diff --git a/packages/components/src/autocomplete/index.js b/packages/components/src/autocomplete/index.js
index 6cc8a87e3a3999..1226ec3bbfd7fe 100644
--- a/packages/components/src/autocomplete/index.js
+++ b/packages/components/src/autocomplete/index.js
@@ -130,7 +130,8 @@ function filterOptions( search, options = [], maxResults = 10 ) {
 }
 
 function getCaretRect() {
-	const range = window.getSelection().getRangeAt( 0 );
+	const selection = window.getSelection();
+	const range = selection.rangeCount ? selection.getRangeAt( 0 ) : null;
 
 	if ( range ) {
 		return getRectangleFromRange( range );
diff --git a/packages/eslint-plugin/CHANGELOG.md b/packages/eslint-plugin/CHANGELOG.md
index 437176bd954de1..61a4a84c98e74f 100644
--- a/packages/eslint-plugin/CHANGELOG.md
+++ b/packages/eslint-plugin/CHANGELOG.md
@@ -3,6 +3,7 @@
 ### New Features
 
 - [`@wordpress/no-unused-vars-before-return`](https://github.com/WordPress/gutenberg/blob/master/packages/eslint-plugin/docs/rules/no-unused-vars-before-return.md) now supports an `excludePattern` option to exempt function calls by name.
+- New Rule: [`@wordpress/no-unguarded-get-range-at`](https://github.com/WordPress/gutenberg/blob/master/packages/eslint-plugin/docs/rules/no-unguarded-get-range-at.md)
 
 ### Improvements
 
diff --git a/packages/eslint-plugin/README.md b/packages/eslint-plugin/README.md
index 2c8ef189000c15..f6f89c95f10819 100644
--- a/packages/eslint-plugin/README.md
+++ b/packages/eslint-plugin/README.md
@@ -55,6 +55,7 @@ Rule|Description|Recommended
 [react-no-unsafe-timeout](/packages/eslint-plugin/docs/rules/react-no-unsafe-timeout.md)|Disallow unsafe `setTimeout` in component|
 [valid-sprintf](/packages/eslint-plugin/docs/rules/valid-sprintf.md)|Enforce valid sprintf usage|✓
 [no-base-control-with-label-without-id](/packages/eslint-plugin/docs/rules/no-base-control-with-label-without-id.md)| Disallow the usage of BaseControl component with a label prop set but omitting the id property|✓
+[no-unguarded-get-range-at](/packages/eslint-plugin/docs/rules/no-unguarded-get-range-at.md)| Disallow the usage of unguarded `getRangeAt` calls|✓
 
 ### Legacy
 
diff --git a/packages/eslint-plugin/configs/custom.js b/packages/eslint-plugin/configs/custom.js
index a09c22148cc592..efb873980b22f4 100644
--- a/packages/eslint-plugin/configs/custom.js
+++ b/packages/eslint-plugin/configs/custom.js
@@ -8,6 +8,7 @@ module.exports = {
 		'@wordpress/no-unused-vars-before-return': 'error',
 		'@wordpress/valid-sprintf': 'error',
 		'@wordpress/no-base-control-with-label-without-id': 'error',
+		'@wordpress/no-unguarded-get-range-at': 'error',
 		'no-restricted-syntax': [
 			'error',
 			{
diff --git a/packages/eslint-plugin/docs/rules/no-unguarded-get-range-at.md b/packages/eslint-plugin/docs/rules/no-unguarded-get-range-at.md
new file mode 100644
index 00000000000000..1dd2e3e3ec44b0
--- /dev/null
+++ b/packages/eslint-plugin/docs/rules/no-unguarded-get-range-at.md
@@ -0,0 +1,18 @@
+# Avoid unguarded getRangeAt (no-unguarded-get-range-at)
+
+Some browsers (e.g. Safari) will throw an error when `getRangeAt` is called and there are no ranges in the selection.
+
+## Rule details
+
+Example of **incorrect** code for this rule:
+
+```js
+window.getSelection().getRangeAt( 0 );
+```
+
+Example of **correct** code for this rule:
+
+```js
+const selection = window.getSelection();
+const range = selection.rangeCount ? selection.getRangeAt( 0 ) : null;
+```
diff --git a/packages/eslint-plugin/rules/__tests__/no-unguarded-get-range-at.js b/packages/eslint-plugin/rules/__tests__/no-unguarded-get-range-at.js
new file mode 100644
index 00000000000000..b3e0a7592f8f08
--- /dev/null
+++ b/packages/eslint-plugin/rules/__tests__/no-unguarded-get-range-at.js
@@ -0,0 +1,29 @@
+/**
+ * External dependencies
+ */
+import { RuleTester } from 'eslint';
+
+/**
+ * Internal dependencies
+ */
+import rule from '../no-unguarded-get-range-at';
+
+const ruleTester = new RuleTester( {
+	parserOptions: {
+		ecmaVersion: 6,
+	},
+} );
+
+ruleTester.run( 'no-unguarded-get-range-at', rule, {
+	valid: [
+		{
+			code: `const selection = window.getSelection(); const range = selection.rangeCount ? selection.getRangeAt( 0 ) : null;`,
+		},
+	],
+	invalid: [
+		{
+			code: `window.getSelection().getRangeAt( 0 );`,
+			errors: [ { message: 'Avoid unguarded getRangeAt' } ],
+		},
+	],
+} );
diff --git a/packages/eslint-plugin/rules/no-unguarded-get-range-at.js b/packages/eslint-plugin/rules/no-unguarded-get-range-at.js
new file mode 100644
index 00000000000000..e74bc775de54f3
--- /dev/null
+++ b/packages/eslint-plugin/rules/no-unguarded-get-range-at.js
@@ -0,0 +1,16 @@
+module.exports = {
+	meta: {
+		type: 'problem',
+		schema: [],
+	},
+	create( context ) {
+		return {
+			'CallExpression[callee.object.callee.object.name="window"][callee.object.callee.property.name="getSelection"][callee.property.name="getRangeAt"]'( node ) {
+				context.report( {
+					node,
+					message: 'Avoid unguarded getRangeAt',
+				} );
+			},
+		};
+	},
+};