diff --git a/crates/ruff/resources/test/fixtures/pycodestyle/E721.py b/crates/ruff/resources/test/fixtures/pycodestyle/E721.py
index a220f58c3d8e4..5f07803832eca 100644
--- a/crates/ruff/resources/test/fixtures/pycodestyle/E721.py
+++ b/crates/ruff/resources/test/fixtures/pycodestyle/E721.py
@@ -58,3 +58,6 @@
 types = StrEnum
 if x == types.X:
     pass
+
+#: E721
+assert type(res) is int
diff --git a/crates/ruff/src/rules/pycodestyle/rules/type_comparison.rs b/crates/ruff/src/rules/pycodestyle/rules/type_comparison.rs
index 553d21319ef0b..1d65bcd9215c1 100644
--- a/crates/ruff/src/rules/pycodestyle/rules/type_comparison.rs
+++ b/crates/ruff/src/rules/pycodestyle/rules/type_comparison.rs
@@ -1,31 +1,33 @@
-use itertools::izip;
-use ruff_python_ast::{self as ast, Arguments, CmpOp, Constant, Expr, Ranged};
-
 use ruff_diagnostics::{Diagnostic, Violation};
 use ruff_macros::{derive_message_formats, violation};
+use ruff_python_ast::helpers::is_const_none;
+use ruff_python_ast::{self as ast, CmpOp, Expr, Ranged};
 
 use crate::checkers::ast::Checker;
 
 /// ## What it does
-/// Checks for object type comparisons without using isinstance().
+/// Checks for object type comparisons without using `isinstance()`.
 ///
 /// ## Why is this bad?
 /// Do not compare types directly.
-/// When checking if an object is a instance of a certain type, keep in mind that it might
-/// be subclassed. E.g. `bool` inherits from `int` or `Exception` inherits from `BaseException`.
+///
+/// When checking if an object is a instance of a certain type, keep in mind
+/// that it might be subclassed. For example, `bool` inherits from `int`, and
+/// `Exception` inherits from `BaseException`.
 ///
 /// ## Example
 /// ```python
 /// if type(obj) is type(1):
 ///     pass
+///
+/// if type(obj) is int:
+///     pass
 /// ```
 ///
 /// Use instead:
 /// ```python
 /// if isinstance(obj, int):
 ///     pass
-/// if type(a1) is type(b1):
-///     pass
 /// ```
 #[violation]
 pub struct TypeComparison;
@@ -44,48 +46,25 @@ pub(crate) fn type_comparison(
     ops: &[CmpOp],
     comparators: &[Expr],
 ) {
-    for (op, right) in izip!(ops, comparators) {
+    for (op, right) in ops.iter().zip(comparators) {
         if !matches!(op, CmpOp::Is | CmpOp::IsNot | CmpOp::Eq | CmpOp::NotEq) {
             continue;
         }
         match right {
             Expr::Call(ast::ExprCall {
-                func,
-                arguments: Arguments { args, .. },
-                ..
+                func, arguments, ..
             }) => {
-                if let Expr::Name(ast::ExprName { id, .. }) = func.as_ref() {
-                    // Ex) `type(False)`
-                    if id == "type" && checker.semantic().is_builtin("type") {
-                        if let Some(arg) = args.first() {
-                            // Allow comparison for types which are not obvious.
-                            if !matches!(
-                                arg,
-                                Expr::Name(_)
-                                    | Expr::Constant(ast::ExprConstant {
-                                        value: Constant::None,
-                                        kind: None,
-                                        range: _
-                                    })
-                            ) {
-                                checker
-                                    .diagnostics
-                                    .push(Diagnostic::new(TypeComparison, expr.range()));
-                            }
-                        }
-                    }
-                }
-            }
-            Expr::Attribute(ast::ExprAttribute { value, .. }) => {
-                if let Expr::Name(ast::ExprName { id, .. }) = value.as_ref() {
-                    // Ex) `types.NoneType`
-                    if id == "types"
-                        && checker
-                            .semantic()
-                            .resolve_call_path(value)
-                            .is_some_and(|call_path| {
-                                call_path.first().is_some_and(|module| *module == "types")
-                            })
+                // Ex) `type(obj) is type(1)`
+                let Expr::Name(ast::ExprName { id, .. }) = func.as_ref() else {
+                    continue;
+                };
+
+                if id == "type" && checker.semantic().is_builtin("type") {
+                    // Allow comparison for types which are not obvious.
+                    if arguments
+                        .args
+                        .first()
+                        .is_some_and(|arg| !arg.is_name_expr() && !is_const_none(arg))
                     {
                         checker
                             .diagnostics
@@ -93,6 +72,30 @@ pub(crate) fn type_comparison(
                     }
                 }
             }
+            Expr::Attribute(ast::ExprAttribute { value, .. }) => {
+                // Ex) `type(obj) is types.NoneType`
+                if checker
+                    .semantic()
+                    .resolve_call_path(value)
+                    .is_some_and(|call_path| matches!(call_path.as_slice(), ["types", ..]))
+                {
+                    checker
+                        .diagnostics
+                        .push(Diagnostic::new(TypeComparison, expr.range()));
+                }
+            }
+            Expr::Name(ast::ExprName { id, .. }) => {
+                // Ex) `type(obj) is int`
+                if matches!(
+                    id.as_str(),
+                    "int" | "str" | "float" | "bool" | "complex" | "bytes"
+                ) && checker.semantic().is_builtin(id)
+                {
+                    checker
+                        .diagnostics
+                        .push(Diagnostic::new(TypeComparison, expr.range()));
+                }
+            }
             _ => {}
         }
     }
diff --git a/crates/ruff/src/rules/pycodestyle/snapshots/ruff__rules__pycodestyle__tests__E721_E721.py.snap b/crates/ruff/src/rules/pycodestyle/snapshots/ruff__rules__pycodestyle__tests__E721_E721.py.snap
index 764b9511eb9cb..897cff081a1d6 100644
--- a/crates/ruff/src/rules/pycodestyle/snapshots/ruff__rules__pycodestyle__tests__E721_E721.py.snap
+++ b/crates/ruff/src/rules/pycodestyle/snapshots/ruff__rules__pycodestyle__tests__E721_E721.py.snap
@@ -155,4 +155,11 @@ E721.py:42:8: E721 Do not compare types, use `isinstance()`
 44 | #: Okay
    |
 
+E721.py:63:8: E721 Do not compare types, use `isinstance()`
+   |
+62 | #: E721
+63 | assert type(res) is int
+   |        ^^^^^^^^^^^^^^^^ E721
+   |
+