diff --git a/.azure/wheels.yml b/.azure/wheels.yml
index 63604a40382c..533d7f010ad3 100644
--- a/.azure/wheels.yml
+++ b/.azure/wheels.yml
@@ -28,13 +28,3 @@ jobs:
           pip install cibuildwheel==2.11.2
           pip install -U twine
           cibuildwheel --output-dir wheelhouse .
-
-      - task: PublishBuildArtifacts@1
-        inputs: {pathtoPublish: 'wheelhouse'}
-        condition: succeededOrFailed()
-
-      - bash: |
-          twine upload wheelhouse/*
-        env:
-          TWINE_USERNAME: "qiskit"
-          TWINE_PASSWORD: $(TWINE_PASSWORD)
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index 3dd7961146ac..e180c6feaa73 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -1,9 +1,9 @@
 ---
 name: Wheel Builds
 on:
-  push:
-    tags:
-      - '*'
+  pull_request:
+    branches: ['main']
+
 jobs:
   build_wheels_s390x:
     name: Build wheels on s390x
@@ -35,11 +35,6 @@ jobs:
           path: ./wheelhouse/*.whl
       - name: Install twine
         run: python -m pip install twine
-      - name: Upload to PyPI
-        run: twine upload ./wheelhouse/*.whl
-        env:
-          TWINE_PASSWORD: ${{ secrets.TWINE_PASSWORD }}
-          TWINE_USERNAME: qiskit
   build_wheels_ppc64le:
     name: Build wheels on ppc64le
     runs-on: ${{ matrix.os }}
@@ -70,11 +65,6 @@ jobs:
           path: ./wheelhouse/*.whl
       - name: Install twine
         run: python -m pip install twine
-      - name: Upload to PyPI
-        run: twine upload ./wheelhouse/*.whl
-        env:
-          TWINE_PASSWORD: ${{ secrets.TWINE_PASSWORD }}
-          TWINE_USERNAME: qiskit
   build_wheels_aarch64:
     name: Build wheels on ${{ matrix.os }}
     runs-on: ${{ matrix.os }}
@@ -104,8 +94,3 @@ jobs:
           path: ./wheelhouse/*.whl
       - name: Install twine
         run: python -m pip install twine
-      - name: Upload to PyPI
-        run: twine upload ./wheelhouse/*.whl
-        env:
-          TWINE_PASSWORD: ${{ secrets.TWINE_PASSWORD }}
-          TWINE_USERNAME: qiskit
diff --git a/azure-pipelines.yml b/azure-pipelines.yml
index 038cc23eb8c0..12a4c363cf0c 100644
--- a/azure-pipelines.yml
+++ b/azure-pipelines.yml
@@ -95,116 +95,7 @@ parameters:
 # need to examine `variables['Build.SourceBranch']` to determine whether it's a
 # branch or a tag.
 stages:
-  # Nightly cron job.
-  - ${{ if eq(variables['Build.Reason'], 'Schedule') }}:
-    - stage: "Nightly"
-      displayName: "Nightly complete matrix tests"
-      jobs:
-        - ${{ each version in parameters.supportedPythonVersions }}:
-          - template: ".azure/test-linux.yml"
-            parameters:
-              pythonVersion: ${{ version }}
-              testQPY: false
-              testImages: false
-
-          - template: ".azure/test-macos.yml"
-            parameters:
-              pythonVersion: ${{ version }}
-
-          - template: ".azure/test-windows.yml"
-            parameters:
-              pythonVersion: ${{ version }}
-
-    - stage: "Nightly_Failure"
-      displayName: "Comment on nightly failure"
-      dependsOn: "Nightly"
-      condition: failed()
-      pool: {vmImage: 'ubuntu-latest'}
-      jobs:
-        - job: "Comment"
-          steps:
-            - task: GitHubComment@0
-              inputs:
-                gitHubConnection: Qiskit
-                repositoryName: ${{ variables['Build.Repository.Name'] }}
-                id: 7864
-                comment: Nightly test job failed at commit $(Build.SourceVersion).  View the logs at $(System.TeamFoundationCollectionUri)$(System.TeamProject)/_build/results?buildId=$(Build.BuildId).
-
-  # Full PR suite.
   - ${{ if eq(variables['Build.Reason'], 'PullRequest') }}:
-    # The preliminary stage should be small in both total runtime (including
-    # provisioning) and resources required.  About half of PR commits result in
-    # a CI failure, and over 90% of these are in linting, documention or a test
-    # failure that would affect _any_ OS or Python version.  The goal in the
-    # first stage is to catch the vast majority of failures with minimal cost.
-    - stage: "Lint_Docs_Prelim_Tests"
-      displayName: "Preliminary tests"
-      jobs:
-        - template: ".azure/lint-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.minimumPythonVersion }}
-
-        - template: ".azure/docs-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.documentationPythonVersion }}
-
-        - template: ".azure/test-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.minimumPythonVersion }}
-            testQPY: false
-            testImages: false
-            rustVersion: ${{ parameters.minimumRustVersion }}
-
-    # The rest of the PR pipeline is to test the oldest and newest supported
-    # versions of Python, along with the integration tests (via the tutorials).
-    # It's very rare for a failure to be specific to an intermediate version of
-    # Python, so we just catch those in the cron-job pipeline to reduce the
-    # amount of resources used.
-    - stage: "Tutorials_and_Tests"
-      displayName: "Main tests"
-      dependsOn: "Lint_Docs_Prelim_Tests"
-      jobs:
-        - template: ".azure/tutorials-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.tutorialsPythonVersion }}
-
-        - template: ".azure/test-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.maximumPythonVersion }}
-            testQPY: true
-            testImages: true
-            installFromSdist: true
-
-        - template: ".azure/test-macos.yml"
-          parameters:
-            pythonVersion: ${{ parameters.minimumPythonVersion }}
-
-        - template: ".azure/test-macos.yml"
-          parameters:
-            pythonVersion: ${{ parameters.maximumPythonVersion }}
-
-        - template: ".azure/test-windows.yml"
-          parameters:
-            pythonVersion: ${{ parameters.minimumPythonVersion }}
-
-        - template: ".azure/test-windows.yml"
-          parameters:
-            pythonVersion: ${{ parameters.maximumPythonVersion }}
-
-  # Push to main or the stable branches.  The triggering branches are set in the
-  # triggers at the top of this file.
-  - ${{ if and(eq(variables['Build.Reason'], 'IndividualCI'), startsWith(variables['Build.SourceBranch'], 'refs/heads/')) }}:
-    - stage: "Push"
-      jobs:
-        - template: ".azure/test-linux.yml"
-          parameters:
-            pythonVersion: ${{ parameters.branchPushPythonVersion }}
-            testQPY: true
-            testImages: true
-
-  # Push to a tag.  The triggering tags are set in the triggers at the top of
-  # this file.
-  - ${{ if and(eq(variables['Build.Reason'], 'IndividualCI'), startsWith(variables['Build.SourceBranch'], 'refs/tags/')) }}:
     - stage: "Deploy"
       jobs:
         - template: ".azure/wheels.yml"
@@ -242,22 +133,3 @@ stages:
                   inputs:
                     versionSpec: ${{ version }}
                     architecture: x64
-
-        - job: 'sdist'
-          pool: {vmImage: 'ubuntu-latest'}
-          steps:
-            - task: UsePythonVersion@0
-            - bash: |
-                set -e
-                python -m pip install --upgrade pip
-                python -m pip install --upgrade setuptools_rust
-                python setup.py sdist
-            - task: PublishBuildArtifacts@1
-              inputs: {pathtoPublish: 'dist'}
-              condition: succeededOrFailed()
-            - bash: |
-                python -m pip install --upgrade twine
-                twine upload dist/*
-              env:
-                TWINE_USERNAME: "qiskit"
-                TWINE_PASSWORD: $(TWINE_PASSWORD)