diff --git a/crates/ruff_linter/resources/test/fixtures/ruff/RUF031.py b/crates/ruff_linter/resources/test/fixtures/ruff/RUF031.py
index 89e06f6bd4e207..4000930038b493 100644
--- a/crates/ruff_linter/resources/test/fixtures/ruff/RUF031.py
+++ b/crates/ruff_linter/resources/test/fixtures/ruff/RUF031.py
@@ -26,4 +26,6 @@
 
 d[1,]
 d[(1,)]
-d[()] # empty tuples should be ignored
\ No newline at end of file
+d[()] # empty tuples should be ignored
+d[:,] # slices in the subscript lead to syntax error if parens are added
+d[1,2,:]
\ No newline at end of file
diff --git a/crates/ruff_linter/resources/test/fixtures/ruff/RUF031_prefer_parens.py b/crates/ruff_linter/resources/test/fixtures/ruff/RUF031_prefer_parens.py
index f3d701ae0df3ac..f546515a743fe0 100644
--- a/crates/ruff_linter/resources/test/fixtures/ruff/RUF031_prefer_parens.py
+++ b/crates/ruff_linter/resources/test/fixtures/ruff/RUF031_prefer_parens.py
@@ -25,4 +25,7 @@
 ] = self._extract_raw_features_from_token
 d[1,]
 d[(1,)]
-d[()] # empty tuples should be ignored
\ No newline at end of file
+d[()] # empty tuples should be ignored
+
+d[:,] # slices in the subscript lead to syntax error if parens are added
+d[1,2,:]
\ No newline at end of file
diff --git a/crates/ruff_linter/src/rules/ruff/rules/incorrectly_parenthesized_tuple_in_subscript.rs b/crates/ruff_linter/src/rules/ruff/rules/incorrectly_parenthesized_tuple_in_subscript.rs
index 01e8638c0d220a..473a0e2f5f8c2c 100644
--- a/crates/ruff_linter/src/rules/ruff/rules/incorrectly_parenthesized_tuple_in_subscript.rs
+++ b/crates/ruff_linter/src/rules/ruff/rules/incorrectly_parenthesized_tuple_in_subscript.rs
@@ -1,6 +1,6 @@
 use ruff_diagnostics::{AlwaysFixableViolation, Diagnostic, Edit, Fix};
 use ruff_macros::{derive_message_formats, violation};
-use ruff_python_ast::ExprSubscript;
+use ruff_python_ast::{Expr, ExprSubscript};
 use ruff_text_size::Ranged;
 
 use crate::checkers::ast::Checker;
@@ -64,6 +64,10 @@ pub(crate) fn subscript_with_parenthesized_tuple(checker: &mut Checker, subscrip
     if tuple_subscript.parenthesized == prefer_parentheses || tuple_subscript.elts.is_empty() {
         return;
     }
+    // Adding parentheses in the presence of a slice leads to a syntax error.
+    if prefer_parentheses && tuple_subscript.elts.iter().any(Expr::is_slice_expr) {
+        return;
+    }
     let locator = checker.locator();
     let source_range = subscript.slice.range();
     let new_source = if prefer_parentheses {
diff --git a/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__RUF031_RUF031.py.snap b/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__RUF031_RUF031.py.snap
index 2c9d230802a60c..4dbad809a6b3df 100644
--- a/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__RUF031_RUF031.py.snap
+++ b/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__RUF031_RUF031.py.snap
@@ -156,6 +156,7 @@ RUF031.py:28:3: RUF031 [*] Avoid parentheses for tuples in subscripts.
 28 | d[(1,)]
    |   ^^^^ RUF031
 29 | d[()] # empty tuples should be ignored
+30 | d[:,] # slices in the subscript lead to syntax error if parens are added
    |
    = help: Remove the parentheses.
 
@@ -166,3 +167,5 @@ RUF031.py:28:3: RUF031 [*] Avoid parentheses for tuples in subscripts.
 28    |-d[(1,)]
    28 |+d[1,]
 29 29 | d[()] # empty tuples should be ignored
+30 30 | d[:,] # slices in the subscript lead to syntax error if parens are added
+31 31 | d[1,2,:]
diff --git a/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__prefer_parentheses_getitem_tuple.snap b/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__prefer_parentheses_getitem_tuple.snap
index 9f776e10124a7b..9af8d5e20bb47d 100644
--- a/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__prefer_parentheses_getitem_tuple.snap
+++ b/crates/ruff_linter/src/rules/ruff/snapshots/ruff_linter__rules__ruff__tests__prefer_parentheses_getitem_tuple.snap
@@ -129,3 +129,5 @@ RUF031_prefer_parens.py:26:3: RUF031 [*] Use parentheses for tuples in subscript
 27 26 | d[(1,)]
    27 |+d[(1,)]
 28 28 | d[()] # empty tuples should be ignored
+29 29 | 
+30 30 | d[:,] # slices in the subscript lead to syntax error if parens are added