MG45 - ADT: Pathology data ETL

modelad_test_config.yaml

@@ -15,3 +15,16 @@ datasets:
       custom_transformations: 1
       column_rename:
         agedeath: age_death
+
+  - pathology:
+      files:
+        - name: pathology
+          id: syn61357279
+          format: csv
+      final_format: json
+      provenance:
+        - syn61357279
+      destination: *dest
+      custom_transformations: 1
+      column_rename:
+        agedeath: age_death

src/agoradatatools/etl/transform/__init__.py

@@ -16,7 +16,9 @@
 )
 from agoradatatools.etl.transform.team_info import transform_team_info
 from agoradatatools.etl.transform.proteomics import transform_proteomics
-from agoradatatools.etl.transform.biomarkers import transform_biomarkers
+from agoradatatools.etl.transform.immunohisto_transform import (
+    immunohisto_transform,
+)
 
 __all__ = [
     "transform_distribution_data",
@@ -29,5 +31,5 @@
     "transform_rnaseq_differential_expression",
     "transform_team_info",
     "transform_proteomics",
-    "transform_biomarkers",
+    "immunohisto_transform",
 ]

src/agoradatatools/etl/transform/immunohisto_transform.py

@@ -0,0 +1,52 @@
+"""
+This module contains the transformation logic for the biomarkers and pathology datasets.
+This is for the Model AD project.
+"""
+
+import pandas as pd
+from typing import Dict, List
+
+
+def immunohisto_transform(
+    datasets: Dict[str, pd.DataFrame],
+    dataset_name: str,
+    group_columns: List[str] = ["model", "type", "age_death", "tissue", "units"],
+    extra_columns: List[str] = ["genotype", "measurement", "sex"],
+    extra_column_name: str = "points",
+) -> pd.DataFrame:
+    """
+    Takes a dictionary of dataset DataFrames, extracts the 'dataset_name'
+    DataFrame, and transforms it into a DataFrame grouped by group_columns.
+    Will include extra_columns in the group.
+
+    Args:
+        datasets (Dict[str, pd.DataFrame]): Dictionary of dataset names mapped to their DataFrame.
+        dataset_name (str): The name of the dataset to transform.
+        group_columns (List[str], optional): List of columns to group by. Defaults to ['model', 'type', 'age_death', 'tissue', 'units'].
+        extra_columns (List[str], optional): List of columns to include in the group. Defaults to ['genotype', 'measurement', 'sex'].
+        extra_column_name (str, optional): Name of the column containing the extra columns. Defaults to 'points'.
+
+    Returns:
+        pd.DataFrame: A DataFrame grouped by the group_columns.
+    """
+    dataset = datasets[dataset_name]
+
+    missing_columns = [
+        col for col in group_columns + extra_columns if col not in dataset.columns
+    ]
+    if missing_columns:
+        raise ValueError(
+            f"{dataset_name} dataset missing columns: {', '.join(missing_columns)}"
+        )
+
+    dataset = dataset.fillna("none")
+    data_rows = []
+
+    grouped = dataset.groupby(group_columns)
+
+    for group_key, group in grouped:
+        entry = dict(zip(group_columns, group_key))
+        entry[extra_column_name] = group[extra_columns].to_dict("records")
+        data_rows.append(entry)
+
+    return pd.DataFrame(data_rows)

src/agoradatatools/process.py

@@ -61,8 +61,10 @@ def apply_custom_transformations(
     if dataset_name in ["proteomics", "proteomics_tmt", "proteomics_srm"]:
         df = datasets[dataset_name]
         return transform.transform_proteomics(df=df)
-    if dataset_name == "biomarkers":
-        return transform.transform_biomarkers(datasets=datasets)
+    if dataset_name in ["biomarkers", "pathology"]:
+        return transform.immunohisto_transform(
+            datasets=datasets, dataset_name=dataset_name
+        )
     else:
         return None
 

tests/transform/test_immunohisto_transform.py

@@ -0,0 +1,85 @@
+import os
+
+import pandas as pd
+import pytest
+
+from agoradatatools.etl.transform.immunohisto_transform import (
+    immunohisto_transform,
+)
+
+
+class TestTransformGeneralModelAD:
+    data_files_path = "tests/test_assets/immunohisto_transform"
+    pass_test_data = [
+        (
+            # Pass with good fake data
+            "immunohisto_transform_good_test_input.csv",
+            "immunohisto_transform_good_test_output.json",
+        ),
+        (
+            # Pass with duplicated data
+            "immunohisto_transform_duplicated_input.csv",
+            "immunohisto_transform_duplicated_output.json",
+        ),
+        (
+            # Pass with none data
+            "immunohisto_transform_none_input.csv",
+            "immunohisto_transform_none_output.json",
+        ),
+        (
+            # Pass with missing data
+            "immunohisto_transform_missing_input.csv",
+            "immunohisto_transform_missing_output.json",
+        ),
+        (
+            # Pass with extra column
+            "immunohisto_transform_extra_column.csv",
+            "immunohisto_transform_extra_column_output.json",
+        ),
+    ]
+    pass_test_ids = [
+        "Pass with good fake data",
+        "Pass with duplicated data",
+        "Pass with none data",
+        "Pass with missing data",
+        "Pass with extra column",
+    ]
+    fail_test_data = [("immunohisto_transform_missing_column.csv")]
+    fail_test_ids = [("Fail with missing column")]
+
+    @pytest.mark.parametrize(
+        "immunohisto_transform_file, expected_output_file",
+        pass_test_data,
+        ids=pass_test_ids,
+    )
+    def test_immunohisto_transform_should_pass(
+        self, immunohisto_transform_file, expected_output_file
+    ):
+        immunohisto_transform_df = pd.read_csv(
+            os.path.join(self.data_files_path, "input", immunohisto_transform_file)
+        )
+        output_df = pd.DataFrame(
+            immunohisto_transform(
+                datasets={"immunohisto_transform": immunohisto_transform_df},
+                dataset_name="immunohisto_transform",
+            )
+        )
+        expected_df = pd.read_json(
+            os.path.join(self.data_files_path, "output", expected_output_file),
+        )
+        pd.testing.assert_frame_equal(output_df, expected_df)
+
+    @pytest.mark.parametrize(
+        "immunohisto_transform_file", fail_test_data, ids=fail_test_ids
+    )
+    def test_immunohisto_transform_should_fail(
+        self, immunohisto_transform_file, error_type: BaseException = ValueError
+    ):
+        immunohisto_transform_df = pd.read_csv(
+            os.path.join(self.data_files_path, "input", immunohisto_transform_file)
+        )
+        with pytest.raises(error_type):
+            immunohisto_transform(
+                datasets={"immunohisto_transform": immunohisto_transform_df},
+                dataset_name="immunohisto_transform",
+            )