diff --git a/pkg/deploy/lattice/targets_manager.go b/pkg/deploy/lattice/targets_manager.go
index 7262233a..747767ce 100644
--- a/pkg/deploy/lattice/targets_manager.go
+++ b/pkg/deploy/lattice/targets_manager.go
@@ -3,6 +3,7 @@ package lattice
 import (
 	"context"
 	"errors"
+
 	"github.com/golang/glog"
 
 	"github.com/aws/aws-sdk-go/aws"
@@ -96,6 +97,11 @@ func (s *defaultTargetsManager) Create(ctx context.Context, targets *latticemode
 		targetList = append(targetList, &t)
 	}
 
+	// No targets to register
+	if len(targetList) == 0 {
+		return nil
+	}
+
 	registerRouteInput := vpclattice.RegisterTargetsInput{
 		TargetGroupIdentifier: &tg.ID,
 		Targets:               targetList,
diff --git a/pkg/deploy/lattice/targets_manager_test.go b/pkg/deploy/lattice/targets_manager_test.go
index 0c2f8b79..6d03c621 100644
--- a/pkg/deploy/lattice/targets_manager_test.go
+++ b/pkg/deploy/lattice/targets_manager_test.go
@@ -120,12 +120,19 @@ func Test_RegisterTargets_Registerfailed(t *testing.T) {
 		Name:          "test",
 		Namespace:     "",
 		TargetGroupID: "123456789",
-		TargetIPList:  nil,
+		TargetIPList: []latticemodel.Target{
+			{
+				TargetIP: "123.456.7.891",
+				Port:     sPort,
+			},
+		},
 	}
+
 	planToRegister := latticemodel.Targets{
 		ResourceMeta: core.ResourceMeta{},
 		Spec:         targetsSpec,
 	}
+
 	registerTargetsOutput := &vpclattice.RegisterTargetsOutput{}
 
 	latticeDataStore := latticestore.NewLatticeDataStore()
@@ -233,3 +240,39 @@ func Test_RegisterTargets_RegisterUnsuccessfully(t *testing.T) {
 	assert.NotNil(t, err)
 	assert.Equal(t, err, errors.New(LATTICE_RETRY))
 }
+
+func Test_RegisterTargets_NoTargets_NoCallRegisterTargets(t *testing.T) {
+	planToRegister := latticemodel.Targets{
+		ResourceMeta: core.ResourceMeta{},
+		Spec: latticemodel.TargetsSpec{
+			Name:          "test",
+			Namespace:     "",
+			TargetGroupID: "123456789",
+			TargetIPList:  []latticemodel.Target{},
+		},
+	}
+
+	latticeDataStore := latticestore.NewLatticeDataStore()
+	tgName := latticestore.TargetGroupName("test", "")
+
+	listTargetOutput := []*vpclattice.TargetSummary{}
+
+	// routename
+	latticeDataStore.AddTargetGroup(tgName, "vpc-123456789", "123456789", "123456789", false, "")
+
+	c := gomock.NewController(t)
+	defer c.Finish()
+	ctx := context.TODO()
+	mockCloud := mocks_aws.NewMockCloud(c)
+	mockVpcLatticeSess := mocks.NewMockLattice(c)
+
+	mockVpcLatticeSess.EXPECT().ListTargetsAsList(ctx, gomock.Any()).Return(listTargetOutput, nil)
+	// Expect not to call RegisterTargets
+	mockVpcLatticeSess.EXPECT().RegisterTargetsWithContext(ctx, gomock.Any()).MaxTimes(0)
+	mockCloud.EXPECT().Lattice().Return(mockVpcLatticeSess).AnyTimes()
+
+	targetsManager := NewTargetsManager(mockCloud, latticeDataStore)
+	err := targetsManager.Create(ctx, &planToRegister)
+
+	assert.Nil(t, err)
+}
diff --git a/pkg/deploy/lattice/targets_synthesizer.go b/pkg/deploy/lattice/targets_synthesizer.go
index d744f87a..93f77e12 100644
--- a/pkg/deploy/lattice/targets_synthesizer.go
+++ b/pkg/deploy/lattice/targets_synthesizer.go
@@ -4,6 +4,7 @@ import (
 	"context"
 	"errors"
 	"fmt"
+
 	"github.com/golang/glog"
 
 	lattice_aws "github.com/aws/aws-application-networking-k8s/pkg/aws"
@@ -49,6 +50,7 @@ func (t *targetsSynthesizer) SynthesizeTargets(ctx context.Context, resTargets [
 			return errors.New(errmsg)
 
 		}
+
 		tgName := latticestore.TargetGroupName(targets.Spec.Name, targets.Spec.Namespace)
 
 		var targetList []latticestore.Target
diff --git a/pkg/gateway/model_build_targets.go b/pkg/gateway/model_build_targets.go
index 2da7d9c4..a06a5615 100644
--- a/pkg/gateway/model_build_targets.go
+++ b/pkg/gateway/model_build_targets.go
@@ -109,6 +109,7 @@ func (t *latticeTargetsModelBuildTask) buildLatticeTargets(ctx context.Context)
 	}
 
 	definedPorts := make(map[int32]struct{})
+
 	if tg.ByServiceExport {
 		serviceExport := &mcs_api.ServiceExport{}
 		err = t.client.Get(ctx, namespacedName, serviceExport)
diff --git a/test/suites/integration/httproute_creation_test.go b/test/suites/integration/httproute_creation_test.go
index 1088774f..12166a1f 100644
--- a/test/suites/integration/httproute_creation_test.go
+++ b/test/suites/integration/httproute_creation_test.go
@@ -12,6 +12,7 @@ import (
 
 	"github.com/aws/aws-application-networking-k8s/pkg/model/core"
 	"github.com/aws/aws-application-networking-k8s/test/pkg/test"
+	"github.com/aws/aws-sdk-go/aws"
 )
 
 var _ = Describe("HTTPRoute Creation", func() {
@@ -82,6 +83,26 @@ var _ = Describe("HTTPRoute Creation", func() {
 		})
 	})
 
+	Context("Order #4: Service, HttpRoute", func() {
+		It("Create lattice resources successfully when no Targets available", func() {
+			httpRoute = testFramework.NewHttpRoute(testGateway, service, "Service")
+
+			// Override port match to make the BackendRef not be able to find
+			// any port causing no available targets to register
+			httpRoute.Spec.Rules[0].BackendRefs[0].BackendRef.Port = (*v1beta1.PortNumber)(aws.Int32(100))
+
+			testFramework.ExpectCreated(
+				ctx,
+				httpRoute,
+				deployment,
+				service,
+			)
+
+			testFramework.GetTargetGroup(ctx, service)
+			testFramework.GetVpcLatticeService(ctx, core.NewHTTPRoute(*httpRoute))
+		})
+	})
+
 	AfterEach(func() {
 		testFramework.ExpectDeleted(ctx, httpRoute)
 		testFramework.SleepForRouteDeletion()