diff --git a/packages/editor/src/components/global-keyboard-shortcuts/save-shortcut.js b/packages/editor/src/components/global-keyboard-shortcuts/save-shortcut.js
index 95069e7ea59efb..db2260386e8996 100644
--- a/packages/editor/src/components/global-keyboard-shortcuts/save-shortcut.js
+++ b/packages/editor/src/components/global-keyboard-shortcuts/save-shortcut.js
@@ -12,21 +12,32 @@ import { store as editorStore } from '../../store';
 
 function SaveShortcut( { resetBlocksOnSave } ) {
 	const { resetEditorBlocks, savePost } = useDispatch( editorStore );
-	const { isEditedPostDirty, getPostEdits } = useSelect( ( select ) => {
-		const {
-			isEditedPostDirty: _isEditedPostDirty,
-			getPostEdits: _getPostEdits,
-		} = select( editorStore );
-
-		return {
-			isEditedPostDirty: _isEditedPostDirty,
-			getPostEdits: _getPostEdits,
-		};
-	}, [] );
+	const { isEditedPostDirty, getPostEdits, isPostSavingLocked } = useSelect(
+		( select ) => {
+			const {
+				isEditedPostDirty: _isEditedPostDirty,
+				getPostEdits: _getPostEdits,
+				isPostSavingLocked: _isPostSavingLocked,
+			} = select( editorStore );
 
+			return {
+				isEditedPostDirty: _isEditedPostDirty,
+				getPostEdits: _getPostEdits,
+				isPostSavingLocked: _isPostSavingLocked,
+			};
+		},
+		[]
+	);
 	useShortcut( 'core/editor/save', ( event ) => {
 		event.preventDefault();
 
+		/**
+		 * Do not save the post if post saving is locked.
+		 */
+		if ( isPostSavingLocked() ) {
+			return;
+		}
+
 		// TODO: This should be handled in the `savePost` effect in
 		// considering `isSaveable`. See note on `isEditedPostSaveable`
 		// selector about dirtiness and meta-boxes.