diff --git a/.github/workflows/macos-homebrew-build.yml b/.github/workflows/macos-homebrew-build.yml
index 5e2c2580b7..47f429d603 100644
--- a/.github/workflows/macos-homebrew-build.yml
+++ b/.github/workflows/macos-homebrew-build.yml
@@ -62,7 +62,7 @@ jobs:
           -DCMAKE_C_COMPILER=/usr/local/opt/llvm/bin/clang
           -DCMAKE_CXX_COMPILER=/usr/local/opt/llvm/bin/clang++
           -DCMAKE_RANLIB=/usr/bin/ranlib
-          -DPYTHON_EXECUTABLE=/usr/local/opt/python@3.11/bin/python3.11
+          -DPython3_EXECUTABLE=/usr/local/opt/python@3.11/bin/python3.11
           -DTALIPOT_BUILD_CORE_ONLY=ON
           -DTALIPOT_BUILD_TESTS=ON
           -DTALIPOT_BUILD_DOC=OFF
diff --git a/.github/workflows/macos-macports-build.yml b/.github/workflows/macos-macports-build.yml
index 27e0e95572..ec3b9a25d8 100644
--- a/.github/workflows/macos-macports-build.yml
+++ b/.github/workflows/macos-macports-build.yml
@@ -83,7 +83,7 @@ jobs:
           -DCMAKE_INSTALL_PREFIX=$PWD/install
           -DCMAKE_C_COMPILER=/opt/local/bin/clang-mp-${{ env.CLANG_VERSION }}
           -DCMAKE_CXX_COMPILER=/opt/local/bin/clang++-mp-${{ env.CLANG_VERSION }}
-          -DPYTHON_EXECUTABLE=/opt/local/bin/python${{ env.PYTHON_VERSION }}
+          -DPython3_EXECUTABLE=/opt/local/bin/python${{ env.PYTHON_VERSION }}
           -DTALIPOT_BUILD_TESTS=ON
           -DTALIPOT_USE_CCACHE=ON
           -DTALIPOT_BUILD_DOC=OFF
diff --git a/.github/workflows/macos-macports-wheels-build.yml b/.github/workflows/macos-macports-wheels-build.yml
index 82aae06b7b..cdf8557c14 100644
--- a/.github/workflows/macos-macports-wheels-build.yml
+++ b/.github/workflows/macos-macports-wheels-build.yml
@@ -76,9 +76,6 @@ jobs:
           graphviz
       - name: Install Python versions to build wheels against
         run: |
-          curl -LO https://www.python.org/ftp/python/3.7.6/python-3.7.6-macosx10.9.pkg
-          sudo installer -pkg python-3.7.6-macosx10.9.pkg -target /
-          sudo /Library/Frameworks/Python.framework/Versions/3.7/bin/pip3 install wheel
           curl -LO https://www.python.org/ftp/python/3.8.1/python-3.8.1-macosx10.9.pkg
           sudo installer -pkg python-3.8.1-macosx10.9.pkg -target /
           sudo /Library/Frameworks/Python.framework/Versions/3.8/bin/pip3 install wheel
@@ -106,7 +103,9 @@ jobs:
               -DCMAKE_CXX_COMPILER=/opt/local/bin/clang++-mp-${{ env.CLANG_VERSION }} \
               -DTALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET=ON \
               -DTALIPOT_PYTHON_TEST_WHEEL_SUFFIX=a2.dev${{ env.DEV_VERSION }}\
-              -DPYTHON_EXECUTABLE=/Library/Frameworks/Python.framework/Versions/$py3Version/bin/python3 \
+              -DPython3_EXECUTABLE=/Library/Frameworks/Python.framework/Versions/$py3Version/bin/python3 \
+              -DPython3_INCLUDE_DIRS=/Library/Frameworks/Python.framework/Versions/$py3Version/include/python$py3Version \
+              -DPython3_LIBRARIES=/Library/Frameworks/Python.framework/Versions/$py3Version/lib/libpython$py3Version.dylib \
               -DTALIPOT_USE_CCACHE=ON \
               -DTALIPOT_BUILD_CORE_ONLY=ON \
               -DTALIPOT_BUILD_DOC=OFF
diff --git a/.github/workflows/windows-mingw64-build.yml b/.github/workflows/windows-mingw64-build.yml
index a60c1b5aba..738d7221d1 100644
--- a/.github/workflows/windows-mingw64-build.yml
+++ b/.github/workflows/windows-mingw64-build.yml
@@ -64,6 +64,7 @@ jobs:
           -DCMAKE_BUILD_TYPE=Release
           -DCMAKE_NEED_RESPONSE=ON
           -DCMAKE_INSTALL_PREFIX=$PWD/install
+          -DPython3_EXECUTABLE=/mingw64/bin/python3
           -DTALIPOT_BUILD_TESTS=ON
           -DTALIPOT_USE_CCACHE=ON ..
       - name: Talipot build
diff --git a/.github/workflows/windows-wheels-build.yml b/.github/workflows/windows-wheels-build.yml
index fd575f2ea0..476b294873 100644
--- a/.github/workflows/windows-wheels-build.yml
+++ b/.github/workflows/windows-wheels-build.yml
@@ -100,7 +100,7 @@ jobs:
           -DCMAKE_INSTALL_PREFIX=$PWD/install
           -DTALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET=ON
           -DTALIPOT_PYTHON_TEST_WHEEL_SUFFIX=a2.dev${{ env.DEV_VERSION }}
-          -DPYTHON_EXECUTABLE=$(cygpath -u "${{ steps.python-install.outputs.python-path }}")
+          -DPython3_EXECUTABLE=$(cygpath -u "${{ steps.python-install.outputs.python-path }}")
           -DTALIPOT_USE_CCACHE=ON
           -DTALIPOT_BUILD_CORE_ONLY=ON
           -DTALIPOT_BUILD_DOC=OFF
diff --git a/CMakeLists.txt b/CMakeLists.txt
index b9e247cb36..7a639cb6d1 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -1,4 +1,4 @@
-CMAKE_MINIMUM_REQUIRED(VERSION 3.10)
+CMAKE_MINIMUM_REQUIRED(VERSION 3.16)
 
 # Remove CMake warnings related to Qt5
 IF(POLICY CMP0020)
diff --git a/appveyor/appveyor_macos.sh b/appveyor/appveyor_macos.sh
index af1064add2..426ca980db 100644
--- a/appveyor/appveyor_macos.sh
+++ b/appveyor/appveyor_macos.sh
@@ -60,7 +60,7 @@ cmake .. -DCMAKE_BUILD_TYPE=Release \
   -DCMAKE_INSTALL_PREFIX=$PWD/install \
   -DCMAKE_C_COMPILER=/opt/local/bin/clang-mp-${CLANG_VERSION} \
   -DCMAKE_CXX_COMPILER=/opt/local/bin/clang++-mp-${CLANG_VERSION} \
-  -DPYTHON_EXECUTABLE=/opt/local/bin/python${PYTHON_VERSION} \
+  -DPython3_EXECUTABLE=/opt/local/bin/python${PYTHON_VERSION} \
   -DTALIPOT_BUILD_TESTS=ON \
   -DTALIPOT_USE_CCACHE=ON \
   -DTALIPOT_BUILD_DOC=$TALIPOT_BUILD_DOC \
diff --git a/appveyor/appveyor_msvc.bat b/appveyor/appveyor_msvc.bat
index 4794d78197..d92113a95b 100644
--- a/appveyor/appveyor_msvc.bat
+++ b/appveyor/appveyor_msvc.bat
@@ -104,7 +104,7 @@ cmake -G "%CMAKE_VS_GENERATOR%"^
   -DCMAKE_INCLUDE_PATH="%INCLUDE_PATH%"^
   -DCMAKE_LIBRARY_PATH="%LIBRARY_PATH%"^
   -DCMAKE_PREFIX_PATH="%QT_DIR%"^
-  -DPYTHON_EXECUTABLE="%PYTHON_HOME%/python.exe"^
+  -DPython3_EXECUTABLE="%PYTHON_HOME%/python.exe"^
   -DTALIPOT_BUILD_CORE_ONLY=%TALIPOT_BUILD_CORE_ONLY%^
   -DTALIPOT_USE_QT6=ON^
   -DTALIPOT_BUILD_DOC=OFF^
diff --git a/bundlers/linux/talipot_appimage_centos_build.sh b/bundlers/linux/talipot_appimage_centos_build.sh
index fd1bbe6978..191d50de83 100644
--- a/bundlers/linux/talipot_appimage_centos_build.sh
+++ b/bundlers/linux/talipot_appimage_centos_build.sh
@@ -73,7 +73,7 @@ cd /talipot/build
 
 cmake -DCMAKE_BUILD_TYPE=Release \
       -DCMAKE_INSTALL_PREFIX=$PWD/install \
-      -DPYTHON_EXECUTABLE=/usr/local/bin/python$PYTHON_VERSION \
+      -DPython3_EXECUTABLE=/usr/local/bin/python$PYTHON_VERSION \
       -DTALIPOT_USE_CCACHE=ON \
       -DTALIPOT_BUILD_FOR_APPIMAGE=ON \
       -DTALIPOT_BUILD_TESTS=ON \
diff --git a/bundlers/linux/talipot_python_wheels_manylinux_build.sh b/bundlers/linux/talipot_python_wheels_manylinux_build.sh
index 32822201e2..2fcfc0f002 100644
--- a/bundlers/linux/talipot_python_wheels_manylinux_build.sh
+++ b/bundlers/linux/talipot_python_wheels_manylinux_build.sh
@@ -11,9 +11,6 @@ yum -y install zlib-devel libzstd-devel yajl-devel qhull-devel graphviz-devel li
 # required to build upstream python cffi from pip
 yum -y install libffi-devel
 
-# ensure python library from based system is present, even if we do
-# not link to it, as cmake will fail to find PythonLibs otherwise
-yum -y install python36-devel
 
 JSON=$(curl -s 'https://test.pypi.org/pypi/talipot/json')
 LAST_VERSION=$(echo $JSON | python3 -c "
@@ -81,7 +78,7 @@ do
   cmake ${TALIPOT_SRC} \
         -DCMAKE_BUILD_TYPE=Release \
         -DCMAKE_INSTALL_PREFIX=/tmp/talipot_install \
-        -DPYTHON_EXECUTABLE=${CPYBIN}/python \
+        -DPython3_EXECUTABLE=${CPYBIN}/python \
         -DTALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET=ON \
         -DTALIPOT_PYTHON_TEST_WHEEL_SUFFIX=a2.dev$DEV_VERSION \
         -DTALIPOT_BUILD_DOC=OFF \
diff --git a/bundlers/mac/talipot_python_wheels_macos_build.sh b/bundlers/mac/talipot_python_wheels_macos_build.sh
index 472afdb18b..8bcdecb950 100644
--- a/bundlers/mac/talipot_python_wheels_macos_build.sh
+++ b/bundlers/mac/talipot_python_wheels_macos_build.sh
@@ -78,7 +78,7 @@ do
     -DCMAKE_CXX_COMPILER=/opt/local/bin/clang++-mp-${CLANG_VERSION} \
     -DTALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET=ON \
     -DTALIPOT_PYTHON_TEST_WHEEL_SUFFIX=a2.dev$DEV_VERSION \
-    -DPYTHON_EXECUTABLE=/Library/Frameworks/Python.framework/Versions/$py3Version/bin/python3 \
+    -DPython3_EXECUTABLE=/Library/Frameworks/Python.framework/Versions/$py3Version/bin/python3 \
     -DTALIPOT_USE_CCACHE=ON \
     -DTALIPOT_BUILD_CORE_ONLY=ON \
     -DTALIPOT_BUILD_DOC=OFF
diff --git a/bundlers/win/talipot_python_wheels_win_amd64.sh b/bundlers/win/talipot_python_wheels_win_amd64.sh
index 83c44b4554..9dfced61b8 100644
--- a/bundlers/win/talipot_python_wheels_win_amd64.sh
+++ b/bundlers/win/talipot_python_wheels_win_amd64.sh
@@ -55,7 +55,7 @@ do
     -DTALIPOT_BUILD_DOC=OFF \
     -DTALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET=ON \
     -DTALIPOT_PYTHON_TEST_WHEEL_SUFFIX=a2.dev${DEV_VERSION} \
-    -DPYTHON_EXECUTABLE=/c/Python$pyVersion-x64/python.exe \
+    -DPython3_EXECUTABLE=/c/Python$pyVersion-x64/python.exe \
     -DTALIPOT_USE_CCACHE=ON ..
   make -j4 test-wheel
 
diff --git a/cmake/FindSIP.cmake b/cmake/FindSIP.cmake
index 6a733b8259..80192e30cc 100644
--- a/cmake/FindSIP.cmake
+++ b/cmake/FindSIP.cmake
@@ -1,3 +1,7 @@
+FIND_PACKAGE(Python3 REQUIRED)
+
+SET(PYTHON_EXECUTABLE ${Python3_EXECUTABLE})
+
 FIND_FILE(
   find_sip_py FindSIP.py
   PATHS ${CMAKE_MODULE_PATH}
diff --git a/cmake/FindSphinx.cmake b/cmake/FindSphinx.cmake
index 9cd218ccbe..7a4f68c8f8 100644
--- a/cmake/FindSphinx.cmake
+++ b/cmake/FindSphinx.cmake
@@ -1,8 +1,6 @@
 # Find the Sphinx documentation generator
 #
-# This modules defines
-#   SPHINX_EXECUTABLE
-#   SPHINX_FOUND
+# This modules defines SPHINX_EXECUTABLE SPHINX_FOUND
 
 # =============================================================================
 # Copyright 2002-2009 Kitware, Inc. Copyright 2009-2011 Peter Colberg
@@ -17,45 +15,43 @@
 # (To distribute this file outside of CMake, substitute the full License text
 # for the above reference.)
 
-FIND_PACKAGE(PythonInterp)
-
-IF(PYTHON_EXECUTABLE)
-
-  EXECUTE_PROCESS(
-    COMMAND ${PYTHON_EXECUTABLE} --version
-    OUTPUT_VARIABLE PYTHON_VERSION_RAW
-    ERROR_VARIABLE PYTHON_VERSION_RAW)
-  STRING(REPLACE "\n" "" PYTHON_VERSION_RAW "${PYTHON_VERSION_RAW}")
-  STRING(REGEX MATCH "[0-9]" PYTHON_VERSION_MAJOR "${PYTHON_VERSION_RAW}")
-
-  IF(WIN32)
-    STRING(REPLACE "python.exe" "Scripts/" SPHINX_PATH "${PYTHON_EXECUTABLE}")
-  ELSEIF(LINUX)
-    GET_FILENAME_COMPONENT(PYTHON_EXECUTABLE_PATH "${PYTHON_EXECUTABLE}"
-                           DIRECTORY)
-    # remove final /bin component
-    GET_FILENAME_COMPONENT(PYTHON_EXECUTABLE_PATH "${PYTHON_EXECUTABLE_PATH}"
-                           DIRECTORY)
-    SET(SPHINX_PATH "/usr/share/sphinx/scripts/python${PYTHON_VERSION_MAJOR}/"
-                    "${PYTHON_EXECUTABLE_PATH}")
-  ELSE()
-    STRING(REGEX MATCH "[0-9].[0-9]" PYTHON_VERSION_MAJOR_MINOR
-                 "${PYTHON_VERSION_RAW}")
-    SET(SPHINX_PATH "$ENV{HOME}/Library/Python/${PYTHON_VERSION_MAJOR_MINOR}")
-  ENDIF()
-
-  FIND_PROGRAM(
-    SPHINX_EXECUTABLE
-    NAMES sphinx-build${PYTHON_VERSION_MAJOR} sphinx-build
-    HINTS ${SPHINX_PATH}
-    PATHS /usr /usr/local /opt/local
-    PATH_SUFFIXES bin
-    DOC "Sphinx documentation generator")
-
-  INCLUDE(FindPackageHandleStandardArgs)
-
-  FIND_PACKAGE_HANDLE_STANDARD_ARGS(Sphinx DEFAULT_MSG SPHINX_EXECUTABLE)
-
-  MARK_AS_ADVANCED(SPHINX_EXECUTABLE)
-
-ENDIF(PYTHON_EXECUTABLE)
+FIND_PACKAGE(Python3 REQUIRED)
+
+SET(PYTHON_EXECUTABLE ${Python3_EXECUTABLE})
+
+EXECUTE_PROCESS(
+  COMMAND ${PYTHON_EXECUTABLE} --version
+  OUTPUT_VARIABLE PYTHON_VERSION_RAW
+  ERROR_VARIABLE PYTHON_VERSION_RAW)
+STRING(REPLACE "\n" "" PYTHON_VERSION_RAW "${PYTHON_VERSION_RAW}")
+STRING(REGEX MATCH "[0-9]" PYTHON_VERSION_MAJOR "${PYTHON_VERSION_RAW}")
+
+IF(WIN32)
+  STRING(REPLACE "python.exe" "Scripts/" SPHINX_PATH "${PYTHON_EXECUTABLE}")
+ELSEIF(LINUX)
+  GET_FILENAME_COMPONENT(PYTHON_EXECUTABLE_PATH "${PYTHON_EXECUTABLE}"
+                         DIRECTORY)
+  # remove final /bin component
+  GET_FILENAME_COMPONENT(PYTHON_EXECUTABLE_PATH "${PYTHON_EXECUTABLE_PATH}"
+                         DIRECTORY)
+  SET(SPHINX_PATH "/usr/share/sphinx/scripts/python${PYTHON_VERSION_MAJOR}/"
+                  "${PYTHON_EXECUTABLE_PATH}")
+ELSE()
+  STRING(REGEX MATCH "[0-9].[0-9]" PYTHON_VERSION_MAJOR_MINOR
+               "${PYTHON_VERSION_RAW}")
+  SET(SPHINX_PATH "$ENV{HOME}/Library/Python/${PYTHON_VERSION_MAJOR_MINOR}")
+ENDIF()
+
+FIND_PROGRAM(
+  SPHINX_EXECUTABLE
+  NAMES sphinx-build${PYTHON_VERSION_MAJOR} sphinx-build
+  HINTS ${SPHINX_PATH}
+  PATHS /usr /usr/local /opt/local
+  PATH_SUFFIXES bin
+  DOC "Sphinx documentation generator")
+
+INCLUDE(FindPackageHandleStandardArgs)
+
+FIND_PACKAGE_HANDLE_STANDARD_ARGS(Sphinx DEFAULT_MSG SPHINX_EXECUTABLE)
+
+MARK_AS_ADVANCED(SPHINX_EXECUTABLE)
diff --git a/cmake/TalipotPython.cmake b/cmake/TalipotPython.cmake
index 08d8f00862..f8d71fc0e8 100644
--- a/cmake/TalipotPython.cmake
+++ b/cmake/TalipotPython.cmake
@@ -1,7 +1,21 @@
 # After finding the Python interpreter, try to find if SIP and its dev tools are
 # installed on the host system. If not, compile the SIP version located in
 # thirdparty.
-FIND_PACKAGE(PythonInterp 3 REQUIRED)
+
+IF(LINUX AND TALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET)
+  SET(PYTHON_COMPONENTS Interpreter)
+ELSE(LINUX AND TALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET)
+  SET(PYTHON_COMPONENTS Interpreter Development)
+ENDIF(LINUX AND TALIPOT_ACTIVATE_PYTHON_WHEEL_TARGET)
+
+FIND_PACKAGE(
+  Python3
+  COMPONENTS ${PYTHON_COMPONENTS}
+  REQUIRED)
+
+SET(PYTHON_EXECUTABLE ${Python3_EXECUTABLE})
+SET(PYTHON_LIBRARY ${Python3_LIBRARIES})
+SET(PYTHON_INCLUDE_DIR ${Python3_INCLUDE_DIRS})
 
 EXECUTE_PROCESS(
   COMMAND ${PYTHON_EXECUTABLE} --version
@@ -55,11 +69,9 @@ ELSEIF(LINUX)
   SET(CMAKE_LIBRARY_PATH ${PYTHON_HOME_PATH}/../lib ${CMAKE_LIBRARY_PATH})
 ENDIF(WIN32)
 
-FIND_PACKAGE(PythonLibs REQUIRED)
-
-IF(NOT WIN32)
+IF(NOT WIN32 AND PYTHON_LIBRARY)
   GET_FILENAME_COMPONENT(PYTHON_LIB_PATH ${PYTHON_LIBRARY} PATH)
-ENDIF(NOT WIN32)
+ENDIF(NOT WIN32 AND PYTHON_LIBRARY)
 
 IF(MINGW)
   # Check if Python is provided by MSYS2 (it is compiled with GCC in that case