diff --git a/src/character.cpp b/src/character.cpp
index 3b6307b2585b0..c02424a5e291a 100644
--- a/src/character.cpp
+++ b/src/character.cpp
@@ -8712,11 +8712,6 @@ bool Character::invoke_item( item *used, const std::string &method, const tripoi
         moves = pre_obtain_moves;
         return false;
     }
-    if( used->is_medication() && !can_use_heal_item( *used ) ) {
-        add_msg_if_player( m_bad, _( "Your biology is not compatible with that healing item." ) );
-        moves = pre_obtain_moves;
-        return false;
-    }
 
     item *actually_used = used->get_usable_item( method );
     if( actually_used == nullptr ) {
diff --git a/src/game_inventory.cpp b/src/game_inventory.cpp
index 32f08207802cb..638c4b43e96b6 100644
--- a/src/game_inventory.cpp
+++ b/src/game_inventory.cpp
@@ -692,7 +692,7 @@ class comestible_inventory_preset : public inventory_selector_preset
                 return _( "Can't drink spilt liquids." );
             }
 
-            if( med.is_medication() && !p.can_use_heal_item( med ) ) {
+            if( med.is_medication() && !p.can_use_heal_item( med ) && !med.is_craft() ) {
                 return _( "Your biology is not compatible with that item." );
             }
 
diff --git a/src/player.cpp b/src/player.cpp
index 209c114f5cbd9..f40ef895da110 100644
--- a/src/player.cpp
+++ b/src/player.cpp
@@ -2014,12 +2014,6 @@ void player::use( item_location loc, int pre_obtain_moves )
     item &used = *loc;
     last_item = used.typeId();
 
-    if( ( *loc ).is_medication() && !can_use_heal_item( *loc ) ) {
-        add_msg_if_player( m_bad, _( "Your biology is not compatible with that healing item." ) );
-        moves = pre_obtain_moves;
-        return;
-    }
-
     if( used.is_tool() ) {
         if( !used.type->has_use() ) {
             add_msg_if_player( _( "You can't do anything interesting with your %s." ), used.tname() );
@@ -2036,6 +2030,13 @@ void player::use( item_location loc, int pre_obtain_moves )
 
     } else if( !used.is_craft() && ( used.is_medication() || ( !used.type->has_use() &&
                                      used.is_food() ) ) ) {
+
+        if( used.is_medication() && !can_use_heal_item( used ) ) {
+            add_msg_if_player( m_bad, _( "Your biology is not compatible with that healing item." ) );
+            moves = pre_obtain_moves;
+            return;
+        }
+
         if( avatar *u = as_avatar() ) {
             const ret_val<edible_rating> ret = u->will_eat( used, true );
             if( !ret.success() ) {