diff --git a/__tests__/Auth0Client/loginWithPopup.test.ts b/__tests__/Auth0Client/loginWithPopup.test.ts
index 8ebb4162b..4a96f0ae7 100644
--- a/__tests__/Auth0Client/loginWithPopup.test.ts
+++ b/__tests__/Auth0Client/loginWithPopup.test.ts
@@ -389,6 +389,16 @@ describe('Auth0Client', () => {
       ).rejects.toThrowError('Timeout');
     });
 
+    it('throws an error if no popup could be opened', async () => {
+      const auth0 = setup();
+
+      // Use auth0.loginWithPopup directly here, which doesn't set up
+      // windowMock and returns null by default (as opposed to using the `loginWithPopup` helper)
+      await expect(auth0.loginWithPopup()).rejects.toThrowError(
+        /unable to open a popup/i
+      );
+    });
+
     it('uses a custom popup specified in the configuration and redirect', async () => {
       const auth0 = setup();
       const popup = {
diff --git a/package-lock.json b/package-lock.json
index a51332d5c..39eddbde4 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -3752,9 +3752,9 @@
       }
     },
     "node_modules/cliui/node_modules/ansi-regex": {
-      "version": "4.1.0",
-      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-      "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+      "version": "4.1.1",
+      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+      "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
       "dev": true,
       "engines": {
         "node": ">=6"
@@ -6793,9 +6793,9 @@
       }
     },
     "node_modules/inquirer/node_modules/ansi-regex": {
-      "version": "4.1.0",
-      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-      "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+      "version": "4.1.1",
+      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+      "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
       "dev": true,
       "engines": {
         "node": ">=6"
@@ -10627,9 +10627,9 @@
       }
     },
     "node_modules/minimist": {
-      "version": "1.2.5",
-      "resolved": "https://registry.npmjs.org/minimist/-/minimist-1.2.5.tgz",
-      "integrity": "sha512-FM9nNUYrRBAELZQT3xeZQ7fmMOBg6nWNmJKTcgsJeaLstP/UODVpGsr5OhXhhXg6f+qtJ8uiZ+PUxkDWcgIXLw==",
+      "version": "1.2.6",
+      "resolved": "https://registry.npmjs.org/minimist/-/minimist-1.2.6.tgz",
+      "integrity": "sha512-Jsjnk4bw3YJqYzbdyBiNsPWHPfO++UGG749Cxs6peCu5Xg4nrena6OVxOYxrQTqww0Jmwt+Ref8rggumkTLz9Q==",
       "dev": true
     },
     "node_modules/mkdirp": {
@@ -13371,9 +13371,9 @@
       }
     },
     "node_modules/table/node_modules/ansi-regex": {
-      "version": "4.1.0",
-      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-      "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+      "version": "4.1.1",
+      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+      "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
       "dev": true,
       "engines": {
         "node": ">=6"
@@ -14913,9 +14913,9 @@
       }
     },
     "node_modules/yargs/node_modules/ansi-regex": {
-      "version": "4.1.0",
-      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-      "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+      "version": "4.1.1",
+      "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+      "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
       "dev": true,
       "engines": {
         "node": ">=6"
@@ -16819,7 +16819,8 @@
       "version": "5.3.2",
       "resolved": "https://registry.npmjs.org/acorn-jsx/-/acorn-jsx-5.3.2.tgz",
       "integrity": "sha512-rq9s+JNhf0IChjtDXxllJ7g41oZk5SlXtp0LHwyA5cejwn7vKmKp4pPri6YEePv2PU65sAsegbXtIinmDFDXgQ==",
-      "dev": true
+      "dev": true,
+      "requires": {}
     },
     "acorn-walk": {
       "version": "7.2.0",
@@ -17944,9 +17945,9 @@
       },
       "dependencies": {
         "ansi-regex": {
-          "version": "4.1.0",
-          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-          "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+          "version": "4.1.1",
+          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+          "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
           "dev": true
         },
         "ansi-styles": {
@@ -20304,9 +20305,9 @@
           "dev": true
         },
         "ansi-regex": {
-          "version": "4.1.0",
-          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-          "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+          "version": "4.1.1",
+          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+          "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
           "dev": true
         },
         "ansi-styles": {
@@ -21564,7 +21565,8 @@
       "version": "1.2.2",
       "resolved": "https://registry.npmjs.org/jest-pnp-resolver/-/jest-pnp-resolver-1.2.2.tgz",
       "integrity": "sha512-olV41bKSMm8BdnuMsewT4jqlZ8+3TCARAXjZGT9jcoSnrfUnRCqnMoF9XEeoWjbzObpqF9dRhHQj0Xb9QdF6/w==",
-      "dev": true
+      "dev": true,
+      "requires": {}
     },
     "jest-regex-util": {
       "version": "27.5.1",
@@ -23288,9 +23290,9 @@
       }
     },
     "minimist": {
-      "version": "1.2.5",
-      "resolved": "https://registry.npmjs.org/minimist/-/minimist-1.2.5.tgz",
-      "integrity": "sha512-FM9nNUYrRBAELZQT3xeZQ7fmMOBg6nWNmJKTcgsJeaLstP/UODVpGsr5OhXhhXg6f+qtJ8uiZ+PUxkDWcgIXLw==",
+      "version": "1.2.6",
+      "resolved": "https://registry.npmjs.org/minimist/-/minimist-1.2.6.tgz",
+      "integrity": "sha512-Jsjnk4bw3YJqYzbdyBiNsPWHPfO++UGG749Cxs6peCu5Xg4nrena6OVxOYxrQTqww0Jmwt+Ref8rggumkTLz9Q==",
       "dev": true
     },
     "mkdirp": {
@@ -24766,7 +24768,8 @@
       "version": "1.6.1",
       "resolved": "https://registry.npmjs.org/rollup-plugin-web-worker-loader/-/rollup-plugin-web-worker-loader-1.6.1.tgz",
       "integrity": "sha512-4QywQSz1NXFHKdyiou16mH3ijpcfLtLGOrAqvAqu1Gx+P8+zj+3gwC2BSL/VW1d+LW4nIHC8F7d7OXhs9UdR2A==",
-      "dev": true
+      "dev": true,
+      "requires": {}
     },
     "rollup-pluginutils": {
       "version": "2.8.2",
@@ -25406,9 +25409,9 @@
       },
       "dependencies": {
         "ansi-regex": {
-          "version": "4.1.0",
-          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-          "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+          "version": "4.1.1",
+          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+          "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
           "dev": true
         },
         "ansi-styles": {
@@ -26550,7 +26553,8 @@
       "version": "7.5.7",
       "resolved": "https://registry.npmjs.org/ws/-/ws-7.5.7.tgz",
       "integrity": "sha512-KMvVuFzpKBuiIXW3E4u3mySRO2/mCHSyZDJQM5NQ9Q9KHWHWh0NHgfbRMLLrceUK5qAL4ytALJbpRMjixFZh8A==",
-      "dev": true
+      "dev": true,
+      "requires": {}
     },
     "xml": {
       "version": "1.0.1",
@@ -26618,9 +26622,9 @@
       },
       "dependencies": {
         "ansi-regex": {
-          "version": "4.1.0",
-          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.0.tgz",
-          "integrity": "sha512-1apePfXM1UOSqw0o9IiFAovVz9M5S1Dg+4TrDwfMewQ6p/rmMueb7tWZjQ1rx4Loy1ArBggoqGpfqqdI4rondg==",
+          "version": "4.1.1",
+          "resolved": "https://registry.npmjs.org/ansi-regex/-/ansi-regex-4.1.1.tgz",
+          "integrity": "sha512-ILlv4k/3f6vfQ4OoP2AGvirOktlQ98ZEL1k9FaQjxa3L1abBgbuTDAdPOpvbGncC0BTVQrl+OM8xZGK6tWXt7g==",
           "dev": true
         },
         "emoji-regex": {
diff --git a/src/Auth0Client.ts b/src/Auth0Client.ts
index ae3bf0acb..ba9c98c85 100644
--- a/src/Auth0Client.ts
+++ b/src/Auth0Client.ts
@@ -474,6 +474,12 @@ export default class Auth0Client {
 
     if (!config.popup) {
       config.popup = openPopup('');
+
+      if (!config.popup) {
+        throw new Error(
+          'Unable to open a popup for loginWithPopup - window.open returned `null`'
+        );
+      }
     }
 
     const { ...authorizeOptions } = options;