diff --git a/setup.py b/setup.py
index ab8b9a42..eedc3779 100644
--- a/setup.py
+++ b/setup.py
@@ -85,7 +85,8 @@
             "pyqt5 >= 5.15.1",
             "pyqt5-stubs",
         ],
-        "pyside2": ["pyside2"],
+        # != 5.15.2 for https://bugreports.qt.io/browse/PYSIDE-1431
+        "pyside2": ["pyside2 != 5.15.2"],
         "testing": [pytest_trio],
     },
     entry_points={"console_scripts": ["qtrio = qtrio._cli:cli"]},