diff --git a/.changeset/fuzzy-jeans-tickle.md b/.changeset/fuzzy-jeans-tickle.md
new file mode 100644
index 0000000000..3925411c4a
--- /dev/null
+++ b/.changeset/fuzzy-jeans-tickle.md
@@ -0,0 +1,5 @@
+---
+'@shopify/hydrogen': patch
+---
+
+Adds ability to add multiple cookies in one response
diff --git a/packages/hydrogen/src/entry-server.tsx b/packages/hydrogen/src/entry-server.tsx
index 442f36025d..831d5cdecb 100644
--- a/packages/hydrogen/src/entry-server.tsx
+++ b/packages/hydrogen/src/entry-server.tsx
@@ -475,14 +475,20 @@ async function stream(
     }
 
     if (await isStreamingSupported()) {
-      return new Response(transform.readable, responseOptions);
+      return new Response(transform.readable, {
+        ...responseOptions,
+        headers: getHeaders(responseOptions.headers),
+      });
     }
 
     const bufferedBody = await bufferReadableStream(
       transform.readable.getReader()
     );
 
-    return new Response(bufferedBody, responseOptions);
+    return new Response(bufferedBody, {
+      ...responseOptions,
+      headers: getHeaders(responseOptions.headers),
+    });
   } else if (response) {
     const {pipe} = ssrRenderToPipeableStream(AppSSR, {
       nonce,
@@ -818,9 +824,22 @@ function getResponseOptions(
   error?: Error
 ) {
   const responseInit = {} as ResponseOptions;
+
   // @ts-ignore
   responseInit.headers = Object.fromEntries(headers.entries());
 
+  // @ts-ignore
+  const rawHeaders = headers.raw();
+  // Warning! Headers.raw is non-standard and might disappear in undici or newer versions of node-fetch
+  // See: https://github.com/whatwg/fetch/issues/973
+  const setCookieKey = Object.keys(rawHeaders).find(
+    (key) => key.toLowerCase() === 'set-cookie'
+  );
+
+  if (setCookieKey) {
+    responseInit.headers['set-cookie'] = rawHeaders[setCookieKey];
+  }
+
   if (error) {
     responseInit.status = 500;
   } else {
@@ -911,3 +930,22 @@ function postRequestTasks(
   logQueryTimings(type, request);
   request.savePreloadQueries();
 }
+
+function getHeaders(rawHeaders: Record<string, String | Array<String>> = {}) {
+  const headers = new Headers();
+
+  for (const [key, values] of Object.entries(rawHeaders)) {
+    // values doesn't have an array prototype, so instanceof doesn't work.
+    // Check for .splice instead
+    // @ts-ignore
+    if (values?.splice) {
+      for (const value of values) {
+        headers.append(key, value as string);
+      }
+    } else {
+      headers.append(key, values as string);
+    }
+  }
+
+  return headers;
+}
diff --git a/packages/playground/server-components/tests/e2e-test-cases.ts b/packages/playground/server-components/tests/e2e-test-cases.ts
index 4330cc29c5..8e7cad259a 100644
--- a/packages/playground/server-components/tests/e2e-test-cases.ts
+++ b/packages/playground/server-components/tests/e2e-test-cases.ts
@@ -184,11 +184,11 @@ export default async function testCases({
     expect(response.status).toEqual(201);
     // statusText cannot be modified in workers
     expect(response.statusText).toEqual(isWorker ? 'Created' : 'hey');
-
     expect(response.headers.get('Accept-Encoding')).toBe('deflate, gzip');
-    expect(response.headers.get('Set-Cookie')).toBe(
-      'hello=world, hello2=world2'
-    );
+    expect(response.headers.raw()['set-cookie']).toEqual([
+      'hello=world',
+      'hello2=world2',
+    ]);
   });
 
   it('uses the provided custom body', async () => {