assays_models.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "id": "28740b2f",
   "metadata": {},
   "source": [
    "# Plans for ML models using RDKit features\n",
    "\n",
    "* Real danger of overfitting so could use regularisation \n",
    "* Could use feature importance to make quicker models\n",
    "\n",
    "* Use FLAML to train models, 85:15 split as FLAML does cross-validation under-the-hood\n",
    "* pIC50 = regression - exclude non-float compounds\n",
    "* clearance_mouse, clearance_human = classification (multi-class) - therefore trees best shout\n",
    "* logd - regression - WHAT IS BEST??\n",
    "* PAMPA - classifcation (multi-class)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "c494ce6f",
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import re\n",
    "import pickle\n",
    "import matplotlib.pyplot as plt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "3ef8d865",
   "metadata": {},
   "outputs": [],
   "source": [
    "df = pd.read_csv('r_group_decomp.csv')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "016f7b8f",
   "metadata": {},
   "outputs": [],
   "source": [
    "import rdkit\n",
    "from rdkit import Chem\n",
    "from rdkit.Chem import Descriptors\n",
    "\n",
    "descriptors = {d[0]: d[1] for d in Descriptors.descList}   \n",
    "rdkit_desc_dict = {}         \n",
    "for i in df.index:\n",
    "    mol = Chem.MolFromSmiles(df.at[i, \"mol\"])\n",
    "    rdkit_desc_dict[i] = {d: descriptors[d](mol) for d in descriptors}"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "97b16e6c",
   "metadata": {},
   "outputs": [],
   "source": [
    "desc_df = pd.DataFrame.from_dict(rdkit_desc_dict)\n",
    "desc_df = desc_df.T\n",
    "# Drops any columns with zero variance and so useless for ML\n",
    "to_drop = desc_df.columns[(desc_df.var() == 0)]\n",
    "desc_df = desc_df.drop(to_drop, axis='columns')\n",
    "desc_df.head()\n",
    "# LGBM models struggle with column names so rename them using this line\n",
    "desc_df = desc_df.rename(columns = lambda x:re.sub('[^A-Za-z0-9_]+', '', x))\n",
    "desc_df.to_csv('r_group_rdkit_features.csv')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "b8ede26e",
   "metadata": {},
   "source": [
    "# pIC50 MODEL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "3bba7a37",
   "metadata": {},
   "outputs": [
    {
     "data": {
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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.model_selection import train_test_split\n",
    "desc_df = pd.read_csv('r_group_rdkit_features.csv', index_col=0)\n",
    "df = pd.read_csv('r_group_decomp.csv')\n",
    "\n",
    "df[\"pic50\"] = pd.to_numeric(df['pic50'], errors='coerce')\n",
    "true_labels = pd.to_numeric(df['pic50'], errors='coerce').dropna()\n",
    "X_train, X_test, y_train, y_test = train_test_split(desc_df.loc[true_labels.index, :], true_labels , test_size=0.15, random_state=42)\n",
    "\n",
    "plt.hist(true_labels, bins =20)\n",
    "plt.title('Distribution of pIC50 values in the whole MMP12 dataset')\n",
    "plt.xlabel('pIC50 value (pIC50 units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_train, bins =20)\n",
    "plt.title('Distribution of pIC50 values in the MMP12 Train set')\n",
    "plt.xlabel('pIC50 value (pIC50 units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_test, bins =20)\n",
    "plt.title('Distribution of pIC50 values in the MMP12 Test set')\n",
    "plt.xlabel('pIC50 value (pIC50 units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "\n",
    "\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "id": "1a2a8723",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[flaml.automl: 06-21 10:20:06] {2007} INFO - task = regression\n",
      "[flaml.automl: 06-21 10:20:06] {2009} INFO - Data split method: uniform\n",
      "[flaml.automl: 06-21 10:20:06] {2013} INFO - Evaluation method: cv\n",
      "[flaml.automl: 06-21 10:20:06] {2113} INFO - Minimizing error metric: 1-r2\n",
      "[flaml.automl: 06-21 10:20:06] {2170} INFO - List of ML learners in AutoML Run: ['xgboost', 'xgb_limitdepth', 'rf', 'extra_tree']\n",
      "[flaml.automl: 06-21 10:20:06] {2437} INFO - iteration 0, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/compat.py:31: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:08] {2550} INFO - Estimated sufficient time budget=23829s. Estimated necessary time budget=104s.\n",
      "[flaml.automl: 06-21 10:20:08] {2597} INFO -  at 3.1s,\testimator xgboost's best error=10.8922,\tbest estimator xgboost's best error=10.8922\n",
      "[flaml.automl: 06-21 10:20:08] {2437} INFO - iteration 1, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:09] {2597} INFO -  at 3.6s,\testimator xgboost's best error=10.8922,\tbest estimator xgboost's best error=10.8922\n",
      "[flaml.automl: 06-21 10:20:09] {2437} INFO - iteration 2, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:09] {2597} INFO -  at 4.1s,\testimator xgboost's best error=2.8205,\tbest estimator xgboost's best error=2.8205\n",
      "[flaml.automl: 06-21 10:20:09] {2437} INFO - iteration 3, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:10] {2597} INFO -  at 4.9s,\testimator xgboost's best error=0.5790,\tbest estimator xgboost's best error=0.5790\n",
      "[flaml.automl: 06-21 10:20:10] {2437} INFO - iteration 4, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:11] {2597} INFO -  at 5.6s,\testimator xgboost's best error=0.5790,\tbest estimator xgboost's best error=0.5790\n",
      "[flaml.automl: 06-21 10:20:11] {2437} INFO - iteration 5, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:11] {2597} INFO -  at 6.2s,\testimator xgboost's best error=0.5790,\tbest estimator xgboost's best error=0.5790\n",
      "[flaml.automl: 06-21 10:20:11] {2437} INFO - iteration 6, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:12] {2597} INFO -  at 7.1s,\testimator xgboost's best error=0.4781,\tbest estimator xgboost's best error=0.4781\n",
      "[flaml.automl: 06-21 10:20:12] {2437} INFO - iteration 7, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:13] {2597} INFO -  at 8.2s,\testimator xgboost's best error=0.4293,\tbest estimator xgboost's best error=0.4293\n",
      "[flaml.automl: 06-21 10:20:13] {2437} INFO - iteration 8, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:14] {2597} INFO -  at 9.0s,\testimator xgboost's best error=0.4293,\tbest estimator xgboost's best error=0.4293\n",
      "[flaml.automl: 06-21 10:20:14] {2437} INFO - iteration 9, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:15] {2597} INFO -  at 10.1s,\testimator xgboost's best error=0.4221,\tbest estimator xgboost's best error=0.4221\n",
      "[flaml.automl: 06-21 10:20:15] {2437} INFO - iteration 10, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:16] {2597} INFO -  at 11.3s,\testimator xgboost's best error=0.4221,\tbest estimator xgboost's best error=0.4221\n",
      "[flaml.automl: 06-21 10:20:16] {2437} INFO - iteration 11, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:17] {2597} INFO -  at 12.5s,\testimator xgboost's best error=0.4221,\tbest estimator xgboost's best error=0.4221\n",
      "[flaml.automl: 06-21 10:20:17] {2437} INFO - iteration 12, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:19] {2597} INFO -  at 13.7s,\testimator xgboost's best error=0.3420,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:19] {2437} INFO - iteration 13, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:19] {2597} INFO -  at 14.4s,\testimator extra_tree's best error=0.7404,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:19] {2437} INFO - iteration 14, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:20] {2597} INFO -  at 14.6s,\testimator extra_tree's best error=0.5415,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:20] {2437} INFO - iteration 15, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:20] {2597} INFO -  at 14.9s,\testimator extra_tree's best error=0.5415,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:20] {2437} INFO - iteration 16, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:21] {2597} INFO -  at 15.9s,\testimator xgboost's best error=0.3420,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:21] {2437} INFO - iteration 17, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:21] {2597} INFO -  at 16.3s,\testimator extra_tree's best error=0.4059,\tbest estimator xgboost's best error=0.3420\n",
      "[flaml.automl: 06-21 10:20:21] {2437} INFO - iteration 18, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:22] {2597} INFO -  at 16.7s,\testimator extra_tree's best error=0.3142,\tbest estimator extra_tree's best error=0.3142\n",
      "[flaml.automl: 06-21 10:20:22] {2437} INFO - iteration 19, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:22] {2597} INFO -  at 17.2s,\testimator extra_tree's best error=0.3142,\tbest estimator extra_tree's best error=0.3142\n",
      "[flaml.automl: 06-21 10:20:22] {2437} INFO - iteration 20, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:23] {2597} INFO -  at 17.8s,\testimator extra_tree's best error=0.2719,\tbest estimator extra_tree's best error=0.2719\n",
      "[flaml.automl: 06-21 10:20:23] {2437} INFO - iteration 21, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:23] {2597} INFO -  at 18.3s,\testimator extra_tree's best error=0.2719,\tbest estimator extra_tree's best error=0.2719\n",
      "[flaml.automl: 06-21 10:20:23] {2437} INFO - iteration 22, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:24] {2597} INFO -  at 19.0s,\testimator extra_tree's best error=0.2476,\tbest estimator extra_tree's best error=0.2476\n",
      "[flaml.automl: 06-21 10:20:24] {2437} INFO - iteration 23, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:24] {2597} INFO -  at 19.4s,\testimator extra_tree's best error=0.2476,\tbest estimator extra_tree's best error=0.2476\n",
      "[flaml.automl: 06-21 10:20:24] {2437} INFO - iteration 24, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:25] {2597} INFO -  at 19.9s,\testimator extra_tree's best error=0.2476,\tbest estimator extra_tree's best error=0.2476\n",
      "[flaml.automl: 06-21 10:20:25] {2437} INFO - iteration 25, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:26] {2597} INFO -  at 21.3s,\testimator extra_tree's best error=0.2476,\tbest estimator extra_tree's best error=0.2476\n",
      "[flaml.automl: 06-21 10:20:26] {2437} INFO - iteration 26, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:27] {2597} INFO -  at 21.6s,\testimator extra_tree's best error=0.2476,\tbest estimator extra_tree's best error=0.2476\n",
      "[flaml.automl: 06-21 10:20:27] {2437} INFO - iteration 27, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:29] {2597} INFO -  at 23.8s,\testimator extra_tree's best error=0.2344,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:29] {2437} INFO - iteration 28, current learner rf\n",
      "[flaml.automl: 06-21 10:20:29] {2597} INFO -  at 24.2s,\testimator rf's best error=0.6986,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:29] {2437} INFO - iteration 29, current learner rf\n",
      "[flaml.automl: 06-21 10:20:30] {2597} INFO -  at 24.7s,\testimator rf's best error=0.5263,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:30] {2437} INFO - iteration 30, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:31] {2597} INFO -  at 26.4s,\testimator xgboost's best error=0.3312,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:31] {2437} INFO - iteration 31, current learner rf\n",
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      "[flaml.automl: 06-21 10:20:32] {2437} INFO - iteration 32, current learner extra_tree\n",
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      "[flaml.automl: 06-21 10:20:33] {2437} INFO - iteration 33, current learner rf\n",
      "[flaml.automl: 06-21 10:20:33] {2597} INFO -  at 28.3s,\testimator rf's best error=0.4300,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:33] {2437} INFO - iteration 34, current learner rf\n",
      "[flaml.automl: 06-21 10:20:34] {2597} INFO -  at 29.3s,\testimator rf's best error=0.3668,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:34] {2437} INFO - iteration 35, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:38] {2597} INFO -  at 32.9s,\testimator extra_tree's best error=0.2344,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:38] {2437} INFO - iteration 36, current learner rf\n",
      "[flaml.automl: 06-21 10:20:39] {2597} INFO -  at 33.7s,\testimator rf's best error=0.3668,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:39] {2437} INFO - iteration 37, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:40] {2597} INFO -  at 34.6s,\testimator extra_tree's best error=0.2344,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:40] {2437} INFO - iteration 38, current learner rf\n",
      "[flaml.automl: 06-21 10:20:40] {2597} INFO -  at 35.5s,\testimator rf's best error=0.3658,\tbest estimator extra_tree's best error=0.2344\n",
      "[flaml.automl: 06-21 10:20:40] {2437} INFO - iteration 39, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:44] {2597} INFO -  at 39.0s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:20:44] {2437} INFO - iteration 40, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:51] {2597} INFO -  at 46.1s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:20:51] {2437} INFO - iteration 41, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:20:53] {2597} INFO -  at 47.6s,\testimator xgboost's best error=0.3312,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:20:53] {2437} INFO - iteration 42, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:20:54] {2597} INFO -  at 49.3s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:20:54] {2437} INFO - iteration 43, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:01] {2597} INFO -  at 55.9s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:01] {2437} INFO - iteration 44, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:03] {2597} INFO -  at 58.1s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:03] {2437} INFO - iteration 45, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:06] {2597} INFO -  at 61.2s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:06] {2437} INFO - iteration 46, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:16] {2597} INFO -  at 70.9s,\testimator extra_tree's best error=0.2339,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:16] {2437} INFO - iteration 47, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:20] {2597} INFO -  at 74.7s,\testimator xgboost's best error=0.2651,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:20] {2437} INFO - iteration 48, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:21] {2597} INFO -  at 76.1s,\testimator xgboost's best error=0.2651,\tbest estimator extra_tree's best error=0.2339\n",
      "[flaml.automl: 06-21 10:21:21] {2437} INFO - iteration 49, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:26] {2597} INFO -  at 81.0s,\testimator extra_tree's best error=0.2245,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:26] {2437} INFO - iteration 50, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:32] {2597} INFO -  at 87.0s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:32] {2437} INFO - iteration 51, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:34] {2597} INFO -  at 89.2s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:34] {2437} INFO - iteration 52, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:49] {2597} INFO -  at 104.3s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:49] {2437} INFO - iteration 53, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:21:53] {2597} INFO -  at 107.6s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:53] {2437} INFO - iteration 54, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:21:56] {2597} INFO -  at 111.1s,\testimator extra_tree's best error=0.2245,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:21:56] {2437} INFO - iteration 55, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:22:03] {2597} INFO -  at 118.2s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:22:03] {2437} INFO - iteration 56, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:22:09] {2597} INFO -  at 123.8s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:22:09] {2437} INFO - iteration 57, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:22:14] {2597} INFO -  at 128.6s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:22:14] {2437} INFO - iteration 58, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:22:15] {2597} INFO -  at 130.4s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2245\n",
      "[flaml.automl: 06-21 10:22:15] {2437} INFO - iteration 59, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:22:27] {2597} INFO -  at 141.9s,\testimator extra_tree's best error=0.2222,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:22:27] {2437} INFO - iteration 60, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:22:43] {2597} INFO -  at 158.2s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:22:43] {2437} INFO - iteration 61, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:22:50] {2597} INFO -  at 165.3s,\testimator extra_tree's best error=0.2222,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:22:50] {2437} INFO - iteration 62, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:23:07] {2597} INFO -  at 182.5s,\testimator extra_tree's best error=0.2222,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:23:07] {2437} INFO - iteration 63, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:23:12] {2597} INFO -  at 186.7s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:23:12] {2437} INFO - iteration 64, current learner extra_tree\n",
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      "[flaml.automl: 06-21 10:23:23] {2437} INFO - iteration 65, current learner extra_tree\n",
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      "[flaml.automl: 06-21 10:23:31] {2437} INFO - iteration 66, current learner rf\n",
      "[flaml.automl: 06-21 10:23:32] {2597} INFO -  at 206.8s,\testimator rf's best error=0.3658,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:23:32] {2437} INFO - iteration 67, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:23:44] {2597} INFO -  at 218.8s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:23:44] {2437} INFO - iteration 68, current learner extra_tree\n",
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      "[flaml.automl: 06-21 10:25:09] {2437} INFO - iteration 74, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:25:16] {2597} INFO -  at 311.1s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:25:16] {2437} INFO - iteration 75, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:26:27] {2597} INFO -  at 382.5s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:26:27] {2437} INFO - iteration 76, current learner rf\n",
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      "[flaml.automl: 06-21 10:26:30] {2437} INFO - iteration 77, current learner rf\n",
      "[flaml.automl: 06-21 10:26:35] {2597} INFO -  at 390.2s,\testimator rf's best error=0.2996,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:26:35] {2437} INFO - iteration 78, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:06] {2597} INFO -  at 420.9s,\testimator xgboost's best error=0.2312,\tbest estimator extra_tree's best error=0.2222\n",
      "[flaml.automl: 06-21 10:27:12] {2815} INFO - retrain extra_tree for 6.3s\n",
      "[flaml.automl: 06-21 10:27:12] {2822} INFO - retrained model: ExtraTreesRegressor(max_features=1.0, max_leaf_nodes=374, n_estimators=129,\n",
      "                    n_jobs=-1)\n",
      "[flaml.automl: 06-21 10:27:12] {2199} INFO - fit succeeded\n",
      "[flaml.automl: 06-21 10:27:12] {2200} INFO - Time taken to find the best model: 141.85358095169067\n"
     ]
    }
   ],
   "source": [
    "from flaml import AutoML\n",
    "automl = AutoML()\n",
    "automl.fit(\n",
    "    X_train,\n",
    "    y_train,\n",
    "    task=\"regression\",\n",
    "    time_budget=420,\n",
    "    estimator_list = [\n",
    "        # 'lgbm',\n",
    "        'xgboost',\n",
    "        'xgb_limitdepth',\n",
    "        # 'catboost',\n",
    "        'rf',\n",
    "        'extra_tree'\n",
    "        ]\n",
    "        )\n",
    "with open(\"automl_pic50_model.pkl\", \"wb\") as f:\n",
    "    pickle.dump(automl, f, pickle.HIGHEST_PROTOCOL)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "8c7b2687",
   "metadata": {},
   "outputs": [],
   "source": [
    "pic50_model = pickle.load(open('automl_pic50_model.pkl', 'rb'))\n",
    "pred = pic50_model.predict(X_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "0da2fec1",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "R^2 = 0.70\n",
      "MAE = 0.35 pIC50 units\n"
     ]
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.metrics import r2_score, mean_absolute_error\n",
    "import matplotlib.pyplot as plt\n",
    "print(f'R^2 = {r2_score(pred, y_test.values):.2f}')\n",
    "print(f'MAE = {mean_absolute_error(pred, y_test.values):.2f} pIC50 units')\n",
    "plt.scatter(y_test.values, pred)\n",
    "plt.title('''True vs predicted pIC50 values of \n",
    "Test dataset for ML model trained on MMP12 dataset''')\n",
    "plt.xlabel('True pIC50 values (pIC50 units)')\n",
    "plt.ylabel('Predicted pIC50 values (pIC50 units)')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "de5bb156",
   "metadata": {},
   "source": [
    "# CLEARANCE MOUSE MODEL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "d5e455d3",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.model_selection import train_test_split\n",
    "desc_df = pd.read_csv('r_group_rdkit_features.csv', index_col=0)\n",
    "df = pd.read_csv('r_group_decomp.csv')\n",
    "\n",
    "plt.hist(df['clearance_mouse'],\n",
    "#  bins=['low (< 3.7)','low (< 5.6)', 'poor', 'medium (5.6-30.5)', 'good', 'fair', 'high (> 30.5)']\n",
    " )\n",
    "plt.title('Distribution of Mouse Clearance labels values in the whole MMP12 dataset')\n",
    "plt.xlabel('Mouse Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "# Drop single compound that has low (< 3.7) as stops scoring and stratified splitting\n",
    "df_cleaned = df[df['clearance_mouse']!='low (< 3.7)']\n",
    "X_train, X_test, y_train, y_test = train_test_split(desc_df.loc[df_cleaned.index, :], df_cleaned['clearance_mouse'], test_size=0.15, stratify=df_cleaned['clearance_mouse'], random_state=42)\n",
    "\n",
    "plt.hist(y_train)\n",
    "plt.title('Distribution of Mouse Clearance labels values in the MMP12 train dataset')\n",
    "plt.xlabel('Mouse Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_test)\n",
    "plt.title('Distribution of Mouse Clearance labels values in the MMP12 test dataset')\n",
    "plt.xlabel('Mouse Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "id": "1e0410da",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[flaml.automl: 06-21 10:27:19] {2007} INFO - task = classification\n",
      "[flaml.automl: 06-21 10:27:19] {2009} INFO - Data split method: stratified\n",
      "[flaml.automl: 06-21 10:27:19] {2013} INFO - Evaluation method: cv\n",
      "[flaml.automl: 06-21 10:27:19] {2113} INFO - Minimizing error metric: log_loss\n",
      "[flaml.automl: 06-21 10:27:19] {2170} INFO - List of ML learners in AutoML Run: ['xgboost', 'xgb_limitdepth', 'rf', 'extra_tree']\n",
      "[flaml.automl: 06-21 10:27:19] {2437} INFO - iteration 0, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:20] {2550} INFO - Estimated sufficient time budget=11022s. Estimated necessary time budget=48s.\n",
      "[flaml.automl: 06-21 10:27:20] {2597} INFO -  at 1.6s,\testimator xgboost's best error=0.8976,\tbest estimator xgboost's best error=0.8976\n",
      "[flaml.automl: 06-21 10:27:20] {2437} INFO - iteration 1, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:21] {2597} INFO -  at 2.5s,\testimator xgboost's best error=0.8976,\tbest estimator xgboost's best error=0.8976\n",
      "[flaml.automl: 06-21 10:27:21] {2437} INFO - iteration 2, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:23] {2597} INFO -  at 3.8s,\testimator xgboost's best error=0.7118,\tbest estimator xgboost's best error=0.7118\n",
      "[flaml.automl: 06-21 10:27:23] {2437} INFO - iteration 3, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:23] {2597} INFO -  at 4.1s,\testimator extra_tree's best error=0.7077,\tbest estimator extra_tree's best error=0.7077\n",
      "[flaml.automl: 06-21 10:27:23] {2437} INFO - iteration 4, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:24] {2597} INFO -  at 5.5s,\testimator xgboost's best error=0.4946,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:24] {2437} INFO - iteration 5, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:24] {2597} INFO -  at 5.8s,\testimator extra_tree's best error=0.6708,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:24] {2437} INFO - iteration 6, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:26] {2597} INFO -  at 7.4s,\testimator xgboost's best error=0.4946,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:26] {2437} INFO - iteration 7, current learner rf\n",
      "[flaml.automl: 06-21 10:27:26] {2597} INFO -  at 7.7s,\testimator rf's best error=0.6576,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:26] {2437} INFO - iteration 8, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:27] {2597} INFO -  at 8.7s,\testimator xgboost's best error=0.4946,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:27] {2437} INFO - iteration 9, current learner rf\n",
      "[flaml.automl: 06-21 10:27:28] {2597} INFO -  at 9.0s,\testimator rf's best error=0.6136,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:28] {2437} INFO - iteration 10, current learner rf\n",
      "[flaml.automl: 06-21 10:27:28] {2597} INFO -  at 9.3s,\testimator rf's best error=0.6136,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:28] {2437} INFO - iteration 11, current learner rf\n",
      "[flaml.automl: 06-21 10:27:29] {2597} INFO -  at 9.8s,\testimator rf's best error=0.6055,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:29] {2437} INFO - iteration 12, current learner rf\n",
      "[flaml.automl: 06-21 10:27:29] {2597} INFO -  at 10.2s,\testimator rf's best error=0.5966,\tbest estimator xgboost's best error=0.4946\n",
      "[flaml.automl: 06-21 10:27:29] {2437} INFO - iteration 13, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:31] {2597} INFO -  at 12.7s,\testimator xgboost's best error=0.4335,\tbest estimator xgboost's best error=0.4335\n",
      "[flaml.automl: 06-21 10:27:31] {2437} INFO - iteration 14, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:32] {2597} INFO -  at 12.9s,\testimator extra_tree's best error=0.6708,\tbest estimator xgboost's best error=0.4335\n",
      "[flaml.automl: 06-21 10:27:32] {2437} INFO - iteration 15, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:34] {2597} INFO -  at 15.8s,\testimator xgboost's best error=0.4026,\tbest estimator xgboost's best error=0.4026\n",
      "[flaml.automl: 06-21 10:27:34] {2437} INFO - iteration 16, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:35] {2597} INFO -  at 16.1s,\testimator extra_tree's best error=0.6527,\tbest estimator xgboost's best error=0.4026\n",
      "[flaml.automl: 06-21 10:27:35] {2437} INFO - iteration 17, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:41] {2597} INFO -  at 22.5s,\testimator xgboost's best error=0.4026,\tbest estimator xgboost's best error=0.4026\n",
      "[flaml.automl: 06-21 10:27:41] {2437} INFO - iteration 18, current learner rf\n",
      "[flaml.automl: 06-21 10:27:42] {2597} INFO -  at 23.0s,\testimator rf's best error=0.5966,\tbest estimator xgboost's best error=0.4026\n",
      "[flaml.automl: 06-21 10:27:42] {2437} INFO - iteration 19, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:51] {2597} INFO -  at 32.7s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:51] {2437} INFO - iteration 20, current learner rf\n",
      "[flaml.automl: 06-21 10:27:52] {2597} INFO -  at 33.2s,\testimator rf's best error=0.5731,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:52] {2437} INFO - iteration 21, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:53] {2597} INFO -  at 34.6s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:53] {2437} INFO - iteration 22, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:27:55] {2597} INFO -  at 36.3s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:55] {2437} INFO - iteration 23, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:56] {2597} INFO -  at 36.9s,\testimator extra_tree's best error=0.6380,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:56] {2437} INFO - iteration 24, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:27:56] {2597} INFO -  at 37.2s,\testimator extra_tree's best error=0.6380,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:27:56] {2437} INFO - iteration 25, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:10] {2597} INFO -  at 51.7s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:10] {2437} INFO - iteration 26, current learner rf\n",
      "[flaml.automl: 06-21 10:28:11] {2597} INFO -  at 52.8s,\testimator rf's best error=0.5127,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:11] {2437} INFO - iteration 27, current learner rf\n",
      "[flaml.automl: 06-21 10:28:12] {2597} INFO -  at 53.4s,\testimator rf's best error=0.5127,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:12] {2437} INFO - iteration 28, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:12] {2597} INFO -  at 53.7s,\testimator extra_tree's best error=0.5900,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:12] {2437} INFO - iteration 29, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:17] {2597} INFO -  at 58.0s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:17] {2437} INFO - iteration 30, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:20] {2597} INFO -  at 61.7s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:20] {2437} INFO - iteration 31, current learner rf\n",
      "[flaml.automl: 06-21 10:28:22] {2597} INFO -  at 62.8s,\testimator rf's best error=0.5127,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:22] {2437} INFO - iteration 32, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:22] {2597} INFO -  at 63.2s,\testimator extra_tree's best error=0.5607,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:22] {2437} INFO - iteration 33, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:23] {2597} INFO -  at 64.1s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:23] {2437} INFO - iteration 34, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:23] {2597} INFO -  at 64.3s,\testimator extra_tree's best error=0.5607,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:23] {2437} INFO - iteration 35, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:24] {2597} INFO -  at 64.8s,\testimator extra_tree's best error=0.5607,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:24] {2437} INFO - iteration 36, current learner rf\n",
      "[flaml.automl: 06-21 10:28:24] {2597} INFO -  at 65.4s,\testimator rf's best error=0.4792,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:24] {2437} INFO - iteration 37, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:25] {2597} INFO -  at 65.9s,\testimator extra_tree's best error=0.5118,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:25] {2437} INFO - iteration 38, current learner rf\n",
      "[flaml.automl: 06-21 10:28:25] {2597} INFO -  at 66.6s,\testimator rf's best error=0.4792,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:25] {2437} INFO - iteration 39, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:25] {2597} INFO -  at 66.8s,\testimator extra_tree's best error=0.5118,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:25] {2437} INFO - iteration 40, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:26] {2597} INFO -  at 67.2s,\testimator extra_tree's best error=0.4601,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:26] {2437} INFO - iteration 41, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:29] {2597} INFO -  at 70.0s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:29] {2437} INFO - iteration 42, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:29] {2597} INFO -  at 70.3s,\testimator extra_tree's best error=0.4601,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:29] {2437} INFO - iteration 43, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:30] {2597} INFO -  at 70.9s,\testimator extra_tree's best error=0.4601,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:30] {2437} INFO - iteration 44, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:30] {2597} INFO -  at 71.3s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:30] {2437} INFO - iteration 45, current learner rf\n",
      "[flaml.automl: 06-21 10:28:31] {2597} INFO -  at 72.0s,\testimator rf's best error=0.4450,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:31] {2437} INFO - iteration 46, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:31] {2597} INFO -  at 72.5s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:31] {2437} INFO - iteration 47, current learner rf\n",
      "[flaml.automl: 06-21 10:28:32] {2597} INFO -  at 73.1s,\testimator rf's best error=0.4450,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:32] {2437} INFO - iteration 48, current learner rf\n",
      "[flaml.automl: 06-21 10:28:34] {2597} INFO -  at 75.3s,\testimator rf's best error=0.4443,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:34] {2437} INFO - iteration 49, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:35] {2597} INFO -  at 75.8s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:35] {2437} INFO - iteration 50, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:35] {2597} INFO -  at 76.5s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:35] {2437} INFO - iteration 51, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:36] {2597} INFO -  at 77.2s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:36] {2437} INFO - iteration 52, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:37] {2597} INFO -  at 78.8s,\testimator xgboost's best error=0.3683,\tbest estimator xgboost's best error=0.3683\n",
      "[flaml.automl: 06-21 10:28:37] {2437} INFO - iteration 53, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:46] {2597} INFO -  at 87.4s,\testimator xgboost's best error=0.3601,\tbest estimator xgboost's best error=0.3601\n",
      "[flaml.automl: 06-21 10:28:46] {2437} INFO - iteration 54, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:28:47] {2597} INFO -  at 88.1s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3601\n",
      "[flaml.automl: 06-21 10:28:47] {2437} INFO - iteration 55, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:48] {2597} INFO -  at 89.7s,\testimator xgboost's best error=0.3601,\tbest estimator xgboost's best error=0.3601\n",
      "[flaml.automl: 06-21 10:28:48] {2437} INFO - iteration 56, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:28:57] {2597} INFO -  at 98.2s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:28:57] {2437} INFO - iteration 57, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:04] {2597} INFO -  at 105.1s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:04] {2437} INFO - iteration 58, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:08] {2597} INFO -  at 109.7s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:08] {2437} INFO - iteration 59, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:23] {2597} INFO -  at 123.8s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:23] {2437} INFO - iteration 60, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:31] {2597} INFO -  at 131.9s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:31] {2437} INFO - iteration 61, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:29:31] {2597} INFO -  at 132.5s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:31] {2437} INFO - iteration 62, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:29:32] {2597} INFO -  at 133.2s,\testimator extra_tree's best error=0.4281,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:32] {2437} INFO - iteration 63, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:42] {2597} INFO -  at 143.1s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:42] {2437} INFO - iteration 64, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:29:43] {2597} INFO -  at 144.1s,\testimator extra_tree's best error=0.4232,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:43] {2437} INFO - iteration 65, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:29:54] {2597} INFO -  at 154.9s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:29:54] {2437} INFO - iteration 66, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:02] {2597} INFO -  at 163.5s,\testimator xgb_limitdepth's best error=0.4027,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:02] {2437} INFO - iteration 67, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:07] {2597} INFO -  at 168.7s,\testimator xgb_limitdepth's best error=0.4027,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:07] {2437} INFO - iteration 68, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:27] {2597} INFO -  at 188.3s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:27] {2437} INFO - iteration 69, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:33] {2597} INFO -  at 194.2s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:33] {2437} INFO - iteration 70, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:37] {2597} INFO -  at 198.0s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:37] {2437} INFO - iteration 71, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:44] {2597} INFO -  at 205.6s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:44] {2437} INFO - iteration 72, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:30:45] {2597} INFO -  at 206.0s,\testimator extra_tree's best error=0.4232,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:45] {2437} INFO - iteration 73, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:47] {2597} INFO -  at 208.5s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:47] {2437} INFO - iteration 74, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:30:48] {2597} INFO -  at 209.1s,\testimator extra_tree's best error=0.4232,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:48] {2437} INFO - iteration 75, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:30:50] {2597} INFO -  at 211.7s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:30:50] {2437} INFO - iteration 76, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:06] {2597} INFO -  at 226.8s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:06] {2437} INFO - iteration 77, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:06] {2597} INFO -  at 227.7s,\testimator extra_tree's best error=0.4189,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:06] {2437} INFO - iteration 78, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:20] {2597} INFO -  at 241.1s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:20] {2437} INFO - iteration 79, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:36] {2597} INFO -  at 257.1s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:36] {2437} INFO - iteration 80, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:37] {2597} INFO -  at 257.9s,\testimator extra_tree's best error=0.4189,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:37] {2437} INFO - iteration 81, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:45] {2597} INFO -  at 266.5s,\testimator xgboost's best error=0.3458,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:45] {2437} INFO - iteration 82, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:46] {2597} INFO -  at 266.9s,\testimator extra_tree's best error=0.4189,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:46] {2437} INFO - iteration 83, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:46] {2597} INFO -  at 267.4s,\testimator extra_tree's best error=0.4042,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:46] {2437} INFO - iteration 84, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:47] {2597} INFO -  at 268.0s,\testimator extra_tree's best error=0.4042,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:47] {2437} INFO - iteration 85, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:48] {2597} INFO -  at 268.8s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:48] {2437} INFO - iteration 86, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:48] {2597} INFO -  at 269.4s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:48] {2437} INFO - iteration 87, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:49] {2597} INFO -  at 270.1s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:49] {2437} INFO - iteration 88, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:55] {2597} INFO -  at 275.9s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:55] {2437} INFO - iteration 89, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:31:56] {2597} INFO -  at 277.0s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:56] {2437} INFO - iteration 90, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:31:58] {2597} INFO -  at 279.7s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:31:58] {2437} INFO - iteration 91, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:32:01] {2597} INFO -  at 282.1s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:01] {2437} INFO - iteration 92, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:32:01] {2597} INFO -  at 282.5s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:01] {2437} INFO - iteration 93, current learner rf\n",
      "[flaml.automl: 06-21 10:32:03] {2597} INFO -  at 283.9s,\testimator rf's best error=0.4177,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:03] {2437} INFO - iteration 94, current learner rf\n",
      "[flaml.automl: 06-21 10:32:04] {2597} INFO -  at 285.0s,\testimator rf's best error=0.4177,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:04] {2437} INFO - iteration 95, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:32:04] {2597} INFO -  at 285.6s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:04] {2437} INFO - iteration 96, current learner rf\n",
      "[flaml.automl: 06-21 10:32:05] {2597} INFO -  at 286.2s,\testimator rf's best error=0.4177,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:05] {2437} INFO - iteration 97, current learner rf\n",
      "[flaml.automl: 06-21 10:32:07] {2597} INFO -  at 288.6s,\testimator rf's best error=0.4177,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:07] {2437} INFO - iteration 98, current learner rf\n",
      "[flaml.automl: 06-21 10:32:10] {2597} INFO -  at 291.3s,\testimator rf's best error=0.4072,\tbest estimator xgboost's best error=0.3458\n",
      "[flaml.automl: 06-21 10:32:10] {2437} INFO - iteration 99, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:32:17] {2597} INFO -  at 298.8s,\testimator xgboost's best error=0.3398,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:32:17] {2437} INFO - iteration 100, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:32:19] {2597} INFO -  at 300.4s,\testimator extra_tree's best error=0.3989,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:32:19] {2437} INFO - iteration 101, current learner rf\n",
      "[flaml.automl: 06-21 10:32:20] {2597} INFO -  at 301.7s,\testimator rf's best error=0.4072,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:32:20] {2437} INFO - iteration 102, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:32:42] {2597} INFO -  at 323.5s,\testimator xgboost's best error=0.3398,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:32:42] {2437} INFO - iteration 103, current learner rf\n",
      "[flaml.automl: 06-21 10:32:46] {2597} INFO -  at 327.5s,\testimator rf's best error=0.3998,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:32:46] {2437} INFO - iteration 104, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:33:05] {2597} INFO -  at 346.0s,\testimator xgb_limitdepth's best error=0.3914,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:05] {2437} INFO - iteration 105, current learner rf\n",
      "[flaml.automl: 06-21 10:33:10] {2597} INFO -  at 351.1s,\testimator rf's best error=0.3998,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:10] {2437} INFO - iteration 106, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:14] {2597} INFO -  at 355.8s,\testimator extra_tree's best error=0.3863,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:14] {2437} INFO - iteration 107, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:33:22] {2597} INFO -  at 363.6s,\testimator xgb_limitdepth's best error=0.3895,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:22] {2437} INFO - iteration 108, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:24] {2597} INFO -  at 365.5s,\testimator extra_tree's best error=0.3863,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:24] {2437} INFO - iteration 109, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:28] {2597} INFO -  at 369.6s,\testimator extra_tree's best error=0.3863,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:28] {2437} INFO - iteration 110, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:33:45] {2597} INFO -  at 386.3s,\testimator xgboost's best error=0.3398,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:45] {2437} INFO - iteration 111, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:47] {2597} INFO -  at 388.4s,\testimator extra_tree's best error=0.3863,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:47] {2437} INFO - iteration 112, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:52] {2597} INFO -  at 393.6s,\testimator extra_tree's best error=0.3625,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:52] {2437} INFO - iteration 113, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:33:55] {2597} INFO -  at 395.9s,\testimator extra_tree's best error=0.3625,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:55] {2437} INFO - iteration 114, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:33:57] {2597} INFO -  at 398.0s,\testimator xgb_limitdepth's best error=0.3895,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:33:57] {2437} INFO - iteration 115, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:34:07] {2597} INFO -  at 408.1s,\testimator xgboost's best error=0.3398,\tbest estimator xgboost's best error=0.3398\n",
      "[flaml.automl: 06-21 10:34:07] {2437} INFO - iteration 116, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:34:16] {2597} INFO -  at 416.8s,\testimator extra_tree's best error=0.3625,\tbest estimator xgboost's best error=0.3398\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:34:22] {2815} INFO - retrain xgboost for 6.7s\n",
      "[flaml.automl: 06-21 10:34:22] {2822} INFO - retrained model: XGBClassifier(base_score=0.5, booster='gbtree',\n",
      "              colsample_bylevel=0.7719520857498233, colsample_bynode=1,\n",
      "              colsample_bytree=0.6926042643938508, gamma=0, gpu_id=-1,\n",
      "              grow_policy='lossguide', importance_type='gain',\n",
      "              interaction_constraints='', learning_rate=0.2315412132847473,\n",
      "              max_delta_step=0, max_depth=0, max_leaves=18,\n",
      "              min_child_weight=5.9494575201678455, missing=nan,\n",
      "              monotone_constraints='()', n_estimators=51, n_jobs=-1,\n",
      "              num_parallel_tree=1, objective='multi:softprob', random_state=0,\n",
      "              reg_alpha=0.4120476708105291, reg_lambda=1.2893806823133136,\n",
      "              scale_pos_weight=None, subsample=0.7848422642108877,\n",
      "              tree_method='hist', use_label_encoder=False,\n",
      "              validate_parameters=1, verbosity=0)\n",
      "[flaml.automl: 06-21 10:34:22] {2199} INFO - fit succeeded\n",
      "[flaml.automl: 06-21 10:34:22] {2200} INFO - Time taken to find the best model: 298.7534899711609\n",
      "[flaml.automl: 06-21 10:34:22] {2211} WARNING - Time taken to find the best model is 71% of the provided time budget and not all estimators' hyperparameter search converged. Consider increasing the time budget.\n"
     ]
    }
   ],
   "source": [
    "from flaml import AutoML\n",
    "automl = AutoML()\n",
    "automl.fit(\n",
    "    X_train,\n",
    "    y_train,\n",
    "    task=\"classification\",\n",
    "    time_budget=420,\n",
    "    estimator_list = [\n",
    "        # 'lgbm',\n",
    "        'xgboost',\n",
    "        'xgb_limitdepth',\n",
    "        # 'catboost',\n",
    "        'rf',\n",
    "        'extra_tree'\n",
    "        ])\n",
    "with open(\"automl_clearance_mouse_model.pkl\", \"wb\") as f:\n",
    "    pickle.dump(automl, f, pickle.HIGHEST_PROTOCOL)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "id": "3abfae53",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n"
     ]
    }
   ],
   "source": [
    "c_mouse_model = pickle.load(open('automl_clearance_mouse_model.pkl', 'rb'))\n",
    "pred = c_mouse_model.predict(X_test)\n",
    "pred_probs = c_mouse_model.predict_proba(X_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "id": "fcd165bc",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/sklearn/utils/deprecation.py:87: FutureWarning: Function plot_confusion_matrix is deprecated; Function `plot_confusion_matrix` is deprecated in 1.0 and will be removed in 1.2. Use one of the class methods: ConfusionMatrixDisplay.from_predictions or ConfusionMatrixDisplay.from_estimator.\n",
      "  warnings.warn(msg, category=FutureWarning)\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n"
     ]
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "AUROC = 0.959\n",
      "F1 = 0.867\n",
      "MCC = 0.741\n"
     ]
    }
   ],
   "source": [
    "from sklearn.metrics import plot_confusion_matrix, roc_auc_score, f1_score, matthews_corrcoef\n",
    "disp = plot_confusion_matrix(c_mouse_model, X_test, y_test,\n",
    "                                 display_labels=set(y_test))\n",
    "plt.xticks(rotation = 90) \n",
    "plt.title('Confusion matrix of predicted and true mouse clearance labels')\n",
    "plt.ylabel('True Mouse Clearance Label')\n",
    "plt.xlabel('Predicted Mouse Clearance Label')\n",
    "plt.show()\n",
    "roc_auc_score_value = roc_auc_score(\n",
    "    y_test, pred_probs, multi_class=\"ovr\", average=\"weighted\"\n",
    "  )\n",
    "f1_score_value = f1_score(y_test, pred, average=\"weighted\")\n",
    "mcc_value = matthews_corrcoef(y_test, pred)\n",
    "print(f'AUROC = {roc_auc_score_value:.3f}')\n",
    "print(f'F1 = {f1_score_value:.3f}')\n",
    "print(f'MCC = {mcc_value:.3f}')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "dd87a4be",
   "metadata": {},
   "source": [
    "# CLEARANCE HUMAN MODEL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "id": "72149ecd",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "2499\n"
     ]
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.model_selection import train_test_split\n",
    "desc_df = pd.read_csv('r_group_rdkit_features.csv', index_col=0)\n",
    "df = pd.read_csv('r_group_decomp.csv')\n",
    "\n",
    "plt.hist(df['clearance_human'],\n",
    "#  bins=['low (< 3.7)','low (< 5.6)', 'poor', 'medium (5.6-30.5)', 'good', 'fair', 'high (> 30.5)']\n",
    " )\n",
    "plt.title('Distribution of Human Clearance labels values in the whole MMP12 dataset')\n",
    "plt.xlabel('Human Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "# Both of these medium classes only have 1 molecule each\n",
    "# df_cleaned = df[df['clearance_human']!='medium (5.6-30.5)']\n",
    "# df_cleaned = df_cleaned[df_cleaned['clearance_human']!='medium (12-44)']\n",
    "print(len(df_cleaned))\n",
    "X_train, X_test, y_train, y_test = train_test_split(desc_df.loc[df_cleaned.index, :], df_cleaned['clearance_human'], test_size=0.15, stratify=df_cleaned['clearance_human'], random_state=42)\n",
    "\n",
    "plt.hist(y_train)\n",
    "plt.title('Distribution of Human Clearance labels values in the MMP12 train dataset')\n",
    "plt.xlabel('Human Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_test)\n",
    "plt.title('Distribution of Human Clearance labels values in the MMP12 test dataset')\n",
    "plt.xlabel('Human Clearance labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "id": "1b94d618",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'\\nNo point having a ML model as only one class to predict\\n'"
      ]
     },
     "execution_count": 39,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "# from flaml import AutoML\n",
    "# automl = AutoML()\n",
    "# automl.fit(\n",
    "#     X_train,\n",
    "#     y_train,\n",
    "#     task=\"classification\",\n",
    "#     time_budget=420,\n",
    "#     estimator_list = [\n",
    "#         # 'lgbm',\n",
    "#         'xgboost',\n",
    "#         'xgb_limitdepth',\n",
    "#         # 'catboost',\n",
    "#         'rf',\n",
    "#         'extra_tree'\n",
    "#         ])\n",
    "# with open(\"automl_clearance_human_model.pkl\", \"wb\") as f:\n",
    "#     pickle.dump(automl, f, pickle.HIGHEST_PROTOCOL)\n",
    "\n",
    "'''\n",
    "No point having a ML model as only one class to predict\n",
    "'''"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "id": "0a8ed58a",
   "metadata": {},
   "outputs": [],
   "source": [
    "# c_human_model = pickle.load(open('automl_clearance_human_model.pkl', 'rb'))\n",
    "# pred = c_human_model.predict(X_test)\n",
    "# pred_probs = c_human_model.predict_proba(X_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 41,
   "id": "8442e768",
   "metadata": {},
   "outputs": [],
   "source": [
    "# from sklearn.metrics import plot_confusion_matrix, roc_auc_score, f1_score, matthews_corrcoef\n",
    "# disp = plot_confusion_matrix(c_human_model, X_test, y_test,\n",
    "#                                  display_labels=set(y_test))\n",
    "# plt.xticks(rotation = 90) \n",
    "# plt.title('Confusion matrix of predicted and true human clearance labels')\n",
    "# plt.ylabel('True Human Clearance Label')\n",
    "# plt.xlabel('Predicted Human Clearance Label')\n",
    "# plt.show()\n",
    "# roc_auc_score_value = roc_auc_score(\n",
    "#     y_test, pred_probs, multi_class=\"ovr\", average=\"weighted\"\n",
    "#   )\n",
    "# f1_score_value = f1_score(y_test, pred, average=\"weighted\")\n",
    "# mcc_value = matthews_corrcoef(y_test, pred)\n",
    "# print(f'AUROC = {roc_auc_score_value:.3f}')\n",
    "# print(f'F1 = {f1_score_value:.3f}')\n",
    "# print(f'MCC = {mcc_value:.3f}')"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "31208551",
   "metadata": {},
   "source": [
    "# PAMPA MODEL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "e0b68f4d",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.model_selection import train_test_split\n",
    "desc_df = pd.read_csv('r_group_rdkit_features.csv', index_col=0)\n",
    "df = pd.read_csv('r_group_decomp.csv')\n",
    "\n",
    "plt.hist(df['pampa'],\n",
    "#  bins=['low (< 3.7)','low (< 5.6)', 'poor', 'medium (5.6-30.5)', 'good', 'fair', 'high (> 30.5)']\n",
    " )\n",
    "plt.title('Distribution of PAMPA labels values in the whole MMP12 dataset')\n",
    "plt.xlabel('PAMPA labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "# Drop single compound that has 'neg' as stops scoring and stratified splitting\n",
    "df_cleaned = df[df['pampa']!='neg']\n",
    "X_train, X_test, y_train, y_test = train_test_split(desc_df.loc[df_cleaned.index, :], df_cleaned['pampa'], test_size=0.15, stratify=df_cleaned['pampa'], random_state=42)\n",
    "\n",
    "plt.hist(y_train)\n",
    "plt.title('Distribution of PAMPA labels values in the MMP12 train dataset')\n",
    "plt.xlabel('PAMPA labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_test)\n",
    "plt.title('Distribution of PAMPA labels values in the MMP12 test dataset')\n",
    "plt.xlabel('PAMPA labels')\n",
    "plt.xticks(rotation = 90) \n",
    "plt.ylabel('Frequency')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "id": "d1b97ac2",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[flaml.automl: 06-21 10:47:14] {2007} INFO - task = classification\n",
      "[flaml.automl: 06-21 10:47:14] {2009} INFO - Data split method: stratified\n",
      "[flaml.automl: 06-21 10:47:14] {2013} INFO - Evaluation method: cv\n",
      "[flaml.automl: 06-21 10:47:14] {2113} INFO - Minimizing error metric: 1-roc_auc\n",
      "[flaml.automl: 06-21 10:47:14] {2170} INFO - List of ML learners in AutoML Run: ['xgboost', 'xgb_limitdepth', 'rf', 'extra_tree']\n",
      "[flaml.automl: 06-21 10:47:14] {2437} INFO - iteration 0, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:15] {2550} INFO - Estimated sufficient time budget=12160s. Estimated necessary time budget=53s.\n",
      "[flaml.automl: 06-21 10:47:15] {2597} INFO -  at 2.2s,\testimator xgboost's best error=0.0314,\tbest estimator xgboost's best error=0.0314\n",
      "[flaml.automl: 06-21 10:47:15] {2437} INFO - iteration 1, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:16] {2597} INFO -  at 2.8s,\testimator xgboost's best error=0.0302,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:16] {2437} INFO - iteration 2, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:17] {2597} INFO -  at 3.3s,\testimator xgboost's best error=0.0302,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:17] {2437} INFO - iteration 3, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:17] {2597} INFO -  at 3.8s,\testimator xgboost's best error=0.0302,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:17] {2437} INFO - iteration 4, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:20] {2597} INFO -  at 6.3s,\testimator xgboost's best error=0.0302,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:20] {2437} INFO - iteration 5, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:20] {2597} INFO -  at 6.8s,\testimator extra_tree's best error=0.0997,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:20] {2437} INFO - iteration 6, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:21] {2597} INFO -  at 7.7s,\testimator xgboost's best error=0.0302,\tbest estimator xgboost's best error=0.0302\n",
      "[flaml.automl: 06-21 10:47:21] {2437} INFO - iteration 7, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 8.5s,\testimator xgboost's best error=0.0267,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 8, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 8.6s,\testimator extra_tree's best error=0.0602,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 9, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 8.8s,\testimator extra_tree's best error=0.0602,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 10, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 8.9s,\testimator extra_tree's best error=0.0474,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 11, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 9.1s,\testimator extra_tree's best error=0.0462,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 12, current learner rf\n",
      "[flaml.automl: 06-21 10:47:22] {2597} INFO -  at 9.2s,\testimator rf's best error=0.0438,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:22] {2437} INFO - iteration 13, current learner rf\n",
      "[flaml.automl: 06-21 10:47:23] {2597} INFO -  at 9.5s,\testimator rf's best error=0.0347,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:23] {2437} INFO - iteration 14, current learner rf\n",
      "[flaml.automl: 06-21 10:47:23] {2597} INFO -  at 9.7s,\testimator rf's best error=0.0347,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:23] {2437} INFO - iteration 15, current learner rf\n",
      "[flaml.automl: 06-21 10:47:23] {2597} INFO -  at 10.0s,\testimator rf's best error=0.0270,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:23] {2437} INFO - iteration 16, current learner rf\n",
      "[flaml.automl: 06-21 10:47:24] {2597} INFO -  at 10.3s,\testimator rf's best error=0.0270,\tbest estimator xgboost's best error=0.0267\n",
      "[flaml.automl: 06-21 10:47:24] {2437} INFO - iteration 17, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:26] {2597} INFO -  at 12.9s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:26] {2437} INFO - iteration 18, current learner rf\n",
      "[flaml.automl: 06-21 10:47:27] {2597} INFO -  at 13.5s,\testimator rf's best error=0.0270,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:27] {2437} INFO - iteration 19, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:28] {2597} INFO -  at 14.3s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:28] {2437} INFO - iteration 20, current learner rf\n",
      "[flaml.automl: 06-21 10:47:28] {2597} INFO -  at 14.5s,\testimator rf's best error=0.0270,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:28] {2437} INFO - iteration 21, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:28] {2597} INFO -  at 15.2s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:28] {2437} INFO - iteration 22, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:29] {2597} INFO -  at 15.8s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:29] {2437} INFO - iteration 23, current learner rf\n",
      "[flaml.automl: 06-21 10:47:29] {2597} INFO -  at 16.2s,\testimator rf's best error=0.0175,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:29] {2437} INFO - iteration 24, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:30] {2597} INFO -  at 16.4s,\testimator extra_tree's best error=0.0405,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:30] {2437} INFO - iteration 25, current learner rf\n",
      "[flaml.automl: 06-21 10:47:30] {2597} INFO -  at 16.6s,\testimator rf's best error=0.0175,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:30] {2437} INFO - iteration 26, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:30] {2597} INFO -  at 16.8s,\testimator extra_tree's best error=0.0387,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:30] {2437} INFO - iteration 27, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:30] {2597} INFO -  at 17.2s,\testimator extra_tree's best error=0.0248,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:30] {2437} INFO - iteration 28, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:31] {2597} INFO -  at 17.4s,\testimator extra_tree's best error=0.0248,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:31] {2437} INFO - iteration 29, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:31] {2597} INFO -  at 18.1s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:31] {2437} INFO - iteration 30, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:32] {2597} INFO -  at 18.5s,\testimator xgboost's best error=0.0165,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:32] {2437} INFO - iteration 31, current learner rf\n",
      "[flaml.automl: 06-21 10:47:32] {2597} INFO -  at 19.2s,\testimator rf's best error=0.0175,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:32] {2437} INFO - iteration 32, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:33] {2597} INFO -  at 19.6s,\testimator extra_tree's best error=0.0248,\tbest estimator xgboost's best error=0.0165\n",
      "[flaml.automl: 06-21 10:47:33] {2437} INFO - iteration 33, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:47:33] {2597} INFO -  at 20.2s,\testimator xgboost's best error=0.0148,\tbest estimator xgboost's best error=0.0148\n",
      "[flaml.automl: 06-21 10:47:33] {2437} INFO - iteration 34, current learner rf\n",
      "[flaml.automl: 06-21 10:47:34] {2597} INFO -  at 20.8s,\testimator rf's best error=0.0105,\tbest estimator rf's best error=0.0105\n",
      "[flaml.automl: 06-21 10:47:34] {2437} INFO - iteration 35, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:47:34] {2597} INFO -  at 21.1s,\testimator extra_tree's best error=0.0189,\tbest estimator rf's best error=0.0105\n",
      "[flaml.automl: 06-21 10:47:34] {2437} INFO - iteration 36, current learner rf\n",
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      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
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      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
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      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
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      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
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      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
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      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:48:54] {2597} INFO -  at 101.1s,\testimator xgboost's best error=0.0070,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:48:54] {2437} INFO - iteration 94, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:48:57] {2597} INFO -  at 104.0s,\testimator extra_tree's best error=0.0056,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:48:57] {2437} INFO - iteration 95, current learner rf\n",
      "[flaml.automl: 06-21 10:49:01] {2597} INFO -  at 108.1s,\testimator rf's best error=0.0075,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:01] {2437} INFO - iteration 96, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:03] {2597} INFO -  at 109.5s,\testimator extra_tree's best error=0.0056,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:03] {2437} INFO - iteration 97, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:05] {2597} INFO -  at 112.1s,\testimator xgboost's best error=0.0069,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:05] {2437} INFO - iteration 98, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:09] {2597} INFO -  at 115.4s,\testimator extra_tree's best error=0.0056,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:09] {2437} INFO - iteration 99, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:10] {2597} INFO -  at 116.3s,\testimator extra_tree's best error=0.0056,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:10] {2437} INFO - iteration 100, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:10] {2597} INFO -  at 117.0s,\testimator extra_tree's best error=0.0056,\tbest estimator extra_tree's best error=0.0056\n",
      "[flaml.automl: 06-21 10:49:10] {2437} INFO - iteration 101, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:13] {2597} INFO -  at 120.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:13] {2437} INFO - iteration 102, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:16] {2597} INFO -  at 122.9s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:16] {2437} INFO - iteration 103, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:19] {2597} INFO -  at 126.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:19] {2437} INFO - iteration 104, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:22] {2597} INFO -  at 129.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:22] {2437} INFO - iteration 105, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:25] {2597} INFO -  at 131.5s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:25] {2437} INFO - iteration 106, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:36] {2597} INFO -  at 142.6s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:36] {2437} INFO - iteration 107, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:42] {2597} INFO -  at 149.1s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:42] {2437} INFO - iteration 108, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:45] {2597} INFO -  at 151.7s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:45] {2437} INFO - iteration 109, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:47] {2597} INFO -  at 153.5s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:47] {2437} INFO - iteration 110, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:48] {2597} INFO -  at 154.9s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:48] {2437} INFO - iteration 111, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:50] {2597} INFO -  at 156.5s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:50] {2437} INFO - iteration 112, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:49:53] {2597} INFO -  at 159.3s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:53] {2437} INFO - iteration 113, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:57] {2597} INFO -  at 164.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:57] {2437} INFO - iteration 114, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:49:59] {2597} INFO -  at 166.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:49:59] {2437} INFO - iteration 115, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:50:01] {2597} INFO -  at 167.3s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:01] {2437} INFO - iteration 116, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:03] {2597} INFO -  at 169.9s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:03] {2437} INFO - iteration 117, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:05] {2597} INFO -  at 172.2s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:05] {2437} INFO - iteration 118, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:50:09] {2597} INFO -  at 175.4s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:09] {2437} INFO - iteration 119, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:50:10] {2597} INFO -  at 176.8s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:10] {2437} INFO - iteration 120, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:50:13] {2597} INFO -  at 179.5s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:13] {2437} INFO - iteration 121, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:15] {2597} INFO -  at 181.9s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:15] {2437} INFO - iteration 122, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:18] {2597} INFO -  at 184.9s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:18] {2437} INFO - iteration 123, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:20] {2597} INFO -  at 187.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:20] {2437} INFO - iteration 124, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:24] {2597} INFO -  at 190.4s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:24] {2437} INFO - iteration 125, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:26] {2597} INFO -  at 192.4s,\testimator xgb_limitdepth's best error=0.0109,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:26] {2437} INFO - iteration 126, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:28] {2597} INFO -  at 194.9s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:28] {2437} INFO - iteration 127, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:32] {2597} INFO -  at 198.3s,\testimator xgb_limitdepth's best error=0.0109,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:32] {2437} INFO - iteration 128, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:35] {2597} INFO -  at 201.4s,\testimator xgb_limitdepth's best error=0.0079,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:35] {2437} INFO - iteration 129, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:37] {2597} INFO -  at 204.3s,\testimator xgb_limitdepth's best error=0.0079,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:38] {2437} INFO - iteration 130, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:42] {2597} INFO -  at 208.7s,\testimator xgb_limitdepth's best error=0.0079,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:42] {2437} INFO - iteration 131, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:43] {2597} INFO -  at 209.8s,\testimator xgb_limitdepth's best error=0.0079,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:43] {2437} INFO - iteration 132, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:48] {2597} INFO -  at 214.4s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:48] {2437} INFO - iteration 133, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:51] {2597} INFO -  at 217.3s,\testimator xgb_limitdepth's best error=0.0079,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:51] {2437} INFO - iteration 134, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:53] {2597} INFO -  at 219.6s,\testimator xgb_limitdepth's best error=0.0074,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:53] {2437} INFO - iteration 135, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:50:54] {2597} INFO -  at 220.6s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:54] {2437} INFO - iteration 136, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:56] {2597} INFO -  at 222.8s,\testimator xgb_limitdepth's best error=0.0074,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:56] {2437} INFO - iteration 137, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:50:57] {2597} INFO -  at 224.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:50:57] {2437} INFO - iteration 138, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:51:00] {2597} INFO -  at 226.9s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:00] {2437} INFO - iteration 139, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:02] {2597} INFO -  at 229.0s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:02] {2437} INFO - iteration 140, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:51:04] {2597} INFO -  at 230.5s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:04] {2437} INFO - iteration 141, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:07] {2597} INFO -  at 234.2s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:07] {2437} INFO - iteration 142, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:51:10] {2597} INFO -  at 236.4s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:10] {2437} INFO - iteration 143, current learner rf\n",
      "[flaml.automl: 06-21 10:51:11] {2597} INFO -  at 238.0s,\testimator rf's best error=0.0075,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:11] {2437} INFO - iteration 144, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:21] {2597} INFO -  at 247.5s,\testimator xgb_limitdepth's best error=0.0071,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:21] {2437} INFO - iteration 145, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:24] {2597} INFO -  at 251.2s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:24] {2437} INFO - iteration 146, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:37] {2597} INFO -  at 264.1s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:37] {2437} INFO - iteration 147, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:50] {2597} INFO -  at 276.3s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:50] {2437} INFO - iteration 148, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:51:59] {2597} INFO -  at 285.4s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:51:59] {2437} INFO - iteration 149, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:00] {2597} INFO -  at 287.2s,\testimator xgboost's best error=0.0054,\tbest estimator xgboost's best error=0.0054\n",
      "[flaml.automl: 06-21 10:52:00] {2437} INFO - iteration 150, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:04] {2597} INFO -  at 291.0s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:04] {2437} INFO - iteration 151, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:07] {2597} INFO -  at 293.4s,\testimator xgb_limitdepth's best error=0.0071,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:07] {2437} INFO - iteration 152, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:10] {2597} INFO -  at 296.7s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:10] {2437} INFO - iteration 153, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:15] {2597} INFO -  at 301.6s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:15] {2437} INFO - iteration 154, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:24] {2597} INFO -  at 310.7s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:24] {2437} INFO - iteration 155, current learner rf\n",
      "[flaml.automl: 06-21 10:52:28] {2597} INFO -  at 314.3s,\testimator rf's best error=0.0075,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:28] {2437} INFO - iteration 156, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:31] {2597} INFO -  at 317.8s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:31] {2437} INFO - iteration 157, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:38] {2597} INFO -  at 325.3s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:38] {2437} INFO - iteration 158, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:43] {2597} INFO -  at 329.7s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:43] {2437} INFO - iteration 159, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:49] {2597} INFO -  at 335.9s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:49] {2437} INFO - iteration 160, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:52:57] {2597} INFO -  at 344.3s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:52:57] {2437} INFO - iteration 161, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:19] {2597} INFO -  at 365.9s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:19] {2437} INFO - iteration 162, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:53:20] {2597} INFO -  at 367.0s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:20] {2437} INFO - iteration 163, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:22] {2597} INFO -  at 368.5s,\testimator xgb_limitdepth's best error=0.0071,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:22] {2437} INFO - iteration 164, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:23] {2597} INFO -  at 370.2s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:23] {2437} INFO - iteration 165, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:25] {2597} INFO -  at 371.9s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:25] {2437} INFO - iteration 166, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:29] {2597} INFO -  at 375.7s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:29] {2437} INFO - iteration 167, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:31] {2597} INFO -  at 377.7s,\testimator xgb_limitdepth's best error=0.0070,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:31] {2437} INFO - iteration 168, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:34] {2597} INFO -  at 381.2s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:34] {2437} INFO - iteration 169, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:36] {2597} INFO -  at 383.1s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:36] {2437} INFO - iteration 170, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:39] {2597} INFO -  at 385.5s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:39] {2437} INFO - iteration 171, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:41] {2597} INFO -  at 387.5s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:41] {2437} INFO - iteration 172, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:42] {2597} INFO -  at 388.8s,\testimator xgboost's best error=0.0049,\tbest estimator xgboost's best error=0.0049\n",
      "[flaml.automl: 06-21 10:53:42] {2437} INFO - iteration 173, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:53:50] {2597} INFO -  at 396.7s,\testimator xgboost's best error=0.0047,\tbest estimator xgboost's best error=0.0047\n",
      "[flaml.automl: 06-21 10:53:50] {2437} INFO - iteration 174, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:54:00] {2597} INFO -  at 406.8s,\testimator xgboost's best error=0.0045,\tbest estimator xgboost's best error=0.0045\n",
      "[flaml.automl: 06-21 10:54:00] {2437} INFO - iteration 175, current learner extra_tree\n",
      "[flaml.automl: 06-21 10:54:01] {2597} INFO -  at 407.4s,\testimator extra_tree's best error=0.0056,\tbest estimator xgboost's best error=0.0045\n",
      "[flaml.automl: 06-21 10:54:01] {2437} INFO - iteration 176, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:54:13] {2597} INFO -  at 420.2s,\testimator xgboost's best error=0.0045,\tbest estimator xgboost's best error=0.0045\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 10:54:15] {2815} INFO - retrain xgboost for 1.5s\n",
      "[flaml.automl: 06-21 10:54:15] {2822} INFO - retrained model: XGBClassifier(base_score=0.5, booster='gbtree',\n",
      "              colsample_bylevel=0.654065786650773, colsample_bynode=1,\n",
      "              colsample_bytree=0.22665724866268988, gamma=0, gpu_id=-1,\n",
      "              grow_policy='lossguide', importance_type='gain',\n",
      "              interaction_constraints='', learning_rate=0.033084285255559266,\n",
      "              max_delta_step=0, max_depth=0, max_leaves=14,\n",
      "              min_child_weight=1.6691428735395684, missing=nan,\n",
      "              monotone_constraints='()', n_estimators=296, n_jobs=-1,\n",
      "              num_parallel_tree=1, random_state=0,\n",
      "              reg_alpha=0.004650257087073091, reg_lambda=0.12373652329868874,\n",
      "              scale_pos_weight=1, subsample=0.576745423492249,\n",
      "              tree_method='hist', use_label_encoder=False,\n",
      "              validate_parameters=1, verbosity=0)\n",
      "[flaml.automl: 06-21 10:54:15] {2199} INFO - fit succeeded\n",
      "[flaml.automl: 06-21 10:54:15] {2200} INFO - Time taken to find the best model: 406.8021059036255\n",
      "[flaml.automl: 06-21 10:54:15] {2211} WARNING - Time taken to find the best model is 97% of the provided time budget and not all estimators' hyperparameter search converged. Consider increasing the time budget.\n"
     ]
    }
   ],
   "source": [
    "from flaml import AutoML\n",
    "automl = AutoML()\n",
    "automl.fit(\n",
    "    X_train,\n",
    "    y_train,\n",
    "    task=\"classification\",\n",
    "    time_budget=420,\n",
    "    estimator_list = [\n",
    "        # 'lgbm',\n",
    "        'xgboost',\n",
    "        'xgb_limitdepth',\n",
    "        # 'catboost',\n",
    "        'rf',\n",
    "        'extra_tree'\n",
    "        ])\n",
    "with open(\"automl_pampa_model.pkl\", \"wb\") as f:\n",
    "    pickle.dump(automl, f, pickle.HIGHEST_PROTOCOL)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "45e85734",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n"
     ]
    }
   ],
   "source": [
    "pampa_model = pickle.load(open('automl_pampa_model.pkl', 'rb'))\n",
    "pred = pampa_model.predict(X_test)\n",
    "pred_probs = pampa_model.predict_proba(X_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "id": "f22ec551",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "339          low\n",
      "1484    med2high\n",
      "1495    med2high\n",
      "2280         low\n",
      "97      med2high\n",
      "          ...   \n",
      "367     med2high\n",
      "743          low\n",
      "1920    med2high\n",
      "1194         low\n",
      "458          low\n",
      "Name: pampa, Length: 375, dtype: object\n"
     ]
    }
   ],
   "source": [
    "print(y_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "id": "5c64d5fa",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/sklearn/utils/deprecation.py:87: FutureWarning: Function plot_confusion_matrix is deprecated; Function `plot_confusion_matrix` is deprecated in 1.0 and will be removed in 1.2. Use one of the class methods: ConfusionMatrixDisplay.from_predictions or ConfusionMatrixDisplay.from_estimator.\n",
      "  warnings.warn(msg, category=FutureWarning)\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n"
     ]
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "AUROC = 0.995\n",
      "F1 = 0.960\n",
      "MCC = 0.915\n"
     ]
    }
   ],
   "source": [
    "from sklearn.metrics import plot_confusion_matrix, roc_auc_score, f1_score, matthews_corrcoef\n",
    "disp = plot_confusion_matrix(pampa_model, X_test, y_test,\n",
    "                                 display_labels=set(y_test))\n",
    "plt.xticks(rotation = 90) \n",
    "plt.title('Confusion matrix of predicted and true human clearance labels')\n",
    "plt.ylabel('True Human Clearance Label')\n",
    "plt.xlabel('Predicted Human Clearance Label')\n",
    "plt.show()\n",
    "roc_auc_score_value = roc_auc_score(\n",
    "    y_test, pred_probs[:, 1]\n",
    "  )\n",
    "f1_score_value = f1_score(y_test, pred, average='weighted')\n",
    "mcc_value = matthews_corrcoef(y_test, pred)\n",
    "print(f'AUROC = {roc_auc_score_value:.3f}')\n",
    "print(f'F1 = {f1_score_value:.3f}')\n",
    "print(f'MCC = {mcc_value:.3f}')\n"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "d7101cb6",
   "metadata": {},
   "source": [
    "# LogD MODEL"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "id": "9c12eb54",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "2500\n"
     ]
    },
    {
     "data": {
      "image/png": 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ZVWlZUoiIPwN71xj/OHBQnWWmAdNaFZOZmXXPv2g2M7OCk4KZmRWcFMzMrOCkYGZmBScFMzMrOCmYmVnBScHMzApOCmZmVnBSMDOzgpOCmZkVnBTMzKzgpGBmZgUnBTMzKzgpmJlZwUnBzMwKTgpmZlZwUjAzs4KTgpmZFZwUzMys4KRgZmYFJwUzMys4KZiZWcFJwczMCk4KZmZWcFIwM7NCy5KCpNGSfitpgaS7JH06j58q6WFJ8/PfYaVlTpW0UNK9kt7eqtjMzKy2jVu47tXAKRFxm6RhwK2SZudp346Ib5RnljQOmATsAewAXCfplRGxpoUxmplZSctqChGxLCJuy8MrgAXAqG4WOQK4KCJWRcQDwEJg31bFZ2Zm6+qTawqSxgB7A7fkUZ+U9GdJ50jaJo8bBSwuLbaEGklE0vGS5kma19XV1cqwzcwGnZYnBUlbApcCJ0fE08APgV2B8cAy4JuVWWssHuuMiJgRERMiYsKIESNaE7SZ2SDV0qQgaSgpIfw8Ii4DiIhHI2JNRPwdOJsXm4iWAKNLi+8ILG1lfGZmtrZW3n0k4CfAgoj4Vmn8yNJs7wbuzMNXAZMkbSppF2AsMLdV8ZmZ2bpaeffR/sCxwB2S5udxpwHHSBpPahpaBHwcICLukjQLuJt059KJvvPIzKxvtSwpRMRN1L5OcE03y0wDprUqJjMz655/0WxmZgUnBTMzKzgpmJlZwUnBzMwKTgpmZlZwUjAzs4KTgpmZFZwUzMys0MpfNFuHGTPlVxu0/KLph/dSJGbWqVxTMDOzgpOCmZkVnBTMzKzgpGBmZgUnBTMzK/juI+t4G3LXlO+YMusZJ4U28EHOzDqVk4L1iQ39jYSZ9Q1fUzAzs4JrCtY0n+2bDXyuKZiZWcFJwczMCk4KZmZWGNTXFNxGbma2NtcUzMys0LKkIGm0pN9KWiDpLkmfzuO3lTRb0n35/zalZU6VtFDSvZLe3qrYzMystlbWFFYDp0TEq4H9gBMljQOmANdHxFjg+vyaPG0SsAdwCHCWpCEtjM/MzKq0LClExLKIuC0PrwAWAKOAI4CZebaZwJF5+AjgoohYFREPAAuBfVsVn5mZratPrilIGgPsDdwCbB8RyyAlDmC7PNsoYHFpsSV5XPW6jpc0T9K8rq6ulsZtZjbYtDwpSNoSuBQ4OSKe7m7WGuNinRERMyJiQkRMGDFiRG+FaWZmNJkUJL1mfVYuaSgpIfw8Ii7Lox+VNDJPHwksz+OXAKNLi+8ILF2f7ZqZ2fpptqbwI0lzJf2LpK2bWUCSgJ8ACyLiW6VJVwGT8/Bk4MrS+EmSNpW0CzAWmNtkfGZm1gua+vFaRPyjpLHAR4F5kuYCP42I2d0stj9wLHCHpPl53GnAdGCWpOOAh4Cj8jbukjQLuJt059KJEbFmPd6TmZmtp6Z/0RwR90k6HZgHfA/YO9cGTis1DZXnv4na1wkADqqzjWnAtGZjMjOz3tXsNYU9JX2bdFvpgcA78+8PDgS+3cL4zMysDzVbUzgTOJtUK3iuMjIilubag5mZDQDNJoXDgOcqbfySNgI2i4hnI+L8lkVnZmZ9qtm7j64DNi+93iKPMzOzAaTZpLBZRKysvMjDW7QmJDMza5dmk8IzkvapvJD0OuC5buY3M7N+qNlrCicDl0iq/MJ4JHB0SyIyM7O2afbHa3+U9Cpgd9JvD+6JiBdaGpmZmfW5njyO8/XAmLzM3pKIiPNaEpWZmbVFU0lB0vnArsB8oNL1RABOCmZmA0izNYUJwLiIWKcrazMzGziavfvoTuDlrQzEzMzar9mawnDg7tw76qrKyIh4V0uiMjOztmg2KUxtZRBmZtYZmr0ldY6knYGxEXGdpC2AIa0NzczM+lqzXWf/M/AL4Md51CjgihbFZGZmbdLsheYTSU9SexrSA3eA7VoVlJmZtUezSWFVRDxfeSFpY9LvFMzMbABpNinMkXQasLmktwKXAL9sXVhmZtYOzSaFKUAXcAfwceAawE9cMzMbYJq9++jvpMdxnt3acKyRMVN+1e4QzGwAa7bvoweocQ0hIl7R6xGZmVnb9KTvo4rNgKOAbXs/HLPetaE1q0XTD++lSMz6h6auKUTE46W/hyPiO8CBrQ3NzMz6WrM/Xtun9DdB0gnAsAbLnCNpuaQ7S+OmSnpY0vz8d1hp2qmSFkq6V9Lb1/sdmZnZemu2+eibpeHVwCLg/Q2WORc4k3WfufDtiPhGeYSkccAkYA9gB+A6Sa+MiDWYmVmfafbuo7f0dMURcaOkMU3OfgRwUUSsAh6QtBDYF/hDT7drZmbrr9m7j/61u+kR8a0ebPOTkj4EzANOiYgnSH0p3VyaZ0keZ2ZmfajZH69NAD5BOlCPAk4AxpGuK3R7baHKD0mP9RwPLOPFZinVmLdmNxqSjpc0T9K8rq6uHmzazMwa6clDdvaJiBWQLhgDl0TEx3qysYh4tDIs6Wzg6vxyCTC6NOuOwNI665gBzACYMGGC+18yM+tFzdYUdgKeL71+HhjT041JGll6+W7SYz4BrgImSdpU0i7AWGBuT9dvZmYbptmawvnAXEmXk5p13s26dxWtRdKFwERguKQlwBnAREnj8zoWkfpRIiLukjQLuJt0d9OJvvPIzKzvNXv30TRJ1wIH5FEfiYg/NVjmmBqjf9LdNoBpzcRjZmat0WzzEcAWwNMR8V1gSW7mMTOzAaTZXzSfAXweODWPGgr8rFVBmZlZezRbU3g38C7gGYCIWErPbkU1M7N+oNmk8HxEBPm3A5Je0rqQzMysXZpNCrMk/RjYWtI/A9fhB+6YmQ04De8+kiTgYuBVwNPA7sAXI2J2i2MzM7M+1jApRERIuiIiXgc4EZiZDWDNNh/dLOn1LY3EzMzartlfNL8FOEHSItIdSCJVIvZsVWBmZtb3uk0KknaKiIeAQ/soHrOOsiHPePbzna0/alRTuILUO+qDki6NiPf2QUxmZtYmja4plJ9z8IpWBmJmZu3XKClEnWEzMxuAGjUf7SXpaVKNYfM8DC9eaH5pS6MzM7M+1W1SiIghfRWI2UDji9TWH/Wk62wzMxvgnBTMzKzgpGBmZgUnBTMzKzgpmJlZwUnBzMwKTgpmZlZwUjAzs4KTgpmZFZwUzMys0LKkIOkcScsl3Vkat62k2ZLuy/+3KU07VdJCSfdKenur4jIzs/paWVM4FzikatwU4PqIGAtcn18jaRwwCdgjL3OWJPe7ZGbWx1qWFCLiRuBvVaOPAGbm4ZnAkaXxF0XEqoh4AFgI7Nuq2MzMrLa+vqawfUQsA8j/t8vjRwGLS/MtyePWIel4SfMkzevq6mppsGZmg02nXGhWjXE1H+oTETMiYkJETBgxYkSLwzIzG1z6Oik8KmkkQP6/PI9fAowuzbcjsLSPYzMzG/T6OilcBUzOw5OBK0vjJ0naVNIuwFhgbh/HZmY26DV6HOd6k3QhMBEYLmkJcAYwHZgl6TjgIeAogIi4S9Is4G5gNXBiRKxpVWxmnc5PbbN2aVlSiIhj6kw6qM7804BprYrHzMwa65QLzWZm1gGcFMzMrOCkYGZmBScFMzMrOCmYmVnBScHMzApOCmZmVnBSMDOzgpOCmZkVnBTMzKzQsm4uzKw93G+SbQjXFMzMrOCkYGZmBScFMzMrOCmYmVnBScHMzApOCmZmVnBSMDOzgpOCmZkVnBTMzKzgpGBmZgV3c2FmhQ3pIgPcTcZA4JqCmZkVnBTMzKzQluYjSYuAFcAaYHVETJC0LXAxMAZYBLw/Ip5oR3xmZoNVO2sKb4mI8RExIb+eAlwfEWOB6/NrMzPrQ53UfHQEMDMPzwSObF8oZmaDU7uSQgC/kXSrpOPzuO0jYhlA/r9drQUlHS9pnqR5XV1dfRSumdng0K5bUvePiKWStgNmS7qn2QUjYgYwA2DChAnRqgDNzAajttQUImJp/r8cuBzYF3hU0kiA/H95O2IzMxvM+jwpSHqJpGGVYeBtwJ3AVcDkPNtk4Mq+js3MbLBrR/PR9sDlkirbvyAifi3pj8AsSccBDwFHtSE2M7NBrc+TQkTcD+xVY/zjwEF9HY+Zmb2ok25JNTOzNnNSMDOzgpOCmZkVnBTMzKzgpGBmZgUnBTMzKzgpmJlZwUnBzMwKTgpmZlZwUjAzs0K7us42swFozJRfrfeyi6Yf3ouR2PpyTcHMzAquKZhZR3AtozO4pmBmZgUnBTMzKzgpmJlZwUnBzMwKTgpmZlbw3Udm1u/5zqXe45qCmZkVXFMws0HNtYy1uaZgZmYFJwUzMys4KZiZWcHXFMzM1tOGXI+Azrwm0XFJQdIhwHeBIcB/RcT0NodkZtYSnXiRu6OajyQNAX4AHAqMA46RNK69UZmZDR4dlRSAfYGFEXF/RDwPXAQc0eaYzMwGjU5rPhoFLC69XgK8oTyDpOOB4/PLlZLu7cXtDwce68X1tYJj7D39IU7H2Hv6Q5xNx6ivbdB2dq43odOSgmqMi7VeRMwAZrRk49K8iJjQinX3FsfYe/pDnI6x9/SHODshxk5rPloCjC693hFY2qZYzMwGnU5LCn8ExkraRdImwCTgqjbHZGY2aHRU81FErJb0SeC/SbeknhMRd/VhCC1plupljrH39Ic4HWPv6Q9xtj1GRUTjuczMbFDotOYjMzNrIycFMzMrDOqkIGlbSbMl3Zf/b1NnvkWS7pA0X9K8PortEEn3SlooaUqN6ZL0vTz9z5L26Yu4ehjjRElP5XKbL+mLbYjxHEnLJd1ZZ3onlGOjGDuhHEdL+q2kBZLukvTpGvN0Qlk2E2dby1PSZpLmSro9x/ilGvO0rywjYtD+AV8HpuThKcDX6sy3CBjeh3ENAf4KvALYBLgdGFc1z2HAtaTfduwH3NLHZddMjBOBq9v8Gb8J2Ae4s870tpZjkzF2QjmOBPbJw8OAv3TaPtmDONtanrl8tszDQ4FbgP06pSwHdU2B1IXGzDw8EziyfaGspZnuPo4AzovkZmBrSSM7LMa2i4gbgb91M0u7y7GZGNsuIpZFxG15eAWwgNQDQVknlGUzcbZVLp+V+eXQ/Fd9x0/bynKwJ4XtI2IZpJ0J2K7OfAH8RtKtuZuNVqvV3Uf1jt3MPK3U7PbfmKvJ10rao29C65F2l2OzOqYcJY0B9iad4ZZ1VFl2Eye0uTwlDZE0H1gOzI6IjinLjvqdQitIug54eY1J/9aD1ewfEUslbQfMlnRPPrtrlYbdfTQ5Tys1s/3bgJ0jYqWkw4ArgLGtDqyH2l2OzeiYcpS0JXApcHJEPF09ucYibSnLBnG2vTwjYg0wXtLWwOWSXhMR5WtKbSvLAV9TiIiDI+I1Nf6uBB6tVMny/+V11rE0/18OXE5qOmmlZrr7aHeXIA23HxFPV6rJEXENMFTS8L4LsSntLseGOqUcJQ0lHWh/HhGX1ZilI8qyUZydUp55+08CNwCHVE1qW1kO+KTQwFXA5Dw8GbiyegZJL5E0rDIMvA2oeZdIL2qmu4+rgA/luxT2A56qNIX1kYYxSnq5JOXhfUn72+N9GGMz2l2ODXVCOebt/wRYEBHfqjNb28uymTjbXZ6SRuQaApI2Bw4G7qmarW1lOeCbjxqYDsySdBzwEHAUgKQdSE99OwzYnlS9g1ReF0TEr1sZVNTp7kPSCXn6j4BrSHcoLASeBT7SypjWM8b3AZ+QtBp4DpgU+daKviLpQtLdJsMlLQHOIF3Y64hybDLGtpcjsD9wLHBHbgsHOA3YqRRn28uS5uJsd3mOBGYqPVRsI2BWRFzdKd9vd3NhZmaFwd58ZGZmJU4KZmZWcFIwM7OCk4KZmRWcFMzMrOCkYG0haWXjueoue4NS76x/lnSPpDMr9333QlyLeuuHTJKOVO6BU9JUSZ9dz/VUevX8U37fN0p6R2/EmNf/ZUkH5+GTJW3RYP5vSDqwt7ZvncVJwfqrD0bEnsCewCpq/PCwA3wOOKuX1vW7iNg7InYHTgLOlHRQb6w4Ir4YEdfllycD3SYF4PukXoVtAHJSsLbKv9j8T0l3Kj2z4ug8fiNJZyn1N3+1pGskva96+dxD6+eAnSTtVbXuT0j6eun1hyV9Pw9fodTB4V2q0cmhpDEqPd9A0mclTc3Du0r6dV7+d5JeVWP5VwKrIuKxGtPGS7o513QuV36Oh6TX53F/qJRJrTKLiPnAl4FP1lj3WjWSXK5j8t8CSWfn9/yb/GtaJJ0r6X2STgJ2AH6r9EyCIXla5bP5TN7+g8DLJNXqU8z6OScFa7f3AOOBvUg/9/9PpX6o3gOMAV4LfAx4Y70V5M7FbgeqD86/yOupOBq4OA9/NCJeB0wATpL0sh7EPAP4VF7+s9SuDexP6nitlvOAz+eazh2kXzAD/BQ4ISLeCKxpEMNtrPt+GxkL/CAi9gCeBN5bnhgR3yP1r/OWiHgL6XMZlfsKe22Or7z9/Xu4fesHnBSs3f4RuDAi1kTEo8Ac4PV5/CUR8feIeAT4bYP1rNOrZER0AfdL2i8f9HcH/jdPPknS7cDNpI7HmuolU6n3zX8ALsndKPyY1G1BtZFAV43ltwK2jog5edRM4E35msiwiPh9Hn9Bo1CaibfKA7mWAXArKel2537gFZK+L+kQoNzb6HJSrcIGmMHe95G1X72DW9MHvdyHzGtJD1SpdjHwflKHY5dHREiaSKqVvDEinpV0A7BZ1XKrWfukqTJ9I+DJiBjfIKzngK2afQ/0/CC/N7Xfb724IV17qVgDbN7dBiLiidwk93bgRFI5frS03ud6GLP1A64pWLvdCByd269HkB5NORe4CXhvvrawPanDuHUodZP8VWBxRPy5xiyXkZ6odwwvNh1tBTyRE8KrSI87rPYosJ2kl0naFHgHpG6XgQckVTpPVPW1jGwBsFv1yIh4CnhC0gF51LHAnIh4Alih1CMmpF5na5K0J/AF4Ac1Ji8iPdoTpef67lJvPXWsID3GknwX1kYRcWneXvk5wa+k9b0FWxu4pmDtdjnpesHtpIeIfC4iHpF0KXAQ6cDzF9LTs54qLfdzSauATYHrqPMo0Hy2ezfpOb1z8+hfAydI+jNwL6kJqXq5FyR9OW/3Adbu2viDwA8lnU7qzfSiHH/ZjcA3JalGD5yTgR/lWz/v58UeMI8Dzpb0DKmP/fL7PUDSn0h3Bi0HToqI62u85UtJXS7PJ3Vv/pca83RnBnCtpGWkO5F+Kqly8ngqFIl4N2BeD9dt/YB7SbWOJWnL/HSsl5FqD/vn6wv9gqTvAr8s3e7ZaP4tKw9/kTQFGBkRn25ljOtD0ruBfSLiC+2OxXqfawrWya7OF2A3Af69PyWE7D+AN/Rg/sMlnUr6Xj4IfLgVQfWCjYFvtjsIaw3XFMzMrOALzWZmVnBSMDOzgpOCmZkVnBTMzKzgpGBmZoX/D65HDQOh8d6dAAAAAElFTkSuQmCC",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    },
    {
     "data": {
      "image/png": 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",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.model_selection import train_test_split\n",
    "desc_df = pd.read_csv('r_group_rdkit_features.csv', index_col=0)\n",
    "df = pd.read_csv('r_group_decomp.csv')\n",
    "\n",
    "df[\"logd\"] = pd.to_numeric(df['logd'], errors='coerce')\n",
    "true_labels = pd.to_numeric(df['logd'], errors='coerce').dropna()\n",
    "print(len(true_labels))\n",
    "X_train, X_test, y_train, y_test = train_test_split(desc_df.loc[true_labels.index, :], true_labels , test_size=0.15, random_state=42)\n",
    "\n",
    "plt.hist(true_labels, bins =20)\n",
    "plt.title('Distribution of logD values in the whole MMP12 dataset')\n",
    "plt.xlabel('logD value (logD units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_train, bins =20)\n",
    "plt.title('Distribution of logD values in the MMP12 Train set')\n",
    "plt.xlabel('logD value (logD units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n",
    "\n",
    "plt.hist(y_test, bins =20)\n",
    "plt.title('Distribution of logD values in the MMP12 Test set')\n",
    "plt.xlabel('logD value (logD units)')\n",
    "plt.ylabel('Frequency')\n",
    "plt.show()\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "id": "a44b05cb",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[flaml.automl: 06-21 11:28:55] {2007} INFO - task = regression\n",
      "[flaml.automl: 06-21 11:28:55] {2009} INFO - Data split method: uniform\n",
      "[flaml.automl: 06-21 11:28:55] {2013} INFO - Evaluation method: cv\n",
      "[flaml.automl: 06-21 11:28:55] {2113} INFO - Minimizing error metric: 1-r2\n",
      "[flaml.automl: 06-21 11:28:55] {2170} INFO - List of ML learners in AutoML Run: ['xgboost', 'xgb_limitdepth', 'rf', 'extra_tree']\n",
      "[flaml.automl: 06-21 11:28:55] {2437} INFO - iteration 0, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:28:56] {2550} INFO - Estimated sufficient time budget=10079s. Estimated necessary time budget=44s.\n",
      "[flaml.automl: 06-21 11:28:56] {2597} INFO -  at 1.7s,\testimator xgboost's best error=0.5286,\tbest estimator xgboost's best error=0.5286\n",
      "[flaml.automl: 06-21 11:28:56] {2437} INFO - iteration 1, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:28:57] {2597} INFO -  at 2.5s,\testimator xgboost's best error=0.5286,\tbest estimator xgboost's best error=0.5286\n",
      "[flaml.automl: 06-21 11:28:57] {2437} INFO - iteration 2, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:28:58] {2597} INFO -  at 3.1s,\testimator xgboost's best error=0.2151,\tbest estimator xgboost's best error=0.2151\n",
      "[flaml.automl: 06-21 11:28:58] {2437} INFO - iteration 3, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:28:58] {2597} INFO -  at 3.4s,\testimator extra_tree's best error=0.2433,\tbest estimator xgboost's best error=0.2151\n",
      "[flaml.automl: 06-21 11:28:58] {2437} INFO - iteration 4, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:28:59] {2597} INFO -  at 3.9s,\testimator xgboost's best error=0.1150,\tbest estimator xgboost's best error=0.1150\n",
      "[flaml.automl: 06-21 11:28:59] {2437} INFO - iteration 5, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:28:59] {2597} INFO -  at 4.5s,\testimator xgboost's best error=0.1150,\tbest estimator xgboost's best error=0.1150\n",
      "[flaml.automl: 06-21 11:28:59] {2437} INFO - iteration 6, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:00] {2597} INFO -  at 5.3s,\testimator xgboost's best error=0.1092,\tbest estimator xgboost's best error=0.1092\n",
      "[flaml.automl: 06-21 11:29:00] {2437} INFO - iteration 7, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:01] {2597} INFO -  at 6.1s,\testimator xgboost's best error=0.0690,\tbest estimator xgboost's best error=0.0690\n",
      "[flaml.automl: 06-21 11:29:01] {2437} INFO - iteration 8, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:02] {2597} INFO -  at 7.0s,\testimator xgboost's best error=0.0519,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:02] {2437} INFO - iteration 9, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:02] {2597} INFO -  at 7.3s,\testimator extra_tree's best error=0.1310,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:02] {2437} INFO - iteration 10, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:02] {2597} INFO -  at 7.6s,\testimator extra_tree's best error=0.1310,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:02] {2437} INFO - iteration 11, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:03] {2597} INFO -  at 7.9s,\testimator extra_tree's best error=0.0823,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:03] {2437} INFO - iteration 12, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:03] {2597} INFO -  at 8.5s,\testimator xgboost's best error=0.0519,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:03] {2437} INFO - iteration 13, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:04] {2597} INFO -  at 9.0s,\testimator extra_tree's best error=0.0525,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:04] {2437} INFO - iteration 14, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:05] {2597} INFO -  at 10.3s,\testimator xgboost's best error=0.0519,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:05] {2437} INFO - iteration 15, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:05] {2597} INFO -  at 10.7s,\testimator extra_tree's best error=0.0525,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:05] {2437} INFO - iteration 16, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:07] {2597} INFO -  at 12.2s,\testimator xgboost's best error=0.0519,\tbest estimator xgboost's best error=0.0519\n",
      "[flaml.automl: 06-21 11:29:07] {2437} INFO - iteration 17, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:08] {2597} INFO -  at 12.9s,\testimator extra_tree's best error=0.0393,\tbest estimator extra_tree's best error=0.0393\n",
      "[flaml.automl: 06-21 11:29:08] {2437} INFO - iteration 18, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:08] {2597} INFO -  at 13.4s,\testimator extra_tree's best error=0.0393,\tbest estimator extra_tree's best error=0.0393\n",
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      "[flaml.automl: 06-21 11:29:09] {2597} INFO -  at 14.3s,\testimator extra_tree's best error=0.0296,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:09] {2437} INFO - iteration 20, current learner rf\n",
      "[flaml.automl: 06-21 11:29:09] {2597} INFO -  at 14.7s,\testimator rf's best error=0.1606,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:09] {2437} INFO - iteration 21, current learner rf\n",
      "[flaml.automl: 06-21 11:29:10] {2597} INFO -  at 15.2s,\testimator rf's best error=0.0967,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:10] {2437} INFO - iteration 22, current learner rf\n",
      "[flaml.automl: 06-21 11:29:10] {2597} INFO -  at 15.7s,\testimator rf's best error=0.0967,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:10] {2437} INFO - iteration 23, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:11] {2597} INFO -  at 16.3s,\testimator extra_tree's best error=0.0296,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:11] {2437} INFO - iteration 24, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:29:13] {2597} INFO -  at 17.9s,\testimator rf's best error=0.0645,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:13] {2437} INFO - iteration 26, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:29:14] {2437} INFO - iteration 27, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:15] {2597} INFO -  at 19.9s,\testimator extra_tree's best error=0.0296,\tbest estimator extra_tree's best error=0.0296\n",
      "[flaml.automl: 06-21 11:29:15] {2437} INFO - iteration 28, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:29:17] {2597} INFO -  at 22.4s,\testimator extra_tree's best error=0.0234,\tbest estimator extra_tree's best error=0.0234\n",
      "[flaml.automl: 06-21 11:29:17] {2437} INFO - iteration 29, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:18] {2597} INFO -  at 23.0s,\testimator xgboost's best error=0.0519,\tbest estimator extra_tree's best error=0.0234\n",
      "[flaml.automl: 06-21 11:29:18] {2437} INFO - iteration 30, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:29:19] {2597} INFO -  at 24.3s,\testimator xgboost's best error=0.0519,\tbest estimator extra_tree's best error=0.0234\n",
      "[flaml.automl: 06-21 11:29:19] {2437} INFO - iteration 31, current learner rf\n",
      "[flaml.automl: 06-21 11:29:20] {2597} INFO -  at 25.3s,\testimator rf's best error=0.0494,\tbest estimator extra_tree's best error=0.0234\n",
      "[flaml.automl: 06-21 11:29:20] {2437} INFO - iteration 32, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:29:23] {2437} INFO - iteration 34, current learner rf\n",
      "[flaml.automl: 06-21 11:29:24] {2597} INFO -  at 29.2s,\testimator rf's best error=0.0407,\tbest estimator extra_tree's best error=0.0234\n",
      "[flaml.automl: 06-21 11:29:24] {2437} INFO - iteration 35, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:29:44] {2597} INFO -  at 49.4s,\testimator rf's best error=0.0407,\tbest estimator extra_tree's best error=0.0209\n",
      "[flaml.automl: 06-21 11:29:44] {2437} INFO - iteration 39, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:29:55] {2437} INFO - iteration 40, current learner extra_tree\n",
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      "[flaml.automl: 06-21 11:30:00] {2437} INFO - iteration 41, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:30:00] {2597} INFO -  at 65.8s,\testimator xgboost's best error=0.0519,\tbest estimator extra_tree's best error=0.0208\n",
      "[flaml.automl: 06-21 11:30:00] {2437} INFO - iteration 42, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:30:23] {2597} INFO -  at 88.2s,\testimator extra_tree's best error=0.0202,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:30:23] {2437} INFO - iteration 43, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:30:37] {2597} INFO -  at 102.7s,\testimator extra_tree's best error=0.0202,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:30:37] {2437} INFO - iteration 44, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:31:28] {2597} INFO -  at 153.4s,\testimator extra_tree's best error=0.0202,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:31:28] {2437} INFO - iteration 45, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:31:30] {2597} INFO -  at 155.4s,\testimator xgboost's best error=0.0484,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:31:30] {2437} INFO - iteration 46, current learner rf\n",
      "[flaml.automl: 06-21 11:31:33] {2597} INFO -  at 158.0s,\testimator rf's best error=0.0351,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:31:33] {2437} INFO - iteration 47, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:31:35] {2597} INFO -  at 160.0s,\testimator xgboost's best error=0.0484,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:31:35] {2437} INFO - iteration 48, current learner rf\n",
      "[flaml.automl: 06-21 11:31:36] {2597} INFO -  at 161.5s,\testimator rf's best error=0.0351,\tbest estimator extra_tree's best error=0.0202\n",
      "[flaml.automl: 06-21 11:31:36] {2437} INFO - iteration 49, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:32:11] {2597} INFO -  at 196.3s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:11] {2437} INFO - iteration 50, current learner rf\n",
      "[flaml.automl: 06-21 11:32:12] {2597} INFO -  at 197.7s,\testimator rf's best error=0.0351,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:12] {2437} INFO - iteration 51, current learner rf\n",
      "[flaml.automl: 06-21 11:32:17] {2597} INFO -  at 202.4s,\testimator rf's best error=0.0351,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:17] {2437} INFO - iteration 52, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:19] {2597} INFO -  at 204.7s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:19] {2437} INFO - iteration 53, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:22] {2597} INFO -  at 206.9s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:22] {2437} INFO - iteration 54, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:25] {2597} INFO -  at 210.7s,\testimator xgboost's best error=0.0297,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:25] {2437} INFO - iteration 55, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:29] {2597} INFO -  at 214.2s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:29] {2437} INFO - iteration 56, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:31] {2597} INFO -  at 216.5s,\testimator xgboost's best error=0.0297,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:31] {2437} INFO - iteration 57, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:36] {2597} INFO -  at 221.6s,\testimator xgboost's best error=0.0222,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:36] {2437} INFO - iteration 58, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:39] {2597} INFO -  at 224.4s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:39] {2437} INFO - iteration 59, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:41] {2597} INFO -  at 226.6s,\testimator xgboost's best error=0.0222,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:41] {2437} INFO - iteration 60, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:44] {2597} INFO -  at 229.1s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:44] {2437} INFO - iteration 61, current learner xgboost\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:58] {2597} INFO -  at 243.5s,\testimator xgboost's best error=0.0221,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:58] {2437} INFO - iteration 62, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:32:59] {2597} INFO -  at 244.7s,\testimator xgb_limitdepth's best error=0.0334,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:32:59] {2437} INFO - iteration 63, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:33:03] {2597} INFO -  at 248.7s,\testimator xgb_limitdepth's best error=0.0308,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:03] {2437} INFO - iteration 64, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:33:10] {2597} INFO -  at 255.7s,\testimator xgb_limitdepth's best error=0.0308,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:10] {2437} INFO - iteration 65, current learner rf\n",
      "[flaml.automl: 06-21 11:33:13] {2597} INFO -  at 258.5s,\testimator rf's best error=0.0351,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:13] {2437} INFO - iteration 66, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:33:31] {2597} INFO -  at 276.4s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:31] {2437} INFO - iteration 67, current learner rf\n",
      "[flaml.automl: 06-21 11:33:35] {2597} INFO -  at 280.7s,\testimator rf's best error=0.0315,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:35] {2437} INFO - iteration 68, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:33:37] {2597} INFO -  at 282.6s,\testimator xgb_limitdepth's best error=0.0308,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:37] {2437} INFO - iteration 69, current learner rf\n",
      "[flaml.automl: 06-21 11:33:40] {2597} INFO -  at 285.7s,\testimator rf's best error=0.0315,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:40] {2437} INFO - iteration 70, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:33:55] {2597} INFO -  at 300.3s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:33:55] {2437} INFO - iteration 71, current learner rf\n",
      "[flaml.automl: 06-21 11:34:04] {2597} INFO -  at 309.6s,\testimator rf's best error=0.0304,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:34:04] {2437} INFO - iteration 72, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:34:16] {2597} INFO -  at 321.4s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:34:16] {2437} INFO - iteration 73, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:35:04] {2597} INFO -  at 368.8s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:04] {2437} INFO - iteration 74, current learner extra_tree\n",
      "[flaml.automl: 06-21 11:35:13] {2597} INFO -  at 378.7s,\testimator extra_tree's best error=0.0199,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:13] {2437} INFO - iteration 75, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:19] {2597} INFO -  at 384.5s,\testimator xgb_limitdepth's best error=0.0308,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:19] {2437} INFO - iteration 76, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:23] {2597} INFO -  at 388.2s,\testimator xgb_limitdepth's best error=0.0269,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:23] {2437} INFO - iteration 77, current learner rf\n",
      "[flaml.automl: 06-21 11:35:28] {2597} INFO -  at 392.8s,\testimator rf's best error=0.0304,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:28] {2437} INFO - iteration 78, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:30] {2597} INFO -  at 395.3s,\testimator xgb_limitdepth's best error=0.0269,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:30] {2437} INFO - iteration 79, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:35] {2597} INFO -  at 400.0s,\testimator xgb_limitdepth's best error=0.0208,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:35] {2437} INFO - iteration 80, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:37] {2597} INFO -  at 402.7s,\testimator xgb_limitdepth's best error=0.0208,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:37] {2437} INFO - iteration 81, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:44] {2597} INFO -  at 409.5s,\testimator xgb_limitdepth's best error=0.0208,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:44] {2437} INFO - iteration 82, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:47] {2597} INFO -  at 412.5s,\testimator xgb_limitdepth's best error=0.0208,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:35:47] {2437} INFO - iteration 83, current learner xgb_limitdepth\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "/Users/guy/miniconda3/envs/dd_game/lib/python3.8/site-packages/xgboost/data.py:192: FutureWarning: pandas.Int64Index is deprecated and will be removed from pandas in a future version. Use pandas.Index with the appropriate dtype instead.\n",
      "  from pandas import MultiIndex, Int64Index\n",
      "[flaml.automl: 06-21 11:35:54] {2597} INFO -  at 419.8s,\testimator xgb_limitdepth's best error=0.0208,\tbest estimator extra_tree's best error=0.0199\n",
      "[flaml.automl: 06-21 11:36:03] {2815} INFO - retrain extra_tree for 9.0s\n",
      "[flaml.automl: 06-21 11:36:03] {2822} INFO - retrained model: ExtraTreesRegressor(max_features=0.9319519178855205, max_leaf_nodes=773,\n",
      "                    n_estimators=235, n_jobs=-1)\n",
      "[flaml.automl: 06-21 11:36:04] {2199} INFO - fit succeeded\n",
      "[flaml.automl: 06-21 11:36:04] {2200} INFO - Time taken to find the best model: 196.28772711753845\n"
     ]
    }
   ],
   "source": [
    "from flaml import AutoML\n",
    "automl = AutoML()\n",
    "automl.fit(\n",
    "    X_train,\n",
    "    y_train,\n",
    "    task=\"regression\",\n",
    "    time_budget=420,\n",
    "    estimator_list = [\n",
    "        # 'lgbm',\n",
    "        'xgboost',\n",
    "        'xgb_limitdepth',\n",
    "        # 'catboost',\n",
    "        'rf',\n",
    "        'extra_tree'\n",
    "        ]\n",
    "        )\n",
    "with open(\"automl_logd_model.pkl\", \"wb\") as f:\n",
    "    pickle.dump(automl, f, pickle.HIGHEST_PROTOCOL)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 37,
   "id": "4933a929",
   "metadata": {},
   "outputs": [],
   "source": [
    "logd_model = pickle.load(open('automl_logd_model.pkl', 'rb'))\n",
    "pred = logd_model.predict(X_test)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "id": "a30b6f17",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "R^2 = 0.99\n",
      "Pearson's R = 0.99\n",
      "MAE = 0.06 logD units\n"
     ]
    },
    {
     "data": {
      "image/png": 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fEJTdGwgj710yyv0SuIPgYJg17fQ/ZnZmgTY3QyFz4i8JSjszwCIV+ixO+51FeLgYQrhWUoMwxvKZ9wAzm60wpf19YLyk6wj/7+FU/xpMxW0U3VlCyKrVnngNt5CwpsvMvmJmexAu5iPZNF9qFertFto63gBekTj/Q8Iwdhcz25owrM8K3Qxh5dFuhKfkrQl/LEqfsewQzUsI0w3J79dmZn+uIH8W3UI8K1yt49gUAhsq902JP0Z5X0l2+OtakBemOi8keY9CrhekvK9yf+cesIQwohidkHVrMytlgOtJ6PVlwDh1T1ubDHveW64hTNc8ZmaZiiqe+wdhpHJtH9vsRrx+LyFcg++p8BCY2WfRxnUN8D/AK82sHbiRTb9b2n8i9x5gZt81s/0JU6e7ErIuVroGi/73KuKKojsXAV/XJgPvGEnHxO1DJO0dDYDPE6akSk915SGny/kNcKSkN0YD1Vfp3vdbxTpfVFjKd2rZ58vr34pwgaxUMLafVTqh/BDNFxFCUu8Zy24j6b057VTiKuBdCmG4Wwk3tpcJU3Q9wsJY+Sjg6LidxlCFRQWlV2tP20khL0x1Zkhy613I9SRF+jrzd+4JZrackGPiWwqhxodI2lnSW2KRq4BPKYT4HkWIrpvF3YTpjs8qhA8/mPC7XdEb2RIyriJMsRRZAv0x4ND4mcJEo/Bwgm2ltEBli0SRHxLm/4+yCtkeye+zYQQ70wpgXRxdvD1x/kngFZK2SRzLvAcohKs/MF7vqwhTa+sLXINp7fQKVxTduYAwp3mLpBcIRs4D47ntCTf8Utjq29l0Q7mAkPLyWUmbpaK0kMbxEwTD2nLC0s/k+ubPEJYEvkD44ctzLcwAfh5XRLyPYMBqIzxR3EXI4FZiCOGGvYxgVHwL8J9RjusIxtIrJD0PPED3Zanl7eRiZo8QwpB/L8pyFOFPtrbSZzPqW2TZKS8h/JHXJF4/6007ZZxNSMF5H2Fq4N54DDO7idDXswkG3Nlln/1cPH5X7M8/EEYARZhB5b7+Dtm/c0/5EOEG9iDh+vsNYQQH4Zq7mZCL5F5yntTjb3s04br5FyGu1IcsO0VsYcxsrplVzChoZn83s7m9aGIC4bopXWNrCMZx4sPhfxDsQP9UZb+qzD6zkJzrUwRl8izhvz0rcf5hwgPKY/H3H0v+PWDreOxZwhTX04TRCuRcgxnt9AqP9eQ4juPk4iMKx3EcJxdXFI7jOE4urigcx3GcXFxROI7jOLkMSIe70aNH28SJExsthuM4Tr9h3rx5/zKzMWnnBqSimDhxInPn9mb1nOM4zuBEUqajo089OY7jOLm4onAcx3FycUXhOI7j5OKKwnEcx8nFFYXjOI6Ty4Bc9eQ4jjOYmDm/k/NufoRlK9cwtr2NaYfvxtRJHZU/WBBXFI7jOP2YmfM7+fy197OmK2QT6Fy5hs9fG3IkVUtZ+NST4zhOP+a8mx/ZqCRKrOlaz3k3P1K1NlxROI7j9GOWrUzPsZR1vDe4onAcx+nHjG1v69Hx3uCKwnEcpx8z7fDdaGtt6XasrbWFaYcXTbZYGTdmO47j9GNKBmtf9eQ4juNkMnVSR1UVQzk+9eQ4juPk4orCcRzHycWnnhzHcRpArb2pq4krCsdxnBqSphCAmntTVxNXFI7jODUiK7zGFkOHZHpTu6JwHMcZRGSF1yg/VqKa3tTVpGHGbEnjJM2R9JCkRZI+nVLmYEnPSVoQX19uhKyO4zi9oac3/mp6U1eTRo4o1gFnmNm9krYC5km61cweLCv3RzM7sgHyOY7j9Imx7W10piiLUSNaealrQ7eRRbW9qatJw0YUZrbczO6N2y8ADwHNNznnOI7TS7LCa5x11J6cc+zedLS3IaCjvY1zjt27Ke0T0CQ2CkkTgUnA3SmnXy9pIbAM+IyZLaqnbI7jOL2lUniNZlUM5cjMGiuAtCVwO/B1M7u27NzWwAYze1HSEcAFZrZLRj0nAycDjB8/fv/HH3+8xpI7juMMHCTNM7PJqefyFIWkHYETgDcBY4E1wAPADcBNZrahj4K1AtcDN5vZ+QXKLwYmm9m/8spNnjzZ5s6d2xfRHMdxekV/cqRLkqcoMqeeJP2MYDO4Hvgm8BQwHNgVeAfwRUnTzeyOXgol4BLgoSwlIWl74EkzM0kHEGwqT/emPcdxnFpTj7SkjSDPRvEtM3sg5fgDwLWShgHj+9D2FOCDwP2SFsRjXyjVaWYXAccBp0paRxjNnGCNnitzHMfJIC8taS0VRa1HMZmKIk1JSBoFjDOz+8xsLfBobxs2sz8BqlDmQuDC3rbhOI5TT+qRlrSceoxiKi6PlXSbpK0lbQssBH4mqaI9wXEcZ7BRj7Sk5eSNYqpFET+KbczseeBY4Gdmtj9wWNUkcBzHGSDUIy1pOfUYxRRRFEMl7QC8j2DYdhzHcVKYOqmj7o509RjFFHG4+wpwM/AnM7tH0k7A36omgeM4TgOolQG41mlJy5l2+G7dbBRQ/VFMEUWx3MxeW9oxs8fcRuE4Tn+mqAG4P/hEVPL+rgYVPbMl3Wtm+1U61ky4w53jDHz6chOfcu7s1GB9He1t3Dn90I31pz2pN3NMpr7QW4e71wNvAMZI+q/Eqa2BlvRPOY7j1J6+LgktYgBulE9EM5JnzB4GbElQJlslXs8THOEcx3EaQl+XhFYyAM+c35k64oCglKacO5tXTb+BKefOZub8zh5I3j/Jc7i7Hbhd0qVm5hH2HMdpGvq6JDTPAFwarWQh2KhEBkqIjkrkTT19x8xOAy6UtJkhw8yOrqVgjuM4kG6LyEoIVHRJaJ4BeMq5szNTlQoovxkOhumovFVPv4zv/1MPQRzHccrJskW8Z/8OrpnX2acloVnLWPNGJVlLf5o113W1yJt6mhffb6+fOI7jOJvIskXMeXgF5xy7d02WhGaNVjriaKUvI5n+SkU/CklTgBnAhFhegJnZTrUVzXGcwU6eLaJWjm2VHNhq7dzWjBRxuLsEOB2YB6RP3DmO49SAvtoiekMRB7Zmd8KrNkUc7u42swPrJE9VcIc7xxkYDDant0bSK4e7BHMknQdcC7xcOmhm91ZJPsdxnFTqEZ7CqUwRRVEaTSQ1jQGHVl8cx3EGC0VDcKTZIvI+2x/iM/U3KioKMzukHoI4jjN46EsIjrzPAgMyZ3WjKbLq6ctpx83sq9UXx3GcwUBf4ihVCt/Rm3p9FJJPkamnVYnt4cCRwEO1EcdxnMFAX0Jw9OazeefqkXO6v1Mxw52ZfSvx+jpwMOC95zhOr+lLVrasMu0jWntVbz1yTvd3iqRCLWcE4M52juP0mt7klp45vzMzjwTAiy+t45Ddx/S43nrknO7vVFQUku6XdF98LQIeAS7oa8OSxkmaI+khSYskfTqljCR9V9Kjsf2mTZbkOE5xeppbujQ9lKUkALo22MbQHj3JWV2PnNP9nSI2iiMT2+uAJ81sXRXaXgecYWb3StoKmCfpVjN7MFHmncAu8XUg8EM2Ldd1HKcf05MQHGnTQ2n0JrRHPXJO93eKLI+tSS4KM1sOLI/bL0h6iGD7SCqKY4BfWHAfv0tSu6Qd4mcdxxkkFJ0G6s0owJ36KlNkRFFzJE0EJgF3l53qAJYk9pfGY5spCkknAycDjB8/viZyOo7TGLJiPiXpyyigVgEGBwq9MWZXFUlbAtcAp5nZ8+WnUz6SGpzKzC42s8lmNnnMmDHVFtNxnB5QMjxXK11omvG7tUW0t7UWtkU4vaeIw107wUYA8Fcze65ajUtqJSiJX5nZtSlFlgLjEvs7Asuq1b7jONWnFn4JPj3UWPJSoQ4DLgamAv8gPN1PkHQdcIqZre1Lw5JECGH+kJmdn1FsFvBJSVcQjNjPuX3CcZqbvnhd5+HTQ40jb0RxJtAKjDOzFwDi6qTvA1+Kr74wBfggcL+kBfHYF4DxAGZ2EXAjcATwKLAa+Ggf23Qcp8a4X8LAI09RHAscYGarSwfi6qT/BO6ij4rCzP5Eug0iWcaAT/SlHcdx6ktesiGPqdQ/yTNmb0gqiRJm9iLZOcYdxxnkZHldH7L7mI1Oc8Ym20VfDd1O7clTFCZplKRty1/AhnoJ6DhO/yLL63rOwys8plI/JW/qaRtCnuzCS1Qdx3Eg3fB8+pULUsu67aL5yVQUZjaxjnI4jjNAKdklsp4u3XbR/BTxo0gLxPcc8HiVYj45jtNP6OkNvdynopyk7cLzQTQvRUJ4/ADYD7iPMA21N7AQeIWkU8zslhrK5zhOk5DlSDf38WeY8/CKzZTHzPmdnHHVQtZb+liiI5atld+FUz1kGT/ixgLB2e1rZrYo7u8BTAO+BlxrZvvWWsieMnnyZJs7d26jxXCcAUVWLgjR3WhZ2i8/Xv6Zf5z7LgAmTr+hYhmn9kiaZ2aT084VGVHsXlISAGb2oKRJZvZYcK52HGcwkGV0LlcGlnG8G8pWECU8H0TzUERRPCLph8AVcf944K+StgC6aiaZ4zhNRZEIrkWpMJEB4Pkgmogi0WM/QgihcRpwOvBYPNYFHFIjuRzHaTIO2X3MZmvlazmn4PaJ5qFI4qI1kr4H3EIYTT5iZqWRxIu1FM5xnOZg5vxOrpnXuZkt4g07b8u9TzxXKPtcT2jxae2mokjO7IOBvwEXElZA/VXSm2srluM4zUTayiQDFj+9ZqMXNmw+wujt7f7EA8dVLuTUjSI2im8BbzezRwAk7QpcDuxfS8Ecx2ksSZ+JLJNCeY7qLD+LrBVT5bRInHjgOM6euncVv4nTV4ooitaSkgAws7/GhEOO4wxQKjnKlShfmZSVM2La4btl1tfe1sqMo/d0m0QTU0RRzJV0CfDLuH8SIQaU4zgDlLSppjQO2b1Y2mHPUNe/KaIoTiXkhPgUYcrxDoKtwnGcAUrRQH1zHl5RuE7PUNd/KbLq6WXg/PhyHGcAUm5baB/RyrOrK7tJeeTXwUFezuz7yXGuNLPX1kQix3GqTl4wv7QYTq1DRGuL6Fqf7xnn3tODg7wRxZF1k8JxnJqRFcwPwnRQmj2ia4PR1jqE7bYazrKVa9imrZVVa9d1UxxtrS3uPT1IyFMUT1iFiIGSVKmM4ziNJS86K5C5bHVN14ZuI4+Tfvx/3Pn3Zzae32/8Nm5zGCRkRo+VdBtwDfBbM3sicXwY8Ebgw8AcM7u09mL2DI8e6zibeNX0GzLnkItML40a0coeO2zVTUmU+MBB493nYYCQFz02zzP7HcB64HJJyyQ9KOkxgpf2icC3m1FJOI7TnSw7QosqKwmAZ1d3pSoJgMvvXtIn2Zz+QaaiMLOXzOwHZjYFmAC8FdjPzCaY2cfNbEFfG5f0U0lPSXog4/zBkp6TtCC+vtzXNh1nsDHt8N1oa23pdqyttSUzoVBPqEYdTvNTJHosZtZlZsvNbGWV27+UMHLJ449mtm98fbXK7TvOgGfqpI6N8ZhEyCx3zrF7M6QKcfc8eN/goIjDXc0wszskTWykDI4zkClfFvvt4/fdmKZ0QxUGAx68b3BQMRVqzQUIiuJ6M9sr5dzBBIP6UmAZ8Jlktr2ysicDJwOMHz9+/8cff7xGEjtO8zNzfidf+d2izZzmSulJW6QeTRu1togDJo7irseeZb2ZB+8bgPQpFaqkkcAaM9sQI8fuDtyUyElRS+4FJpjZi5KOAGYCu6QVNLOLgYshrHqqg2yO05TMnN/JtKsX0pUyZCgdyVMSHzhoPNcvXM7KNeEvPmpEK2cd5UH7BjNFpp7uAN4kaRTwv8BcQjrUk2opGICZPZ/YvlHSDySNNrN/1bptx+mPzJzfyelXLsjPV12ByRO29ZGC040ixmyZ2WrgWOB7ZvZuYI/aihUblraXgrVM0gEEeZ+uR9uO098oeWD3dThdcsRznBJFRhSS9HrCCOJjPfhckYovBw4GRktaCpwFtAKY2UXAccCpktYBa4AT3BPccdJjNxUNDV4JD/TnlFPkhn8a8HngOjNbJGknYE41GjezEyucv5CQgtVxnEhW7KZq5a3eps3zkjndKRJm/Hbg9mjUxsweI+SmcBynAWTFbuopI4e1sGrt5p9z1winnIo2Ckmvl/Qg8FDc30eSJy5ynAZRramh1SlKAmBlgTwUzuCiiDH7O8DhRCOymS0E3lxDmRzHyaEaOSA62tsy6/EcE045RUN4lEf+qs5kqOM4PaZonuosSnkksmJAeY4Jp5wixuwlkt4AWAwx/iniNJTjOPWnJ3mqy0lznsvKfOc4JYooilOAC4AOQiiNW4BP1FIoxxnM5KUthb7ZKF7q2tBtf+qkDlcMTkUaHuupFnjiIqe/Ur70FTbFZxo1ohUzNobW6C0d7W3cOf3QvgnqDDj6GuvpZ7C5s6eZ/VsVZHMcJ0Ha0tfSn688wF9vcYc6p6cUmXq6PrE9HHg3IZKr4zhVph43cV/V5PSUIg531yT3Y9iNP9RMIscZRJTbI7Zpa+3z1FIevqrJ6Q29idm0CzC+2oI4Tn+hkrG5J/WUh+JobamuW3Rrixg5bCjPrenyVU1Orylio3iBME1asqn9E/hcjeVynKYkK84S0OMbcJo9omt99RaXtEicd9w+rhicPlNk6mmregjiOP2BrDhL5938SLcbcpFRRzXsEaNGtGYauTeYuZJwqkKmopC0X94Hzeze6ovjOM1NZ8bNPXnTTxt1nH7lAk67cgEdCaUxtr0ts76irFzdRXuGXcON1k61yBtRfCvnnAG+ENsZVMyc37lx/rWc0k155vxOzrhq4WapRkt7yamqaYfv1ufw4KXRSnk9brR2qkmmojCzQ+opiOM0O+fd/Ehm9rhph++2cSSRl48aNk1VlZze0hRLUZJTWh6Kw6kVhVY9SdqLkP50eOmYmf2iVkI5TjNSyabQkwxzpSmn0s28NyOLttYhGz/voTicWlIkH8VZwPfi6xDgv4GjayyX4zQdeXP+5938SI/sDSJMU0G4yZ9z7N50tLchgoG6va0VEcJtZFEet8lxakWRMOPHAW8F/mlmHwX2AbaoqVSO00Bmzu9kyrmzedX0G5hy7uyNN/S8Of+ermAygnIpMXVSB9MO342x7W2sXN3FyC2G8u3j9+XO6YdmKgs3Vjv1ooiiWGNmG4B1krYGngJ2qq1YjtMYSnaGzpVrMDYZn2fO72TqpA7aM/JJ9+amnbZSKq1dzxvhNJoiimKupHbgx8A84F7gL7UUynEaRZafxGlXLmDSV2/hyH12SL1p9yaZUFK5VPLPSE5NdbS3cc6xe7tNwqkbRRzu/jNuXiTp98DWZnZfNRqX9FPgSOApM9sr5bwIuTCOAFYDH3H/DacaZDnE5U0hPbu6i8vueoKRw1pob2vtFhYjOY1UzhCg3JpQPiLIandZwujtisFpFEWM2b+V9H5JI81scbWURORS4B05599JiC21C3Ay8MMqtu0MUrKmec6ceT9DVDnW0qq161m1dt1GG0IlBdPSIqbsvC0tse4Wiffs3/3G7/mrnWamyNTT+cAbgQclXS3pOEnDK32oCGZ2B/BMTpFjgF9Y4C6gXdIO1WjbGbxkTfNcdtcThf0ZutYbX/ndoo37eTf0rvXGn//+zMa615txzbzOjUZywO0QTlNTUVGY2e1x+mkn4GLgfQSDdj3oAJYk9pfGY5sh6WRJcyXNXbGi9zmFnYFPtXI+JGMsVbqhl6ufNV3rOeOqhZlLZN0O4TQTRR3u2oCjgOOB/YCf11KoZNMpx1If+czsYoIiY/LkyQMvv6tTNaoRY6mcqZM6+MrvFvUoC916M067cgEzZi1ixtF7uh3CaVqK2CiuBB4ixHb6PrCzmf2/WgsWWQqMS+zviGfXc/pItaZzypfKnnXUnrQO6Xk+iZVrujYuhXWcZqSIjeJnBOVwipnNjj4V9WIW8CEFDgKeM7PldWzfGYDk+UMkqZREaMbRe25W73nv3adb3aNGtPKBg8ZvZn8op7QU1nGakSLLY39fq8ZjWtWDgdGSlgJnAa2x3YuAGwlLYx8lLI/9aK1kcQYXM47ec7P4Sq1DxJbDh7Jy9aZlr1fPfYI7/775eospO2+bOk2UNX00ecK2FYP/1SNftuP0ht6kQq0aZnZihfMGfKJO4jiDhJIPxZqu9bRIrDfrliciSdZT/uKne3ZTLxL8z5fCOs1KQxWF49Sb8qRC6826LUPd40s3sToG25MgawDQG2N4SVmkGb19KazTzOQqCklDCU5vu8dDDwG/N7N1tRbMcWpBlg/FjFmLeP6lLjYkFEOeS0VLAce8NEpTU0VSpTpOs5CXCnUsMAdYDswnLFU9EviWpEPMzFcfOf2OLDtAWirRPHqbaKiEL4V1+hN5I4pvAD80s+8kD0r6FHAO8OEayuU4PaL8Cf2Q3ccw5+EVmz2xb5ORX7qn5OWJcJyBRp6iOMjMPlJ+0My+K8nX8TlNQ7ndoXPlGi6764mN55N5qns5Y7QZbk9wBhN5fhR51rrV1RbEcXpLkRSkJT+FnnhO53H6lQu6JTVynIFM3ohiG0nHphwXsHWN5HGcHlPU/6Bz5ZqNy2H7SjLqLOD2BmdAk6cobifEd0rjjhrI4ji9oiexm6qhJJIkkws5zkAlU1HE/NiOUxOquTx02uG7Me3qhXRtaEwsSPeodgY6FR3uJP1XyuHngHlmtqDqEjkDnjTjc1+mcHoTubUoLRIbzBjb3sbqtetS23CPamegU8Qze3J8/S7uvwu4BzhF0tVm9t+1Es4ZmFTKD51H1khkZQ2URFtrS7ecEOUKrlTGV0A5A50iiuIVwH5m9iKApLOA3wBvBuYBriicHlEpP3SSpGJoH9HKiy+t2zjFVBqJzH38GYZUwUg9onUIo0ZukTkdVtp2j2pnsFFEUYwH1ib2u4AJZrZG0su1EcsZyGQZn0tTOCXl0LlyDWJTpqq0aZ81Xev51V1PpGez6iHDhrZw5/RDc8u4R7UzGCmSj+LXwF2SzpI0A7gTuFzSSODBWgrnDEzy8kOXpndKiqSIAqiWCfu5KnhsO85ApEg+iq9JuhF4I8GH4hQzmxtPn1RL4ZyBSd4UzpRzZ1d0nqsVbpR2nHSKhhlfB2wgPLz5Y5fTZ7KmcBq11NSN0o6TTZGc2Z8GfgWMBrYDLpNUr5zZziCjHk/1Aj5w0Hg62tsQIcBfcnWT4zjdKTKi+BhwoJmtApD0TeD/gO/VUjBncDLt8N04/coFVbM7lCPgpIPGc/bUvWvUguMMPIooCgHJSeP18ZjjVJ2pkzqY+/gzVVvJBN2d5nw5q+P0nCKK4mfA3ZKui/tTgUtqJpEz4KkUvuPsqXszecK2nHblgj63Ve405zhOz5EVcFKStB+bVj3dYWbzay1YX5g8ebLNnTu3ckGn7qR5N5d8JTrKEg711Ymuw0cQjlMYSfPMbHLaubxUqNsmdhfH18ZzZvZMtQR0Bgcz53dyxlULN7v5l/bKEw4VURLDWsTa9ZuX62hvq+g85zhOMfKmnuYR/sMle0Tp31h6ANypr41LegdwAdAC/MTMzi07fzDwW+Af8dC1ZvbVvrbr1J/SSKIvI4Skl3aJdSlKAuCQ3cf0uh3HcbqTF2b8VbVsWFIL8H3gbcBS4B5Js8ys3Nv7j2Z2ZC1lcWpHMhxHX0lTCRsyys55eEWf23McJ1DU4a4WHAA8amaPAUi6AjgGDwvS75g5v5MZsxaxMobAGDWilbOO2hNgM3tEvfAcEY5TPRqpKDqAJYn9pcCBKeVeL2khsAz4jJktSqtM0snAyQDjx4+vsqgDn94mEpo5v5P/unJBtyf7Z1d3Me03C2kdItZ0ZT3z1xYPx+E41aNIUMBakeaLUT67cC8hUu0+BAe/mVmVmdnFZjbZzCaPGePz0z0hGYgvmQt65vzOip+dMWtR6vRP13pjdZ2URGtL90vJw3E4TnXJVBSSts17VaHtpcC4xP6OhFHDRszs+VIeDDO7EWiVNLoKbTsJ8hIJ5TFzfufG6aZGMXJYC+cdt4+H43CcGlJ01dN44Nm43Q48AfTV2H0PsIukVwGdwAnA+5MFJG0PPGlmJukAgmJ7uo/tOmX0JJFQidIopNGsXrvec0Q4To2puOpJ0kXArPhEj6R3Aof1tWEzWyfpk8DNhOWxPzWzRZJOiecvAo4DTpW0DlgDnGBFPASdHlEpkVCSaq5iKkpHexurXl6XOnpxW4Tj1J4iNorXlZQEgJndBLylGo2b2Y1mtquZ7WxmX4/HLopKAjO70Mz2NLN9zOwgM/tzNdp1upOXSChJeVKhetAicef0Q5lx9J6FZHQcp/oUWfX0L0lnApcRpqI+gE//DCiK5oJOs2XUmpKDnuerdpzGUURRnAicBVxHUBR3xGPOAKLIPH8jfBNatGlFk9siHKcxFEmF+gzwaUlbllYgOQODNN8JyH5qz7Jl1JITDxxXuZDjODWlYvRYSW8AfgJsaWbjJe0D/IeZ/Wc9BOwNHj22MmlRXFtbBAZdGzZdE61DxJbDh7JydRftI1p5dnV9lsO2SJx44DhPMOQ4daJX0WMTfBs4HJgFYGYLJb25ivI5DSDN3tCVEmCva4NtVA71UBIC/nHuu2rejuM4xSnkmW1mS8oO1T94j1NVmjUWki93dZzmo4iiWBKnn0zSMEmfAR6qsVxOjWnGG7Ivd3Wc5qSIojgF+AQhiN9SYF+gae0TTjHSfCfqRYvEd47fl+8cv6+H3nCcfkARG8VuZnZS8oCkKcCdtRHJqQdTJ3Uw9/Fn+NVdT6TmeagW5cmGynNYu2JwnOanyIjiewWPOf2MOQ+vqKmSgE25sH3U4Dj9l7yc2a8H3gCMkfRfiVNbE2IzOQ2mtzkkStTDJ8JzVztO/ydv6mkYsGUss1Xi+POEYH1OAyn3gyjlkIBi0zkz53em5qCuJm6cdpyBQV702NuB2yVdamaP11Emh8qjhbwcElMndRT6fLWVhIDhrUN4qWuDx2JynAFEEc/sW4H3mtnKuD8KuMLMDq+9eL2jv3tmp3lNlxuBXzX9hswbfXtbK6vWruvmQFcaPXTEG/hpVy6omfztba3MOHpPVxKO04/I88wuYsweXVISAGb2LLBdlWRzUiiScS7PD2Llmq7NvKxLe50r1zDt6oVVkzWr/aKpVB3HaX6KKIoNksaXdiRNoLZT24OeIhnn+uIHkYzlVCuKpFJ1HKd/UMSP4ovAnyTdHvffDJxcO5GcIhnnkvkZ6h3RtUSLtDFfRBrNGibEcZyeUXFEYWa/B/YDrgSuAvY3s5trLdhgpmjGuamTOrhz+qF0VDEch8r221pb+MBB41PlOfHAcbmjmmYME+I4Ts/JVBSSdo/v+wHjgWVAJzA+HnNqxNRJHZxz7N6FHdWqGY7D2JQsqEXiPft3cPbUvVPlKR0fNaJ1s3p8aazjDBwyVz1J+rGZfVzSnJTTZmZN60XV31c99YbScthqT0OVr7aq1L6nKXWc/kmv8lGY2cfj+yG1EsypLqvXrqt6nUnfjDw8TanjDFzyQngcm/dBM7u2r41LegdwASEkyE/M7Nyy84rnjwBWAx8xs3v72u5AYub8Tr7yu0U1TSrkRmnHGdzkrXo6Kr5vR4j5NDvuHwLcBvRJUUhqAb4PvI0QvvweSbPM7MFEsXcCu8TXgcAP4/ugYub8TmbMWsTKNUEZjBrRyllH7QmwmWNeLXCjtOMMbvKmnj4KIOl6YA8zWx73dyDc4PvKAcCjZvZYrPcK4BggqSiOAX5hwZByl6R2STuUZBkMzJzfybSrF3bzfXh2dRfTfrOQLbcYWnMlAbhR2nEGOUUc7iaW3ZifBHatQtsdQDLF6tJ4rKdlAJB0sqS5kuauWLGiCuI1B+fd/Eiqg1zXeqvKdNPIYS20t22+aqlEe1ur2x4cZ5BTxOHuNkk3A5cTVk+eAKSthOop5Uv2YXOP7yJlwkGzi4GLIax66ptozUMt7AMC/nHuu7ody4ovNePoPTee91VNjjM4qagozOyTkt5N8MgGuNjMrqtC20uBcYn9HQm+Gj0tMyAp3ZhrofHSbA5JT+9yZdDXkOaO4/RviowoAO4FXjCzP0gaIWkrM3uhj23fA+wi6VUER74TgPeXlZkFfDLaLw4EnuvP9okiT+W1XsWU5wiXtcS1Ukhzx3EGNhUVhaSPE2I7bQvsTLARXAS8tS8Nm9k6SZ8EbiYsj/2pmS2SdEo8fxFwI2Fp7KOE5bEf7UubjSTvqRw2xWyqdjKh9rZWRm4xtE9TRkWCFDqOM3ApMqL4BGGF0t0AZvY3SVUJM25mNxKUQfLYRYlti+33e7KeymfMWsTL6zZsPFftqabn1nSx4Ky396mOIkEKHccZuBRZ9fSyma0t7UgaiocZ7zFZT98r13TVdIlrNW7mRYMUOo4zMCmiKG6X9AWgTdLbgKuB39VWrIFHI56+q3Uz72mQQsdxBhZFUqEK+Hfg7YSVlTcTwm007aiiGYMCpjnOtQ4R6zZYTYZnHb6E1XGcHtCroIDxg0OA+8xsL+DHtRBuUFHmFVLLTHN3Tm/a4L6O4/QzcqeezGwDsDCZCtXpHTNmLdosj7XjOE5/oMiqpx2ARZL+AqwqHTSzo2sm1QDjzJn3bwzoVw/SEgk5juP0liKK4is1l2IAkXSq26atla71G1i1tvaB+0q0tmhjZFnHcZxqkJePYjhwCvBq4H7gEjOrfmacAUS5U12tRxFtrS28Z/8O5jy8wmMwOY5TM/JGFD8HuoA/EvJC7AF8uh5C9VfSnOqqweIYwM8D8zmO0wjyFMUeZrY3gKRLgL/UR6T+Q3lCoVrQkfC/8HSjjuM0gjxFsfHuF+My1UGc/kOaX0S1EZ40yHGcxpOnKPaR9HzcFsEz+/m4bWa2dc2la2KyEgpVCwEnHTTeRxCO4zScvFSoLVnnBiPl9oG0IHnVwr2qHcdpJormoxjUpIUIrwVtrS0eQ8lxnKbDFUUBarWaKYmPIhzHaVZcURSgltNMEJSEx2ZyHKdZKRJmfNDTUsMVX57XwXGcZsdHFBnUKnd1e1srEqxc3eVOc47j9AtcUSQorWyq9lRTaanr2VP3rmq9juM49cAVRaR8ZVNfGSIww0cNjuP0e1xRRKq9sun89+3rysFxnAGBG7Mjy6o83eRKwnGcgUJDFIWkbSXdKulv8X1URrnFku6XtEBSTZNgt3uyH8dxnFQaNaKYDvyvme0C/G/cz+IQM9s3K+l3NZg5v5MXX6peqo1kxFfHcZz+TqMUxTGEfBfE96kNkgPofYC/USNaaR3S3cfC/SIcxxloNMqY/UozWw5gZsslbZdRzoBbJBnwIzO7OKtCSScDJwOMHz++R8L0xD4xonUI3zj2tRttEJ5MyHGcgU7NFIWkPwDbp5z6Yg+qmWJmy6IiuVXSw2Z2R1rBqEQuBpg8eXKPhgd50WArxWDyZEKO4wx0aqYozOywrHOSnpS0QxxN7AA8lVHHsvj+lKTrgAOAVEXRF6YdvttmPhQeydVxHCfQKBvFLODDcfvDwG/LC0gaKWmr0jbwduCBWggzdVIH5xy7Nx3tbYgwinAl4TiOE2iUjeJc4CpJHwOeAN4LIGks8BMzOwJ4JXBdTME6FPi1mf2+VgL5FJLjOE46DVEUZvY08NaU48uAI+L2Y8A+dRbNcRzHKcM9sx3HcZxcXFE4juM4ubiicBzHcXJxReE4juPkIrOeh65odiStAB6vQlWjgX9VoZ560h9lBpe73rjc9aU/yD3BzMaknRiQiqJaSJpby2CEtaA/ygwud71xuetLf5W7hE89OY7jOLm4onAcx3FycUWRT2a02iamP8oMLne9cbnrS3+VG3AbheM4jlMBH1E4juM4ubiicBzHcXJxRRGRtK2kWyX9Lb6Pyii3WNL9khZImltvORNyvEPSI5IelbRZznEFvhvP3ydpv0bIWU4BuQ+W9Fzs3wWSvtwIOctk+qmkpySlhrlv4r6uJHcz9vU4SXMkPSRpkaRPp5Rpuv4uKHfT9XdhzMxfwU7z38D0uD0d+GZGucXA6AbL2gL8HdgJGAYsBPYoK3MEcBMg4CDg7ibo4yJyHwxc32hZy2R6M7Af8EDG+abr64JyN2Nf7wDsF7e3Av7aT67tInI3XX8XffmIYhPHAD+P2z8HpjZOlIocADxqZo+Z2VrgCoL8SY4BfmGBu4D2mE2wkRSRu+mwkH73mZwizdjXReRuOsxsuZndG7dfAB4CyhPFNF1/F5S73+KKYhOvNLPlEH50YLuMcgbcImmepJPrJl13OoAlif2lbH5RFilTb4rK9HpJCyXdJGnP+ojWJ5qxr4vStH0taSIwCbi77FRT93eO3NDE/Z1HozLcNQRJfwC2Tzn1xR5UM8XMlknaDrhV0sPxya2eKOVY+TrnImXqTRGZ7iXEnHlR0hHATGCXWgvWR5qxr4vQtH0taUvgGuA0M3u+/HTKR5qivyvI3bT9XYlBNaIws8PMbK+U12+BJ0vD1/j+VEYdy+L7U8B1hOmUerMUGJfY3xFY1osy9aaiTGb2vJm9GLdvBFolja6fiL2iGfu6Is3a15JaCTfbX5nZtSlFmrK/K8ndrP1dhEGlKCowC/hw3P4w8NvyApJGStqqtA28HUhdUVJj7gF2kfQqScOAEwjyJ5kFfCiuEDkIeK40tdZAKsotaXspJEqXdADhGn267pL2jGbs64o0Y19HeS4BHjKz8zOKNV1/F5G7Gfu7KINq6qkC5wJXSfoY8ATwXgBJY4GfmNkRwCuB6+JvPRT4tZn9vt6Cmtk6SZ8EbiasJPqpmS2SdEo8fxFwI2F1yKPAauCj9ZaznIJyHwecKmkdsAY4weKSkUYh6XLCipXRkpYCZwGt0Lx9DYXkbrq+BqYAHwTul7QgHvsCMB6aur+LyN2M/V0ID+HhOI7j5OJTT47jOE4urigcx3GcXFxROI7jOLm4onAcx3FycUXhOI7j5OKKwqkqkl6RiI75T0mdif1hVWrjNkm9SlQvaUZCpr9JulbSHlWS61JJx1Wjroz6JWm2pK3j/ot9qOs2hSi+90l6WNKFktqrJOdYSb+J2/tGL+S88mMk1X2ZuVMcVxROVTGzp81sXzPbF7gI+HZp38zWSmoG352STLsAVwKzJY1ptFAFOAJYmBIaorecZGavBV4LvEyKk2lvMLNlZlZSmPsS5M4rvwJYLmlKNdp3qo8rCqfmxCft8yXNAb4Zn+o/kzj/QAykhqQPSPpLfOL/kaSWCnWfqJAf5AFJ30wc/5ikv8Yn5x9LujDt82Z2JXAL8P6yel8j6S+J/YmS7ovbX5Z0T2zz4pK3bdnnFyuGZ5A0WdJtcXukQp6IeyTNl3RMPL5n4nvfJyktBtBJpEcMkKTzojz3Szo+Hh8i6QcK+RGul3Rj2ognRvL9LDBe0j4p9b+Y2D5O0qVx+1KFvBB/lvRYqe7YVw/EEeRXgePj9zpe0lsSI8z5ipEOCHGPTkr5zk4T4IrCqRe7AoeZ2RlZBSS9BjieEHhxX2A9OTcPBa/5bwKHEp5cXydpajz+JUKugrcBu1eQ7d7yMmb2EDBM0k7x0PHAVXH7QjN7nZntBbQBR1aoP8kXgdlm9jrgEOA8hXAwpwAXxO89mRDPqJwpwLyU48cSvv8+wGGxzh3i8YnA3sC/A6/PEsrM1hPyg1Tqq3J2AN5I6INzy+pcC3wZuDKO4K4EPgN8In7PNxE8lAHmxn2nCXFF4dSLq+PNKI+3AvsD98QwCG8lJDnK4nXAbWa2wszWAb8iJOs5ALjdzJ4xsy7g6grtpkUjhaAY3he3jydMUwEcIuluSfcTlFRPwkW/HZgev99twHBCmIf/A74g6XOECKNrUj67bcx1UM4bgcvNbL2ZPQncTuibNxL6fYOZ/ROYU0G2rH7IY2as/0FCiJtK3AmcL+lTQHv83SAE4Rzbi/adOtAM88XO4GBVYnsd3R9Shsd3AT83s88XrDPrxtbTG94kwhNtOVcCV0u6FjAz+5uk4cAPgMlmtkTSDDbJnyT5HZPnBbzHzB4pK/+QpLuBdwE3S/p3M5tdXqekIWa2oex4n/shTvHtTUi4U04yzk/5d325J+2Z2bmSbiDYLe6SdJiZPRzrTVOOThPgIwqnESwmpOhEId/xq+Lx/wWOU8j1UcpjPiGnnruBt0gaHW90JxKepv8Sj4+KxvP3ZFUg6T2Ep/zLy8+Z2d8J019fYtNoonSj/JdC7oGsVU6LCaMjytq/Gfh/JbuGpEnxfSfgMTP7LiE66mtT6nyE9BHWHQQ7QEs0yr+Z0Ad/At4TbRWvJAQI3AyF8NjnAEvM7L6UIk9Gm80Q4N0Z3zeLFwipQUtt7Wxm95vZNwnKuTTVtSuNicTsFMAVhdMIrgG2jdMvpxLyCxOnL84kZBC8D7iVMAeeSgwt/XnClMpC4F4z+62ZdQLfICiSPwAPAs8lPnp6NKb+DfgAcGhceZPGlbHMVbHNlcCPgfsJBth7Mj73FeACSX8kKJsSXyNEcL1P0gNxH8LU1gOxT3YHfpFS5w2k3+yvA+4j9MFs4LNxqukagq3jAeBHhP5I9sOvYj8/AIwkOy3tdOD6WHdPw3nPAfYoGbOB06KheyFhBHFTLHdI/H5OE+LRY50BiaQtYyaxoYQb6U/N7LpGy9UXooH6F2b2th58ptQPryCMMqZEJdJUSLoDOMbMnm20LM7muI3CGajMkHQYYaroFsLTf7/GzJbHpb5b98CX4noFR7phwNeaVEmMAc53JdG8+IjCcRzHycVtFI7jOE4urigcx3GcXFxROI7jOLm4onAcx3FycUXhOI7j5PL/AXsUwIloaOBNAAAAAElFTkSuQmCC",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from sklearn.metrics import r2_score, mean_absolute_error\n",
    "from scipy.stats import pearsonr\n",
    "import matplotlib.pyplot as plt\n",
    "print(f'R^2 = {r2_score(pred, y_test.values):.2f}')\n",
    "print(f\"Pearson's R = {pearsonr(pred, y_test.values)[0]:.2f}\")\n",
    "print(f'MAE = {mean_absolute_error(pred, y_test.values):.2f} logD units')\n",
    "plt.scatter(y_test.values, pred)\n",
    "plt.title('''True vs predicted logD values of \n",
    "Test dataset for ML model trained on MMP12 dataset''')\n",
    "plt.xlabel('True logD values (logD units)')\n",
    "plt.ylabel('Predicted logD values (logD units)')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "id": "e043c58c",
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
 "metadata": {
  "interpreter": {
   "hash": "77b02c0e1da6aaff65db19a2013d155c0c3fa2151372aae34caa6d2644385446"
  },
  "kernelspec": {
   "display_name": "Python 3.8.5 ('dd_game')",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.8.5"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}