diff --git a/.mypy.ini b/.mypy.ini
index 6803a4f3c6d..86b5c86f345 100644
--- a/.mypy.ini
+++ b/.mypy.ini
@@ -35,6 +35,9 @@ ignore_missing_imports = True
 [mypy-brotli]
 ignore_missing_imports = True
 
+[mypy-brotlicffi]
+ignore_missing_imports = True
+
 [mypy-gunicorn.*]
 ignore_missing_imports = True
 
diff --git a/CHANGES/7611.feature b/CHANGES/7611.feature
new file mode 100644
index 00000000000..ce1b4b2ac1a
--- /dev/null
+++ b/CHANGES/7611.feature
@@ -0,0 +1 @@
+Support using ``brotlicffi`` Python package alternatively to ``brotli``, as the latter does not work on PyPy.
diff --git a/aiohttp/compression_utils.py b/aiohttp/compression_utils.py
index 8abc4fa7c3c..52791fe5015 100644
--- a/aiohttp/compression_utils.py
+++ b/aiohttp/compression_utils.py
@@ -4,7 +4,10 @@
 from typing import Optional, cast
 
 try:
-    import brotli
+    try:
+        import brotlicffi as brotli
+    except ImportError:
+        import brotli
 
     HAS_BROTLI = True
 except ImportError:  # pragma: no cover
diff --git a/docs/client_quickstart.rst b/docs/client_quickstart.rst
index d5915dddbe6..47ba40023c5 100644
--- a/docs/client_quickstart.rst
+++ b/docs/client_quickstart.rst
@@ -184,7 +184,8 @@ The ``gzip`` and ``deflate`` transfer-encodings are automatically
 decoded for you.
 
 You can enable ``brotli`` transfer-encodings support,
-just install  `brotli <https://github.com/python-hyper/Brotli>`_.
+just install `Brotli <https://pypi.org/project/Brotli/>`_
+or `brotlicffi <https://pypi.org/project/brotlicffi/>`_.
 
 JSON Request
 ============
diff --git a/docs/glossary.rst b/docs/glossary.rst
index 4bfe7c55126..392ef740cd1 100644
--- a/docs/glossary.rst
+++ b/docs/glossary.rst
@@ -40,6 +40,13 @@
 
       https://pypi.org/project/Brotli/
 
+   brotlicffi
+
+      An alternative implementation of :term:`Brotli` built using the CFFI
+      library. This implementation supports PyPy correctly.
+
+      https://pypi.org/project/brotlicffi/
+
    callable
 
       Any object that can be called. Use :func:`callable` to check
diff --git a/docs/index.rst b/docs/index.rst
index f7f913c7152..881654429cc 100644
--- a/docs/index.rst
+++ b/docs/index.rst
@@ -159,7 +159,8 @@ Dependencies
 
      $ pip install aiodns
 
-- *Optional* :term:`Brotli` for brotli (:rfc:`7932`) client compression support.
+- *Optional* :term:`Brotli` or :term:`brotlicffi` for brotli (:rfc:`7932`)
+  client compression support.
 
   .. code-block:: bash
 
diff --git a/docs/spelling_wordlist.txt b/docs/spelling_wordlist.txt
index 7346fd0b8c2..d3ee117d475 100644
--- a/docs/spelling_wordlist.txt
+++ b/docs/spelling_wordlist.txt
@@ -39,6 +39,7 @@ boolean
 botocore
 brotli
 Brotli
+brotlicffi
 brotlipy
 bugfix
 Bugfixes
diff --git a/requirements/runtime-deps.in b/requirements/runtime-deps.in
index 2d782c551e7..2bfb21ecd18 100644
--- a/requirements/runtime-deps.in
+++ b/requirements/runtime-deps.in
@@ -7,4 +7,5 @@ yarl >= 1.0, < 2.0
 frozenlist >= 1.1.1
 aiosignal >= 1.1.2
 aiodns; sys_platform=="linux" or sys_platform=="darwin"
-Brotli
+Brotli; platform_python_implementation == 'CPython'
+brotlicffi; platform_python_implementation != 'CPython'
diff --git a/setup.cfg b/setup.cfg
index 054ee7e9008..18b29652f9a 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -63,7 +63,8 @@ install_requires =
 speedups =
   # required c-ares (aiodns' backend) will not build on windows
   aiodns; sys_platform=="linux" or sys_platform=="darwin"
-  Brotli
+  Brotli; platform_python_implementation == 'CPython'
+  brotlicffi; platform_python_implementation != 'CPython'
 
 [options.packages.find]
 exclude =
diff --git a/tests/test_http_parser.py b/tests/test_http_parser.py
index 0227c2a847c..7f3992604f8 100644
--- a/tests/test_http_parser.py
+++ b/tests/test_http_parser.py
@@ -21,7 +21,10 @@
 )
 
 try:
-    import brotli
+    try:
+        import brotlicffi as brotli
+    except ImportError:
+        import brotli
 except ImportError:
     brotli = None
 
diff --git a/tests/test_web_functional.py b/tests/test_web_functional.py
index b1c7268793d..1f81aa7bffe 100644
--- a/tests/test_web_functional.py
+++ b/tests/test_web_functional.py
@@ -7,7 +7,6 @@
 from typing import Optional
 from unittest import mock
 
-import brotli
 import pytest
 from multidict import CIMultiDictProxy, MultiDict
 from yarl import URL
@@ -18,6 +17,11 @@
 from aiohttp.test_utils import make_mocked_coro
 from aiohttp.typedefs import Handler
 
+try:
+    import brotlicffi as brotli
+except ImportError:
+    import brotli
+
 try:
     import ssl
 except ImportError: