diff --git a/Changelog.md b/Changelog.md
index 45e65ae2d..6ab95cfaf 100644
--- a/Changelog.md
+++ b/Changelog.md
@@ -8,6 +8,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ## [Unreleased]
 
 * Add support for building bin bindings wheels with multiple platform tags in [#928](https://github.com/PyO3/maturin/pull/928)
+* Skip auditwheel for non-compliant linux environment automatically in [#931](https://github.com/PyO3/maturin/pull/931)
 
 ## [0.12.17] - 2022-05-18
 
diff --git a/src/build_context.rs b/src/build_context.rs
index d6dd5c43c..c2df703db 100644
--- a/src/build_context.rs
+++ b/src/build_context.rs
@@ -277,11 +277,25 @@ impl BuildContext {
         &self,
         artifact: &Path,
         platform_tag: &[PlatformTag],
+        python_interpreter: Option<&PythonInterpreter>,
     ) -> Result<(Policy, Vec<Library>)> {
         if self.skip_auditwheel || self.editable {
             return Ok((Policy::default(), Vec::new()));
         }
 
+        if let Some(python_interpreter) = python_interpreter {
+            if platform_tag.is_empty()
+                && self.target.is_linux()
+                && !python_interpreter.support_portable_wheels()
+            {
+                println!(
+                    "🐍 Skipping auditwheel because {} does not support manylinux/musllinux wheels",
+                    python_interpreter
+                );
+                return Ok((Policy::default(), Vec::new()));
+            }
+        }
+
         let mut musllinux: Vec<_> = platform_tag
             .iter()
             .filter(|tag| tag.is_musllinux())
@@ -454,7 +468,8 @@ impl BuildContext {
             python_interpreter,
             Some(&self.project_layout.extension_name),
         )?;
-        let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag)?;
+        let (policy, external_libs) =
+            self.auditwheel(&artifact, &self.platform_tag, python_interpreter)?;
         let platform_tags = if self.platform_tag.is_empty() {
             vec![policy.platform_tag()]
         } else {
@@ -528,7 +543,8 @@ impl BuildContext {
                 Some(python_interpreter),
                 Some(&self.project_layout.extension_name),
             )?;
-            let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag)?;
+            let (policy, external_libs) =
+                self.auditwheel(&artifact, &self.platform_tag, Some(python_interpreter))?;
             let platform_tags = if self.platform_tag.is_empty() {
                 vec![policy.platform_tag()]
             } else {
@@ -624,7 +640,7 @@ impl BuildContext {
     pub fn build_cffi_wheel(&self) -> Result<Vec<BuiltWheelMetadata>> {
         let mut wheels = Vec::new();
         let artifact = self.compile_cdylib(None, None)?;
-        let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag)?;
+        let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag, None)?;
         let platform_tags = if self.platform_tag.is_empty() {
             vec![policy.platform_tag()]
         } else {
@@ -702,7 +718,7 @@ impl BuildContext {
             .cloned()
             .ok_or_else(|| anyhow!("Cargo didn't build a binary"))?;
 
-        let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag)?;
+        let (policy, external_libs) = self.auditwheel(&artifact, &self.platform_tag, None)?;
         let platform_tags = if self.platform_tag.is_empty() {
             vec![policy.platform_tag()]
         } else {
diff --git a/src/python_interpreter/mod.rs b/src/python_interpreter/mod.rs
index df7c89324..4b76c8fb6 100644
--- a/src/python_interpreter/mod.rs
+++ b/src/python_interpreter/mod.rs
@@ -661,6 +661,36 @@ impl PythonInterpreter {
             Ok(ok) => Ok(String::from_utf8(ok.stdout)?),
         }
     }
+
+    /// Whether this Python interpreter support portable manylinux/musllinux wheels
+    ///
+    /// Returns `true` if we can not decide
+    pub fn support_portable_wheels(&self) -> bool {
+        if !self.runnable {
+            return true;
+        }
+        let out = Command::new(&self.executable)
+            .args(&[
+                "-m",
+                "pip",
+                "debug",
+                "--verbose",
+                "--disable-pip-version-check",
+            ])
+            .output();
+
+        match out {
+            Err(_) => true,
+            Ok(ok) if !ok.status.success() => true,
+            Ok(ok) => {
+                if let Ok(stdout) = String::from_utf8(ok.stdout) {
+                    stdout.contains("manylinux") || stdout.contains("musllinux")
+                } else {
+                    true
+                }
+            }
+        }
+    }
 }
 
 impl fmt::Display for PythonInterpreter {