diff --git a/packages/jest-expo/CHANGELOG.md b/packages/jest-expo/CHANGELOG.md
index 27603aa9fccac5..054af3fa178c7e 100644
--- a/packages/jest-expo/CHANGELOG.md
+++ b/packages/jest-expo/CHANGELOG.md
@@ -13,6 +13,7 @@
 - Mock `EventEmitter` from `expo-modules-core`. ([#26945](https://github.com/expo/expo/pull/26945) by [@aleqsio](https://github.com/aleqsio))
 - Remove most of Constants.appOwnership. ([#26313](https://github.com/expo/expo/pull/26313) by [@wschurman](https://github.com/wschurman))
 - Simulate the mocked `expo-modules-core.EventEmitter` like a true EventEmitter. ([#27257](https://github.com/expo/expo/pull/27257) by [@kudo](https://github.com/kudo))
+- Add mock for `window.__REACT_DEVTOOLS_GLOBAL_HOOK__` if undefined. ([#27434](https://github.com/expo/expo/pull/27434) by [@marklawlor](https://github.com/marklawlor))
 
 ## 50.0.2 - 2024-02-06
 
diff --git a/packages/jest-expo/src/preset/setup.js b/packages/jest-expo/src/preset/setup.js
index eac77843dd1fa9..b93cf333cc49ff 100644
--- a/packages/jest-expo/src/preset/setup.js
+++ b/packages/jest-expo/src/preset/setup.js
@@ -18,6 +18,21 @@ if (typeof window !== 'object') {
   globalThis.window.navigator = {};
 }
 
+if (typeof globalThis.__REACT_DEVTOOLS_GLOBAL_HOOK__ === 'undefined') {
+  // RN 0.74 checks for the __REACT_DEVTOOLS_GLOBAL_HOOK__ on startup if getInspectorDataForViewAtPoint is used
+  // React Navigation uses getInspectorDataForViewAtPoint() for improved log box integration in non-production builds
+  globalThis.__REACT_DEVTOOLS_GLOBAL_HOOK__ = {
+    isDisabled: true, // Used by `react-test-renderer` https://github.com/facebook/react/blob/113ab9af08c46e8a548a397154f5c9dfeb96ab6a/packages/react-reconciler/src/ReactFiberDevToolsHook.js#L60
+    renderers: {
+      // https://github.com/facebook/react-native/blob/fbbb4246707d85b692c006e0cb3b186a7c9068bc/packages/react-native/Libraries/Inspector/getInspectorDataForViewAtPoint.js#L40
+      values: () => [],
+    },
+    on() {}, // https://github.com/facebook/react-native/blob/fbbb4246707d85b692c006e0cb3b186a7c9068bc/packages/react-native/Libraries/Inspector/getInspectorDataForViewAtPoint.js#L45
+  };
+  // React is inconsistent with how it checks for the global hook
+  globalThis.window.__REACT_DEVTOOLS_GLOBAL_HOOK__ = globalThis.__REACT_DEVTOOLS_GLOBAL_HOOK__;
+}
+
 const mockImageLoader = {
   configurable: true,
   enumerable: true,