diff --git a/packages/s3-request-presigner/README.md b/packages/s3-request-presigner/README.md
index 5fd6ec91f424..94af66e42b95 100644
--- a/packages/s3-request-presigner/README.md
+++ b/packages/s3-request-presigner/README.md
@@ -34,6 +34,10 @@ You can get signed URL for other S3 operations too, like `PutObjectCommand`.
 `expiresIn` config from the examples above is optional. If not set, it's default
 at `900`.
 
+If your request contains server-side encryption(`SSE*`) configurations, because
+of S3 limitation, you need to send corresponding headers along with the
+presigned url. For more information, please go to [S3 SSE reference](https://docs.aws.amazon.com/AmazonS3/latest/dev/KMSUsingRESTAPI.html)
+
 If you already have a request, you can pre-sign the request following the
 section bellow.
 
@@ -50,7 +54,7 @@ const signer = new S3Presigner({
   credentials: credentialsProvider,
   sha256: nodeSha256, //if the signer is used in browser, use `browserSha256` then
 });
-const url = await signer.presign(request);
+const presigned = await signer.presign(request);
 ```
 
 ES6 Example:
@@ -64,7 +68,7 @@ const signer = new S3RequestPresigner({
   credentials: credentialsProvider,
   sha256: nodeSha256, //if the signer is used in browser, use `browserSha256` then
 });
-const url = await signer.presign(request);
+const presigned = await signer.presign(request);
 ```
 
 To avoid redundant construction parameters when instantiating the s3 presigner,
@@ -77,3 +81,12 @@ const signer = new S3RequestPresigner({
   ...s3.config,
 });
 ```
+
+If your request contains server-side encryption(`x-amz-server-side-encryption*`)
+headers, because of S3 limitation, you need to send these headers along
+with the presigned url. That is to say, the url only from calling `formatUrl()`
+to `presigned` is not sufficient to make a request. You need to send the
+server-side encryption headers along with url. These headers remain in the
+`presigned.headers`
+
+For more information, please go to [S3 SSE reference](https://docs.aws.amazon.com/AmazonS3/latest/dev/KMSUsingRESTAPI.html)
diff --git a/packages/s3-request-presigner/src/presigner.spec.ts b/packages/s3-request-presigner/src/presigner.spec.ts
index b9f0896198b1..e4ee300c7e3c 100644
--- a/packages/s3-request-presigner/src/presigner.spec.ts
+++ b/packages/s3-request-presigner/src/presigner.spec.ts
@@ -87,4 +87,19 @@ describe("s3 presigner", () => {
       [EXPIRES_QUERY_PARAM]: "900",
     });
   });
+
+  it("should disable hoisting server-side-encryption headers to query", async () => {
+    const signer = new S3RequestPresigner(s3ResolvedConfig);
+    const signed = await signer.presign({
+      ...minimalRequest,
+      headers: {
+        ...minimalRequest.headers,
+        "x-amz-server-side-encryption": "kms",
+      },
+    });
+    expect(signed.headers).toMatchObject({
+      "x-amz-server-side-encryption": "kms",
+    });
+    expect(signed.query?.["X-Amz-SignedHeaders"]).toEqual(expect.stringContaining("x-amz-server-side-encryption"));
+  });
 });
diff --git a/packages/s3-request-presigner/src/presigner.ts b/packages/s3-request-presigner/src/presigner.ts
index 437ededa5e11..5525c6be2bd3 100644
--- a/packages/s3-request-presigner/src/presigner.ts
+++ b/packages/s3-request-presigner/src/presigner.ts
@@ -31,13 +31,22 @@ export class S3RequestPresigner implements RequestPresigner {
 
   public async presign(
     requestToSign: IHttpRequest,
-    { unsignableHeaders = new Set(), ...options }: RequestPresigningArguments = {}
+    { unsignableHeaders = new Set(), unhoistableHeaders = new Set(), ...options }: RequestPresigningArguments = {}
   ): Promise<IHttpRequest> {
     unsignableHeaders.add("content-type");
+    // S3 requires SSE headers to be signed in headers instead of query
+    // See: https://github.com/aws/aws-sdk-js-v3/issues/1576
+    Object.keys(requestToSign.headers)
+      .map((header) => header.toLowerCase())
+      .filter((header) => header.startsWith("x-amz-server-side-encryption"))
+      .forEach((header) => {
+        unhoistableHeaders.add(header);
+      });
     requestToSign.headers[SHA256_HEADER] = UNSIGNED_PAYLOAD;
     return this.signer.presign(requestToSign, {
       expiresIn: 900,
       unsignableHeaders,
+      unhoistableHeaders,
       ...options,
     });
   }