diff --git a/tox.ini b/tox.ini
index f973c697..f821f0b4 100644
--- a/tox.ini
+++ b/tox.ini
@@ -104,7 +104,9 @@ deps =
     ext-django-4: Django >=4.0,<5.0
     ext-django: django-fake-model
 
-    ext-pynamodb: pynamodb >= 3.3.1
+    py{27,34,35}-ext-pynamodb: pynamodb >=3.3.1,<4.4
+    py{27,34,35}-ext-pynamodb: botocore <1.28
+    py{36,37,38,39}-ext-pynamodb: pynamodb >=3.3.1
 
     ext-psycopg2: psycopg2
     ext-psycopg2: testing.postgresql