diff --git a/.config/nextest.toml b/.config/nextest.toml
new file mode 100644
index 000000000..5b3871d63
--- /dev/null
+++ b/.config/nextest.toml
@@ -0,0 +1,3 @@
+[profile.default]
+# Terminate slow tests after 5 minutes
+slow-timeout = { period = "60s", terminate-after = 5 }
diff --git a/src/compile.rs b/src/compile.rs
index 1dd593613..80b01d348 100644
--- a/src/compile.rs
+++ b/src/compile.rs
@@ -350,7 +350,12 @@ fn compile_target(
                 || (matches!(bindings_crate, BridgeModel::BindingsAbi3(_, _))
                     && interpreter.interpreter_kind.is_pypy())
             {
-                build_command.env("PYO3_PYTHON", &interpreter.executable);
+                build_command
+                    .env("PYO3_PYTHON", &interpreter.executable)
+                    .env(
+                        "PYO3_ENVIRONMENT_SIGNATURE",
+                        interpreter.environment_signature(),
+                    );
             }
 
             // rust-cpython, and legacy pyo3 versions
diff --git a/src/python_interpreter/mod.rs b/src/python_interpreter/mod.rs
index d46a45d58..f44a33dbc 100644
--- a/src/python_interpreter/mod.rs
+++ b/src/python_interpreter/mod.rs
@@ -846,6 +846,16 @@ impl PythonInterpreter {
             }
         }
     }
+
+    /// An opaque string that uniquely identifies this Python interpreter.
+    /// Used to trigger rebuilds for `pyo3` when the Python interpreter changes.
+    pub fn environment_signature(&self) -> String {
+        let pointer_width = self.pointer_width.unwrap_or(64);
+        format!(
+            "{}-{}.{}-{}bit",
+            self.implmentation_name, self.major, self.minor, pointer_width
+        )
+    }
 }
 
 impl fmt::Display for PythonInterpreter {