diff --git a/crates/uv-cli/src/lib.rs b/crates/uv-cli/src/lib.rs
index c6e9d3e429c2..fc52da503819 100644
--- a/crates/uv-cli/src/lib.rs
+++ b/crates/uv-cli/src/lib.rs
@@ -2427,6 +2427,13 @@ pub struct RunArgs {
     #[arg(long)]
     pub isolated: bool,
 
+    /// Avoid syncing the virtual environment.
+    ///
+    /// Implies `--frozen`, as the project dependencies will be ignored (i.e., the lockfile will not
+    /// be updated, since the environment will not be synced regardless).
+    #[arg(long, conflicts_with = "frozen")]
+    pub no_sync: bool,
+
     /// Assert that the `uv.lock` will remain unchanged.
     ///
     /// Requires that the lockfile is up-to-date. If the lockfile is missing or
@@ -2728,7 +2735,7 @@ pub struct AddArgs {
     #[arg(long)]
     pub extra: Option<Vec<ExtraName>>,
 
-    /// Avoid syncing the virtual environment after re-locking the project.
+    /// Avoid syncing the virtual environment.
     #[arg(long, conflicts_with = "frozen")]
     pub no_sync: bool,
 
diff --git a/crates/uv/src/commands/project/run.rs b/crates/uv/src/commands/project/run.rs
index a2094f3cc06d..535de1006fa4 100644
--- a/crates/uv/src/commands/project/run.rs
+++ b/crates/uv/src/commands/project/run.rs
@@ -49,6 +49,7 @@ pub(crate) async fn run(
     show_resolution: bool,
     locked: bool,
     frozen: bool,
+    no_sync: bool,
     isolated: bool,
     package: Option<PackageName>,
     no_project: bool,
@@ -258,6 +259,11 @@ pub(crate) async fn run(
                 "`--frozen` is a no-op for Python scripts with inline metadata, which always run in isolation"
             );
         }
+        if no_sync {
+            warn_user!(
+                "`--no-sync` is a no-op for Python scripts with inline metadata, which always run in isolation"
+            );
+        }
         if isolated {
             warn_user!(
                 "`--isolated` is a no-op for Python scripts with inline metadata, which always run in isolation"
@@ -318,6 +324,9 @@ pub(crate) async fn run(
             if frozen {
                 warn_user!("`--frozen` has no effect when used alongside `--no-project`");
             }
+            if no_sync {
+                warn_user!("`--no-sync` has no effect when used alongside `--no-project`");
+            }
         } else if project.is_none() {
             // If we can't find a project and the user provided a project-only setting, warn.
             if !extras.is_empty() {
@@ -329,8 +338,8 @@ pub(crate) async fn run(
             if locked {
                 warn_user!("`--locked` has no effect when used outside of a project");
             }
-            if frozen {
-                warn_user!("`--frozen` has no effect when used outside of a project");
+            if no_sync {
+                warn_user!("`--no-sync` has no effect when used outside of a project");
             }
         }
 
@@ -408,60 +417,64 @@ pub(crate) async fn run(
                 .await?
             };
 
-            let result = match project::lock::do_safe_lock(
-                locked,
-                frozen,
-                project.workspace(),
-                venv.interpreter(),
-                settings.as_ref().into(),
-                if show_resolution {
-                    Box::new(DefaultResolveLogger)
-                } else {
-                    Box::new(SummaryResolveLogger)
-                },
-                connectivity,
-                concurrency,
-                native_tls,
-                cache,
-                printer,
-            )
-            .await
-            {
-                Ok(result) => result,
-                Err(ProjectError::Operation(operations::Error::Resolve(
-                    uv_resolver::ResolveError::NoSolution(err),
-                ))) => {
-                    let report = miette::Report::msg(format!("{err}")).context(err.header());
-                    eprint!("{report:?}");
-                    return Ok(ExitStatus::Failure);
-                }
-                Err(err) => return Err(err.into()),
-            };
+            if no_sync {
+                debug!("Skipping environment synchronization due to `--no-sync`");
+            } else {
+                let result = match project::lock::do_safe_lock(
+                    locked,
+                    frozen,
+                    project.workspace(),
+                    venv.interpreter(),
+                    settings.as_ref().into(),
+                    if show_resolution {
+                        Box::new(DefaultResolveLogger)
+                    } else {
+                        Box::new(SummaryResolveLogger)
+                    },
+                    connectivity,
+                    concurrency,
+                    native_tls,
+                    cache,
+                    printer,
+                )
+                .await
+                {
+                    Ok(result) => result,
+                    Err(ProjectError::Operation(operations::Error::Resolve(
+                        uv_resolver::ResolveError::NoSolution(err),
+                    ))) => {
+                        let report = miette::Report::msg(format!("{err}")).context(err.header());
+                        eprint!("{report:?}");
+                        return Ok(ExitStatus::Failure);
+                    }
+                    Err(err) => return Err(err.into()),
+                };
 
-            let install_options = InstallOptions::default();
-
-            project::sync::do_sync(
-                InstallTarget::from(&project),
-                &venv,
-                result.lock(),
-                &extras,
-                dev,
-                install_options,
-                Modifications::Sufficient,
-                settings.as_ref().into(),
-                &state,
-                if show_resolution {
-                    Box::new(DefaultInstallLogger)
-                } else {
-                    Box::new(SummaryInstallLogger)
-                },
-                connectivity,
-                concurrency,
-                native_tls,
-                cache,
-                printer,
-            )
-            .await?;
+                let install_options = InstallOptions::default();
+
+                project::sync::do_sync(
+                    InstallTarget::from(&project),
+                    &venv,
+                    result.lock(),
+                    &extras,
+                    dev,
+                    install_options,
+                    Modifications::Sufficient,
+                    settings.as_ref().into(),
+                    &state,
+                    if show_resolution {
+                        Box::new(DefaultInstallLogger)
+                    } else {
+                        Box::new(SummaryInstallLogger)
+                    },
+                    connectivity,
+                    concurrency,
+                    native_tls,
+                    cache,
+                    printer,
+                )
+                .await?;
+            }
 
             venv.into_interpreter()
         } else {
diff --git a/crates/uv/src/lib.rs b/crates/uv/src/lib.rs
index df4780c0a9ba..7e2ef8fcee15 100644
--- a/crates/uv/src/lib.rs
+++ b/crates/uv/src/lib.rs
@@ -1123,6 +1123,7 @@ async fn run_project(
                 args.show_resolution || globals.verbose > 0,
                 args.locked,
                 args.frozen,
+                args.no_sync,
                 args.isolated,
                 args.package,
                 args.no_project,
diff --git a/crates/uv/src/settings.rs b/crates/uv/src/settings.rs
index 1aae167b540c..1bf7a398d050 100644
--- a/crates/uv/src/settings.rs
+++ b/crates/uv/src/settings.rs
@@ -217,6 +217,7 @@ pub(crate) struct RunSettings {
     pub(crate) show_resolution: bool,
     pub(crate) package: Option<PackageName>,
     pub(crate) no_project: bool,
+    pub(crate) no_sync: bool,
     pub(crate) python: Option<String>,
     pub(crate) refresh: Refresh,
     pub(crate) settings: ResolverInstallerSettings,
@@ -237,6 +238,7 @@ impl RunSettings {
             with_editable,
             with_requirements,
             isolated,
+            no_sync,
             locked,
             frozen,
             installer,
@@ -266,6 +268,7 @@ impl RunSettings {
             show_resolution,
             package,
             no_project,
+            no_sync,
             python,
             refresh: Refresh::from(refresh),
             settings: ResolverInstallerSettings::combine(
diff --git a/crates/uv/tests/run.rs b/crates/uv/tests/run.rs
index c12fd5cd6442..dae69c97e266 100644
--- a/crates/uv/tests/run.rs
+++ b/crates/uv/tests/run.rs
@@ -976,6 +976,62 @@ fn run_frozen() -> Result<()> {
     Ok(())
 }
 
+#[test]
+fn run_no_sync() -> Result<()> {
+    let context = TestContext::new("3.12");
+
+    let pyproject_toml = context.temp_dir.child("pyproject.toml");
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "project"
+        version = "0.1.0"
+        requires-python = ">=3.12"
+        dependencies = ["anyio==3.7.0"]
+
+        [build-system]
+        requires = ["setuptools>=42"]
+        build-backend = "setuptools.build_meta"
+        "#,
+    )?;
+
+    // Running with `--no-sync` should succeed error, even if the lockfile isn't present.
+    uv_snapshot!(context.filters(), context.run().arg("--no-sync").arg("--").arg("python").arg("--version"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    Python 3.12.[X]
+
+    ----- stderr -----
+    "###);
+
+    context.lock().assert().success();
+
+    // Running with `--no-sync` should not install any requirements.
+    uv_snapshot!(context.filters(), context.run().arg("--no-sync").arg("--").arg("python").arg("--version"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    Python 3.12.[X]
+
+    ----- stderr -----
+    "###);
+
+    context.sync().assert().success();
+
+    // But it should have access to the installed packages.
+    uv_snapshot!(context.filters(), context.run().arg("--no-sync").arg("--").arg("python").arg("-c").arg("import anyio; print(anyio.__name__)"), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+    anyio
+
+    ----- stderr -----
+    "###);
+
+    Ok(())
+}
+
 #[test]
 fn run_empty_requirements_txt() -> Result<()> {
     let context = TestContext::new("3.12");
diff --git a/docs/reference/cli.md b/docs/reference/cli.md
index 3aeef064e7ae..4a8b8ba80056 100644
--- a/docs/reference/cli.md
+++ b/docs/reference/cli.md
@@ -265,6 +265,10 @@ uv run [OPTIONS] <COMMAND>
 
 </dd><dt><code>--no-sources</code></dt><dd><p>Ignore the <code>tool.uv.sources</code> table when resolving dependencies. Used to lock against the standards-compliant, publishable package metadata, as opposed to using any local or Git sources</p>
 
+</dd><dt><code>--no-sync</code></dt><dd><p>Avoid syncing the virtual environment.</p>
+
+<p>Implies <code>--frozen</code>, as the project dependencies will be ignored (i.e., the lockfile will not be updated, since the environment will not be synced regardless).</p>
+
 </dd><dt><code>--offline</code></dt><dd><p>Disable network access.</p>
 
 <p>When disabled, uv will only use locally cached data and locally available files.</p>
@@ -721,7 +725,7 @@ uv add [OPTIONS] <PACKAGES|--requirements <REQUIREMENTS>>
 
 </dd><dt><code>--no-sources</code></dt><dd><p>Ignore the <code>tool.uv.sources</code> table when resolving dependencies. Used to lock against the standards-compliant, publishable package metadata, as opposed to using any local or Git sources</p>
 
-</dd><dt><code>--no-sync</code></dt><dd><p>Avoid syncing the virtual environment after re-locking the project</p>
+</dd><dt><code>--no-sync</code></dt><dd><p>Avoid syncing the virtual environment</p>
 
 </dd><dt><code>--offline</code></dt><dd><p>Disable network access.</p>