diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index d246682044..0d3ca20e93 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -485,18 +485,24 @@ jobs:
       matrix:
         configuration:
           - env_vars:
+              CTIMETESTS: 'yes'
               CFLAGS: '-fsanitize=memory -fsanitize-recover=memory -g'
           - env_vars:
               ECMULTGENKB: 2
               ECMULTWINDOW: 2
+              CTIMETESTS: 'yes'
               CFLAGS: '-fsanitize=memory -fsanitize-recover=memory -g -O3'
+          - env_vars:
+              # -fsanitize-memory-param-retval is clang's default, but our build system disables it
+              # when ctime_tests when enabled.
+              CFLAGS: '-fsanitize=memory -fsanitize-recover=memory -fsanitize-memory-param-retval -g'
+              CTIMETESTS: 'no'
 
     env:
       ECDH: 'yes'
       RECOVERY: 'yes'
       SCHNORRSIG: 'yes'
       ELLSWIFT: 'yes'
-      CTIMETESTS: 'yes'
       CC: 'clang'
       SECP256K1_TEST_ITERS: 32
       ASM: 'no'
diff --git a/build-aux/m4/bitcoin_secp.m4 b/build-aux/m4/bitcoin_secp.m4
index 11adef4f22..fee2d7b4db 100644
--- a/build-aux/m4/bitcoin_secp.m4
+++ b/build-aux/m4/bitcoin_secp.m4
@@ -45,6 +45,18 @@ fi
 AC_MSG_RESULT($has_valgrind)
 ])
 
+AC_DEFUN([SECP_MSAN_CHECK], [
+AC_MSG_CHECKING(whether MemorySanitizer is enabled)
+AC_COMPILE_IFELSE([AC_LANG_SOURCE([[
+  #if defined(__has_feature)
+  #  if __has_feature(memory_sanitizer)
+  #    error "MemorySanitizer is enabled."
+  #  endif
+  #endif
+  ]])], [msan_enabled=no], [msan_enabled=yes])
+AC_MSG_RESULT([$msan_enabled])
+])
+
 dnl SECP_TRY_APPEND_CFLAGS(flags, VAR)
 dnl Append flags to VAR if CC accepts them.
 AC_DEFUN([SECP_TRY_APPEND_CFLAGS], [
diff --git a/configure.ac b/configure.ac
index 8b62e1dbfd..9640a67399 100644
--- a/configure.ac
+++ b/configure.ac
@@ -247,6 +247,20 @@ if test x"$enable_ctime_tests" = x"auto"; then
     enable_ctime_tests=$enable_valgrind
 fi
 
+print_msan_notice=no
+if test x"$enable_ctime_tests" = x"yes" && test x"$GCC" = x"yes"; then
+  SECP_MSAN_CHECK
+  # MSan on Clang >=16 reports unitialized memory in function parameters and return values, even if
+  # the uninitalized variable is never actually "used". This is called "eager" checking, and it's
+  # sounds like good idea for normal use of MSan. However, it yields many false positives in the
+  # ctime_tests because many return values depend on secret (i.e., "uninitialized") values, and
+  # we're only interested in detecting branches (which count as "uses") on secret data.
+  if test x"$msan_enabled" = x"yes"; then
+    SECP_TRY_APPEND_CFLAGS([-fno-sanitize-memory-param-retval], SECP_CFLAGS)
+    print_msan_notice=yes
+  fi
+fi
+
 if test x"$enable_coverage" = x"yes"; then
     SECP_CONFIG_DEFINES="$SECP_CONFIG_DEFINES -DCOVERAGE=1"
     SECP_CFLAGS="-O0 --coverage $SECP_CFLAGS"
@@ -426,12 +440,7 @@ fi
 ### Check for --enable-experimental if necessary
 ###
 
-if test x"$enable_experimental" = x"yes"; then
-  AC_MSG_NOTICE([******])
-  AC_MSG_NOTICE([WARNING: experimental build])
-  AC_MSG_NOTICE([Experimental features do not have stable APIs or properties, and may not be safe for production use.])
-  AC_MSG_NOTICE([******])
-else
+if test x"$enable_experimental" = x"no"; then
   if test x"$set_asm" = x"arm32"; then
     AC_MSG_ERROR([ARM32 assembly is experimental. Use --enable-experimental to allow.])
   fi
@@ -492,3 +501,17 @@ echo "  CPPFLAGS                = $CPPFLAGS"
 echo "  SECP_CFLAGS             = $SECP_CFLAGS"
 echo "  CFLAGS                  = $CFLAGS"
 echo "  LDFLAGS                 = $LDFLAGS"
+
+if test x"$print_msan_notice" = x"yes"; then
+  echo
+  echo "Note:"
+  echo "  MemorySanitizer detected, tried to add -fno-sanitize-memory-param-retval to SECP_CFLAGS"
+  echo "  to avoid false positives in ctime_tests. Pass --disable-ctime-tests to avoid this."
+fi
+
+if test x"$enable_experimental" = x"yes"; then
+  echo
+  echo "WARNING: Experimental build"
+  echo "  Experimental features do not have stable APIs or properties, and may not be safe for"
+  echo "  production use."
+fi