/extensions_api_client.cc
index 11286a449ac02a..49cc8e6b9ab25c 100644
--- a/extensions/browser/api/extensions_api_client.cc
+++ b/extensions/browser/api/extensions_api_client.cc
@@ -110,11 +110,11 @@ ExtensionsAPIClient::CreateDevicePermissionsPrompt(
   return nullptr;
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 bool ExtensionsAPIClient::ShouldAllowDetachingUsb(int vid, int pid) const {
   return false;
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 std::unique_ptr<VirtualKeyboardDelegate>
 ExtensionsAPIClient::CreateVirtualKeyboardDelegate(
diff --git a/extensions/browser/api/extensions_api_client.h b/extensions/browser/api/extensions_api_client.h
index 441e5b7373cacd..5fcca481bf6a2b 100644
--- a/extensions/browser/api/extensions_api_client.h
+++ b/extensions/browser/api/extensions_api_client.h
@@ -161,10 +161,10 @@ class ExtensionsAPIClient {
   virtual std::unique_ptr<DevicePermissionsPrompt>
   CreateDevicePermissionsPrompt(content::WebContents* web_contents) const;
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   // Returns true if device policy allows detaching a given USB device.
   virtual bool ShouldAllowDetachingUsb(int vid, int pid) const;
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   // Returns a delegate for some of VirtualKeyboardAPI's behavior.
   virtual std::unique_ptr<VirtualKeyboardDelegate>
diff --git a/extensions/browser/api/usb/usb_apitest.cc b/extensions/browser/api/usb/usb_apitest.cc
index 436d0e7d9873c8..6290db8e296b73 100644
--- a/extensions/browser/api/usb/usb_apitest.cc
+++ b/extensions/browser/api/usb/usb_apitest.cc
@@ -114,11 +114,11 @@ class TestExtensionsAPIClient : public ShellExtensionsAPIClient {
     return std::make_unique<TestDevicePermissionsPrompt>(web_contents);
   }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   bool ShouldAllowDetachingUsb(int vid, int pid) const override {
     return vid == 1 && pid == 2;
   }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 };
 
 class UsbApiTest : public ShellApiTest {
@@ -365,7 +365,7 @@ IN_PROC_BROWSER_TEST_F(UsbApiTest, GetUserSelectedDevices) {
   ASSERT_TRUE(result_listener.WaitUntilSatisfied());
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 IN_PROC_BROWSER_TEST_F(UsbApiTest, MassStorage) {
   ExtensionTestMessageListener ready_listener("ready", false);
   ready_listener.set_failure_message("failure");
@@ -397,6 +397,6 @@ IN_PROC_BROWSER_TEST_F(UsbApiTest, MassStorage) {
 
   ASSERT_TRUE(result_listener.WaitUntilSatisfied());
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 }  // namespace extensions
diff --git a/extensions/browser/api/usb/usb_device_manager.cc b/extensions/browser/api/usb/usb_device_manager.cc
index 31c4c0aaf06c94..a0b7ccdcf4148e 100644
--- a/extensions/browser/api/usb/usb_device_manager.cc
+++ b/extensions/browser/api/usb/usb_device_manager.cc
@@ -52,12 +52,12 @@ bool ShouldExposeDevice(const device::mojom::UsbDeviceInfo& device_info) {
     }
   }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   if (ExtensionsAPIClient::Get()->ShouldAllowDetachingUsb(
           device_info.vendor_id, device_info.product_id)) {
     return true;
   }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   return false;
 }
@@ -212,14 +212,14 @@ bool UsbDeviceManager::UpdateActiveConfig(const std::string& guid,
   return true;
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 void UsbDeviceManager::CheckAccess(
     const std::string& guid,
     device::mojom::UsbDeviceManager::CheckAccessCallback callback) {
   EnsureConnectionWithDeviceManager();
   device_manager_->CheckAccess(guid, std::move(callback));
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 void UsbDeviceManager::EnsureConnectionWithDeviceManager() {
   if (device_manager_)
diff --git a/extensions/browser/api/usb/usb_device_manager.h b/extensions/browser/api/usb/usb_device_manager.h
index 318320986b65f6..13eacd113427ef 100644
--- a/extensions/browser/api/usb/usb_device_manager.h
+++ b/extensions/browser/api/usb/usb_device_manager.h
@@ -70,11 +70,11 @@ class UsbDeviceManager : public BrowserContextKeyedAPI,
   const device::mojom::UsbDeviceInfo* GetDeviceInfo(const std::string& guid);
   bool UpdateActiveConfig(const std::string& guid, uint8_t config_value);
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   void CheckAccess(
       const std::string& guid,
       device::mojom::UsbDeviceManager::CheckAccessCallback callback);
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   void EnsureConnectionWithDeviceManager();
 
diff --git a/services/device/hid/hid_service_linux.cc b/services/device/hid/hid_service_linux.cc
index b975851f15eac0..9a9c71e61e0102 100644
--- a/services/device/hid/hid_service_linux.cc
+++ b/services/device/hid/hid_service_linux.cc
@@ -36,11 +36,9 @@
 #include "device/udev_linux/udev_watcher.h"
 #include "services/device/hid/hid_connection_linux.h"
 
-// TODO(huangs): Enable for IS_CHROMEOS_LACROS. This will simplify crosapi so
-// that it won't need to pass HidManager around (crbug.com/1109621).
 #if BUILDFLAG(IS_CHROMEOS_ASH)
 #include "base/system/sys_info.h"
-#include "chromeos/dbus/permission_broker/permission_broker_client.h"  // nogncheck
+#include "chromeos/dbus/permission_broker/permission_broker_client.h"
 #endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 namespace device {
diff --git a/services/device/public/cpp/test/fake_usb_device_manager.cc b/services/device/public/cpp/test/fake_usb_device_manager.cc
index 1a3868e06770cf..39818ca37fb1b1 100644
--- a/services/device/public/cpp/test/fake_usb_device_manager.cc
+++ b/services/device/public/cpp/test/fake_usb_device_manager.cc
@@ -84,7 +84,7 @@ void FakeUsbDeviceManager::RefreshDeviceInfo(
 }
 #endif
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 void FakeUsbDeviceManager::CheckAccess(const std::string& guid,
                                        CheckAccessCallback callback) {
   std::move(callback).Run(true);
@@ -99,7 +99,7 @@ void FakeUsbDeviceManager::OpenFileDescriptor(
       base::FilePath(FILE_PATH_LITERAL("/dev/null")),
       base::File::FLAG_OPEN | base::File::FLAG_READ | base::File::FLAG_WRITE));
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 void FakeUsbDeviceManager::SetClient(
     mojo::PendingAssociatedRemote<mojom::UsbDeviceManagerClient> client) {
diff --git a/services/device/public/cpp/test/fake_usb_device_manager.h b/services/device/public/cpp/test/fake_usb_device_manager.h
index 7a91db76ddc892..d90eec1262ad3a 100644
--- a/services/device/public/cpp/test/fake_usb_device_manager.h
+++ b/services/device/public/cpp/test/fake_usb_device_manager.h
@@ -86,7 +86,7 @@ class FakeUsbDeviceManager : public mojom::UsbDeviceManager {
                          RefreshDeviceInfoCallback callback) override;
 #endif
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   void CheckAccess(const std::string& guid,
                    CheckAccessCallback callback) override;
 
@@ -94,7 +94,7 @@ class FakeUsbDeviceManager : public mojom::UsbDeviceManager {
                           uint32_t drop_privileges_mask,
                           mojo::PlatformHandle lifeline_fd,
                           OpenFileDescriptorCallback callback) override;
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   void SetClient(mojo::PendingAssociatedRemote<mojom::UsbDeviceManagerClient>
                      client) override;
diff --git a/services/device/public/mojom/usb_manager.mojom b/services/device/public/mojom/usb_manager.mojom
index ec78190001a98d..d48d42cb92abba 100644
--- a/services/device/public/mojom/usb_manager.mojom
+++ b/services/device/public/mojom/usb_manager.mojom
@@ -41,7 +41,7 @@ interface UsbDeviceManager {
 
   // Check whether permission_broker will allow a future Open call for
   // a given USB device to succeed.
-  [EnableIf=is_chromeos]
+  [EnableIf=is_chromeos_ash]
   CheckAccess(string guid) => (bool success);
 
   // Attempt to open a USB device using permission_broker and return
@@ -49,7 +49,7 @@ interface UsbDeviceManager {
   // |allowed_interfaces_mask|. The |lifeline_fd| should be the remote end of
   // a pipe created locally, and when this pipe is closed permission_broker
   // reattaches any kernel drivers that may have been detached when opening.
-  [EnableIf=is_chromeos]
+  [EnableIf=is_chromeos_ash]
   OpenFileDescriptor(string guid, uint32 allowed_interfaces_mask,
                      handle<platform> lifeline_fd)
       => (mojo_base.mojom.File? fd);
diff --git a/services/device/serial/serial_io_handler.cc b/services/device/serial/serial_io_handler.cc
index f6d87157ce3164..b26b3d970df217 100644
--- a/services/device/serial/serial_io_handler.cc
+++ b/services/device/serial/serial_io_handler.cc
@@ -19,9 +19,9 @@
 #include "build/chromeos_buildflags.h"
 #include "components/device_event_log/device_event_log.h"
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
-#include "chromeos/dbus/permission_broker/permission_broker_client.h"  // nogncheck
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
+#include "chromeos/dbus/permission_broker/permission_broker_client.h"
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 namespace device {
 
@@ -51,7 +51,7 @@ void SerialIoHandler::Open(const mojom::SerialConnectionOptions& options,
   DCHECK(ui_thread_task_runner_.get());
   MergeConnectionOptions(options);
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   // Note: dbus clients are destroyed in PostDestroyThreads so passing |client|
   // as unretained is safe.
   auto* client = chromeos::PermissionBrokerClient::Get();
@@ -73,10 +73,10 @@ void SerialIoHandler::Open(const mojom::SerialConnectionOptions& options,
       {base::MayBlock(), base::TaskShutdownBehavior::CONTINUE_ON_SHUTDOWN},
       base::BindOnce(&SerialIoHandler::StartOpen, this,
                      base::ThreadTaskRunnerHandle::Get()));
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 
 void SerialIoHandler::OnPathOpened(
     scoped_refptr<base::SingleThreadTaskRunner> io_thread_task_runner,
@@ -105,7 +105,7 @@ void SerialIoHandler::ReportPathOpenError(const std::string& error_name,
   std::move(open_complete_).Run(false);
 }
 
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif
 
 void SerialIoHandler::MergeConnectionOptions(
     const mojom::SerialConnectionOptions& options) {
diff --git a/services/device/serial/serial_io_handler.h b/services/device/serial/serial_io_handler.h
index 118e0ef24b42e7..bbc0426a7862fb 100644
--- a/services/device/serial/serial_io_handler.h
+++ b/services/device/serial/serial_io_handler.h
@@ -44,7 +44,7 @@ class SerialIoHandler : public base::RefCountedThreadSafe<SerialIoHandler> {
   virtual void Open(const mojom::SerialConnectionOptions& options,
                     OpenCompleteCallback callback);
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   // Signals that the port has been opened.
   void OnPathOpened(
       scoped_refptr<base::SingleThreadTaskRunner> io_thread_task_runner,
@@ -59,7 +59,7 @@ class SerialIoHandler : public base::RefCountedThreadSafe<SerialIoHandler> {
   // Reports the open error from the permission broker.
   void ReportPathOpenError(const std::string& error_name,
                            const std::string& error_message);
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   // Performs an async read operation. Behavior is undefined if this is called
   // while a read is already pending. Otherwise, |callback| will eventually be
diff --git a/services/device/usb/BUILD.gn b/services/device/usb/BUILD.gn
index 348e9227a1d0d3..834c3473a8a3de 100644
--- a/services/device/usb/BUILD.gn
+++ b/services/device/usb/BUILD.gn
@@ -149,7 +149,7 @@ static_library("usb") {
     ]
   }
 
-  if (is_chromeos_ash || is_chromeos_lacros) {
+  if (is_chromeos_ash) {
     deps += [
       "//chromeos/dbus/permission_broker",
       "//dbus",
diff --git a/services/device/usb/mojo/device_manager_impl.cc b/services/device/usb/mojo/device_manager_impl.cc
index 2ba6ce101d3e94..3c963cc43297e3 100644
--- a/services/device/usb/mojo/device_manager_impl.cc
+++ b/services/device/usb/mojo/device_manager_impl.cc
@@ -25,10 +25,10 @@
 #include "services/device/usb/usb_device.h"
 #include "services/device/usb/usb_service.h"
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
-#include "chromeos/dbus/permission_broker/permission_broker_client.h"  // nogncheck
+#if BUILDFLAG(IS_CHROMEOS_ASH)
+#include "chromeos/dbus/permission_broker/permission_broker_client.h"
 #include "services/device/usb/usb_device_linux.h"
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 namespace device {
 namespace usb {
@@ -118,7 +118,7 @@ void DeviceManagerImpl::OnPermissionGrantedToRefresh(
 }
 #endif  // defined(OS_ANDROID)
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 void DeviceManagerImpl::CheckAccess(const std::string& guid,
                                     CheckAccessCallback callback) {
   scoped_refptr<UsbDevice> device = usb_service_->GetDevice(guid);
@@ -172,7 +172,7 @@ void DeviceManagerImpl::OnOpenFileDescriptorError(
              << message;
   std::move(callback).Run(base::File());
 }
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 void DeviceManagerImpl::SetClient(
     mojo::PendingAssociatedRemote<mojom::UsbDeviceManagerClient> client) {
diff --git a/services/device/usb/mojo/device_manager_impl.h b/services/device/usb/mojo/device_manager_impl.h
index b57cdee9168a3a..38b7f9daa168d6 100644
--- a/services/device/usb/mojo/device_manager_impl.h
+++ b/services/device/usb/mojo/device_manager_impl.h
@@ -71,7 +71,7 @@ class DeviceManagerImpl : public mojom::UsbDeviceManager,
                                     bool granted);
 #endif  // defined(OS_ANDROID)
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   void CheckAccess(const std::string& guid,
                    CheckAccessCallback callback) override;
 
@@ -86,7 +86,7 @@ class DeviceManagerImpl : public mojom::UsbDeviceManager,
   void OnOpenFileDescriptorError(OpenFileDescriptorCallback callback,
                                  const std::string& error_name,
                                  const std::string& message);
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
   void SetClient(mojo::PendingAssociatedRemote<mojom::UsbDeviceManagerClient>
                      client) override;
diff --git a/services/device/usb/usb_device_linux.cc b/services/device/usb/usb_device_linux.cc
index 47fbedc9693d9e..de5e39df436b8e 100644
--- a/services/device/usb/usb_device_linux.cc
+++ b/services/device/usb/usb_device_linux.cc
@@ -23,13 +23,13 @@
 #include "services/device/usb/usb_device_handle_usbfs.h"
 #include "services/device/usb/usb_service.h"
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 #include "chromeos/dbus/permission_broker/permission_broker_client.h"
 
 namespace {
 constexpr uint32_t kAllInterfacesMask = ~0U;
 }  // namespace
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 namespace device {
 
@@ -40,7 +40,7 @@ UsbDeviceLinux::UsbDeviceLinux(const std::string& device_path,
 
 UsbDeviceLinux::~UsbDeviceLinux() = default;
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 
 void UsbDeviceLinux::CheckUsbAccess(ResultCallback callback) {
   DCHECK_CALLED_ON_VALID_SEQUENCE(sequence_checker_);
@@ -48,12 +48,12 @@ void UsbDeviceLinux::CheckUsbAccess(ResultCallback callback) {
                                                            std::move(callback));
 }
 
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 void UsbDeviceLinux::Open(OpenCallback callback) {
   DCHECK_CALLED_ON_VALID_SEQUENCE(sequence_checker_);
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   // create the pipe used as a lifetime to re-attach the original kernel driver
   // to the USB device in permission_broker.
   base::ScopedFD read_end, write_end;
@@ -78,10 +78,10 @@ void UsbDeviceLinux::Open(OpenCallback callback) {
       base::BindOnce(&UsbDeviceLinux::OpenOnBlockingThread, this,
                      std::move(callback), base::ThreadTaskRunnerHandle::Get(),
                      blocking_task_runner));
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 }
 
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
 
 void UsbDeviceLinux::OnOpenRequestComplete(OpenCallback callback,
                                            base::ScopedFD lifeline_fd,
@@ -122,7 +122,7 @@ void UsbDeviceLinux::OpenOnBlockingThread(
   }
 }
 
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
 
 void UsbDeviceLinux::Opened(
     base::ScopedFD fd,
diff --git a/services/device/usb/usb_device_linux.h b/services/device/usb/usb_device_linux.h
index 2ea0f61296196e..70a10700893eef 100644
--- a/services/device/usb/usb_device_linux.h
+++ b/services/device/usb/usb_device_linux.h
@@ -29,9 +29,9 @@ struct UsbDeviceDescriptor;
 class UsbDeviceLinux : public UsbDevice {
  public:
 // UsbDevice implementation:
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   void CheckUsbAccess(ResultCallback callback) override;
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
   void Open(OpenCallback callback) override;
 
   const std::string& device_path() const { return device_path_; }
@@ -52,7 +52,7 @@ class UsbDeviceLinux : public UsbDevice {
   ~UsbDeviceLinux() override;
 
  private:
-#if BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#if BUILDFLAG(IS_CHROMEOS_ASH)
   void OnOpenRequestComplete(OpenCallback callback,
                              base::ScopedFD fd,
                              base::ScopedFD lifeline_fd);
@@ -64,7 +64,7 @@ class UsbDeviceLinux : public UsbDevice {
       OpenCallback callback,
       scoped_refptr<base::SequencedTaskRunner> task_runner,
       scoped_refptr<base::SequencedTaskRunner> blocking_task_runner);
-#endif  // BUILDFLAG(IS_CHROMEOS_ASH) || BUILDFLAG(IS_CHROMEOS_LACROS)
+#endif  // BUILDFLAG(IS_CHROMEOS_ASH)
   void Opened(base::ScopedFD fd,
               base::ScopedFD lifeline_fd,
               OpenCallback callback,