diff --git a/packages/components/src/higher-order/with-focus-outside/test/index.js b/packages/components/src/higher-order/with-focus-outside/test/index.js
index f310506f2d9dc..feea9e8f2ff02 100644
--- a/packages/components/src/higher-order/with-focus-outside/test/index.js
+++ b/packages/components/src/higher-order/with-focus-outside/test/index.js
@@ -1,7 +1,8 @@
 /**
  * External dependencies
  */
-import TestUtils from 'react-dom/test-utils';
+import { render, screen } from '@testing-library/react';
+import userEvent from '@testing-library/user-event';
 
 /**
  * WordPress dependencies
@@ -12,9 +13,8 @@ import { Component } from '@wordpress/element';
  * Internal dependencies
  */
 import withFocusOutside from '../';
-import ReactDOM from 'react-dom';
 
-let wrapper, onFocusOutside;
+let onFocusOutside;
 
 describe( 'withFocusOutside', () => {
 	let origHasFocus;
@@ -28,7 +28,7 @@ describe( 'withFocusOutside', () => {
 			render() {
 				return (
 					<div>
-						<input />
+						<input type="text" />
 						<input type="button" />
 					</div>
 				);
@@ -36,24 +36,11 @@ describe( 'withFocusOutside', () => {
 		}
 	);
 
-	// This is needed because TestUtils does not accept a stateless component.
-	// anything run through a HOC ends up as a stateless component.
-	const getTestComponent = ( WrappedComponent, props ) => {
-		class TestComponent extends Component {
-			render() {
-				return <WrappedComponent { ...props } />;
-			}
+	class TestComponent extends Component {
+		render() {
+			return <EnhancedComponent { ...this.props } />;
 		}
-		return <TestComponent />;
-	};
-
-	const simulateEvent = ( event, index = 0 ) => {
-		const element = TestUtils.scryRenderedDOMComponentsWithTag(
-			wrapper,
-			'input'
-		);
-		TestUtils.Simulate[ event ]( element[ index ] );
-	};
+	}
 
 	beforeEach( () => {
 		// Mock document.hasFocus() to always be true for testing
@@ -62,9 +49,6 @@ describe( 'withFocusOutside', () => {
 		document.hasFocus = () => true;
 
 		onFocusOutside = jest.fn();
-		wrapper = TestUtils.renderIntoDocument(
-			getTestComponent( EnhancedComponent, { onFocusOutside } )
-		);
 	} );
 
 	afterEach( () => {
@@ -72,24 +56,31 @@ describe( 'withFocusOutside', () => {
 	} );
 
 	it( 'should not call handler if focus shifts to element within component', () => {
-		simulateEvent( 'focus' );
-		simulateEvent( 'blur' );
-		simulateEvent( 'focus', 1 );
+		render( <TestComponent onFocusOutside={ onFocusOutside } /> );
+
+		const input = screen.getByRole( 'textbox' );
+		const button = screen.getByRole( 'button' );
+
+		input.focus();
+		input.blur();
+		button.focus();
 
 		jest.runAllTimers();
 
 		expect( onFocusOutside ).not.toHaveBeenCalled();
 	} );
 
-	it( 'should not call handler if focus transitions via click to button', () => {
-		simulateEvent( 'focus' );
-		simulateEvent( 'mouseDown', 1 );
-		simulateEvent( 'blur' );
+	it( 'should not call handler if focus transitions via click to button', async () => {
+		const user = userEvent.setup( {
+			advanceTimers: jest.advanceTimersByTime,
+		} );
+		render( <TestComponent onFocusOutside={ onFocusOutside } /> );
 
-		// In most browsers, the input at index 1 would receive a focus event
-		// at this point, but this is not guaranteed, which is the intention of
-		// the normalization behavior tested here.
-		simulateEvent( 'mouseUp', 1 );
+		const input = screen.getByRole( 'textbox' );
+		const button = screen.getByRole( 'button' );
+
+		input.focus();
+		await user.click( button );
 
 		jest.runAllTimers();
 
@@ -97,8 +88,11 @@ describe( 'withFocusOutside', () => {
 	} );
 
 	it( 'should call handler if focus doesn’t shift to element within component', () => {
-		simulateEvent( 'focus' );
-		simulateEvent( 'blur' );
+		render( <TestComponent onFocusOutside={ onFocusOutside } /> );
+
+		const input = screen.getByRole( 'textbox' );
+		input.focus();
+		input.blur();
 
 		jest.runAllTimers();
 
@@ -106,12 +100,15 @@ describe( 'withFocusOutside', () => {
 	} );
 
 	it( 'should not call handler if focus shifts outside the component when the document does not have focus', () => {
+		render( <TestComponent onFocusOutside={ onFocusOutside } /> );
+
 		// Force document.hasFocus() to return false to simulate the window/document losing focus
 		// See https://developer.mozilla.org/en-US/docs/Web/API/Document/hasFocus.
 		document.hasFocus = () => false;
 
-		simulateEvent( 'focus' );
-		simulateEvent( 'blur' );
+		const input = screen.getByRole( 'textbox' );
+		input.focus();
+		input.blur();
 
 		jest.runAllTimers();
 
@@ -119,14 +116,16 @@ describe( 'withFocusOutside', () => {
 	} );
 
 	it( 'should cancel check when unmounting while queued', () => {
-		simulateEvent( 'focus' );
-		simulateEvent( 'input' );
-
-		ReactDOM.unmountComponentAtNode(
-			// eslint-disable-next-line react/no-find-dom-node
-			ReactDOM.findDOMNode( wrapper ).parentNode
+		const { rerender } = render(
+			<TestComponent onFocusOutside={ onFocusOutside } />
 		);
 
+		const input = screen.getByRole( 'textbox' );
+		input.focus();
+		input.blur();
+
+		rerender( <div /> );
+
 		jest.runAllTimers();
 
 		expect( onFocusOutside ).not.toHaveBeenCalled();