GARD_qdecomp.master.03.qtd.xml

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<QuestionAnnotationFile>
  <Request docID="GARD_Q_0201">
    <Text>How can I cure my nail of anonychia congenita and get a fresh, good nail?</Text>
    <Focus start="26" len="19" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Management" attrs="Error">How can I cure my nail of anonychia congenita and get a fresh, good nail?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0202">
    <Text>How can I find a physician with expertise in ALPS to see my adult son?</Text>
    <Focus start="45" len="4" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="PersonOrg">How can I find a physician with expertise in ALPS to see my adult son?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0203">
    <Text>How can I find information on treatment for polyarteritis nodosa? Are there any dietary supplements or other alternative therapies that have been used to treat polyarteritis nodosa?</Text>
    <Focus start="44" len="20" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Management">How can I find information on treatment for polyarteritis nodosa?</SubQuestion>
    </Question>
    <Question id="T2" start="66" len="115">
      <SubQuestion qt="Management">Are there any dietary supplements that have been used to treat polyarteritis nodosa?</SubQuestion>
      <SubQuestion qt="Management">Are there any other alternative therapies that have been used to treat polyarteritis nodosa?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0204">
    <Text>How can I find other families with children with Blount disease?</Text>
    <Focus start="49" len="14" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="PersonOrg">How can I find other families with children with Blount disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0205">
    <Text>How can I find out more about the status of research on inflammatory myfibroblastic tumor?</Text>
    <Focus start="56" len="33" />
    <Question id="T1" start="0" len="90">
      <SubQuestion qt="Information" attrs="Research">How can I find out more about the status of research on inflammatory myfibroblastic tumor?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0206">
    <Text>How can I find research or treatment studies on trichotillomania? Our teenage daughter has suffered from the condition for many years and we have not found an effective treatment.</Text>
    <Focus start="48" len="16" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Information" attrs="Research">How can I find research studies on trichotillomania?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">How can I find treatment studies on trichotillomania?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0207">
    <Text>How can I learn about research involving myotonia congenita? Is gene therapy available for myotonia congenita?</Text>
    <Focus start="41" len="18" />
    <Question id="T1" start="0" len="60">
      <SubQuestion qt="Information" attrs="Research">How can I learn about research involving myotonia congenita?</SubQuestion>
    </Question>
    <Question id="T3" start="61" len="49">
      <SubQuestion qt="Management">Is gene therapy available for myotonia congenita?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0208">
    <Text>How can I learn about research involving primary ciliary dyskinesia and Kartagener syndrome?</Text>
    <Focus start="41" len="26" />
    <Focus start="72" len="19" />
    <Question id="T1" start="0" len="92">
      <SubQuestion qt="Information" attrs="Research">How can I learn about research involving primary ciliary dyskinesia?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">How can I learn about research involving Kartagener syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0209">
    <Text>How can I learn about research opportunities at the National Institutes of Health (NIH) that are enrolling children with Proteus syndrome?</Text>
    <Focus start="121" len="16" />
    <Question id="T1" start="0" len="138">
      <SubQuestion qt="PersonOrg" attrs="Research">How can I learn about research opportunities at the National Institutes of Health (NIH) that are enrolling children with Proteus syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0210">
    <Text>How can I learn more about learning disabilities in women and girls with Turner syndrome?</Text>
    <Focus start="73" len="15" />
    <Question id="T1" start="0" len="89">
      <SubQuestion qt="Information">How can I learn more about learning disabilities in women with Turner syndrome?</SubQuestion>
      <SubQuestion qt="Information">How can I learn more about learning disabilities in girls with Turner syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0211">
    <Text>How can I learn more about the pull-through operation for Hirschsprung disease? I am considering this procedure for my son.</Text>
    <Focus start="58" len="20" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Management">How can I learn more about the pull-through operation for Hirschsprung disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0212">
    <Text>How can I meet other families with children with Russell-Silver syndrome? My granddaughter was recently diagnosed with this condition. I want to know how I can best support and help her as she grows.</Text>
    <Focus start="49" len="23" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="PersonOrg">How can I meet other families with children with Russell-Silver syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0213">
    <Text>How can I obtain information about treatment options for familial idiopathic basal ganglia calcification (FIBGC)? Is there any research being done to find a treatment or cure for this condition?</Text>
    <Focus start="57" len="55" />
    <Question id="T1" start="0" len="113">
      <SubQuestion qt="Management">How can I obtain information about treatment options for familial idiopathic basal ganglia calcification (FIBGC)?</SubQuestion>
    </Question>
    <Question id="T3" start="114" len="80">
      <SubQuestion qt="Management" attrs="Research">Is there any research being done to find a treatment for this condition?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Is there any research being done to find a cure for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0214">
    <Text>How can I treat fibromyalgia? How can I reduce the pain associated with this condition?</Text>
    <Focus start="16" len="12" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Management">How can I treat fibromyalgia?</SubQuestion>
    </Question>
    <Question id="T3" start="30" len="57">
      <SubQuestion qt="Management">How can I reduce the pain associated with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0215">
    <Text>How can one anticipate the progression of their disorder, as in how bad their condition is? How does one know what type of retinitis pigmentosa they have if their condition is inherited, developed in childhood, and their parents don't have it?</Text>
    <Focus start="123" len="20" />
    <Question id="T1" start="0" len="91">
      <SubQuestion qt="Prognosis">How can one anticipate the progression of their disorder, as in how bad their condition is?</SubQuestion>
    </Question>
    <Question id="T2" start="92" len="151">
      <SubQuestion qt="Information">How does one know what type of retinitis pigmentosa they have if their condition is inherited, developed in childhood, and their parents don't have it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0216">
    <Text>How can you detect Freeman Sheldon syndrome?</Text>
    <Focus start="19" len="24" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Diagnosis">How can you detect Freeman Sheldon syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0217">
    <Text>How common is congenital anosmia?  Is there a cure or any treatment?</Text>
    <Focus start="14" len="18" />
    <Question id="T1" start="0" len="33">
      <SubQuestion qt="Susceptibility">How common is congenital anosmia?</SubQuestion>
    </Question>
    <Question id="T2" start="35" len="33">
      <SubQuestion qt="Management">Is there a cure?</SubQuestion>
      <SubQuestion qt="Management">Is there any treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0218">
    <Text>How common is corpus callosum agenesis? How many people in the United States have this diagnosis? What is the average lifespan for people with this diagnosis?</Text>
    <Focus start="14" len="24" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Susceptibility">How common is corpus callosum agenesis?</SubQuestion>
    </Question>
    <Question id="T3" start="40" len="57">
      <SubQuestion qt="Susceptibility">How many people in the United States have this diagnosis?</SubQuestion>
    </Question>
    <Question id="T4" start="98" len="60">
      <SubQuestion qt="Prognosis">What is the average lifespan for people with this diagnosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0219">
    <Text>How common is Kohler disease? I keep reading that it is rare but can't find stats on just how rare it is.</Text>
    <Focus start="14" len="14" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Susceptibility">How common is Kohler disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0220">
    <Text>How common is lactate dehydrogenase A deficiency and how might this condition be managed (for instance, should complex carbohydrates be avoided)?</Text>
    <Focus start="14" len="34" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Susceptibility">How common is lactate dehydrogenase A deficiency?</SubQuestion>
    </Question>
    <Question id="T3" start="49" len="96">
      <SubQuestion qt="Management">How might this condition be managed?</SubQuestion>
      <SubQuestion qt="Management">How might this condition be managed (for instance, should complex carbohydrates be avoided)?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0221">
    <Text>How common is Sertoli cell-only syndrome? Are there any studies regarding this condition? I was diagnosed recently and I can't find much information about it.</Text>
    <Focus start="14" len="26" />
    <Question id="T1" start="0" len="41">
      <SubQuestion qt="Susceptibility">How common is Sertoli cell-only syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="42" len="47">
      <SubQuestion qt="Information" attrs="Research">Are there any studies regarding this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0222">
    <Text>How common is spitz nevi in children near 7 years-old?</Text>
    <Focus start="14" len="10" />
    <Question id="T1" start="0" len="54">
      <SubQuestion qt="Susceptibility">How common is spitz nevi in children near 7 years-old?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0223">
    <Text>How common or rare is this condition? Can it be linked to prematurity as a cause?</Text>
    <Focus start="22" len="14" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Susceptibility">How common or rare is this condition?</SubQuestion>
    </Question>
    <Question id="T2" start="38" len="43">
      <SubQuestion qt="OtherEffect">Can it be linked to prematurity as a cause?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0224">
    <Text>How did Knobloch syndrome get its name? Is severe myopia one of the main symptoms?</Text>
    <Focus start="8" len="17" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Other">How did Knobloch syndrome get its name?</SubQuestion>
    </Question>
    <Question id="T2" start="40" len="42">
      <SubQuestion qt="Manifestation">Is severe myopia one of the main symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0225">
    <Text>How do doctors test for erythromelalgia? I have flare ups on my hands, feet, and face.</Text>
    <Focus start="24" len="15" />
    <Question id="T1" start="0" len="40">
      <SubQuestion qt="Diagnosis">How do doctors test for erythromelalgia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0226">
    <Text>How does androgen insensitivity syndrome affect gender identity?</Text>
    <Focus start="9" len="31" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="OtherEffect">How does androgen insensitivity syndrome affect gender identity?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0227">
    <Text>How does a person contract FUMHD? How is a person tested for FUMHD? If it is genetic, can other children of the same parents be tested for it? How can doctors ensure they have not wrongly diagnosed someone that has FUMHD (in my loved one FUMHD was confused with chicken pox)? At what point does the disease stop being PLEVA and become FUMHD? What are the signs and symptoms that someone has FUMHD? How do doctors determine whether or not the treatments being administered for FUMD are working? At what point should Methotrexate be used to treat FUMHD? When should MRI's and X-rays be used to look for disease affecting the interior?</Text>
    <Focus start="27" len="5" />
    <Question id="T1" start="0" len="33">
      <SubQuestion qt="Susceptibility">How does a person contract FUMHD?</SubQuestion>
    </Question>
    <Question id="T2" start="34" len="33">
      <SubQuestion qt="Diagnosis">How is a person tested for FUMHD?</SubQuestion>
    </Question>
    <Question id="T3" start="68" len="74">
      <SubQuestion qt="Diagnosis">If it is genetic, can other children of the same parents be tested for it?</SubQuestion>
    </Question>
    <Question id="T4" start="143" len="132">
      <SubQuestion qt="Diagnosis">How can doctors ensure they have not wrongly diagnosed someone that has FUMHD (in my loved one FUMHD was confused with chicken pox)?</SubQuestion>
    </Question>
    <Question id="T5" start="276" len="65">
      <SubQuestion qt="Other">At what point does the disease stop being PLEVA and become FUMHD?</SubQuestion>
    </Question>
    <Question id="T6" start="342" len="55">
      <SubQuestion qt="Manifestation">What are the signs that someone has FUMHD?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms that someone has FUMHD?</SubQuestion>
    </Question>
    <Question id="T7" start="398" len="95">
      <SubQuestion qt="Management">How do doctors determine whether or not the treatments being administered for FUMD are working?</SubQuestion>
    </Question>
    <Question id="T8" start="494" len="57">
      <SubQuestion qt="Management">At what point should Methotrexate be used to treat FUMHD?</SubQuestion>
    </Question>
    <Question id="T9" start="552" len="80">
      <SubQuestion qt="Diagnosis">When should MRI's be used to look for disease affecting the interior?</SubQuestion>
      <SubQuestion qt="Diagnosis">When should X-rays be used to look for disease affecting the interior?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0228">
    <Text>How does cardiofaciocutaneous syndrome affect an individual's livelihood?</Text>
    <Focus start="9" len="29" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Prognosis">How does cardiofaciocutaneous syndrome affect an individual's livelihood?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0229">
    <Text>How does diet affect lichen sclerosus?  Are there certain foods that should be avoided?</Text>
    <Focus start="21" len="16" />
    <Question id="T1" start="0" len="38">
      <SubQuestion qt="Management">How does diet affect lichen sclerosus?</SubQuestion>
    </Question>
    <Question id="T2" start="40" len="47">
      <SubQuestion qt="Management">Are there certain foods that should be avoided?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0230">
    <Text>How does Klippel Trenaunay syndrome (KTS) occur? How, if it is not inherited, does it come about? Which gene is associated with it?</Text>
    <Focus start="9" len="32" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Susceptibility">How does Klippel Trenaunay syndrome (KTS) occur?</SubQuestion>
    </Question>
    <Question id="T2" start="49" len="48">
      <SubQuestion qt="Susceptibility">How, if it is not inherited, does it come about?</SubQuestion>
    </Question>
    <Question id="T3" start="98" len="33">
      <SubQuestion qt="Cause">Which gene is associated with it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0231">
    <Text>How does one get tested for pityriasis lichenoides chronica?</Text>
    <Focus start="28" len="31" />
    <Question id="T1" start="0" len="60">
      <SubQuestion qt="Diagnosis">How does one get tested for pityriasis lichenoides chronica?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0232">
    <Text>How does Sturge-Weber syndrome affect adults? I'm a 43-year-old person who has this disorder and had my birthmark removed at age 4.</Text>
    <Focus start="9" len="21" />
    <Question id="T1" start="0" len="45">
      <SubQuestion qt="OtherEffect">How does Sturge-Weber syndrome affect adults?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0233">
    <Text>How does this syndrome begin in a lineage? Is the TP53 gene mutation a sudden and spontaneous mutation at conception? Does it have environmental causes? Is it a gradual generational erosion of gene integrity finally resulting in the full mutation that causes this syndrome? Are some TP53 genes mutated worse than others? We are trying to trace this through our family tree.</Text>
    <Focus start="50" len="18" />
    <Question id="T1" start="0" len="42">
      <SubQuestion qt="Susceptibility">How does this syndrome begin in a lineage?</SubQuestion>
    </Question>
    <Question id="T2" start="43" len="74">
      <SubQuestion qt="Susceptibility">Is the TP53 gene mutation a sudden and spontaneous mutation at conception?</SubQuestion>
    </Question>
    <Question id="T3" start="118" len="34">
      <SubQuestion qt="Cause">Does it have environmental causes?</SubQuestion>
    </Question>
    <Question id="T4" start="153" len="120">
      <SubQuestion qt="Cause">Is it a gradual generational erosion of gene integrity finally resulting in the full mutation that causes this syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="274" len="46">
      <SubQuestion qt="NotDisease">Are some TP53 genes mutated worse than others?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0234">
    <Text>How do I get rid of MYH 9 related thrombocytopenia?</Text>
    <Focus start="20" len="30" />
    <Question id="T1" start="0" len="51">
      <SubQuestion qt="Management">How do I get rid of MYH 9 related thrombocytopenia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0235">
    <Text>How do people inherit pseudoachondroplasia?</Text>
    <Focus start="22" len="20" />
    <Question id="T1" start="0" len="43">
      <SubQuestion qt="Susceptibility">How do people inherit pseudoachondroplasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0236">
    <Text>How is amyloidosis diagnosed in those with familial Mediterranean fever? How is the effectiveness of colchicine monitored?</Text>
    <Focus start="7" len="11" />
    <Focus start="43" len="28" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Diagnosis">How is amyloidosis diagnosed in those with familial Mediterranean fever?</SubQuestion>
    </Question>
    <Question id="T2" start="73" len="49">
      <SubQuestion qt="Management">How is the effectiveness of colchicine monitored?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0237">
    <Text>How is diabetic mastopathy diagnosed and treated?</Text>
    <Focus start="7" len="19" />
    <Question id="T1" start="0" len="49">
      <SubQuestion qt="Diagnosis">How is diabetic mastopathy diagnosed?</SubQuestion>
      <SubQuestion qt="Management">How is diabetic mastopathy treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0238">
    <Text>How is fibrosing mediastinitis treated? How can I learn more about research?</Text>
    <Focus start="7" len="23" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Management">How is fibrosing mediastinitis treated?</SubQuestion>
    </Question>
    <Question id="T2" start="40" len="36">
      <SubQuestion qt="Information" attrs="Research">How can I learn more about research?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0239">
    <Text>How is Fox-Fordyce disease treated? Are there over-the-counter drugs that will help? What can I do for maintanence?</Text>
    <Focus start="7" len="19" />
    <Question id="T2" start="0" len="35">
      <SubQuestion qt="Management">How is Fox-Fordyce disease treated?</SubQuestion>
    </Question>
    <Question id="T4" start="36" len="48">
      <SubQuestion qt="Management">Are there over-the-counter drugs that will help?</SubQuestion>
    </Question>
    <Question id="T1" start="85" len="30">
      <SubQuestion qt="Management">What can I do for maintanence?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0240">
    <Text>How is gene therapy being used to treat conditions like retinitis pigmentosa? Does gene therapy involve transplanting healthy human eye cells in the diseased retina? How can I learn more about clinical trials and research studies investigating new treatments for retinitis pigmentosa?</Text>
    <Focus start="56" len="20" />
    <Question id="T1" start="0" len="77">
      <SubQuestion qt="Management">How is gene therapy being used to treat conditions like retinitis pigmentosa?</SubQuestion>
    </Question>
    <Question id="T3" start="78" len="87">
      <SubQuestion qt="Management">Does gene therapy involve transplanting healthy human eye cells in the diseased retina?</SubQuestion>
    </Question>
    <Question id="T4" start="166" len="118">
      <SubQuestion qt="Management" attrs="Research">How can I learn more about clinical trials investigating new treatments for retinitis pigmentosa?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">How can I learn more about research studies investigating new treatments for retinitis pigmentosa?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0241">
    <Text>How is immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) found in a woman's body?  And also how rare is this disease?</Text>
    <Focus start="7" len="66" />
    <Question id="T1" start="0" len="98">
      <SubQuestion qt="Diagnosis">How is immunodysregulation polyendocrinopathy enteropathy x-linked (IPEX) found in a woman's body?</SubQuestion>
    </Question>
    <Question id="T2" start="100" len="34">
      <SubQuestion qt="Susceptibility">How rare is this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0242">
    <Text>How is N-acetylglutamate synthase deficiency inherited? Are there any new research studies enrolling people with N-acetylglutamate synthase deficiency? How can I get my loved one seen at the National Institutes of Health?</Text>
    <Focus start="7" len="37" />
    <Question id="T2" start="0" len="55">
      <SubQuestion qt="Susceptibility">How is N-acetylglutamate synthase deficiency inherited?</SubQuestion>
    </Question>
    <Question id="T4" start="56" len="95">
      <SubQuestion qt="PersonOrg" attrs="Research">Are there any new research studies enrolling people with N-acetylglutamate synthase deficiency?</SubQuestion>
    </Question>
    <Question id="T1" start="152" len="69">
      <SubQuestion qt="PersonOrg" attrs="Research">How can I get my loved one seen at the National Institutes of Health?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0243">
    <Text>How is neurofibromatosis inherited?</Text>
    <Focus start="7" len="17" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Susceptibility">How is neurofibromatosis inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0244">
    <Text>How is optic neuritis diagnosed?</Text>
    <Focus start="7" len="14" />
    <Question id="T1" start="0" len="32">
      <SubQuestion qt="Diagnosis">How is optic neuritis diagnosed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0245">
    <Text>How is orotic aciduria type I diagnosed?  How is it treated?</Text>
    <Focus start="7" len="22" />
    <Question id="T1" start="0" len="40">
      <SubQuestion qt="Diagnosis">How is orotic aciduria type I diagnosed?</SubQuestion>
    </Question>
    <Question id="T3" start="42" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0246">
    <Text>How is pseudotumor cerebri treated? What is the prognosis for patients with this condition?</Text>
    <Focus start="7" len="19" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Management">How is pseudotumor cerebri treated?</SubQuestion>
    </Question>
    <Question id="T2" start="36" len="55">
      <SubQuestion qt="Prognosis">What is the prognosis for patients with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0247">
    <Text>How is Rotor syndrome diagnosed?</Text>
    <Focus start="7" len="14" />
    <Question id="T1" start="0" len="32">
      <SubQuestion qt="Diagnosis">How is Rotor syndrome diagnosed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0248">
    <Text>How is the diagnosis of Shwachman-Diamond syndrome confirmed?</Text>
    <Focus start="24" len="26" />
    <Question id="T1" start="0" len="61">
      <SubQuestion qt="Diagnosis">How is the diagnosis of Shwachman-Diamond syndrome confirmed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0249">
    <Text>How is trigeminal neuralgia treated? What is the long-term outlook for individuals with this condition?</Text>
    <Focus start="7" len="20" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Management">How is trigeminal neuralgia treated?</SubQuestion>
    </Question>
    <Question id="T2" start="37" len="66">
      <SubQuestion qt="Prognosis">What is the long-term outlook for individuals with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0250">
    <Text>How is yellow nail syndrome treated? Can it be treated or not?</Text>
    <Focus start="7" len="20" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Management">How is yellow nail syndrome treated?</SubQuestion>
    </Question>
    <Question id="T3" start="37" len="25">
      <SubQuestion qt="Management">Can it be treated or not?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0251">
    <Text>How many cases of polyembryoma have been reported worldwide?  What is the prognosis for polyembryoma?  How might this condition be treated?  What causes polyembryoma?</Text>
    <Focus start="18" len="12" />
    <Question id="T1" start="0" len="60">
      <SubQuestion qt="Susceptibility">How many cases of polyembryoma have been reported worldwide?</SubQuestion>
    </Question>
    <Question id="T2" start="62" len="39">
      <SubQuestion qt="Prognosis">What is the prognosis for polyembryoma?</SubQuestion>
    </Question>
    <Question id="T4" start="103" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
    <Question id="T5" start="141" len="25">
      <SubQuestion qt="Cause">What causes polyembryoma?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0252">
    <Text>How many cases of schizencephaly have been reported in Florida, and worldwide? Will my child always have develomental delay, and will this get worse with every seizure? What is the prognosis for this condition?</Text>
    <Focus start="18" len="14" />
    <Question id="T1" start="0" len="78">
      <SubQuestion qt="Susceptibility">How many cases of schizencephaly have been reported in Florida?</SubQuestion>
      <SubQuestion qt="Susceptibility">How many cases of schizencephaly have been reported in worldwide?</SubQuestion>
    </Question>
    <Question id="T2" start="79" len="45">
      <SubQuestion qt="Prognosis">Will my child always have develomental delay?</SubQuestion>
    </Question>
    <Question id="T3" start="125" len="43">
      <SubQuestion qt="Prognosis">Will this get worse with every seizure?</SubQuestion>
    </Question>
    <Question id="T4" start="169" len="41">
      <SubQuestion qt="Prognosis">What is the prognosis for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0253">
    <Text>How many individuals in the United States have been diagnosed with hereditary mucoepithelial dysplasia (HMD)? Is there any research on HMD in progress? Are there any HMD support groups?</Text>
    <Focus start="67" len="41" />
    <Question id="T1" start="0" len="109">
      <SubQuestion qt="Susceptibility">How many individuals in the United States have been diagnosed with hereditary mucoepithelial dysplasia (HMD)?</SubQuestion>
    </Question>
    <Question id="T3" start="110" len="41">
      <SubQuestion qt="Information" attrs="Research">Is there any research on HMD in progress?</SubQuestion>
    </Question>
    <Question id="T4" start="152" len="33">
      <SubQuestion qt="PersonOrg">Are there any HMD support groups?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0254">
    <Text>How many people are affected by Alexander disease?</Text>
    <Focus start="32" len="17" />
    <Question id="T1" start="0" len="50">
      <SubQuestion qt="Susceptibility">How many people are affected by Alexander disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0255">
    <Text>How many people are affected by dysfibrinogenemia?</Text>
    <Focus start="32" len="17" />
    <Question id="T1" start="0" len="50">
      <SubQuestion qt="Susceptibility">How many people are affected by dysfibrinogenemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0256">
    <Text>How many people are diagnosed with myostatin-related muscle hypertrophy?</Text>
    <Focus start="35" len="36" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Susceptibility">How many people are diagnosed with myostatin-related muscle hypertrophy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0257">
    <Text>How many people have acute promyelocytic leukemia?</Text>
    <Focus start="21" len="28" />
    <Question id="T1" start="0" len="50">
      <SubQuestion qt="Susceptibility">How many people have acute promyelocytic leukemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0258">
    <Text>How many people have been diagnosed with Christianson syndrome?</Text>
    <Focus start="41" len="21" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Susceptibility">How many people have been diagnosed with Christianson syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0259">
    <Text>How many people in the world have potassium aggravated myotonia?</Text>
    <Focus start="34" len="29" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="Susceptibility">How many people in the world have potassium aggravated myotonia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0260">
    <Text>How many types of pachyonychia congenita are there? How are they caused? Is the condition more likely to occur in certain groups of people? How many individuals have this condition and what is the mortality rate?</Text>
    <Focus start="18" len="22" />
    <Question id="T1" start="0" len="51">
      <SubQuestion qt="Information">How many types of pachyonychia congenita are there?</SubQuestion>
    </Question>
    <Question id="T3" start="52" len="20">
      <SubQuestion qt="Cause">How are they caused?</SubQuestion>
    </Question>
    <Question id="T4" start="73" len="66">
      <SubQuestion qt="Susceptibility">Is the condition more likely to occur in certain groups of people?</SubQuestion>
    </Question>
    <Question id="T5" start="140" len="40">
      <SubQuestion qt="Susceptibility">How many individuals have this condition?</SubQuestion>
    </Question>
    <Question id="T6" start="181" len="31">
      <SubQuestion qt="Prognosis">What is the mortality rate?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0261">
    <Text>How might ataxia telangiectasia affect a person's ability to move and speak?</Text>
    <Focus start="10" len="21" />
    <Question id="T1" start="0" len="76">
      <SubQuestion qt="Prognosis">How might ataxia telangiectasia affect a person's ability to move?</SubQuestion>
      <SubQuestion qt="Prognosis">How might ataxia telangiectasia affect a person's ability to speak?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0262">
    <Text>How might Brown-Sequard syndrome be treated?</Text>
    <Focus start="10" len="22" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Management">How might Brown-Sequard syndrome be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0263">
    <Text>How might Brown syndrome be treated?</Text>
    <Focus start="10" len="14" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Management">How might Brown syndrome be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0264">
    <Text>How might Crohn's disease be treated?</Text>
    <Focus start="10" len="15" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Management">How might Crohn's disease be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0265">
    <Text>How might Eagle syndrome be treated?</Text>
    <Focus start="10" len="14" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Management">How might Eagle syndrome be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0266">
    <Text>How might Maffucci syndrome be treated?</Text>
    <Focus start="10" len="17" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Management">How might Maffucci syndrome be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0267">
    <Text>How might multicentric Castleman's disease be treated?</Text>
    <Focus start="10" len="32" />
    <Question id="T1" start="0" len="54">
      <SubQuestion qt="Management">How might multicentric Castleman's disease be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0268">
    <Text>How might neuronal intranuclear inclusion disease affect a person over time?</Text>
    <Focus start="10" len="39" />
    <Question id="T1" start="0" len="76">
      <SubQuestion qt="Prognosis">How might neuronal intranuclear inclusion disease affect a person over time?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0269">
    <Text>How might pain caused by transverse myelitis be treated?</Text>
    <Focus start="25" len="19" />
    <Question id="T1" start="0" len="56">
      <SubQuestion qt="Management">How might pain caused by transverse myelitis be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0270">
    <Text>How might scleroderma be treated?</Text>
    <Focus start="10" len="11" />
    <Question id="T1" start="0" len="33">
      <SubQuestion qt="Management">How might scleroderma be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0271">
    <Text>How might tyrosinemia type 2 be treated?</Text>
    <Focus start="10" len="18" />
    <Question id="T1" start="0" len="40">
      <SubQuestion qt="Management">How might tyrosinemia type 2 be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0272">
    <Text>How quickly do desmoid tumors typically progress?  Is five months a significant period of time with regard to the growth of such a tumor?</Text>
    <Focus start="15" len="14" />
    <Question id="T1" start="0" len="49">
      <SubQuestion qt="Prognosis">How quickly do desmoid tumors typically progress?</SubQuestion>
    </Question>
    <Question id="T3" start="51" len="86">
      <SubQuestion qt="Prognosis">Is five months a significant period of time with regard to the growth of such a tumor?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0273">
    <Text>How rare is adult-onset vitelliform macular dystrophy?</Text>
    <Focus start="12" len="41" />
    <Question id="T1" start="0" len="54">
      <SubQuestion qt="Susceptibility">How rare is adult-onset vitelliform macular dystrophy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0274">
    <Text>How rare is autoimmune polyglandular syndrome type 1?</Text>
    <Focus start="12" len="40" />
    <Question id="T1" start="0" len="53">
      <SubQuestion qt="Susceptibility">How rare is autoimmune polyglandular syndrome type 1?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0275">
    <Text>How rare is Bannayan-Riley-Ruvalcaba syndrome?  Can affected individuals die from this condition?</Text>
    <Focus start="12" len="33" />
    <Question id="T1" start="0" len="46">
      <SubQuestion qt="Susceptibility">How rare is Bannayan-Riley-Ruvalcaba syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="48" len="49">
      <SubQuestion qt="Prognosis">Can affected individuals die from this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0276">
    <Text>How rare is Barakat syndrome?</Text>
    <Focus start="12" len="16" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Susceptibility">How rare is Barakat syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0277">
    <Text>How rare is Eagle syndrome?  Is surgery the best treatment? What kind of doctor would perform this surgery?</Text>
    <Focus start="12" len="14" />
    <Question id="T1" start="0" len="27">
      <SubQuestion qt="Susceptibility">How rare is Eagle syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="29" len="30">
      <SubQuestion qt="Management">Is surgery the best treatment?</SubQuestion>
    </Question>
    <Question id="T3" start="60" len="47">
      <SubQuestion qt="PersonOrg">What kind of doctor would perform this surgery?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0278">
    <Text>How rare is hypopituitarism?</Text>
    <Focus start="12" len="15" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Susceptibility">How rare is hypopituitarism?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0279">
    <Text>How rare is multiple endocrine neoplasia type 2A? How is this condition inherited?</Text>
    <Focus start="12" len="36" />
    <Question id="T1" start="0" len="49">
      <SubQuestion qt="Susceptibility">How rare is multiple endocrine neoplasia type 2A?</SubQuestion>
    </Question>
    <Question id="T3" start="50" len="32">
      <SubQuestion qt="Susceptibility">How is this condition inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0280">
    <Text>How rare is Pelizaeus-Merzbacher disease?</Text>
    <Focus start="12" len="28" />
    <Question id="T1" start="0" len="41">
      <SubQuestion qt="Susceptibility">How rare is Pelizaeus-Merzbacher disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0281">
    <Text>How rare is retinochoroidal coloboma? What percentage of people with ocular coloboma have retinochoroidal?</Text>
    <Focus start="12" len="24" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Susceptibility">How rare is retinochoroidal coloboma?</SubQuestion>
    </Question>
    <Question id="T3" start="38" len="68">
      <SubQuestion qt="Susceptibility">What percentage of people with ocular coloboma have retinochoroidal?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0282">
    <Text>How rare is this disease? How many Americans are diagnosed with it?</Text>
    <Focus start="12" len="12" />
    <Question id="T1" start="0" len="25">
      <SubQuestion qt="Susceptibility">How rare is this disease?</SubQuestion>
    </Question>
    <Question id="T2" start="26" len="41">
      <SubQuestion qt="Susceptibility">How many Americans are diagnosed with it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0283">
    <Text>How should patients with Birt Hogg Dube syndrome be monitored (i.e. for kidney tumors)?</Text>
    <Focus start="25" len="23" />
    <Question id="T1" start="0" len="87">
      <SubQuestion qt="Management">How should patients with Birt Hogg Dube syndrome be monitored (i.e. for kidney tumors)?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0284">
    <Text>How soon after birth can this be diagnosed? When is it known how severely an individual is affected? Is it possible to live a normal life?</Text>
    <Focus start="25" len="4" />
    <Question id="T1" start="0" len="43">
      <SubQuestion qt="Diagnosis">How soon after birth can this be diagnosed?</SubQuestion>
    </Question>
    <Question id="T2" start="44" len="56">
      <SubQuestion qt="Prognosis">When is it known how severely an individual is affected?</SubQuestion>
    </Question>
    <Question id="T3" start="101" len="37">
      <SubQuestion qt="Prognosis">Is it possible to live a normal life?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0285">
    <Text>How was hepatic encephalopathy discovered, and who first described it? Is there a chance of passing this condition along to my children?</Text>
    <Focus start="8" len="22" />
    <Question id="T1" start="0" len="42">
      <SubQuestion qt="Other">How was hepatic encephalopathy discovered?</SubQuestion>
    </Question>
    <Question id="T2" start="43" len="27">
      <SubQuestion qt="Other">Who first described it?</SubQuestion>
    </Question>
    <Question id="T3" start="71" len="65">
      <SubQuestion qt="Susceptibility">Is there a chance of passing this condition along to my children?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0286">
    <Text>Hypolipoproteinemia runs in my family. I can't find much information on this topic. I'd like to know if the symptoms I am experiencing are due to this condition. Who can I talk to?</Text>
    <Focus start="0" len="19" />
    <Question id="T4" start="84" len="77">
      <SubQuestion qt="Manifestation">I'd like to know if the symptoms I am experiencing are due to this condition.</SubQuestion>
    </Question>
    <Question id="T5" start="162" len="18">
      <SubQuestion qt="PersonOrg">Who can I talk to?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0287">
    <Text>I am 23 years old. For 3 years I have been suffering from this critical problem. Please suggest how I might get rid of it so I can enjoy my life.</Text>
    <Focus start="58" len="21" />
    <Question id="T3" start="81" len="64">
      <SubQuestion qt="Management">Please suggest how I might get rid of it so I can enjoy my life.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0288">
    <Text>I am 26 years old and I have wandering spleen. I would like to know what is the best treatment option for my problem. Can I have a healthy pregnancy with my condition? What are the consequences of spleen removal surgery?</Text>
    <Focus start="29" len="16" />
    <Question id="T2" start="47" len="70">
      <SubQuestion qt="Management">I would like to know what is the best treatment option for my problem.</SubQuestion>
    </Question>
    <Question id="T3" start="118" len="49">
      <SubQuestion qt="OtherEffect">Can I have a healthy pregnancy with my condition?</SubQuestion>
    </Question>
    <Question id="T4" start="168" len="52">
      <SubQuestion qt="NotDisease">What are the consequences of spleen removal surgery?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0289">
    <Text>I am 31 years old and my husband and I are considering starting a family. I was born with a bifid nose which was repaired as a child. I am wondering if you can explain the role of genetics and the bifid nose.</Text>
    <Focus start="92" len="10" />
    <Question id="T4" start="134" len="74">
      <SubQuestion qt="Susceptibility">I am wondering if you can explain the role of genetics and the bifid nose.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0290">
    <Text>I am 4 feet, 11 inches tall with many medical complications since childhood. How can I find out if I have dwarfism or any other condition?</Text>
    <Focus start="106" len="8" />
    <Question id="T2" start="77" len="61">
      <SubQuestion qt="Diagnosis" attrs="Error">How can I find out if I have dwarfism or any other condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0291">
    <Text>I am 52 years old.  I have had this illness for almost ten years. I had anterior neck surgery in 2008 and posterior neck surgery in 2009, with four titanium screws. May I ask you to help me or to guide me so I can treat this illness?  Because of this illness I lost everything. I am now totally disabled.</Text>
    <Focus start="31" len="12" />
    <Question id="T4" start="165" len="68">
      <SubQuestion qt="Management" attrs="Error">May I ask you to help me or to guide me so I can treat this illness?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0292">
    <Text>I am 58-years-old, and in the last year I have lost my fingerprints. When researching why this may have happened, I came across Naegeli syndrome and discovered that there were more symptoms that matched mine.Could you tell me how this condition is diagnosed? Is there a way to cure or halt the symptoms of the syndrome?</Text>
    <Focus start="128" len="16" />
    <Question id="T4" start="208" len="50">
      <SubQuestion qt="Diagnosis">Could you tell me how this condition is diagnosed?</SubQuestion>
    </Question>
    <Question id="T5" start="259" len="60">
      <SubQuestion qt="Management">Is there a way to cure the symptoms of the syndrome?</SubQuestion>
      <SubQuestion qt="Management">Is there a way to halt the symptoms of the syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0293">
    <Text>I am 6 months pregnant and was told that my baby has colpocephaly. I would like to learn more about this condition and what the prognosis is for a baby born with it.</Text>
    <Focus start="53" len="12" />
    <Question id="T3" start="67" len="98">
      <SubQuestion qt="Information">I would like to learn more about this condition.</SubQuestion>
      <SubQuestion qt="Prognosis">I would like to learn what the prognosis is for a baby born with it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0294">
    <Text>I am a 46 year old female who was born with Polands Syndrome. I was missing the upper ribs and the chest wall on my right side. As a result I am now facing multiple spinal problems and am looking for the correct treatment by the correct specialists. How do I go about finding spine specialists who have worked with this condition?</Text>
    <Focus start="44" len="16" />
    <Question id="T5" start="250" len="80">
      <SubQuestion qt="PersonOrg">How do I go about finding spine specialists who have worked with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0295">
    <Text>I am a black female and was recently diagnosed with pityriasis rotunda after a skin biopsy. There is not much information about this condition. The little information I found on the Internet is somewhat disturbing. I'm looking for more information and what should be the next step to follow.</Text>
    <Focus start="52" len="18" />
    <Question id="T5" start="215" len="76">
      <SubQuestion qt="Information">I'm looking for more information.</SubQuestion>
      <SubQuestion qt="Information">I'm looking for what should be the next step to follow.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0296">
    <Text>I am a carrier for recombinant chromosome 8 syndrome. Should my children have a blood test to see if they are also carriers?</Text>
    <Focus start="19" len="33" />
    <Question id="T2" start="54" len="70">
      <SubQuestion qt="Diagnosis">Should my children have a blood test to see if they are also carriers?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0297">
    <Text>I am a carrier of Duchenne muscular dystrophy. I am experiencing some symptoms which I believe go beyond the realm of aging. Upon reflection, other women in my family also experienced symptoms, including loss of feeling in the legs and heart failure. Can carrier females of Duchenne muscular dystrophy exhibit symptoms?</Text>
    <Focus start="18" len="27" />
    <Question id="T4" start="251" len="68">
      <SubQuestion qt="Manifestation">Can carrier females of Duchenne muscular dystrophy exhibit symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0298">
    <Text>I am a dermatologist and I have a patient requesting patient-friendly information on this condition. Can you provide this and direct me to some appropriate resources?</Text>
    <Focus start="85" len="14" />
    <Question id="T2" start="101" len="65">
      <SubQuestion qt="Information" attrs="Error">Can you provide this and direct me to some appropriate resources?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0299">
    <Text>I am affected by familial autosomal dominant periodic fever, as are two of my three children. Can you provide us with information about this condition?</Text>
    <Focus start="17" len="42" />
    <Question id="T3" start="94" len="57">
      <SubQuestion qt="Information">Can you provide us with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0300">
    <Text>I am a genetic counselor.  We recently made a diagnosis of Sjogren-Larsson in a young child, and I am on the search for patient information for her family.  I have found very little information so far (besides medical journal articles).  Would you be able to point me to any other source of information (besides FIRST) where I can find information to pass along to this family?  The family will be coming back early next week to discuss the diagnosis.</Text>
    <Focus start="59" len="15" />
    <Question id="T4" start="238" len="139">
      <SubQuestion qt="Information">Would you be able to point me to any other source of information (besides FIRST) where I can find information to pass along to this family?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0301">
    <Text>I am a healthcare provider for a 4-year-old girl with cytochrome C oxidase deficiency. How does this condition manifest? What is the life expectancy for a child with this diagnosis? She continues to gain new skills, but will she at some point show a regression in skills? She is diagnosed as having cortical visual impairment, though she continues to rely on her vision to gain information about her environment. Will she eventually go completely blind?</Text>
    <Focus start="54" len="31" />
    <Question id="T2" start="87" len="33">
      <SubQuestion qt="Manifestation">How does this condition manifest?</SubQuestion>
    </Question>
    <Question id="T4" start="121" len="60">
      <SubQuestion qt="Prognosis">What is the life expectancy for a child with this diagnosis?</SubQuestion>
    </Question>
    <Question id="T5" start="182" len="89">
      <SubQuestion qt="Prognosis">She continues to gain new skills, but will she at some point show a regression in skills?</SubQuestion>
    </Question>
    <Question id="T7" start="413" len="40">
      <SubQuestion qt="Prognosis">Will she eventually go completely blind?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0302">
    <Text>I am a layperson and many articles I have seen are geared toward those with medical backgrounds.  Has it been determined that pentalogy of Cantrell is genetic?  Is it X-linked?  Does this mean that male children are at risk?  And how does this impact future siblings?</Text>
    <Focus start="126" len="21" />
    <Question id="T2" start="98" len="61">
      <SubQuestion qt="Susceptibility">Has it been determined that pentalogy of Cantrell is genetic?</SubQuestion>
    </Question>
    <Question id="T3" start="161" len="15">
      <SubQuestion qt="Information">Is it X-linked?</SubQuestion>
    </Question>
    <Question id="T4" start="178" len="46">
      <SubQuestion qt="Susceptibility">Does this mean that male children are at risk?</SubQuestion>
    </Question>
    <Question id="T5" start="226" len="41">
      <SubQuestion qt="Susceptibility">How does this impact future siblings?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0303">
    <Text>I am an adult woman who has been recently diagnosed with Ménétrier disease.  My symptoms seem to be worsening.  I am seeking information about the symptoms, cause(s), prognosis, genetic association, and treatment.  I am eager to hear from you and appreciate your assistance.</Text>
    <Focus start="57" len="17" />
    <Question id="T3" start="112" len="101">
      <SubQuestion qt="Manifestation">I am seeking information about the symptoms.</SubQuestion>
      <SubQuestion qt="Cause">I am seeking information about the cause(s).</SubQuestion>
      <SubQuestion qt="Prognosis">I am seeking information about the prognosis.</SubQuestion>
      <SubQuestion qt="Susceptibility">I am seeking information about the genetic association.</SubQuestion>
      <SubQuestion qt="Management">I am seeking information about the treatment.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0304">
    <Text>I am a nurse, and I have a patient that presents with some of the classic signs of Rett syndrome. I want to locate a specialist in Rett syndrome genetics. Could your agency send me a list of practicing physicians and clinics with expertise in this area?</Text>
    <Focus start="83" len="13" />
    <Question id="T3" start="98" len="56">
      <SubQuestion qt="PersonOrg">I want to locate a specialist in Rett syndrome genetics.</SubQuestion>
    </Question>
    <Question id="T4" start="155" len="98">
      <SubQuestion qt="PersonOrg">Could your agency send me a list of practicing physicians and clinics with expertise in this area?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0305">
    <Text>I am a personal trainer working with a client who has HD.  While I have seen progress with the exercises we are doing, I am looking for more information regarding the types of exercises that are found to be most effective or certain exercises that should be avoided.</Text>
    <Focus start="54" len="2" />
    <Question id="T2" start="59" len="207">
      <SubQuestion qt="Management">While I have seen progress with the exercises we are doing, I am looking for more information regarding the types of exercises that are found to be most effective.</SubQuestion>
      <SubQuestion qt="Management">While I have seen progress with the exercises we are doing, I am looking for more information regarding certain exercises that should be avoided.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0306">
    <Text>I am a physician who frequently sees patients with Becker muscular dystrophy. Can you provide me with patient-friendly information about this condition?</Text>
    <Focus start="51" len="25" />
    <Question id="T2" start="78" len="74">
      <SubQuestion qt="Information">Can you provide me with patient-friendly information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0307">
    <Text>I am a school nurse and have a new student attending our school with this diagnosis. I would like to learn more about the disease and what we can do to make this student as comfortable as possible.</Text>
    <Focus start="69" len="14" />
    <Question id="T2" start="85" len="112">
      <SubQuestion qt="Information">I would like to learn more about the disease.</SubQuestion>
      <SubQuestion qt="Management">I would like to learn what we can do to make this student as comfortable as possible.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0308">
    <Text>I am a special education teacher. My new student is 5-years-old and is very impacted by this condition. Is his intelligence presumed to be typical? Also are his fungal infections contagious to other students and staff?</Text>
    <Focus start="88" len="14" />
    <Question id="T4" start="104" len="43">
      <SubQuestion qt="OtherEffect">Is his intelligence presumed to be typical?</SubQuestion>
    </Question>
    <Question id="T5" start="148" len="70">
      <SubQuestion qt="Susceptibility">Are his fungal infections contagious to other students and staff?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0309">
    <Text>I am a special educator working with an 18-year-old female who was recently diagnosed with Juvenile Huntington disease. We are attempting to develop an education and health safety plan and would appreciate any information you could provide.</Text>
    <Focus start="91" len="27" />
    <Question id="T2" start="120" len="120">
      <SubQuestion qt="Management">We are attempting to develop an education plan and would appreciate any information you could provide.</SubQuestion>
      <SubQuestion qt="Management">We are attempting to develop an health safety plan and would appreciate any information you could provide.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0310">
    <Text>I am a speech language pathologist with a child affected by Marshall-Smith syndrome on my caseload. Do the symptoms of this syndrome vary widely between patients? Is there any information regarding speech / language prognosis for these children?</Text>
    <Focus start="60" len="23" />
    <Question id="T2" start="100" len="62">
      <SubQuestion qt="Manifestation">Do the symptoms of this syndrome vary widely between patients?</SubQuestion>
    </Question>
    <Question id="T3" start="163" len="82">
      <SubQuestion qt="Prognosis">Is there any information regarding speech prognosis for these children?</SubQuestion>
      <SubQuestion qt="Prognosis">Is there any information regarding language prognosis for these children?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0311">
    <Text>I am associated with a hospital in India as a trainee. Recently, we came across a case of Hereditary spastic paraplegia in a patient. We are unaware of the proper genetic testing to be carried out.  Is a sample for genetic testing are required?</Text>
    <Focus start="90" len="29" />
    <Question id="T4" start="199" len="45">
      <SubQuestion qt="Diagnosis">Is a sample for genetic testing are required?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0312">
    <Text>I am a teacher and I have a student with FEVR. I would like to know if there are any strategies for me to implement to help him. He has undergone laser surgery and wears glasses. He is a second grader and I would like him to meet with success.</Text>
    <Focus start="41" len="4" />
    <Question id="T3" start="47" len="81">
      <SubQuestion qt="Management">I would like to know if there are any strategies for me to implement to help him.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0313">
    <Text>I am a therapist in need of additional information regarding Sotos syndrome.  Are there any support groups with local state chapters?  I have a client that has been diagnosed with Sotos syndrome and I would like to refer the parents to a support group.</Text>
    <Focus start="61" len="14" />
    <Question id="T2" start="78" len="55">
      <SubQuestion qt="PersonOrg">Are there any support groups with local state chapters?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0314">
    <Text>I am curious if this condition can or will effect hearing. Not necessarily hearing loss, but muffled sounds, feeling pressure, etc.</Text>
    <Focus start="16" len="14" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="OtherEffect">I am curious if this condition can or will effect hearing.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0315">
    <Text>I am curious to know if there is a genetic link to Sheehan syndrome. My maternal grandmother hemorrhaged after her 5th child and ended up losing all of the hair on her body, less the hair on her head. My maternal aunt also hemorrhaged after her 4th child and she too lost all body hair less the hair on her head. Neither were diagnosed with Sheehan syndrome at that time.</Text>
    <Focus start="51" len="16" />
    <Question id="T1" start="0" len="68">
      <SubQuestion qt="Susceptibility">I am curious to know if there is a genetic link to Sheehan syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0316">
    <Text>I am going to be tutoring 2 brothers who have this condition. Information is relatively difficult to find. Is there any information you can email me in regards to symptoms/characteristics that relate to the education of these children? I am just looking for an overview that could help me in providing the best possible strategies for success.</Text>
    <Focus start="46" len="14" />
    <Question id="T3" start="107" len="128">
      <SubQuestion qt="Manifestation">Is there any information you can email me in regards to symptoms that relate to the education of these children?</SubQuestion>
      <SubQuestion qt="OtherEffect">Is there any information you can email me in regards to characteristics that relate to the education of these children?</SubQuestion>
    </Question>
    <Question id="T4" start="236" len="107">
      <SubQuestion qt="Management">I am just looking for an overview that could help me in providing the best possible strategies for success.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0317">
    <Text>I am heterozygous for a factor V Leiden mutation. I was on oral contraceptives for 10 years before trying to get pregnant. After two miscarriages, I was tested and I found out that I had this condition. I saw where you discuss oral contraceptives; but I didn't know if an IUD such as Mirena may be safer to use than an oral contraceptives?</Text>
    <Focus start="24" len="24" />
    <Question id="T4" start="203" len="136">
      <SubQuestion qt="NotDisease">I saw where you discuss oral contraceptives; but I didn't know if an IUD such as Mirena may be safer to use than an oral contraceptives?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0318">
    <Text>I am inquiring about information in regards to BOOP. My husband was recently diagnosed with this rare disease. I am very concerned because I do not understand what is happening to his body. We are dumbfounded on why and how he contracted this disease. Please forward me any info you have to share.</Text>
    <Focus start="47" len="4" />
    <Question id="T1" start="0" len="52">
      <SubQuestion qt="Information">I am inquiring about information in regards to BOOP.</SubQuestion>
    </Question>
    <Question id="T5" start="190" len="61">
      <SubQuestion qt="Susceptibility">We are dumbfounded on why he contracted this disease.</SubQuestion>
      <SubQuestion qt="Susceptibility">We are dumbfounded on how he contracted this disease.</SubQuestion>
    </Question>
    <Question id="T6" start="252" len="45">
      <SubQuestion qt="Information">Please forward me any info you have to share.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0319">
    <Text>I am interested in a good treatment for the condition. I was told that antibiotics are not necessarily good for this.</Text>
    <Focus start="40" len="13" />
    <Question id="T1" start="0" len="54">
      <SubQuestion qt="Management">I am interested in a good treatment for the condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0320">
    <Text>I am interested in finding out information related to dihydropyrimidine dehydrogenase (DPD) in children - I am not interested in the form that presents after exposure to the cancer drug 5-fluorouracil. My son is about to turn 5 years old and was diagnosed with DPD at 4 months. Are there any specific articles that speak about infants and children that suffer from the deficiency?</Text>
    <Focus start="54" len="37" />
    <Question id="T1" start="0" len="105">
      <SubQuestion qt="Information">I am interested in finding out information related to dihydropyrimidine dehydrogenase (DPD) in children.</SubQuestion>
    </Question>
    <Question id="T2" start="106" len="95">
      <SubQuestion qt="Information">I am not interested in the form that presents after exposure to the cancer drug 5-fluorouracil.</SubQuestion>
    </Question>
    <Question id="T5" start="278" len="102">
      <SubQuestion qt="Information" attrs="Research">Are there any specific articles that speak about infants that suffer from the deficiency?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Are there any specific articles that speak about children that suffer from the deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0321">
    <Text>I am interested in learning about Tay syndrome.  Can you help? I wish to know: What it is? When was it first described? What are the main symptoms? What are the treatments? What is the average life expectancy for sufferers?</Text>
    <Focus start="34" len="12" />
    <Question id="T1" start="0" len="47">
      <SubQuestion qt="Information">I am interested in learning about Tay syndrome.</SubQuestion>
    </Question>
    <Question id="T2" start="49" len="13">
      <SubQuestion qt="Information">Can you help?</SubQuestion>
    </Question>
    <Question id="T3" start="63" len="27">
      <SubQuestion qt="Information">I wish to know: What it is?</SubQuestion>
    </Question>
    <Question id="T4" start="91" len="28">
      <SubQuestion qt="Other">When was it first described?</SubQuestion>
    </Question>
    <Question id="T5" start="120" len="27">
      <SubQuestion qt="Manifestation">What are the main symptoms?</SubQuestion>
    </Question>
    <Question id="T6" start="148" len="24">
      <SubQuestion qt="Management">What are the treatments?</SubQuestion>
    </Question>
    <Question id="T7" start="173" len="50">
      <SubQuestion qt="Prognosis">What is the average life expectancy for sufferers?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0322">
    <Text>I am interested in learning more about Sheehan syndrome. What information can you provide?</Text>
    <Focus start="39" len="16" />
    <Question id="T1" start="0" len="56">
      <SubQuestion qt="Information">I am interested in learning more about Sheehan syndrome.</SubQuestion>
    </Question>
    <Question id="T3" start="57" len="33">
      <SubQuestion qt="Information">What information can you provide?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0323">
    <Text>I am interested in reading the most up-to-date research on the use of bisphosphonate therapy in treating adult PFD. What I have found in my search so far is that while it does seem to treat pain associated with PFD, it doesn't actually stop the progression of the condition.  Also, I understand that long-term (over 3 years) use of bisphosphonates actually makes bones subject to fracture.  So I was just looking for some answers.</Text>
    <Focus start="111" len="3" />
    <Question id="T1" start="0" len="115">
      <SubQuestion qt="Management" attrs="Research">I am interested in reading the most up-to-date research on the use of bisphosphonate therapy in treating adult PFD.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0324">
    <Text>I am living in Israel, and my father has the rare disease familial amyloid polyneuropathy. What are the treatment options for this disease? Have people been successfully treated?</Text>
    <Focus start="58" len="31" />
    <Question id="T3" start="91" len="48">
      <SubQuestion qt="Management">What are the treatment options for this disease?</SubQuestion>
    </Question>
    <Question id="T4" start="140" len="38">
      <SubQuestion qt="Management">Have people been successfully treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0325">
    <Text>I am looking for any info about heavy metal toxicity, symptoms, treatment, outcomes.  Especially combined toxicity (e.g., nickle and mercury).  Also looking for diagnostic tools available for heavy metal in humans.</Text>
    <Focus start="32" len="20" />
    <Question id="T1" start="0" len="84">
      <SubQuestion qt="Manifestation">I am looking for any info about heavy metal toxicity, symptoms.</SubQuestion>
      <SubQuestion qt="Management">I am looking for any info about heavy metal toxicity, treatment.</SubQuestion>
      <SubQuestion qt="Prognosis">I am looking for any info about heavy metal toxicity, outcomes.</SubQuestion>
    </Question>
    <Question id="T2" start="86" len="56">
      <SubQuestion qt="Information" attrs="Error">Especially combined toxicity (e.g., nickle and mercury).</SubQuestion>
    </Question>
    <Question id="T3" start="144" len="70">
      <SubQuestion qt="Diagnosis">Looking for diagnostic tools available for heavy metal in humans.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0326">
    <Text>I am looking for any information on Prinzmetal's variant angina, including clinical studies. The medicine they have me on just isn't working for me. What treatment options are available?</Text>
    <Focus start="36" len="27" />
    <Question id="T1" start="0" len="92">
      <SubQuestion qt="Information">I am looking for any information on Prinzmetal's variant angina.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">I am looking for any information on Prinzmetal's variant angina, including clinical studies.</SubQuestion>
    </Question>
    <Question id="T3" start="149" len="37">
      <SubQuestion qt="Management">What treatment options are available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0327">
    <Text>I am looking for any information on treatments and causes for burning mouth syndrome.</Text>
    <Focus start="62" len="22" />
    <Question id="T1" start="0" len="85">
      <SubQuestion qt="Management">I am looking for any information on treatments for burning mouth syndrome.</SubQuestion>
      <SubQuestion qt="Cause">I am looking for any information on causes for burning mouth syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0328">
    <Text>I am looking for information about pseudocholinesterase deficiency in layman's terms for myself and others. Can you tell me more about this condition?</Text>
    <Focus start="35" len="31" />
    <Question id="T1" start="0" len="107">
      <SubQuestion qt="Information">I am looking for information about pseudocholinesterase deficiency in layman's terms for myself and others.</SubQuestion>
    </Question>
    <Question id="T3" start="108" len="42">
      <SubQuestion qt="Information">Can you tell me more about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0329">
    <Text>I am looking for information about this disease and also what types of treatments are available.</Text>
    <Focus start="35" len="12" />
    <Question id="T1" start="0" len="96">
      <SubQuestion qt="Information">I am looking for information about this disease.</SubQuestion>
      <SubQuestion qt="Management">I am looking for information about also what types of treatments are available.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0330">
    <Text>I am looking for information about Von-Hippel Lindau syndrome, including how it might be treated.</Text>
    <Focus start="35" len="26" />
    <Question id="T1" start="0" len="97">
      <SubQuestion qt="Information">I am looking for information about Von-Hippel Lindau syndrome.</SubQuestion>
      <SubQuestion qt="Management">I am looking for information about Von-Hippel Lindau syndrome, including how it might be treated.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0331">
    <Text>I am looking for more general information on granulomatous slack skin syndrome. How many total cases of this condition have been reported?</Text>
    <Focus start="45" len="33" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Information">I am looking for more general information on granulomatous slack skin syndrome.</SubQuestion>
    </Question>
    <Question id="T2" start="80" len="58">
      <SubQuestion qt="Susceptibility">How many total cases of this condition have been reported?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0332">
    <Text>I am looking for more information on wrinkly skin syndrome; its symptoms, body changes, treatment, what to expect, effects on different ages, and cases.</Text>
    <Focus start="37" len="21" />
    <Question id="T1" start="0" len="152">
      <SubQuestion qt="Manifestation" attrs="Error">I am looking for more information on wrinkly skin syndrome; its symptoms.</SubQuestion>
      <SubQuestion qt="OtherEffect">I am looking for more information on wrinkly skin syndrome; its body changes.</SubQuestion>
      <SubQuestion qt="Management">I am looking for more information on wrinkly skin syndrome; its treatment.</SubQuestion>
      <SubQuestion qt="Prognosis">I am looking for more information on wrinkly skin syndrome; its what to expect.</SubQuestion>
      <SubQuestion qt="OtherEffect">I am looking for more information on wrinkly skin syndrome; its effects on different ages.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">I am looking for more information on wrinkly skin syndrome; its cases.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0333">
    <Text>I am looking for recent information on ovarian carcinosarcoma and the chemotherapy regime that is most effective for treating this.</Text>
    <Focus start="39" len="22" />
    <Question id="T1" start="0" len="131">
      <SubQuestion qt="Information">I am looking for recent information on ovarian carcinosarcoma.</SubQuestion>
      <SubQuestion qt="Management">I am looking for the chemotherapy regime that is most effective for treating this.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0334">
    <Text>I am looking for treatment information for PKAN.   My brother was diagnosed with it a little over a year ago. It started about age 3 with all the classic signs. He now is in very bad shape. I am looking for any help. He may start a clinical trial of deferiprone treatment if approved by the FDA.</Text>
    <Focus start="43" len="4" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Management">I am looking for treatment information for PKAN.</SubQuestion>
    </Question>
    <Question id="T5" start="190" len="26">
      <SubQuestion qt="Other">I am looking for any help.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0335">
    <Text>I am receiving genetic testing for spinocerebellar ataxia type 8 in approximately a week. How do I know if I inherited it from my mom or dad? Both are deceased and there is no family history of the disease. I am 62 yrs. old and first noticed symptoms approximately 4 years ago.</Text>
    <Focus start="35" len="29" />
    <Question id="T2" start="90" len="51">
      <SubQuestion qt="Susceptibility">How do I know if I inherited it from my mom or dad?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0336">
    <Text>I am researcher and I'm looking for more information about Gorham Stout disease.</Text>
    <Focus start="59" len="20" />
    <Question id="T1" start="0" len="80">
      <SubQuestion qt="Information" attrs="Research">I am researcher and I'm looking for more information about Gorham Stout disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0337">
    <Text>I am researching the link between Greig cephalopolysyndactyly syndrome, hydrocephalus, and seizures. I am curious about the reason for the hydrocephalus: is it a blockage issue or a slow draining issue?</Text>
    <Focus start="34" len="36" />
    <Focus start="72" len="13" />
    <Focus start="91" len="8" />
    <Question id="T2" start="101" len="101">
      <SubQuestion qt="OtherEffect">I am curious about the reason for the hydrocephalus: is it a blockage issue?</SubQuestion>
      <SubQuestion qt="OtherEffect">I am curious about the reason for the hydrocephalus: is it a slow draining issue?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0338">
    <Text>I am severely affected with Klippel Feil syndrome and my symptoms are worsening with time. Are there any research studies that I could participate in? I am also concerned about the risk to my future offspring. How can I learn more about this risk?</Text>
    <Focus start="28" len="21" />
    <Question id="T2" start="91" len="59">
      <SubQuestion qt="PersonOrg">Are there any research studies that I could participate in?</SubQuestion>
    </Question>
    <Question id="T3" start="151" len="58">
      <SubQuestion qt="Susceptibility">I am also concerned about the risk to my future offspring.</SubQuestion>
    </Question>
    <Question id="T4" start="210" len="37">
      <SubQuestion qt="Information">How can I learn more about this risk?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0339">
    <Text>I am suffering from Kikuchi disease. What kind of treatment should I undergo and is taking painkillers the right treatment?</Text>
    <Focus start="20" len="15" />
    <Question id="T2" start="37" len="39">
      <SubQuestion qt="Management">What kind of treatment should I undergo?</SubQuestion>
    </Question>
    <Question id="T3" start="77" len="46">
      <SubQuestion qt="Management">Is taking painkillers the right treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0340">
    <Text>I am the oldest person alive with Omenn Syndrome.  I don't know much about it except what my grandmother has told me.  She told me that it is an immune deficiency.  Can you tell me more about it?</Text>
    <Focus start="34" len="14" />
    <Question id="T5" start="165" len="30">
      <SubQuestion qt="Information">Can you tell me more about it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0341">
    <Text>I am the parent of a 10-year-old boy with Duchenne muscular dystrophy (DMD). We are seeking information on his specific mutation, he is missing 2 nucleotides on exon 44 causing a frameshift onto exon 45 resulting in mild DMD or severe Becker symptoms. We can't locate any other person with that specific mutation. We have used the Leiden Data Base and Duchenne Connect, and we have asked an expert at the University of Utah. We are trying to determine the potential course this disease will take. Can you offer any suggestions as to how we can find out if another person has the same mutation?</Text>
    <Focus start="42" len="33" />
    <Question id="T2" start="77" len="174">
      <SubQuestion qt="Information">We are seeking information on his specific mutation, he is missing 2 nucleotides on exon 44 causing a frameshift onto exon 45 resulting in mild DMD or severe Becker symptoms.</SubQuestion>
    </Question>
    <Question id="T5" start="425" len="71">
      <SubQuestion qt="Prognosis">We are trying to determine the potential course this disease will take.</SubQuestion>
    </Question>
    <Question id="T6" start="497" len="96">
      <SubQuestion qt="PersonOrg">Can you offer any suggestions as to how we can find out if another person has the same mutation?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0342">
    <Text>I am the parent of a child with GSD type III. I would love to receive any information about the disease, treatments being done, research studies, etc. Thank you for your time.</Text>
    <Focus start="32" len="12" />
    <Question id="T3" start="46" len="104">
      <SubQuestion qt="Information">I would love to receive any information about the disease.</SubQuestion>
      <SubQuestion qt="Management">I would love to receive any information about treatments being done.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">I would love to receive any information about research studies.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0343">
    <Text>I am trying to find a doctor in my area that knows something about pain management for my disease.</Text>
    <Focus start="87" len="10" />
    <Question id="T1" start="0" len="98">
      <SubQuestion qt="PersonOrg">I am trying to find a doctor in my area that knows something about pain management for my disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0344">
    <Text>I am trying to find information about transmission of hepatitis X.  Is it found in Europe or just the USA?</Text>
    <Focus start="54" len="11" />
    <Question id="T1" start="0" len="66">
      <SubQuestion qt="Susceptibility">I am trying to find information about transmission of hepatitis X.</SubQuestion>
    </Question>
    <Question id="T2" start="68" len="38">
      <SubQuestion qt="Susceptibility">Is it found in Europe or just the USA?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0345">
    <Text>I am trying to find more information about osteomyelitis. Can you provide me with the information that I need?</Text>
    <Focus start="43" len="13" />
    <Question id="T1" start="0" len="57">
      <SubQuestion qt="Information">I am trying to find more information about osteomyelitis.</SubQuestion>
    </Question>
    <Question id="T3" start="58" len="52">
      <SubQuestion qt="Information">Can you provide me with the information that I need?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0346">
    <Text>I am trying to find out more information about how to treat my condition.</Text>
    <Focus start="60" len="12" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Management">I am trying to find out more information about how to treat my condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0347">
    <Text>I am trying to find out more information about teratomas with malignant transformation, specifically related to prognosis.  I had a single mass removed with clean margins and no infiltration.  Any studies that have been done about treatment options would be helpful.  Also, are there any other published cases of teratoma and astrocytoma?  I guess I am trying to find out if my type of teratoma would portend a better or worse prognosis than other types, especially given how fast mine developed.</Text>
    <Focus start="47" len="39" />
    <Question id="T1" start="0" len="122">
      <SubQuestion qt="Prognosis">I am trying to find out more information about teratomas with malignant transformation, specifically related to prognosis.</SubQuestion>
    </Question>
    <Question id="T3" start="193" len="73">
      <SubQuestion qt="Management" attrs="Research">Any studies that have been done about treatment options would be helpful.</SubQuestion>
    </Question>
    <Question id="T4" start="268" len="70">
      <SubQuestion qt="Information" attrs="Research">Are there any other published cases of teratoma?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Are there any other published cases of astrocytoma?</SubQuestion>
    </Question>
    <Question id="T6" start="340" len="156">
      <SubQuestion qt="Prognosis">I guess I am trying to find out if my type of teratoma would portend a better or worse prognosis than other types, especially given how fast mine developed.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0348">
    <Text>I am trying to find out more information on anaplastic oligoastrocytoma.</Text>
    <Focus start="44" len="27" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Information">I am trying to find out more information on anaplastic oligoastrocytoma.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0349">
    <Text>I am trying to find studies discussing the potential of genetic inheritance of desmoplastic small round cell tumor.  My friend's brother is now suffering from desmoplastic small round cell tumor and she is concerned about her risks to develop this condition.</Text>
    <Focus start="79" len="35" />
    <Question id="T1" start="0" len="115">
      <SubQuestion qt="Susceptibility" attrs="Research">I am trying to find studies discussing the potential of genetic inheritance of desmoplastic small round cell tumor.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0350">
    <Text>I am trying to research current information for my friend who has been diagnosed with Triple A syndrome. She is looking for understandable information about the disease and possible treatment options. Is there recent information about what might help to treat neuropathy? How can we reach out to other people affected by the condition? How can we find out about current research that is being done to find better treatment alternatives?</Text>
    <Focus start="86" len="17" />
    <Question id="T1" start="0" len="104">
      <SubQuestion qt="Information">I am trying to research current information for my friend who has been diagnosed with Triple A syndrome.</SubQuestion>
    </Question>
    <Question id="T2" start="105" len="95">
      <SubQuestion qt="Information">She is looking for understandable information about the disease.</SubQuestion>
      <SubQuestion qt="Management">She is looking for understandable information about possible treatment options.</SubQuestion>
    </Question>
    <Question id="T3" start="201" len="70">
      <SubQuestion qt="Management">Is there recent information about what might help to treat neuropathy?</SubQuestion>
    </Question>
    <Question id="T4" start="272" len="63">
      <SubQuestion qt="PersonOrg">How can we reach out to other people affected by the condition?</SubQuestion>
    </Question>
    <Question id="T5" start="336" len="100">
      <SubQuestion qt="Management" attrs="Research">How can we find out about current research that is being done to find better treatment alternatives?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0351">
    <Text>I am wondering about Townes-Brock syndrome because I was born with this condition and I don't know anything about it. Can you provide me with all the information that you have on Townes-Brock syndrome?</Text>
    <Focus start="21" len="21" />
    <Question id="T3" start="118" len="83">
      <SubQuestion qt="Information">Can you provide me with all the information that you have on Townes-Brock syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0352">
    <Text>I am writing an English research paper on Tourette syndrome. Can Tourette syndrome be cured? What are the treatment options? Please provide any available information.</Text>
    <Focus start="42" len="17" />
    <Question id="T3" start="61" len="31">
      <SubQuestion qt="Management">Can Tourette syndrome be cured?</SubQuestion>
    </Question>
    <Question id="T4" start="93" len="31">
      <SubQuestion qt="Management">What are the treatment options?</SubQuestion>
    </Question>
    <Question id="T5" start="125" len="41">
      <SubQuestion qt="Information">Please provide any available information.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0353">
    <Text>I am writing to ask for some information on hyperprolinemia type 2. Do individuals with this condition have a shortened lifespan? Is there any treatment for people who have severe symptoms? Are there any clinical trials studying the use of vitamin B6?</Text>
    <Focus start="44" len="22" />
    <Question id="T1" start="0" len="67">
      <SubQuestion qt="Information">I am writing to ask for some information on hyperprolinemia type 2.</SubQuestion>
    </Question>
    <Question id="T3" start="68" len="61">
      <SubQuestion qt="Prognosis">Do individuals with this condition have a shortened lifespan?</SubQuestion>
    </Question>
    <Question id="T4" start="130" len="59">
      <SubQuestion qt="Management">Is there any treatment for people who have severe symptoms?</SubQuestion>
    </Question>
    <Question id="T5" start="190" len="61">
      <SubQuestion qt="Management" attrs="Research">Are there any clinical trials studying the use of vitamin B6?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0354">
    <Text>I believe I have hereditary neuralgic amyotrophy. Can this condition affect the legs? I am having an attack in my right leg which seems to be very similar to what I have had in my shoulders and arms for 20 years.</Text>
    <Focus start="17" len="31" />
    <Question id="T3" start="50" len="35">
      <SubQuestion qt="Anatomy">Can this condition affect the legs?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0355">
    <Text>I believe I may have occipital horn syndrome.  How can I be tested for this? Is it important, for personal or research purposes, that I get tested?</Text>
    <Focus start="21" len="23" />
    <Question id="T2" start="47" len="29">
      <SubQuestion qt="Diagnosis">How can I be tested for this?</SubQuestion>
    </Question>
    <Question id="T3" start="77" len="70">
      <SubQuestion qt="Diagnosis">Is it important, for personal purposes, that I get tested?</SubQuestion>
      <SubQuestion qt="Diagnosis">Is it important, for research purposes, that I get tested?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0356">
    <Text>I believe my daughter may have cerebrotendinous xanthomatosis. Can you provide me with more information on this condition?</Text>
    <Focus start="31" len="30" />
    <Question id="T3" start="63" len="59">
      <SubQuestion qt="Information">Can you provide me with more information on this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0357">
    <Text>I believe that I may have Aase syndrome. Can you provide me with information about this condition?</Text>
    <Focus start="26" len="13" />
    <Question id="T3" start="41" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0358">
    <Text>I believe that I may have geographic tongue.  Is there treatment for the condition?  At what age do symptoms of the condition typically start?  I have a family history of psoriasis.  Is geographic tongue related to psoriasis?  Are the two conditions genetic?  Is genetic counseling appropriate for geographic tongue and psoriasis?</Text>
    <Focus start="26" len="17" />
    <Question id="T3" start="46" len="37">
      <SubQuestion qt="Management">Is there treatment for the condition?</SubQuestion>
    </Question>
    <Question id="T4" start="85" len="57">
      <SubQuestion qt="Manifestation">At what age do symptoms of the condition typically start?</SubQuestion>
    </Question>
    <Question id="T6" start="183" len="42">
      <SubQuestion qt="OtherEffect">Is geographic tongue related to psoriasis?</SubQuestion>
    </Question>
    <Question id="T7" start="227" len="31">
      <SubQuestion qt="Susceptibility">Are the two conditions genetic?</SubQuestion>
    </Question>
    <Question id="T8" start="260" len="70">
      <SubQuestion qt="Diagnosis">Is genetic counseling appropriate for geographic tongue?</SubQuestion>
      <SubQuestion qt="Diagnosis">Is genetic counseling appropriate for psoriasis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0359">
    <Text>I can not find any help in regards to this disease.  Since I was diagnosed with this I have been left to deal with it myself and its getting to the point of no return.  So any help in getting me pointed in the right direction would be helpful.</Text>
    <Focus start="38" len="12" />
    <Question id="T4" start="169" len="74">
      <SubQuestion qt="Management">So any help in getting me pointed in the right direction would be helpful.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0360">
    <Text>I carry a mutation in the SOX9 gene but I do not have any signs or symptoms of campomelic dysplasia. I have had several pregnancies; one resulted in a child with the condition who later passed away, two resulted in pregnancy termination because the fetuses were found to have the condition, and 2 resulted in miscarriages. I was told that the risk for each of my pregnancies to be affected with this condition was 50%. If this is the case, why does it seem like all of my pregnancies have been affected?</Text>
    <Focus start="79" len="20" />
    <Question id="T5" start="419" len="84">
      <SubQuestion qt="OtherEffect">If this is the case, why does it seem like all of my pregnancies have been affected?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0361">
    <Text>I developed a nonseminomatous germ cell tumor in my 20's. I've since been deemed cured, but wonder if my children are at an increased risk for developing this cancer.</Text>
    <Focus start="14" len="31" />
    <Question id="T3" start="58" len="108">
      <SubQuestion qt="Susceptibility">I've since been deemed cured, but wonder if my children are at an increased risk for developing this cancer.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0362">
    <Text>I developed patulous eustacian tube following gastric bypass surgery. Are there treatments for this condition?</Text>
    <Focus start="12" len="23" />
    <Question id="T3" start="70" len="40">
      <SubQuestion qt="Management">Are there treatments for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0363">
    <Text>I'd like to know all about Ehlers-Danlos syndrome progeroid type.</Text>
    <Focus start="27" len="37" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Information">I'd like to know all about Ehlers-Danlos syndrome progeroid type.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0364">
    <Text>I'd like to know as much as possible about Leigh syndrome. Could you also tell me what type of testing is available for the condition? I am particularly interested in learning more about genetic testing for the syndrome.</Text>
    <Focus start="43" len="14" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="Information">I'd like to know as much as possible about Leigh syndrome.</SubQuestion>
    </Question>
    <Question id="T2" start="59" len="75">
      <SubQuestion qt="Diagnosis">Could you also tell me what type of testing is available for the condition?</SubQuestion>
    </Question>
    <Question id="T3" start="135" len="85">
      <SubQuestion qt="Diagnosis">I am particularly interested in learning more about genetic testing for the syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0365">
    <Text>I'd like to learn more about megalocytic interstitial nephritis with malakoplakia.</Text>
    <Focus start="29" len="34" />
    <Focus start="69" len="12" />
    <Question id="T1" start="0" len="82">
      <SubQuestion qt="Information">I'd like to learn more about megalocytic interstitial nephritis with malakoplakia.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0366">
    <Text>I experienced a headache followed by left sided numbness. I believe my doctor said I had hemiplegic migraine. During these episodes the left side of my body will feel like tiny pinpricks and go completely numb. When it gets really bad it spreads over to my right side and i cannot operate my car. When this happens I do not always get headaches. Is there any information you can give me?</Text>
    <Focus start="89" len="19" />
    <Question id="T7" start="346" len="41">
      <SubQuestion qt="Information">Is there any information you can give me?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0367">
    <Text>If a child is the only one affected with perisylvian syndrome in his family, can the inheritance of the syndrome be determined? Would perisylvian syndrome in a male child come from the mother or the father, or both? Is genetic testing for this syndrome available?</Text>
    <Focus start="41" len="20" />
    <Question id="T1" start="0" len="127">
      <SubQuestion qt="Susceptibility">If a child is the only one affected with perisylvian syndrome in his family, can the inheritance of the syndrome be determined?</SubQuestion>
    </Question>
    <Question id="T3" start="128" len="87">
      <SubQuestion qt="Susceptibility">Would perisylvian syndrome in a male child come from the mother or the father, or both?</SubQuestion>
    </Question>
    <Question id="T4" start="216" len="47">
      <SubQuestion qt="Diagnosis">Is genetic testing for this syndrome available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0368">
    <Text>If a couple has a child with Krabbe leukodystrophy, what is the likelihood of having another child with the condition?</Text>
    <Focus start="29" len="21" />
    <Question id="T1" start="0" len="118">
      <SubQuestion qt="Susceptibility">If a couple has a child with Krabbe leukodystrophy, what is the likelihood of having another child with the condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0369">
    <Text>If a couple's first baby is diagnosed with Leigh syndrome, what is the chance that future children will have it as well? Is this condition inherited from the mother or father?</Text>
    <Focus start="43" len="14" />
    <Question id="T1" start="0" len="120">
      <SubQuestion qt="Susceptibility">If a couple's first baby is diagnosed with Leigh syndrome, what is the chance that future children will have it as well?</SubQuestion>
    </Question>
    <Question id="T3" start="121" len="54">
      <SubQuestion qt="Susceptibility">Is this condition inherited from the mother or father?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0370">
    <Text>If a first child is affected by Duane syndrome, what is the likelihood that subsequent children will also be affected? Should genetic counseling be done prior to attempting a second pregnancy?</Text>
    <Focus start="32" len="14" />
    <Question id="T1" start="0" len="118">
      <SubQuestion qt="Susceptibility">If a first child is affected by Duane syndrome, what is the likelihood that subsequent children will also be affected?</SubQuestion>
    </Question>
    <Question id="T3" start="119" len="73">
      <SubQuestion qt="Diagnosis">Should genetic counseling be done prior to attempting a second pregnancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0371">
    <Text>If anencephaly occurred in a previous pregnancy, what are the chances of this condition affecting the next pregnancy if we take the recommended medication?  How long should the medication be taken before attempting another pregnancy?</Text>
    <Focus start="3" len="11" />
    <Question id="T1" start="0" len="155">
      <SubQuestion qt="Susceptibility">If anencephaly occurred in a previous pregnancy, what are the chances of this condition affecting the next pregnancy if we take the recommended medication?</SubQuestion>
    </Question>
    <Question id="T3" start="157" len="76">
      <SubQuestion qt="Management">How long should the medication be taken before attempting another pregnancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0372">
    <Text>If a person with congenital central hypoventilation syndrome has a child, what are the odds that the child will need a tracheotomy?</Text>
    <Focus start="17" len="43" />
    <Question id="T1" start="0" len="131">
      <SubQuestion qt="Susceptibility">If a person with congenital central hypoventilation syndrome has a child, what are the odds that the child will need a tracheotomy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0373">
    <Text>If a woman has a XXY karyotype, does this mean that she has Klinefelter syndrome?</Text>
    <Focus start="17" len="13" />
    <Focus start="60" len="20" />
    <Question id="T1" start="0" len="81">
      <SubQuestion qt="Information">If a woman has a XXY karyotype, does this mean that she has Klinefelter syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0374">
    <Text>If glucose 6 phosphate dehydrogenase is needed to metabolize carbohydrates and it's missing, then what happens to the sugar in the blood?  Where does it go?</Text>
    <Focus start="3" len="33" />
    <Question id="T1" start="0" len="137">
      <SubQuestion qt="Other">If glucose 6 phosphate dehydrogenase is needed to metabolize carbohydrates and it's missing, then what happens to the sugar in the blood?</SubQuestion>
    </Question>
    <Question id="T3" start="139" len="17">
      <SubQuestion qt="NotDisease">Where does it go?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0375">
    <Text>I find all kinds of information about infants and NEC but cannot find any information about children in their late teens and into adulthood. I have identical twin sons now age 19. One twin developed NEC and the other did not. He asks many questions about his prognosis as an adult including life expectancy. Do you have any information I can give him or some internet sources that may answer questions for him that are not infant or child related?</Text>
    <Focus start="50" len="3" />
    <Question id="T6" start="308" len="139">
      <SubQuestion qt="Information">Do you have any information I can give him?</SubQuestion>
      <SubQuestion qt="Information" attrs="Error">Do you have some internet sources that may answer questions for him that are not infant?</SubQuestion>
      <SubQuestion qt="Information" attrs="Error">Do you have child related?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0376">
    <Text>If my father had a TP53 mutation, does that mean all his children have the mutation or each has a 50% chance of having it?  If my father had the mutation and I do not have it, do my own children have a chance of having it or are they and all successive generations in the clear?  If my family clearly meets the criteria for diagnosing this condition, but no one demonstrates the TP53 mutation in genetic testing, is it possible to determine if a given relative never diagnosed with cancer has the predisposition?</Text>
    <Focus start="19" len="13" />
    <Question id="T1" start="0" len="122">
      <SubQuestion qt="Susceptibility">If my father had a TP53 mutation, does that mean all his children have the mutation or each has a 50% chance of having it?</SubQuestion>
    </Question>
    <Question id="T2" start="124" len="154">
      <SubQuestion qt="Susceptibility">If my father had the mutation and I do not have it, do my own children have a chance of having it or are they and all successive generations in the clear?</SubQuestion>
    </Question>
    <Question id="T3" start="280" len="232">
      <SubQuestion qt="Susceptibility">If my family clearly meets the criteria for diagnosing this condition, but no one demonstrates the TP53 mutation in genetic testing, is it possible to determine if a given relative never diagnosed with cancer has the predisposition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0377">
    <Text>If one child has Shwachman-Diamond syndrome, will the second child have it as well if the parents are the same?</Text>
    <Focus start="17" len="26" />
    <Question id="T1" start="0" len="111">
      <SubQuestion qt="Susceptibility">If one child has Shwachman-Diamond syndrome, will the second child have it as well if the parents are the same?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0378">
    <Text>If the symptoms of paraneoplastic neurologic disorders are caused by cancer, why do the symptoms appear before cancer is diagnosed? What is the prognosis for people with a paraneoplastic neurologic disorder?</Text>
    <Focus start="19" len="35" />
    <Question id="T1" start="0" len="131">
      <SubQuestion qt="Manifestation">If the symptoms of paraneoplastic neurologic disorders are caused by cancer, why do the symptoms appear before cancer is diagnosed?</SubQuestion>
    </Question>
    <Question id="T2" start="132" len="75">
      <SubQuestion qt="Prognosis">What is the prognosis for people with a paraneoplastic neurologic disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0379">
    <Text>If TSH levels are found to be out of range in a new born baby, does this mean that the baby will have permanent or temporary deficiency?</Text>
    <Focus start="3" len="10" />
    <Question id="T1" start="0" len="136">
      <SubQuestion qt="Prognosis">If TSH levels are found to be out of range in a new born baby, does this mean that the baby will have permanent or temporary deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0380">
    <Text>If you are diagnosed with lentigo maligna melanoma (LMM), what are the chances of having another, completely separate LMM at another site?  Is LMM genetic?</Text>
    <Focus start="26" len="30" />
    <Question id="T1" start="0" len="138">
      <SubQuestion qt="Prognosis">If you are diagnosed with lentigo maligna melanoma (LMM), what are the chances of having another, completely separate LMM at another site?</SubQuestion>
    </Question>
    <Question id="T2" start="140" len="15">
      <SubQuestion qt="Susceptibility">Is LMM genetic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0381">
    <Text>I had a brain stem stroke one year ago and acquired Wallenberg syndrome.  Is there any research programs which I could volunteer for? How can I find out about any research being done on Wallenberg syndrome?</Text>
    <Focus start="52" len="19" />
    <Question id="T3" start="74" len="59">
      <SubQuestion qt="PersonOrg" attrs="Research">Is there any research programs which I could volunteer for?</SubQuestion>
    </Question>
    <Question id="T4" start="134" len="72">
      <SubQuestion qt="Information" attrs="Research">How can I find out about any research being done on Wallenberg syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0382">
    <Text>I had a glomus jugulare tumor.  It was removed, but it grew back in my neck several years later and now I can't swallow.  How many people in the United States get a glomus jugulare tumor - I know that it's really rare.</Text>
    <Focus start="8" len="21" />
    <Question id="T4" start="122" len="96">
      <SubQuestion qt="Susceptibility">How many people in the United States get a glomus jugulare tumor - I know that it's really rare.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0383">
    <Text>I had a sacrococcygeal teratoma removed when I was very young.  I have since had numerous surgeries to remove scar tissue and a total hysterectomy.  I have been trying to get information as to what problems I may have because of this history.  I have started having a lot problems and I now have to walk with a cane.  I also have had horrible lower back pain for years - could this be due to this rare condition?</Text>
    <Focus start="8" len="23" />
    <Question id="T4" start="149" len="93">
      <SubQuestion qt="Complication">I have been trying to get information as to what problems I may have because of this history.</SubQuestion>
    </Question>
    <Question id="T6" start="318" len="94">
      <SubQuestion qt="OtherEffect">I also have had horrible lower back pain for years - could this be due to this rare condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0384">
    <Text>I had a sibling with Neu-Laxova and I was always told growing up that I would have a 1 in 4 chance of having a child with this condition. I was wondering if that probability was still the same?</Text>
    <Focus start="21" len="10" />
    <Question id="T3" start="138" len="55">
      <SubQuestion qt="Susceptibility">I was wondering if that probability was still the same?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0385">
    <Text>I had a spinal cord stroke this past summer. My neurologist thinks it may have been a fibrocartilaginous embolism. What might I expect? Will this happen to me again? What is the amount of recovery on average with this type of injury and what caused it?</Text>
    <Focus start="86" len="27" />
    <Question id="T4" start="115" len="20">
      <SubQuestion qt="Prognosis">What might I expect?</SubQuestion>
    </Question>
    <Question id="T5" start="136" len="29">
      <SubQuestion qt="Prognosis">Will this happen to me again?</SubQuestion>
    </Question>
    <Question id="T6" start="166" len="66">
      <SubQuestion qt="Prognosis">What is the amount of recovery on average with this type of injury?</SubQuestion>
    </Question>
    <Question id="T7" start="233" len="19">
      <SubQuestion qt="Cause">What caused it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0386">
    <Text>I had chronic osteomyelitis in my left femur as a child.  I had extensive surgeries on the femur over a period of 10 years.  After many years of being OK excepting a bit of arthritis, I had a bad fall two months ago, hurting my lower back.  The pain has now gone into my hip and femur. I am wondering if this could have triggered anything relating to the osteomyelitis or would it be completely cured by now?</Text>
    <Focus start="6" len="21" />
    <Question id="T6" start="286" len="122">
      <SubQuestion qt="Cause">I am wondering if this could have triggered anything relating to the osteomyelitis or would it be completely cured by now?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0387">
    <Text>I had craniosynostosis and now my daughter has this disorder. I'd like to know more about the genetics involved with this condition.</Text>
    <Focus start="6" len="16" />
    <Question id="T2" start="62" len="70">
      <SubQuestion qt="Susceptibility">I'd like to know more about the genetics involved with this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0388">
    <Text>I had preeclampsia and HELLP syndrome with what I believe to be my first and only pregnancy. I believe my sister had eclampsia with her second pregnancy. I also believe that our mother may have had this condition but little was known at the time of my birth. Both my sister and I now have a daughter. Given our history, does this mean that they are at a higher risk for having these problems? My daughter is just learning of these things and is concerned that she will have the same complications as we did, so I told her I would look into it for her.</Text>
    <Focus start="6" len="12" />
    <Focus start="23" len="14" />
    <Question id="T7" start="301" len="91">
      <SubQuestion qt="Susceptibility">Given our history, does this mean that they are at a higher risk for having these problems?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0389">
    <Text>I had surgery 5 years ago to remove sclerosing mesenteritis. Can this come back?</Text>
    <Focus start="36" len="23" />
    <Question id="T3" start="61" len="19">
      <SubQuestion qt="Prognosis">Can this come back?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0390">
    <Text>I had two brothers with the severe form of Hunter syndrome and both have passed away.  I was never tested to see if I am a carrier, and now my daughter would like to know if she is a carrier. Is there a definitive test to determine if one is a carrier? Who do we contact to be tested?</Text>
    <Focus start="43" len="15" />
    <Question id="T3" start="87" len="104">
      <SubQuestion qt="Diagnosis">I was never tested to see if I am a carrier, and now my daughter would like to know if she is a carrier.</SubQuestion>
    </Question>
    <Question id="T4" start="192" len="60">
      <SubQuestion qt="Diagnosis">Is there a definitive test to determine if one is a carrier?</SubQuestion>
    </Question>
    <Question id="T5" start="253" len="31">
      <SubQuestion qt="PersonOrg">Who do we contact to be tested?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0391">
    <Text>I had two thalamic strokes in 2009, which left me with chronic pain on my left side. What can I do for this condition?</Text>
    <Focus start="10" len="16" />
    <Question id="T2" start="85" len="33">
      <SubQuestion qt="Management">What can I do for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0392">
    <Text>I have 2 sons, a 12 year old and 22 year old. Both were blind after the birth and diagnosed with Norrie. Do you know if any progress has been made anywhere on earth to restore vision including but not limited to stem cell treatments?</Text>
    <Focus start="97" len="6" />
    <Question id="T4" start="105" len="128">
      <SubQuestion qt="Management">Do you know if any progress has been made anywhere on earth to restore vision?</SubQuestion>
      <SubQuestion qt="Management">Do you know if any progress has been made anywhere on earth to restore vision including but not limited to stem cell treatments?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0393">
    <Text>I have 3 brothers (and one that died 3 years ago) suffering from a genetic rare disease, neuroacanthocytosis. I am looking for any information about new medicines or any other suggestions.</Text>
    <Focus start="89" len="19" />
    <Question id="T3" start="110" len="78">
      <SubQuestion qt="Management">I am looking for any information about new medicines.</SubQuestion>
      <SubQuestion qt="Management">I am looking for any other suggestions.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0394">
    <Text>I have a 12-year-old granddaughter who has Desbuquois syndrome. Can you provide some information to help me understand this condition?</Text>
    <Focus start="43" len="19" />
    <Question id="T3" start="64" len="70">
      <SubQuestion qt="Information">Can you provide some information to help me understand this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0395">
    <Text>I have a 24-month-old niece who has the following symptoms of Cohen syndrome: hypotonia (e.g. unable to stand), congenital cataract, narrow feet with overlapping fingers, slow learning, smaller than normal head size, and aggressive behavior. This is all new to my family and I would like seek your help in learning more about this condition, including what to expect.</Text>
    <Focus start="62" len="14" />
    <Question id="T2" start="242" len="125">
      <SubQuestion qt="Information">This is all new to my family and I would like seek your help in learning more about this condition.</SubQuestion>
      <SubQuestion qt="Prognosis">This is all new to my family and I would like seek your help in learning more about this condition, including what to expect.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0396">
    <Text>I have a 4 year old son who was diagnosed with XYY karotype about a year ago.  Lately, he has had a lot of behavior issues; he is very strong and he does throw several temper tantrums a day.  I am looking for any advice how I can redirect him and get through to him on a positive note.</Text>
    <Focus start="47" len="12" />
    <Question id="T4" start="192" len="93">
      <SubQuestion qt="Management">I am looking for any advice how I can redirect him.</SubQuestion>
      <SubQuestion qt="Management">I am looking for any advice how I can get through to him on a positive note.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0397">
    <Text>I have a 7 year old daughter with this condition. What are the chances of having another child with the same condition?</Text>
    <Focus start="34" len="14" />
    <Question id="T2" start="50" len="69">
      <SubQuestion qt="Susceptibility">What are the chances of having another child with the same condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0398">
    <Text>I have a 7 year old patient diagnosed with PLEVA by skin biopsy.  He has a chronic and relapsing course and we are trying to find more information for the family regarding this condition, its outcomes, and long-term complications.</Text>
    <Focus start="43" len="5" />
    <Question id="T2" start="66" len="164">
      <SubQuestion qt="Information">He has a chronic and relapsing course and we are trying to find more information for the family regarding this condition.</SubQuestion>
      <SubQuestion qt="Prognosis">He has a chronic and relapsing course and we are trying to find more information for the family regarding this condition, its outcomes.</SubQuestion>
      <SubQuestion qt="Complication">He has a chronic and relapsing course and we are trying to find more information for the family regarding this condition, its long-term complications.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0399">
    <Text>I have a 7-year-old son with Coffin-Lowry syndrome. Are there any foods or supplements that have been shown to benefit people with Coffin-Lowry syndrome? How might Coffin-Lowry be treated? Thanks for your help.</Text>
    <Focus start="29" len="21" />
    <Question id="T3" start="52" len="101">
      <SubQuestion qt="Management">Are there any foods that have been shown to benefit people with Coffin-Lowry syndrome?</SubQuestion>
      <SubQuestion qt="Management">Are there any supplements that have been shown to benefit people with Coffin-Lowry syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="154" len="34">
      <SubQuestion qt="Management">How might Coffin-Lowry be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0400">
    <Text>I have a brother with X-linked spondyloepiphyseal dysplasia. I would like general information about this condition, including hip replacement surgery. I am also looking for doctors that might be able to help with the hip pain.</Text>
    <Focus start="22" len="37" />
    <Question id="T2" start="61" len="89">
      <SubQuestion qt="Information">I would like general information about this condition.</SubQuestion>
      <SubQuestion qt="Management">I would like general information about this condition, including hip replacement surgery.</SubQuestion>
    </Question>
    <Question id="T3" start="151" len="75">
      <SubQuestion qt="PersonOrg">I am also looking for doctors that might be able to help with the hip pain.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0401">
    <Text>I have accessory navicular bone and the condition is causing me considerable pain. How is this condition treated?</Text>
    <Focus start="7" len="24" />
    <Question id="T2" start="83" len="30">
      <SubQuestion qt="Management">How is this condition treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0402">
    <Text>I have achalasia. What causes this condition? How might it be treated? Where can I learn about research related to this condition?</Text>
    <Focus start="7" len="9" />
    <Question id="T2" start="18" len="27">
      <SubQuestion qt="Cause">What causes this condition?</SubQuestion>
    </Question>
    <Question id="T3" start="46" len="24">
      <SubQuestion qt="Management">How might it be treated?</SubQuestion>
    </Question>
    <Question id="T4" start="71" len="59">
      <SubQuestion qt="Information" attrs="Research">Where can I learn about research related to this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0403">
    <Text>I have a chance to work with a child who has Emanuel sydrome. What is a child with this capable of learning?   Is there a Web page that summarizes this syndrome and would be helpful to me?</Text>
    <Focus start="45" len="15" />
    <Question id="T3" start="62" len="46">
      <SubQuestion qt="OtherEffect">What is a child with this capable of learning?</SubQuestion>
    </Question>
    <Question id="T4" start="111" len="77">
      <SubQuestion qt="Information" attrs="Error">Is there a Web page that summarizes this syndrome and would be helpful to me?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0404">
    <Text>I have a close friend whose neonate was born with severe hydrocephalus which was diagnosed at 32 weeks gestation. At 3 weeks of age the baby was diagnosed with a choroid plexus papilloma through MRI. The physicians plan to do a spinal MRI to see if it has spread. Have you found that children developing this condition in utero are more or less likely to have long term complications?</Text>
    <Focus start="50" len="20" />
    <Question id="T5" start="264" len="120">
      <SubQuestion qt="Complication">Have you found that children developing this condition in utero are more or less likely to have long term complications?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0405">
    <Text>I have a close relative affected by aspergillosis. Can you tell me if there are any new treatments on the horizon for this condition?</Text>
    <Focus start="36" len="13" />
    <Question id="T3" start="51" len="82">
      <SubQuestion qt="Management">Can you tell me if there are any new treatments on the horizon for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0406">
    <Text>I have a cousin with osteogenesis imperfecta. Neither of his parents has the dominant gene. Is there a genetic test that can be done to determine whether I am a carrier?</Text>
    <Focus start="21" len="23" />
    <Question id="T4" start="92" len="77">
      <SubQuestion qt="Diagnosis">Is there a genetic test that can be done to determine whether I am a carrier?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0407">
    <Text>I have acquired amegakaryocytic thrombocytopenia. Can you help me find more information on this disease, its treatment, and its long-term prognosis?</Text>
    <Focus start="7" len="41" />
    <Question id="T2" start="50" len="98">
      <SubQuestion qt="Information">Can you help me find more information on this disease?</SubQuestion>
      <SubQuestion qt="Management">Can you help me find more information on its treatment?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you help me find more information on its long-term prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0408">
    <Text>I have acromesomelic dysplasia. As a result of an accident, I have back and knee injuries. I was told that this bone disease makes my bones weaker and age quicker. What is the prognosis of acromesomelic dysplasia? My doctors are not familiar with this condition. Also, what is the life expectancy?</Text>
    <Focus start="7" len="23" />
    <Question id="T4" start="164" len="49">
      <SubQuestion qt="Prognosis">What is the prognosis of acromesomelic dysplasia?</SubQuestion>
    </Question>
    <Question id="T6" start="263" len="34">
      <SubQuestion qt="Prognosis">What is the life expectancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0409">
    <Text>I have a daughter with megalencephalic leukoencephalopathy with subcortical cysts. Can I expect to have a healthy baby in the next pregnancy? Who can I talk to about this?</Text>
    <Focus start="23" len="35" />
    <Question id="T3" start="83" len="58">
      <SubQuestion qt="Susceptibility">Can I expect to have a healthy baby in the next pregnancy?</SubQuestion>
    </Question>
    <Question id="T4" start="142" len="29">
      <SubQuestion qt="PersonOrg">Who can I talk to about this?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0410">
    <Text>I have a daughter with this skin condition. I would like to know if there is a cure for it yet, and what sort of treatments are best. I heard about the Garra rufa "skin eating fish" being used in some places to treat certain skin disorders; will using this fish work for this type of skin disorder?</Text>
    <Focus start="23" len="19" />
    <Question id="T3" start="44" len="89">
      <SubQuestion qt="Management">I would like to know if there is a cure for it yet.</SubQuestion>
      <SubQuestion qt="Management">I would like to know what sort of treatments are best.</SubQuestion>
    </Question>
    <Question id="T5" start="134" len="164">
      <SubQuestion qt="Management">I heard about the Garra rufa "skin eating fish" being used in some places to treat certain skin disorders; will using this fish work for this type of skin disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0411">
    <Text>I have a fairly large schwannoma / myxoma tumor in my right arm in the tricept. I would like to know if I'm likely to have other such tumors in other parts of my body.</Text>
    <Focus start="22" len="25" />
    <Question id="T3" start="80" len="87">
      <SubQuestion qt="Prognosis">I would like to know if I'm likely to have other such tumors in other parts of my body.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0412">
    <Text>I have a family history of Huntington's disease.  My mother was diagnosed with it about 5 years ago.  I just needed to know some information about where I can get tested.  Also, how early can they start treatment if I am diagnosed with it?  I'm only 21 years old.  I just thought that maybe the sooner they start the better.</Text>
    <Focus start="27" len="20" />
    <Question id="T3" start="102" len="68">
      <SubQuestion qt="PersonOrg">I just needed to know some information about where I can get tested.</SubQuestion>
    </Question>
    <Question id="T4" start="172" len="67">
      <SubQuestion qt="Management">How early can they start treatment if I am diagnosed with it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0413">
    <Text>I have a family history of Usher syndrome.  How can I find out whether I am a carrier of Usher syndrome?</Text>
    <Focus start="27" len="14" />
    <Question id="T3" start="44" len="60">
      <SubQuestion qt="Diagnosis">How can I find out whether I am a carrier of Usher syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0414">
    <Text>I have a few questions related to Jacobsen syndrome. Do children with this condition have any issues related to fine and/or gross motor skills? Are there problems with speech or social skills? Do they always have intellectual disabilities? If so, what level of intellectual disability is expected?</Text>
    <Focus start="34" len="17" />
    <Question id="T2" start="53" len="90">
      <SubQuestion qt="OtherEffect" attrs="Error">Do children with this condition have any issues related to fine and/or gross motor skills?</SubQuestion>
    </Question>
    <Question id="T3" start="144" len="48">
      <SubQuestion qt="OtherEffect">Are there problems with speech?</SubQuestion>
      <SubQuestion qt="OtherEffect">Are there problems with social skills?</SubQuestion>
    </Question>
    <Question id="T4" start="193" len="46">
      <SubQuestion qt="OtherEffect">Do they always have intellectual disabilities?</SubQuestion>
    </Question>
    <Question id="T5" start="240" len="57">
      <SubQuestion qt="OtherEffect">If so, what level of intellectual disability is expected?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0415">
    <Text>I have a friend who has adult-onset Tay-Sachs disease. His symptoms began during middle school. What is the life-expectancy for individuals with this condition?</Text>
    <Focus start="36" len="17" />
    <Question id="T4" start="96" len="64">
      <SubQuestion qt="Prognosis">What is the life-expectancy for individuals with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0416">
    <Text>I have a friend who has been diagnosed with multiple epiphyseal dysplasia. There is no other incidence of the condition within his family however his mother was born with a cleft palate. He believes he has passed on his mutation to both of his children. Based on this information do you think that his mutation is a result of random mutation or could there be a link between his mothers cleft palate and his condition? Is this condition dominant? And if so, what is the likelihood he could pass it on to his next child?</Text>
    <Focus start="44" len="29" />
    <Question id="T4" start="254" len="164">
      <SubQuestion qt="Susceptibility">Based on this information do you think that his mutation is a result of random mutation or could there be a link between his mothers cleft palate and his condition?</SubQuestion>
    </Question>
    <Question id="T5" start="419" len="27">
      <SubQuestion qt="Susceptibility">Is this condition dominant?</SubQuestion>
    </Question>
    <Question id="T6" start="447" len="72">
      <SubQuestion qt="Susceptibility">If so, what is the likelihood he could pass it on to his next child?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0417">
    <Text>I have a friend who is affected by progressive hemifacial atrophy. How is this condition treated? How can I locate doctors who are familiar with the management of this condition?</Text>
    <Focus start="35" len="30" />
    <Question id="T3" start="67" len="30">
      <SubQuestion qt="Management">How is this condition treated?</SubQuestion>
    </Question>
    <Question id="T4" start="98" len="80">
      <SubQuestion qt="PersonOrg">How can I locate doctors who are familiar with the management of this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0418">
    <Text>I have a friend whose 8 month-old baby was recently diagnosed with Tay-Sach disease. Very few other children in the my country have been diagnosed with this disease and I’m desperate to learn more about it such its treatment and the availability of clinical trials.</Text>
    <Focus start="67" len="16" />
    <Question id="T3" start="85" len="180">
      <SubQuestion qt="Management" attrs="Error">Very few other children in the my country have been diagnosed with this disease and I’m desperate to learn more about it such its treatment.</SubQuestion>
      <SubQuestion qt="PersonOrg" attrs="Error,Research">Very few other children in the my country have been diagnosed with this disease and I’m desperate to learn more about it such its the availability of clinical trials.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0419">
    <Text>I have a friend whose grandson recently died from complications associated with Stevens-Johnson syndrome. I have not been able to find information about this condition. What information can you provide?</Text>
    <Focus start="80" len="24" />
    <Question id="T4" start="169" len="33">
      <SubQuestion qt="Information">What information can you provide?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0420">
    <Text>I have a friend whose husband has Crohn's disease. She may be pregnant and is wondering what the likelihood is that her baby will have this disease.  Is there a test that can diagnose Crohn's disease during pregnancy?</Text>
    <Focus start="34" len="15" />
    <Question id="T3" start="51" len="97">
      <SubQuestion qt="Susceptibility">She may be pregnant and is wondering what the likelihood is that her baby will have this disease.</SubQuestion>
    </Question>
    <Question id="T4" start="150" len="67">
      <SubQuestion qt="Diagnosis">Is there a test that can diagnose Crohn's disease during pregnancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0421">
    <Text>I have a friend whose toddler son was diagnosed with Cockayne syndrome. I would really like some more information about this condition and the survival rate for his son.</Text>
    <Focus start="53" len="17" />
    <Question id="T3" start="72" len="97">
      <SubQuestion qt="Information">I would really like some more information about this condition for his son.</SubQuestion>
      <SubQuestion qt="Prognosis">I would really like some more information about the survival rate for his son.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0422">
    <Text>I have a friend who was diagnosed with Jarcho-Levin syndrome at birth. Is there information available about this condition that might be relevant to an adult?</Text>
    <Focus start="39" len="21" />
    <Question id="T3" start="71" len="87">
      <SubQuestion qt="Information">Is there information available about this condition that might be relevant to an adult?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0423">
    <Text>I have a good friend who has a 15 year-old son. The boy suffers from microvillus inclusion disease. They live in Russia. Local doctors have told her that there is no treatment for that rare disease, but we suppose that Western medicine is more developed and there is a solution. How might this condition be treated?</Text>
    <Focus start="69" len="29" />
    <Question id="T6" start="279" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0424">
    <Text>I have a loved one with hereditary leiomyomatosis and renal cell cancer who has a lot of skin leiomyomas. Does this mean he is at a particularly increased risk for developing renal cell carcinoma?</Text>
    <Focus start="24" len="25" />
    <Focus start="54" len="17" />
    <Question id="T2" start="106" len="90">
      <SubQuestion qt="Complication">Does this mean he is at a particularly increased risk for developing renal cell carcinoma?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0425">
    <Text>I have a low white blood cell count as well as several other symptoms.  Although I have undergone testing, I still do not have a diagnosis.  I recently learned about a young lady who had IRAK4 deficiency.  I would like to know more about the conditon.</Text>
    <Focus start="187" len="16" />
    <Question id="T4" start="206" len="45">
      <SubQuestion qt="Information">I would like to know more about the conditon.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0426">
    <Text>I have already had extensive surgery to remove a microcystic adnexal carcinoma from my forehead and eyelid.  Is radiation therapy recommended for this type of cancer?</Text>
    <Focus start="49" len="29" />
    <Question id="T2" start="109" len="57">
      <SubQuestion qt="Management">Is radiation therapy recommended for this type of cancer?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0427">
    <Text>I have a nephew who has Eagle-Barrett syndrome. I am interested in finding out what causes this to happen to babies, and surgical procedures that could fix some of the damage caused by this.  Because of my nephew, I want to be involved in some way to help facilitate more research to find out the causes of this syndrome, and how to prevent it.  If there is any information you can give on who to talk to about this, or where to start I would greatly appreciate it.</Text>
    <Focus start="24" len="22" />
    <Question id="T2" start="48" len="142">
      <SubQuestion qt="Cause">I am interested in finding out what causes this to happen to babies.</SubQuestion>
      <SubQuestion qt="Management">I am interested in finding out surgical procedures that could fix some of the damage caused by this.</SubQuestion>
    </Question>
    <Question id="T5" start="192" len="152">
      <SubQuestion qt="Cause" attrs="Research">Because of my nephew, I want to be involved in some way to help facilitate more research to find out the causes of this syndrome.</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Because of my nephew, I want to be involved in some way to help facilitate more research to find out how to prevent it.</SubQuestion>
    </Question>
    <Question id="T7" start="346" len="119">
      <SubQuestion qt="PersonOrg">If there is any information you can give on who to talk to about this I would greatly appreciate it.</SubQuestion>
      <SubQuestion qt="Information">If there is any information you can give on where to start I would greatly appreciate it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0428">
    <Text>I have an infant daughter with Coffin Siris Syndrome. I am trying to find information about the disease as well as connect with other families who have an affected child.</Text>
    <Focus start="31" len="21" />
    <Question id="T2" start="54" len="116">
      <SubQuestion qt="Information">I am trying to find information about the disease.</SubQuestion>
      <SubQuestion qt="PersonOrg">I am trying to connect with other families who have an affected child.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0429">
    <Text>I have an orbital varix in my left eye. It affects my vision and causes eye pain. How can it be managed?</Text>
    <Focus start="10" len="13" />
    <Question id="T4" start="82" len="22">
      <SubQuestion qt="Management">How can it be managed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0430">
    <Text>I have a patient who is suspected of having glycogen storage disease type 0. Is genetic testing for this condition available?</Text>
    <Focus start="44" len="31" />
    <Question id="T3" start="77" len="48">
      <SubQuestion qt="Diagnosis">Is genetic testing for this condition available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0431">
    <Text>I have a patient who may have Williams syndrome. His mother was previously diagnosed with familial Mediterrranean fever, but she has facial features consistent with Williams syndrome. Do Williams syndrome and familial Mediterranean fever share any signs or symptoms?</Text>
    <Focus start="30" len="17" />
    <Focus start="90" len="29" />
    <Question id="T5" start="184" len="82">
      <SubQuestion qt="Manifestation">Do Williams syndrome and familial Mediterranean fever share any signs?</SubQuestion>
      <SubQuestion qt="Manifestation">Do Williams syndrome and familial Mediterranean fever share any symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0432">
    <Text>I have a patient with Muir-Torre syndrome. Can you provide me with information related to this condition?</Text>
    <Focus start="22" len="19" />
    <Question id="T2" start="43" len="62">
      <SubQuestion qt="Information">Can you provide me with information related to this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0433">
    <Text>I have a patient with urine citrulline levels at twice the upper limit of normal. All other urinary amino acids were low-normal. This patient has legitimate complaints of decreased energy as well. Standard CPE labs were normal. What is the typical presentation of citrullinemia type II? How is it diagnosed? How is it treated? Who is conducting research into this condition.</Text>
    <Focus start="264" len="21" />
    <Question id="T5" start="228" len="58">
      <SubQuestion qt="Manifestation">What is the typical presentation of citrullinemia type II?</SubQuestion>
    </Question>
    <Question id="T6" start="287" len="20">
      <SubQuestion qt="Diagnosis">How is it diagnosed?</SubQuestion>
    </Question>
    <Question id="T7" start="308" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
    <Question id="T8" start="327" len="47">
      <SubQuestion qt="PersonOrg" attrs="Research">Who is conducting research into this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0434">
    <Text>I have a pregnant colleague that has been told her unborn child has Mohr syndrome (also known as orofaciodigital syndrome 2). I work in the health care field and have never heard of this disorder. I am looking for credible information that will help me understand this syndrome. I want to be informed.</Text>
    <Focus start="68" len="13" />
    <Question id="T4" start="197" len="81">
      <SubQuestion qt="Information">I am looking for credible information that will help me understand this syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0435">
    <Text>I have a problem. My hospital doesn't know a lot about Ochoa syndrome. I would like to know more if there are possibilities to live with it. I really can't handle it anymore. I'm 20 years old and I'm living since my birth with it. Please let me know.</Text>
    <Focus start="55" len="14" />
    <Question id="T4" start="71" len="69">
      <SubQuestion qt="Management">I would like to know more if there are possibilities to live with it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0436">
    <Text>I have a relative who has essential tremor. How might this condition affect the activities of daily living? Are there ways to manage the symptoms?</Text>
    <Focus start="26" len="16" />
    <Question id="T3" start="44" len="63">
      <SubQuestion qt="Prognosis">How might this condition affect the activities of daily living?</SubQuestion>
    </Question>
    <Question id="T4" start="108" len="38">
      <SubQuestion qt="Management">Are there ways to manage the symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0437">
    <Text>I have a single palmar crease on both of my hands.  Do I have an increased chance of having a child with Down syndrome or another chromosome disorder?</Text>
    <Focus start="105" len="13" />
    <Question id="T3" start="52" len="98">
      <SubQuestion qt="Susceptibility">Do I have an increased chance of having a child with Down syndrome?</SubQuestion>
      <SubQuestion qt="Susceptibility">Do I have an increased chance of having a child with another chromosome disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0438">
    <Text>I have a son who is 18 months old. He has Sturge-Weber and we are wondering what the percentage is that his birthmark will protrude from his face. What are the pros and cons of laser surgery? If we were to get the surgery, when would be the best time to get it done?</Text>
    <Focus start="42" len="12" />
    <Question id="T2" start="35" len="111">
      <SubQuestion qt="Complication">He has Sturge-Weber and we are wondering what the percentage is that his birthmark will protrude from his face.</SubQuestion>
    </Question>
    <Question id="T4" start="147" len="44">
      <SubQuestion qt="Management" attrs="Error">What are the pros and cons of laser surgery?</SubQuestion>
    </Question>
    <Question id="T5" start="192" len="74">
      <SubQuestion qt="Management">If we were to get the surgery, when would be the best time to get it done?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0439">
    <Text>I have a student who appears to have some of the symptoms of agnosia. He had the cord wrapped around the neck at birth. Most of what I've read about visual agnosia is that it happens when older patients have a stroke. Would it be possible for a child, such as this student, to have this condition?</Text>
    <Focus start="61" len="7" />
    <Question id="T5" start="218" len="79">
      <SubQuestion qt="Susceptibility" attrs="Error">Would it be possible for a child, such as this student, to have this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0440">
    <Text>I have autoimmune hepatitis. Can you provide me with new information about this condition?</Text>
    <Focus start="7" len="20" />
    <Question id="T3" start="29" len="61">
      <SubQuestion qt="Information">Can you provide me with new information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0441">
    <Text>I have Axenfeld-Rieger syndrome.  My symptoms include dislocated pupils and very high astigmatism with a detaching lens. I recently learned that a flattened mid-face, missing teeth, and mid section anomalies are also symptoms of this disorder.  I would like to start a family; however I would first like to learn more about the chances of passing this on to my future children and the likelihood that their condition would be more serious than my own.  Also, the lens in one of my eyes is detaching and migrating away from my displaced pupil.  Is this a common effect of the disease? Can it be treated?</Text>
    <Focus start="7" len="24" />
    <Question id="T5" start="245" len="206">
      <SubQuestion qt="Susceptibility" attrs="Error">I would like to start a family; however I would first like to learn more about the chances of passing this on to my future children and the likelihood that their condition would be more serious than my own.</SubQuestion>
    </Question>
    <Question id="T7" start="544" len="39">
      <SubQuestion qt="OtherEffect">Is this a common effect of the disease?</SubQuestion>
    </Question>
    <Question id="T8" start="584" len="18">
      <SubQuestion qt="Management">Can it be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0442">
    <Text>I have a young friend who is affected by acute febrile neutrophilic dermatosis (Sweet syndrome). Can you provide me with information about this condition that can be shared with her physicians?</Text>
    <Focus start="41" len="54" />
    <Question id="T2" start="97" len="96">
      <SubQuestion qt="Information">Can you provide me with information about this condition that can be shared with her physicians?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0443">
    <Text>I have Beals syndrome (also known as congenital contractural arachnodactyly). I am a 19-year-old female and I was wondering how tall I would be because of this condition? The symptom is having a tall stature, but how tall? I'm 5'3 right now.</Text>
    <Focus start="7" len="14" />
    <Question id="T3" start="78" len="92">
      <SubQuestion qt="OtherEffect">I am a 19-year-old female and I was wondering how tall I would be because of this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="171" len="51">
      <SubQuestion qt="OtherEffect">The symptom is having a tall stature, but how tall?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0444">
    <Text>I have Becker's nevus on the top of my right pectoral. I'm heavily into fitness and weight lifting. I've noticed that it is impossible for me to develop an even chest. Muscle seems to not grow where my nevus is located. Does Becker's nevus prohibit muscle development? Does the nevus affect me in that manner, and if so, is there any way to fix this?</Text>
    <Focus start="7" len="14" />
    <Question id="T5" start="220" len="48">
      <SubQuestion qt="OtherEffect">Does Becker's nevus prohibit muscle development?</SubQuestion>
    </Question>
    <Question id="T6" start="269" len="40">
      <SubQuestion qt="OtherEffect">Does the nevus affect me in that manner?</SubQuestion>
    </Question>
    <Question id="T8" start="310" len="40">
      <SubQuestion qt="Management">If so, is there any way to fix this?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0445">
    <Text>I have been diagnosed with a benign pseudomyxoma peritonei.  Most of the information I have found relates to the malignant type.  I had a hysterectomy and appendectomy with debulking three weeks ago.  I was told I had a large ovarian tumor plus a tumor on my appendix, which seemed to be the one secreting mucus. What is the treatment for this condition?</Text>
    <Focus start="29" len="29" />
    <Question id="T5" start="313" len="41">
      <SubQuestion qt="Management">What is the treatment for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0446">
    <Text>I have been diagnosed with Behcet's disease. Although I have other symptoms, my eyes have been causing me the most trouble. Please tell me more about the ocular issues with Behcet's and how they might be treated.</Text>
    <Focus start="27" len="16" />
    <Question id="T3" start="124" len="88">
      <SubQuestion qt="OtherEffect">Please tell me more about the ocular issues with Behcet's.</SubQuestion>
      <SubQuestion qt="Management">Please tell me more about how they might be treated.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0447">
    <Text>I have been diagnosed with cholesteatoma. I am looking for general information about this condition, including the chances of being affected.</Text>
    <Focus start="27" len="13" />
    <Question id="T2" start="42" len="99">
      <SubQuestion qt="Information">I am looking for general information about this condition.</SubQuestion>
      <SubQuestion qt="Susceptibility">I am looking for general information about this condition, including the chances of being affected.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0448">
    <Text>I have been diagnosed with CPVT. I've been off medication for a few years and have been playing sports regularly.  I've never had any syncope. I just read that if untreated CPVT is highly lethal. And now I'm starting to care. I have some questions about this disease: Is there any case of remission? Is it curable? Are sports under treatment better than without treatment? Is there a CPVT specialist anywhere in the world? What is the most up-to-date article/research about this disease?</Text>
    <Focus start="27" len="4" />
    <Question id="T6" start="226" len="73">
      <SubQuestion qt="Prognosis">I have some questions about this disease: Is there any case of remission?</SubQuestion>
    </Question>
    <Question id="T7" start="300" len="14">
      <SubQuestion qt="Management">Is it curable?</SubQuestion>
    </Question>
    <Question id="T8" start="315" len="57">
      <SubQuestion qt="Management">Are sports under treatment better than without treatment?</SubQuestion>
    </Question>
    <Question id="T9" start="373" len="49">
      <SubQuestion qt="PersonOrg">Is there a CPVT specialist anywhere in the world?</SubQuestion>
    </Question>
    <Question id="T10" start="423" len="64">
      <SubQuestion qt="Information" attrs="Research">What is the most up-to-date article about this disease?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">What is the most up-to-date research about this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0449">
    <Text>I have been diagnosed with erythromelalgia, and received a prescription for mexiletine.  I noticed on the patient information sheet that it said that this medication is an anti-arrhythmic used to treat irregular heartbeat.  Have you heard about mexiletine being used for erythromelalgia?</Text>
    <Focus start="27" len="15" />
    <Question id="T3" start="224" len="63">
      <SubQuestion qt="Management">Have you heard about mexiletine being used for erythromelalgia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0450">
    <Text>I have been diagnosed with familial adenomatous polyposis (FAP), and my 9-year-old daughter is now having the same signs and symptoms as me. I know you can not give out medical advice, but I'm stuck and need some help for my daughter. How do I find a specialist for children with FAP?  At what age do children begin having genetic testing for FAP?</Text>
    <Focus start="27" len="36" />
    <Question id="T3" start="235" len="49">
      <SubQuestion qt="PersonOrg">How do I find a specialist for children with FAP?</SubQuestion>
    </Question>
    <Question id="T4" start="286" len="61">
      <SubQuestion qt="Diagnosis">At what age do children begin having genetic testing for FAP?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0451">
    <Text>I have been diagnosed with familial hemiplegic migraine.  Even though I have been taking medication, I am experiencing unsteadiness, headache pain, facial drooping, and I can't walk without getting off balance. It is normal to have these symptoms for three weeks when taking medication for the condition? Will this condition go away with age?</Text>
    <Focus start="27" len="28" />
    <Question id="T4" start="211" len="93">
      <SubQuestion qt="Management">It is normal to have these symptoms for three weeks when taking medication for the condition?</SubQuestion>
    </Question>
    <Question id="T5" start="305" len="37">
      <SubQuestion qt="Prognosis">Will this condition go away with age?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0452">
    <Text>I have been diagnosed with frontal fibrosing hair loss (alopecia).  Is this condition going to cause all of my hair to fall out or will the hair loss stop at some point?  Will medication help, or are the side effects too concerning?</Text>
    <Focus start="27" len="38" />
    <Question id="T2" start="68" len="101">
      <SubQuestion qt="OtherEffect">Is this condition going to cause all of my hair to fall out or will the hair loss stop at some point?</SubQuestion>
    </Question>
    <Question id="T3" start="171" len="61">
      <SubQuestion qt="Management">Will medication help, or are the side effects too concerning?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0453">
    <Text>I have been diagnosed with intralobular pulmonary sequestration. What are the symptoms of this condition? How is it treated?</Text>
    <Focus start="27" len="36" />
    <Question id="T3" start="65" len="40">
      <SubQuestion qt="Manifestation">What are the symptoms of this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="106" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0454">
    <Text>I have been diagnosed with Isaac's syndrome. I would like to learn more about this condition and how I can locate physicians familiar with it's management.</Text>
    <Focus start="27" len="16" />
    <Question id="T3" start="45" len="47">
      <SubQuestion qt="Information">I would like to learn more about this condition.</SubQuestion>
    </Question>
    <Question id="T4" start="93" len="62">
      <SubQuestion qt="PersonOrg">How I can locate physicians familiar with it's management.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0455">
    <Text>I have been diagnosed with Melnick-Needles syndrome.  How can I learn more about this disease?</Text>
    <Focus start="27" len="24" />
    <Question id="T2" start="54" len="40">
      <SubQuestion qt="Information">How can I learn more about this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0456">
    <Text>I have been diagnosed with MERRF and I am looking for information and treatment options for this condition that I can share with my local doctor.</Text>
    <Focus start="27" len="5" />
    <Question id="T1" start="0" len="145">
      <SubQuestion qt="Information">I have been diagnosed with MERRF and I am looking for information for this condition that I can share with my local doctor.</SubQuestion>
      <SubQuestion qt="Management">I have been diagnosed with MERRF and I am looking for treatment options for this condition that I can share with my local doctor.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0457">
    <Text>I have been diagnosed with morphea. Can you please provide me with patient-friendly information about this disease?</Text>
    <Focus start="27" len="7" />
    <Question id="T3" start="36" len="79">
      <SubQuestion qt="Information">Can you please provide me with patient-friendly information about this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0458">
    <Text>I have been diagnosed with Mucha-Haberman disease. I don't know how I contracted this disease. For a couple of years, I was very sick and couldn't seem to get well. Now my symptoms flare up occasionally but I have blisters all of the time. What causes this condition? How is it treated?</Text>
    <Focus start="27" len="22" />
    <Question id="T5" start="240" len="27">
      <SubQuestion qt="Cause">What causes this condition?</SubQuestion>
    </Question>
    <Question id="T6" start="268" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0459">
    <Text>I have been diagnosed with Norum disease, a condition also known as lecithin cholesterol acyltransferase (LCAT) deficiency. I would appreciate any information that you could provide and post about this disease, as three generations of my family have been identified with it.</Text>
    <Focus start="27" len="13" />
    <Question id="T2" start="124" len="150">
      <SubQuestion qt="Information">I would appreciate any information that you could provide about this disease, as three generations of my family have been identified with it.</SubQuestion>
      <SubQuestion qt="Information">I would appreciate any information that you could post about this disease, as three generations of my family have been identified with it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0460">
    <Text>I have been diagnosed with pheochromocytoma but believe that there is more to this than has been tested thus far. After reading numerous literature on everything I could find, I realized that something genetic and family based was taking place. Can you help me?</Text>
    <Focus start="27" len="16" />
    <Question id="T4" start="245" len="16">
      <SubQuestion qt="Susceptibility">Can you help me?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0461">
    <Text>I have been diagnosed with pigmented purpuric eruption. What are the symptoms of this condition? What causes it? Can it be treated? Will it eventually go away?</Text>
    <Focus start="27" len="27" />
    <Question id="T3" start="56" len="40">
      <SubQuestion qt="Manifestation">What are the symptoms of this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="97" len="15">
      <SubQuestion qt="Cause">What causes it?</SubQuestion>
    </Question>
    <Question id="T5" start="113" len="18">
      <SubQuestion qt="Management">Can it be treated?</SubQuestion>
    </Question>
    <Question id="T6" start="132" len="27">
      <SubQuestion qt="Prognosis">Will it eventually go away?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0462">
    <Text>I have been diagnosed with polycystic ovarian syndrome (PCOS), but the medication I am taking does not seem to be working. I recently learned that late-onset congenital adrenal hyperplasia can be misdiagnosed as PCOS in some women. Can you help me find information on PCOS and late-onset congenital adrenal hyperplasia?</Text>
    <Focus start="27" len="34" />
    <Question id="T4" start="232" len="87">
      <SubQuestion qt="Diagnosis" attrs="Error">Can you help me find information on PCOS?</SubQuestion>
      <SubQuestion qt="Diagnosis" attrs="Error">Can you help me find information on late-onset congenital adrenal hyperplasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0463">
    <Text>I have been diagnosed with primary melanoma of the small intestine. I can't find any information on this type of cancer. Can you help? Is there anyway to find other people with this condition?</Text>
    <Focus start="27" len="39" />
    <Question id="T4" start="121" len="13">
      <SubQuestion qt="Information">Can you help?</SubQuestion>
    </Question>
    <Question id="T5" start="135" len="57">
      <SubQuestion qt="PersonOrg">Is there anyway to find other people with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0464">
    <Text>I have been diagnosed with prurigo nodularis. Three years ago I was started on thalidomide for treatment. Since then I have developed many side effects, yet the prurigo nodularis has not been cured. How can this condition be treated? Is research being conducted to learn more about possible treatment options?</Text>
    <Focus start="27" len="17" />
    <Question id="T4" start="199" len="34">
      <SubQuestion qt="Management">How can this condition be treated?</SubQuestion>
    </Question>
    <Question id="T5" start="234" len="75">
      <SubQuestion qt="Management" attrs="Research">Is research being conducted to learn more about possible treatment options?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0465">
    <Text>I have been diagnosed with pudendal neuralgia. My doctor has treated it with with pudendal nerve entrapment surgery and botox injections.  Is there any scientific evidence from controlled trials or research studies that show botox is an effective treatment?  Also, are there any other recommended treatments other than what my doctor has already tried for this condition?</Text>
    <Focus start="27" len="18" />
    <Question id="T3" start="139" len="118">
      <SubQuestion qt="Management" attrs="Research">Is there any scientific evidence from controlled trials that show botox is an effective treatment?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Is there any scientific evidence from research studies that show botox is an effective treatment?</SubQuestion>
    </Question>
    <Question id="T5" start="259" len="112">
      <SubQuestion qt="Management">Are there any other recommended treatments other than what my doctor has already tried for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0466">
    <Text>I have been diagnosed with retroperitoneal fibrosis. Can you provide me with information about this disease?</Text>
    <Focus start="27" len="24" />
    <Question id="T3" start="53" len="55">
      <SubQuestion qt="Information">Can you provide me with information about this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0467">
    <Text>I have been diagnosed with sarcoidosis. This condition has caused me severe pain and I wish to learn anything that might be useful to share with my doctors. Could this condition be the result of working in a hot silk-screen paint shop? Will I ever get over this condition? How can I manage the symptoms?</Text>
    <Focus start="27" len="11" />
    <Question id="T3" start="40" len="116">
      <SubQuestion qt="Information">This condition has caused me severe pain and I wish to learn anything that might be useful to share with my doctors.</SubQuestion>
    </Question>
    <Question id="T4" start="157" len="78">
      <SubQuestion qt="Cause">Could this condition be the result of working in a hot silk-screen paint shop?</SubQuestion>
    </Question>
    <Question id="T5" start="236" len="36">
      <SubQuestion qt="Prognosis">Will I ever get over this condition?</SubQuestion>
    </Question>
    <Question id="T6" start="273" len="30">
      <SubQuestion qt="Management">How can I manage the symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0468">
    <Text>I have been diagnosed with Takayasu arteritis. It has changed my life in many ways and I am yet to accept this condition. It has been very difficult for me to deal with this diagnosis and I'm not sure who to talk to or who to get information from.</Text>
    <Focus start="27" len="18" />
    <Question id="T3" start="122" len="125">
      <SubQuestion qt="PersonOrg">It has been very difficult for me to deal with this diagnosis and I'm not sure who to talk to.</SubQuestion>
      <SubQuestion qt="Information">It has been very difficult for me to deal with this diagnosis and I'm not sure who to get information from.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0469">
    <Text>I have been diagnosed with Tarlov cyst disease. Is there a cure for this condition? How is it treated? Are there surgical options? How can I find a doctor who is knowledgeable about Tarlov cysts?</Text>
    <Focus start="27" len="19" />
    <Question id="T3" start="48" len="35">
      <SubQuestion qt="Management">Is there a cure for this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="84" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
    <Question id="T5" start="103" len="27">
      <SubQuestion qt="Management">Are there surgical options?</SubQuestion>
    </Question>
    <Question id="T6" start="131" len="64">
      <SubQuestion qt="PersonOrg">How can I find a doctor who is knowledgeable about Tarlov cysts?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0470">
    <Text>I have been diagnosed with trabecular fiber myopathy and can find nothing about it. I would like any information you can give me.</Text>
    <Focus start="27" len="25" />
    <Question id="T2" start="84" len="45">
      <SubQuestion qt="Information">I would like any information you can give me.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0471">
    <Text>I have been diagnosed with urachal cancer. Are there any new studies or treatments available for this rare disease?</Text>
    <Focus start="27" len="14" />
    <Question id="T2" start="43" len="72">
      <SubQuestion qt="Information" attrs="Research">Are there any new studies available for this rare disease?</SubQuestion>
      <SubQuestion qt="Management">Are there any new treatments available for this rare disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0472">
    <Text>I have been diagnosed with Wells syndrome. How is this condition treated?</Text>
    <Focus start="27" len="14" />
    <Question id="T3" start="43" len="30">
      <SubQuestion qt="Management">How is this condition treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0473">
    <Text>I have been diagnosed with Wilson disease. What are the long-term effects of this disease? Will I need to be on medication for the rest of my life? Does Wilson disease count as a disability because an affected person has it all of their life? What are the chances that my children will have Wilson disease?</Text>
    <Focus start="27" len="14" />
    <Question id="T3" start="43" len="47">
      <SubQuestion qt="Prognosis">What are the long-term effects of this disease?</SubQuestion>
    </Question>
    <Question id="T4" start="91" len="56">
      <SubQuestion qt="Management">Will I need to be on medication for the rest of my life?</SubQuestion>
    </Question>
    <Question id="T5" start="148" len="94">
      <SubQuestion qt="Other">Does Wilson disease count as a disability because an affected person has it all of their life?</SubQuestion>
    </Question>
    <Question id="T6" start="243" len="63">
      <SubQuestion qt="Susceptibility">What are the chances that my children will have Wilson disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0474">
    <Text>I have been having very bad upper stomach pains and wanted to know if any of the pains are coming from the Crigler Najjar syndrome, type 2 that I have? I’ve been experiencing this pain for two months.</Text>
    <Focus start="107" len="31" />
    <Question id="T1" start="0" len="151">
      <SubQuestion qt="OtherEffect">I have been having very bad upper stomach pains and wanted to know if any of the pains are coming from the Crigler Najjar syndrome, type 2 that I have?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0475">
    <Text>I have been on hemodialysis for a year as a result of Alport syndrome. My two uncles died of kidney disease associated with this condition. What treatments are available for this condition?</Text>
    <Focus start="54" len="15" />
    <Question id="T4" start="140" len="49">
      <SubQuestion qt="Management">What treatments are available for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0476">
    <Text>I have been recently diagnosed with antisynthetase syndrome, acute interstitial lung disease, muscle weakness, skin involvement, scleroderma, and dermatomyositis. Could you please provide me with information on antisynthetase syndrome?  I am also interested in learning about prognosis, treatment, and clinical trials.</Text>
    <Focus start="36" len="23" />
    <Focus start="61" len="31" />
    <Focus start="94" len="15" />
    <Focus start="111" len="16" />
    <Focus start="129" len="11" />
    <Focus start="146" len="15" />
    <Question id="T2" start="163" len="72">
      <SubQuestion qt="Information">Could you please provide me with information on antisynthetase syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="237" len="81">
      <SubQuestion qt="Prognosis">I am also interested in learning about prognosis.</SubQuestion>
      <SubQuestion qt="Management">I am also interested in learning about treatment.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">I am also interested in learning about clinical trials.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0477">
    <Text>I have been recently diagnosed with Evans syndrome. Can you provide me with information about this condition, including treatment options and mortality rates?</Text>
    <Focus start="36" len="14" />
    <Question id="T2" start="52" len="106">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
      <SubQuestion qt="Management">Can you provide me with information about this condition, including treatment options?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you provide me with information about this condition, including mortality rates?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0478">
    <Text>I have been recently diagnosed with superior mesenteric artery syndrome. Can you provide me with information about this condition?</Text>
    <Focus start="36" len="35" />
    <Question id="T3" start="73" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0479">
    <Text>I have been recovering from Parsonage Turner syndrome for years. I still have some pain, the fatigue is still with me and my quality of life is compromised. Can this develop into something else? Also, is it normal that I still have fatigue after 5 plus years?</Text>
    <Focus start="28" len="25" />
    <Question id="T4" start="157" len="37">
      <SubQuestion qt="OtherEffect">Can this develop into something else?</SubQuestion>
    </Question>
    <Question id="T5" start="195" len="64">
      <SubQuestion qt="OtherEffect">Is it normal that I still have fatigue after 5 plus years?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0480">
    <Text>I have been researching familial hypercholesterolemia. A couple of web sites have called it autosomal dominant. If I remember correctly that would mean that in order for a person to have FH, he would have to have a parent with FH. Is my thinking correct on this matter?</Text>
    <Focus start="24" len="29" />
    <Question id="T4" start="231" len="38">
      <SubQuestion qt="Susceptibility">Is my thinking correct on this matter?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0481">
    <Text>I have been told that I probably have Marfan's Syndrome and at this point it appears to be a mild form of the condition (aortic aneurysm and mitral valve prolapse). I am a 60 year old mother of 4 children. My question is that because this is a genetic condition, what are the chances that my children and grandchildren have inherited it and will they also inherit the mild form?</Text>
    <Focus start="38" len="17" />
    <Question id="T3" start="206" len="172">
      <SubQuestion qt="Susceptibility">My question is that because this is a genetic condition, what are the chances that my children have inherited it?</SubQuestion>
      <SubQuestion qt="Susceptibility">My question is that because this is a genetic condition, what are the chances that my grandchildren have inherited it?</SubQuestion>
      <SubQuestion qt="Susceptibility">My question is that because this is a genetic condition, will they also inherit the mild form?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0482">
    <Text>I have cherubism. I was diagnosed at age 3 and had the tumor surgically removed at age 13. Then I had implants placed for permanent teeth at age 20. Today I live normally. My main concern and reason for contact is: I'd like to know more about the cause of cherubism. How or why did I get it? There is no history in either of my families of cherubism. What are the signs and symptoms of cherubism? Do my future children run a strong risk? Can I be tested to see if I am a carrier? If I find that I am not a carrier can they still turn up with the disease? Is there prenatal testing available for cherubism. As you can see, I am mostly concerned for the future of my family. I do not have kids yet, but do plan to.</Text>
    <Focus start="7" len="9" />
    <Question id="T6" start="172" len="94">
      <SubQuestion qt="Cause">My main concern and reason for contact is: I'd like to know more about the cause of cherubism.</SubQuestion>
    </Question>
    <Question id="T7" start="267" len="24">
      <SubQuestion qt="Cause">How did I get it?</SubQuestion>
      <SubQuestion qt="Cause">Why did I get it?</SubQuestion>
    </Question>
    <Question id="T10" start="351" len="45">
      <SubQuestion qt="Manifestation">What are the signs of cherubism?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms of cherubism?</SubQuestion>
    </Question>
    <Question id="T11" start="397" len="40">
      <SubQuestion qt="Susceptibility">Do my future children run a strong risk?</SubQuestion>
    </Question>
    <Question id="T12" start="438" len="41">
      <SubQuestion qt="Diagnosis">Can I be tested to see if I am a carrier?</SubQuestion>
    </Question>
    <Question id="T13" start="480" len="74">
      <SubQuestion qt="Susceptibility">If I find that I am not a carrier can they still turn up with the disease?</SubQuestion>
    </Question>
    <Question id="T14" start="555" len="50">
      <SubQuestion qt="Diagnosis">Is there prenatal testing available for cherubism.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0483">
    <Text>I have cone-rod dystrophy. I have looked all over the internet for answers about my condition. Do you have information about treatments or possible future treatments? Are there any studies or trials that are being done that I might be able to take part in?</Text>
    <Focus start="7" len="18" />
    <Question id="T3" start="95" len="71">
      <SubQuestion qt="Management">Do you have information about treatments?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Do you have information about possible future treatments?</SubQuestion>
    </Question>
    <Question id="T4" start="167" len="89">
      <SubQuestion qt="Information" attrs="Research">Are there any studies that are being done that I might be able to take part in?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Are there any trials that are being done that I might be able to take part in?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0484">
    <Text>I have congenital ichthyosiform erythroderma since birth. I want to know if there is any treatment because I am really looking to get treatment for this disease.</Text>
    <Focus start="7" len="37" />
    <Question id="T3" start="58" len="103">
      <SubQuestion qt="Management">I want to know if there is any treatment because I am really looking to get treatment for this disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0485">
    <Text>I have dense deposit disease. Are nausea and vomiting symptoms of the disease?</Text>
    <Focus start="7" len="21" />
    <Question id="T3" start="30" len="48">
      <SubQuestion qt="Manifestation" attrs="Error">Is nausea symptoms of the disease?</SubQuestion>
      <SubQuestion qt="Manifestation" attrs="Error">Is vomiting symptoms of the disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0486">
    <Text>I have diffuse idiopathic skeletal hyperostosis (DISH), a condition also known as Forestier disease. I would like to learn more about this disease, including how it is treated.</Text>
    <Focus start="7" len="47" />
    <Question id="T3" start="101" len="75">
      <SubQuestion qt="Information">I would like to learn more about this disease.</SubQuestion>
      <SubQuestion qt="Management">I would like to learn more about this disease, including how it is treated.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0487">
    <Text>I have disseminated granuloma annular. Will this condition cause my tissue to die? Have there been reports of granuloma annular following ingestion of allopurinol?</Text>
    <Focus start="20" len="17" />
    <Question id="T2" start="39" len="43">
      <SubQuestion qt="OtherEffect">Will this condition cause my tissue to die?</SubQuestion>
    </Question>
    <Question id="T3" start="83" len="80">
      <SubQuestion qt="Cause">Have there been reports of granuloma annular following ingestion of allopurinol?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0488">
    <Text>I have Duane syndrome. These is no known family history. What the probability of passing this condition on to any future offspring?</Text>
    <Focus start="7" len="14" />
    <Question id="T4" start="57" len="74">
      <SubQuestion qt="Susceptibility">What the probability of passing this condition on to any future offspring?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0489">
    <Text>I have Dubin-Johnson syndrome. Can this condition be passed along to another individual through sexual intercourse?</Text>
    <Focus start="7" len="22" />
    <Question id="T3" start="31" len="84">
      <SubQuestion qt="Susceptibility">Can this condition be passed along to another individual through sexual intercourse?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0490">
    <Text>I have endocarditis for the fourth time. Each time it has been caused by the same bacteria. How can I prevent reinfection?</Text>
    <Focus start="7" len="12" />
    <Question id="T4" start="92" len="30">
      <SubQuestion qt="Management">How can I prevent reinfection?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0491">
    <Text>I have epidermolysis bullosa acquisita. Occasionally I have to have my fingernails removed, as they act like ingrown toe nails. My doctors tell me there is no other way to prevent them from growing back, except for phenol carbolic acid, and I had a reaction to that when they took off a toe nail. In addition, I would like to contact other people with epidermolysis bullosa acquisita.</Text>
    <Focus start="7" len="31" />
    <Question id="T5" start="297" len="87">
      <SubQuestion qt="PersonOrg">In addition, I would like to contact other people with epidermolysis bullosa acquisita.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0492">
    <Text>I have erythema elevatum diutinum. How might this condition be treated? Will I ever be able to take less medication? Can diet affect this condition? Will it ever go away? Is this condition genetic?</Text>
    <Focus start="7" len="26" />
    <Question id="T3" start="35" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
    <Question id="T4" start="72" len="44">
      <SubQuestion qt="Management">Will I ever be able to take less medication?</SubQuestion>
    </Question>
    <Question id="T5" start="117" len="31">
      <SubQuestion qt="Management">Can diet affect this condition?</SubQuestion>
    </Question>
    <Question id="T6" start="149" len="21">
      <SubQuestion qt="Prognosis">Will it ever go away?</SubQuestion>
    </Question>
    <Question id="T7" start="171" len="26">
      <SubQuestion qt="Susceptibility">Is this condition genetic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0493">
    <Text>I have experienced several bouts of hiccups that go on for several weeks to months with no relief. I have had all of the normal tests to determine a cause, but no cause has been identified. I also have other stomach problems. What causes intractable hiccups? What tests may be conducted to determine the underlying cause of intractable hiccups? Can intractable hiccups be related to other stomach problems? How might intractable hiccups be treated?</Text>
    <Focus start="36" len="7" />
    <Question id="T4" start="226" len="32">
      <SubQuestion qt="Cause">What causes intractable hiccups?</SubQuestion>
    </Question>
    <Question id="T5" start="259" len="85">
      <SubQuestion qt="Diagnosis">What tests may be conducted to determine the underlying cause of intractable hiccups?</SubQuestion>
    </Question>
    <Question id="T6" start="345" len="61">
      <SubQuestion qt="OtherEffect">Can intractable hiccups be related to other stomach problems?</SubQuestion>
    </Question>
    <Question id="T7" start="407" len="41">
      <SubQuestion qt="Management">How might intractable hiccups be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0494">
    <Text>I have factor V Leiden and was wondering if it's safe to use oral contraceptives. I want to take the pill called Levlin.</Text>
    <Focus start="7" len="15" />
    <Question id="T1" start="0" len="81">
      <SubQuestion qt="OtherEffect">I have factor V Leiden and was wondering if it's safe to use oral contraceptives.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0495">
    <Text>I have familial adenomatous polyposis (FAP). Recently, my physicians have identified polyps in the upper portion of my intestine, my gall bladder, and my stomach. Are these all the same type of polyps?</Text>
    <Focus start="7" len="36" />
    <Question id="T3" start="163" len="38">
      <SubQuestion qt="Information">Are these all the same type of polyps?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0496">
    <Text>I have fibrodysplasia ossificans progressiva and recently had my first fracture.  I am currently taking medication but continue to have pain in my leg, hand, and elbow.  What are the risks of operation?  Can myositis ossificans be passed to the next generation?</Text>
    <Focus start="7" len="37" />
    <Question id="T4" start="170" len="32">
      <SubQuestion qt="Management">What are the risks of operation?</SubQuestion>
    </Question>
    <Question id="T5" start="204" len="57">
      <SubQuestion qt="Susceptibility">Can myositis ossificans be passed to the next generation?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0497">
    <Text>I have fibromuscular dysplasia in several of my arteries. My doctor says this condition is usually caused from smoking, but I have never smoked. What would cause this disease to occur in so many arteries?</Text>
    <Focus start="7" len="23" />
    <Question id="T4" start="145" len="59">
      <SubQuestion qt="Cause">What would cause this disease to occur in so many arteries?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0498">
    <Text>I have fibromyalgia and am concerned that my family members will develop, especially my daughter who is beginning to have symptoms of the condition.  Is fibromyalgia genetic?  Is there genetic testing for the condition?</Text>
    <Focus start="7" len="12" />
    <Question id="T2" start="150" len="24">
      <SubQuestion qt="Susceptibility">Is fibromyalgia genetic?</SubQuestion>
    </Question>
    <Question id="T3" start="176" len="43">
      <SubQuestion qt="Diagnosis">Is there genetic testing for the condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0499">
    <Text>I have glycogen storage disease type 5. I have also had fatty liver for as long as I can remember. In addition my CPK levels on a good day can be 800. Can my liver problems be attributed to glycogen storage disease type 5?</Text>
    <Focus start="7" len="31" />
    <Question id="T4" start="151" len="71">
      <SubQuestion qt="OtherEffect">Can my liver problems be attributed to glycogen storage disease type 5?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_0500">
    <Text>I have green eyes with a yellow/brown tint, but one fourth of my right eye is dark brown.  I've been wanting to know more about heterochromia iridis: what is it and how rare is it?</Text>
    <Focus start="128" len="20" />
    <Question id="T2" start="91" len="89">
      <SubQuestion qt="Information">I've been wanting to know more about heterochromia iridis: what is it?</SubQuestion>
      <SubQuestion qt="Susceptibility">I've been wanting to know more about heterochromia iridis: how rare is it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1001">
    <Text>My father had arachnoiditis. Can you provide information about this condition, including symptoms, causes, and if it is genetic?</Text>
    <Focus start="14" len="13" />
    <Question id="T2" start="29" len="99">
      <SubQuestion qt="Information">Can you provide information about this condition?</SubQuestion>
      <SubQuestion qt="Manifestation">Can you provide information about this condition, including symptoms?</SubQuestion>
      <SubQuestion qt="Cause">Can you provide information about this condition, including causes?</SubQuestion>
      <SubQuestion qt="Susceptibility">Can you provide information about this condition, including if it is genetic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1002">
    <Text>My father has Buschke Fischer keratoderma palmo-plantaris. Is there any treatment for this condition?</Text>
    <Focus start="14" len="43" />
    <Question id="T3" start="59" len="42">
      <SubQuestion qt="Management">Is there any treatment for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1003">
    <Text>My father has Crohn's disease for which he has had many surgeries in his lifetime. His brother (my uncle) also had this disease as a young adult.  Can you tell me what percent chance I would have of having this disease as well? My fathers other young adult children do not have it as of yet.</Text>
    <Focus start="14" len="15" />
    <Question id="T4" start="147" len="80">
      <SubQuestion qt="Susceptibility">Can you tell me what percent chance I would have of having this disease as well?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1004">
    <Text>My father has multiple system atrophy with orthostatic hypotension.  Is this hereditary?  Is this something my brother and sisters or our children should make our doctors aware of in case symptoms start appearing?</Text>
    <Focus start="14" len="52" />
    <Question id="T3" start="69" len="19">
      <SubQuestion qt="Susceptibility">Is this hereditary?</SubQuestion>
    </Question>
    <Question id="T4" start="90" len="123">
      <SubQuestion qt="Diagnosis">Is this something my brother should make our doctors aware of in case symptoms start appearing?</SubQuestion>
      <SubQuestion qt="Diagnosis">Is this something my sisters should make our doctors aware of in case symptoms start appearing?</SubQuestion>
      <SubQuestion qt="Diagnosis" attrs="Error">Is this something my our children should make our doctors aware of in case symptoms start appearing?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1005">
    <Text>My father is 63 years old and suffers from Shapiro syndrome. So far no doctor or treatment plan has helped. The condition and length of time of the attacks continue to get worst.</Text>
    <Focus start="43" len="16" />
    <Question id="T1" start="61" len="46">
      <SubQuestion qt="PersonOrg">So far no doctor has helped.</SubQuestion>
      <SubQuestion qt="Management">So far no treatment plan has helped.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1006">
    <Text>My father may have this disease. Should I be tested? Where? How? If this is caught early can anything be done about it? What treatment opportunities are there? Is this limited to French Canadians? We cannot trace our genealogy back to French Canada but we do know that some of our ancestors came from Europe.</Text>
    <Focus start="19" len="12" />
    <Question id="T4" start="33" len="19">
      <SubQuestion qt="Diagnosis">Should I be tested?</SubQuestion>
    </Question>
    <Question id="T5" start="53" len="6">
      <SubQuestion qt="PersonOrg">Where?</SubQuestion>
    </Question>
    <Question id="T6" start="60" len="4">
      <SubQuestion qt="Diagnosis">How?</SubQuestion>
    </Question>
    <Question id="T7" start="65" len="54">
      <SubQuestion qt="Management">If this is caught early can anything be done about it?</SubQuestion>
    </Question>
    <Question id="T8" start="120" len="39">
      <SubQuestion qt="Management">What treatment opportunities are there?</SubQuestion>
    </Question>
    <Question id="T9" start="160" len="36">
      <SubQuestion qt="Susceptibility">Is this limited to French Canadians?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1007">
    <Text>My father was diagnosed with cerebellar degeneration. He isn't on any medication and he feels terrible all the time. Is there anything out there that can help him such as medications or alternative therapies?</Text>
    <Focus start="29" len="23" />
    <Question id="T4" start="117" len="91">
      <SubQuestion qt="Management">Is there anything out there that can help him?</SubQuestion>
      <SubQuestion qt="Management">Is there anything out there that can help him such as medications?</SubQuestion>
      <SubQuestion qt="Management">Is there anything out there that can help him such as alternative therapies?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1008">
    <Text>My father was diagnosed with dermatomyositis and has some long-lasting symptoms.  Is it possible that radiation exposure could be contributing to his condition?</Text>
    <Focus start="29" len="15" />
    <Question id="T3" start="82" len="78">
      <SubQuestion qt="Cause">Is it possible that radiation exposure could be contributing to his condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1009">
    <Text>My father was diagnosed with epidermoid carcinoma in his mouth. Is this curable?</Text>
    <Focus start="29" len="20" />
    <Question id="T3" start="64" len="16">
      <SubQuestion qt="Management">Is this curable?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1010">
    <Text>My first child has the gene responsible for pyruvate kinase deficiency. Are there ways to monitor for this condition prenatally? Where can we access genetic testing for pyruvate kinase deficiency?</Text>
    <Focus start="44" len="26" />
    <Question id="T3" start="72" len="56">
      <SubQuestion qt="Diagnosis">Are there ways to monitor for this condition prenatally?</SubQuestion>
    </Question>
    <Question id="T4" start="129" len="67">
      <SubQuestion qt="Diagnosis">Where can we access genetic testing for pyruvate kinase deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1011">
    <Text>My first episode of Behcet's disease was pretty mild. Is my next episode likely to be the same or progress to a more aggressive event?</Text>
    <Focus start="20" len="16" />
    <Question id="T3" start="54" len="80">
      <SubQuestion qt="Prognosis">Is my next episode likely to be the same or progress to a more aggressive event?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1012">
    <Text>My foster child will be tested for Prader-Willi syndrome, but has a very high IQ. Is it possible for people with Prader-Willi to have high IQs?</Text>
    <Focus start="35" len="21" />
    <Question id="T3" start="82" len="61">
      <SubQuestion qt="OtherEffect">Is it possible for people with Prader-Willi to have high IQs?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1013">
    <Text>My four-year-old daughter has been diagnosed with hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC).  It is apparently quite rare and we would like information on this condition.</Text>
    <Focus start="50" len="68" />
    <Question id="T3" start="121" len="76">
      <SubQuestion qt="Information">It is apparently quite rare and we would like information on this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1014">
    <Text>My friend has a relative who has asternia.  What are the symptoms of asternia?  What are the treatments for this condition?</Text>
    <Focus start="33" len="8" />
    <Question id="T3" start="44" len="34">
      <SubQuestion qt="Manifestation">What are the symptoms of asternia?</SubQuestion>
    </Question>
    <Question id="T4" start="80" len="43">
      <SubQuestion qt="Management">What are the treatments for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1015">
    <Text>My friend has been diagnosed with Boeck's sarcoidosis. What is it? What can be done and how does it work? What natural therapy can be used?</Text>
    <Focus start="34" len="19" />
    <Question id="T2" start="55" len="11">
      <SubQuestion qt="Information">What is it?</SubQuestion>
    </Question>
    <Question id="T3" start="67" len="16">
      <SubQuestion qt="Management">What can be done?</SubQuestion>
    </Question>
    <Question id="T4" start="84" len="21">
      <SubQuestion qt="Management">How does it work?</SubQuestion>
    </Question>
    <Question id="T5" start="106" len="33">
      <SubQuestion qt="Management">What natural therapy can be used?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1016">
    <Text>My friend has Best disease in his right eye. His vision in this eye is quite stable, although he sees a black spot wherever he focuses. Will his vision remain the same or it can it deteriorate? Is there any way to improve his vision? What are the chances of his left eye also developing Best disease?</Text>
    <Focus start="14" len="12" />
    <Question id="T4" start="136" len="57">
      <SubQuestion qt="OtherEffect">Will his vision remain the same or it can it deteriorate?</SubQuestion>
    </Question>
    <Question id="T5" start="194" len="39">
      <SubQuestion qt="Management">Is there any way to improve his vision?</SubQuestion>
    </Question>
    <Question id="T6" start="234" len="66">
      <SubQuestion qt="Prognosis">What are the chances of his left eye also developing Best disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1017">
    <Text>My friend has hidradenitis suppurativa. Can you please help me find more information?</Text>
    <Focus start="14" len="24" />
    <Question id="T3" start="40" len="45">
      <SubQuestion qt="Information">Can you please help me find more information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1018">
    <Text>My friend is 48-years-old and has had hypertension for more than 15 years. Her potassium levels are always elevated and her doctors do not know why. Her serum creatinin is normal. Do you think she has pseudohypoaldosteronism type II?</Text>
    <Focus start="201" len="31" />
    <Question id="T4" start="180" len="53">
      <SubQuestion qt="Diagnosis">Do you think she has pseudohypoaldosteronism type II?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1019">
    <Text>My friend's 3-year-old daughter was just diagnosed with Rett Syndrome. A boy sibling was born last week, and he does not have Rett syndrome. Where can we find more information? How do you become part of a clinical trial?</Text>
    <Focus start="56" len="13" />
    <Question id="T4" start="141" len="35">
      <SubQuestion qt="Information">Where can we find more information?</SubQuestion>
    </Question>
    <Question id="T5" start="177" len="43">
      <SubQuestion qt="PersonOrg" attrs="Research">How do you become part of a clinical trial?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1020">
    <Text>My friends little boy is 3-years-old and has been diagnosed with Chiari malformation type 1. Could you tell me how it will affect his life? Is the outcome good or bad? He suffers from headaches at the moment.</Text>
    <Focus start="65" len="26" />
    <Question id="T3" start="93" len="46">
      <SubQuestion qt="Prognosis">Could you tell me how it will affect his life?</SubQuestion>
    </Question>
    <Question id="T4" start="140" len="27">
      <SubQuestion qt="Prognosis">Is the outcome good or bad?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1021">
    <Text>My friend was diagnosed with chronic inflammatory demyelinating polyneuropathy several months ago. He has been treated with platelet transfusions and gabapentin without relief. Are there other options for treatment? What is the outlook for this condition?</Text>
    <Focus start="29" len="49" />
    <Question id="T4" start="177" len="38">
      <SubQuestion qt="Management">Are there other options for treatment?</SubQuestion>
    </Question>
    <Question id="T5" start="216" len="39">
      <SubQuestion qt="Prognosis">What is the outlook for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1022">
    <Text>My friend was recently diagnosed with Horner syndrome. I am trying to find information and resources regarding this topic.</Text>
    <Focus start="38" len="15" />
    <Question id="T2" start="55" len="67">
      <SubQuestion qt="Information">I am trying to find information regarding this topic.</SubQuestion>
      <SubQuestion qt="Information">I am trying to find resources regarding this topic.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1023">
    <Text>My girlfriend has Best vitelliform macular dystrophy and I feel helpless because she tells me there is nothing anyone could do. Are there any clinical trials or research studies for this type of disease? Is there any treatment that can help? Also, can you go completely blind from this condition?</Text>
    <Focus start="18" len="34" />
    <Question id="T3" start="128" len="75">
      <SubQuestion qt="Information" attrs="Research">Are there any clinical trials for this type of disease?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Are there any research studies for this type of disease?</SubQuestion>
    </Question>
    <Question id="T5" start="204" len="37">
      <SubQuestion qt="Management">Is there any treatment that can help?</SubQuestion>
    </Question>
    <Question id="T6" start="242" len="54">
      <SubQuestion qt="OtherEffect">Can you go completely blind from this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1024">
    <Text>My girlfriend has this disease. Can you please provide some basic information on this disease including treatment and possible outcomes? How long does it take for eye sight to deteriorate?</Text>
    <Focus start="18" len="12" />
    <Question id="T2" start="32" len="104">
      <SubQuestion qt="Information">Can you please provide some basic information on this disease?</SubQuestion>
      <SubQuestion qt="Management">Can you please provide some basic information on this disease including treatment?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you please provide some basic information on this disease including possible outcomes?</SubQuestion>
    </Question>
    <Question id="T3" start="137" len="51">
      <SubQuestion qt="Prognosis">How long does it take for eye sight to deteriorate?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1025">
    <Text>My girlfriend's grandmother has Myotonic dystrophy type 1.  Fortunately neither my girlfriend's mother nor father is affected, but this disease is quite common in her mother's family.  I want to know the probability that either my girlfriend or our children could get this disease.</Text>
    <Focus start="32" len="25" />
    <Question id="T4" start="185" len="96">
      <SubQuestion qt="Susceptibility">I want to know the probability that my girlfriend could get this disease.</SubQuestion>
      <SubQuestion qt="Susceptibility">I want to know the probability that our children could get this disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1026">
    <Text>My girlfriend's maternal aunt has vitiligo. What are the chances for our children to have vitiligo?</Text>
    <Focus start="34" len="8" />
    <Question id="T3" start="44" len="55">
      <SubQuestion qt="Susceptibility">What are the chances for our children to have vitiligo?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1027">
    <Text>My girlfriend's physicians think that she may have Susac syndrome. Can you provide us with some more information about this disease, particularly how it is treated and what we might expect in terms of prognosis?</Text>
    <Focus start="51" len="14" />
    <Question id="T3" start="67" len="144">
      <SubQuestion qt="Information">Can you provide us with some more information about this disease?</SubQuestion>
      <SubQuestion qt="Management">Can you provide us with some more information about this disease, particularly how it is treated?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you provide us with some more information about this disease, particularly what we might expect in terms of prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1028">
    <Text>My granddaughter had familial hemophagocytic lymphohistiocytosis when she was 8 months old. Can her brothers also develop this disease? I have noticed that both of the boys have had skin problems but the older one, now 13, has developed asthma and unexplained headaches. My granddaughter received a BMT from the 2nd born who is now 11 years old. Is there any testing we can have done to check the boys for the presence or absence of the disease?</Text>
    <Focus start="21" len="43" />
    <Question id="T3" start="92" len="43">
      <SubQuestion qt="Susceptibility">Can her brothers also develop this disease?</SubQuestion>
    </Question>
    <Question id="T6" start="346" len="99">
      <SubQuestion qt="Diagnosis">Is there any testing we can have done to check the boys for the presence or absence of the disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1029">
    <Text>My granddaughter has been diagnosed with pyruvate kinase deficiency. I have many questions about this condition, including how many people may be affected and if it is more common in any particular population. Any information you could provide would be helpful.</Text>
    <Focus start="41" len="26" />
    <Question id="T3" start="69" len="140">
      <SubQuestion qt="Information">I have many questions about this condition.</SubQuestion>
      <SubQuestion qt="Susceptibility">I have many questions about this condition, including how many people may be affected.</SubQuestion>
      <SubQuestion qt="Susceptibility">I have many questions about this condition, including if it is more common in any particular population.</SubQuestion>
    </Question>
    <Question id="T6" start="210" len="51">
      <SubQuestion qt="Information">Any information you could provide would be helpful.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1030">
    <Text>My granddaughter has just been diagnosed with glycine encephalopathy. She is 3 months old. All the articles we have read are very complicated. What is glycine encephalopathy about? What treatment is there and what are her survival chances?</Text>
    <Focus start="46" len="22" />
    <Question id="T5" start="143" len="37">
      <SubQuestion qt="Information">What is glycine encephalopathy about?</SubQuestion>
    </Question>
    <Question id="T6" start="181" len="23">
      <SubQuestion qt="Management">What treatment is there?</SubQuestion>
    </Question>
    <Question id="T7" start="205" len="34">
      <SubQuestion qt="Prognosis">What are her survival chances?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1031">
    <Text>My granddaughter is 6-months-old and has microcephaly. The geneticist said there is a slight possibility she has COFS syndrome. Can you please give us more information?</Text>
    <Focus start="113" len="13" />
    <Question id="T4" start="128" len="40">
      <SubQuestion qt="Information">Can you please give us more information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1032">
    <Text>My granddaughter was diagnosed from a genetic blood test with Noonan syndrome, and has a mutation in the SOS1 gene. She is only 3 months old and has already had 3 operations due to stridor. She also has a heart murmur and pulmonary stenosis. She is not eating and has had to have a feeding tube. My daughter and son-in-law need help in knowing what is best to do for her.</Text>
    <Focus start="62" len="15" />
    <Question id="T6" start="296" len="75">
      <SubQuestion qt="Management">My daughter and son-in-law need help in knowing what is best to do for her.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1033">
    <Text>My granddaughter was recently diagnosed with arachnoid cysts. Can you provide me with information about this condition? Is it genetic?</Text>
    <Focus start="45" len="15" />
    <Question id="T3" start="62" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="120" len="14">
      <SubQuestion qt="Susceptibility">Is it genetic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1034">
    <Text>My grandfather just recently found out he has polycystic kidney disease, and I am curious to know if I have it also. I am 20 years old and have experienced some symptoms. What is the best way to go about testing for this condition? What kinds of tests do they run?</Text>
    <Focus start="46" len="25" />
    <Question id="T4" start="171" len="60">
      <SubQuestion qt="Diagnosis">What is the best way to go about testing for this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="232" len="32">
      <SubQuestion qt="Diagnosis">What kinds of tests do they run?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1035">
    <Text>My grandmother on my dad's side has two copies of the factor V Leiden gene mutation. I have one copy. Do I need to go and see a hematologist to get on blood thinners, or is there really nothing that they would do since I only have the one copy? Also, if I have one copy does that mean that my father has two copies of it or could he possibly have only the one copy as well?</Text>
    <Focus start="54" len="29" />
    <Question id="T4" start="102" len="142">
      <SubQuestion qt="Management">Do I need to go and see a hematologist to get on blood thinners, or is there really nothing that they would do since I only have the one copy?</SubQuestion>
    </Question>
    <Question id="T5" start="245" len="128">
      <SubQuestion qt="Susceptibility">If I have one copy does that mean that my father has two copies of it or could he possibly have only the one copy as well?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1036">
    <Text>My grandson has been diagnosed with hereditary fructose intolerance. The family has not been able to see a dietician, and they are having a hard time finding good recipes. Please give me some info so I can help them.</Text>
    <Focus start="36" len="31" />
    <Question id="T4" start="172" len="44">
      <SubQuestion qt="Information">Please give me some info so I can help them.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1037">
    <Text>My grandson has been diagnosed with LEOPARD syndrome. We have just noticed that his eyes are beginning to cross. Is this a sign also?</Text>
    <Focus start="36" len="16" />
    <Question id="T4" start="113" len="20">
      <SubQuestion qt="Manifestation">Is this a sign also?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1038">
    <Text>My grandson has Joubert syndrome, autism, and ADHD.  Is autism related to Joubert syndrome?</Text>
    <Focus start="16" len="16" />
    <Focus start="34" len="6" />
    <Question id="T4" start="53" len="38">
      <SubQuestion qt="OtherEffect">Is autism related to Joubert syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1039">
    <Text>My grandson has Lenz microphthalmia syndrome. Is there any information in the medical literaure, research studies, or clinical trials regarding the effectiveness of expansion thoracostomy (VEPTR) for treatment of children with this syndrome?</Text>
    <Focus start="16" len="28" />
    <Question id="T3" start="46" len="195">
      <SubQuestion qt="Management" attrs="Research">Is there any information in the medical literaure regarding the effectiveness of expansion thoracostomy (VEPTR) for treatment of children with this syndrome?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Is there any information in research studies regarding the effectiveness of expansion thoracostomy (VEPTR) for treatment of children with this syndrome?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Is there any information in clinical trials regarding the effectiveness of expansion thoracostomy (VEPTR) for treatment of children with this syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1040">
    <Text>My grandson has the condition. I want to know if there is medication that will result in a normal stature.</Text>
    <Focus start="16" len="13" />
    <Question id="T2" start="31" len="75">
      <SubQuestion qt="Management">I want to know if there is medication that will result in a normal stature.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1041">
    <Text>My grandson was diagnosed with IVA at birth. He seems to be quite healthy. He's 8 years old, very active and grades are great at school. His diet is mostly potatoes and fruit. He will not eat meat or poultry, but on some occasions. Will this condition be with him throughout his life, or is it possible that it will clear up?</Text>
    <Focus start="31" len="3" />
    <Question id="T7" start="232" len="93">
      <SubQuestion qt="Prognosis">Will this condition be with him throughout his life, or is it possible that it will clear up?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1042">
    <Text>My grandson was recently diagnosed with hemimegalencephaly.  He's currently on-track developmentally.  Are there degrees of severity with this condition?  Where can we find the best information or an expert we could talk to?</Text>
    <Focus start="40" len="18" />
    <Question id="T4" start="103" len="50">
      <SubQuestion qt="Information">Are there degrees of severity with this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="155" len="69">
      <SubQuestion qt="Information">Where can we find the best information?</SubQuestion>
      <SubQuestion qt="PersonOrg">Where can we find an expert we could talk to?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1043">
    <Text>My husband and I are adopting a 7 year old boy who has been diagnosed with Hanhart syndrome. We need help. Is there anybody who could give us information and guidance about this condition?</Text>
    <Focus start="75" len="16" />
    <Question id="T4" start="107" len="81">
      <SubQuestion qt="Information">Is there anybody who could give us information about this condition?</SubQuestion>
      <SubQuestion qt="PersonOrg">Is there anybody who could give us guidance about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1044">
    <Text>My husband and son have been diagnosed with stiff person syndrome. I am concerned about my other son and my grandson. Is there genetic testing for stiff person syndrome?</Text>
    <Focus start="44" len="21" />
    <Question id="T4" start="118" len="51">
      <SubQuestion qt="Diagnosis">Is there genetic testing for stiff person syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1045">
    <Text>My husband had a bleed 20 yrs ago and has multiple cerebral cavernous malformations (CCM). My son had a bleed and was also diagnosed with multiple CCMs.  Does our family need genetic testing?</Text>
    <Focus start="51" len="38" />
    <Question id="T4" start="154" len="37">
      <SubQuestion qt="Diagnosis">Does our family need genetic testing?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1046">
    <Text>My husband had a mole on his leg and a biopsy confirmed that it is a dermatofibrosarcoma protuberans.  Is this very harmful like other cancers?  Is there any chance it could spread to other parts of the body?  What is the chance for recurrence?  What are the available treatments?  Are there precautions to take to avoid recurrence?</Text>
    <Focus start="69" len="31" />
    <Question id="T2" start="103" len="40">
      <SubQuestion qt="Prognosis">Is this very harmful like other cancers?</SubQuestion>
    </Question>
    <Question id="T4" start="145" len="63">
      <SubQuestion qt="Prognosis">Is there any chance it could spread to other parts of the body?</SubQuestion>
    </Question>
    <Question id="T5" start="210" len="34">
      <SubQuestion qt="Prognosis">What is the chance for recurrence?</SubQuestion>
    </Question>
    <Question id="T6" start="246" len="34">
      <SubQuestion qt="Management">What are the available treatments?</SubQuestion>
    </Question>
    <Question id="T7" start="282" len="50">
      <SubQuestion qt="Management">Are there precautions to take to avoid recurrence?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1047">
    <Text>My husband had dermatofibrosarcoma protuberans on his thigh.  Will it spread to other parts of the body by the lymph?  If it spreads, what are the symptoms?  Can dermatofibrosarcoma affect heart, lungs, liver, kidney or other internal organs?  If so, what are the symptoms?  Can any symptoms be found during a complete body checkup before it spreads?</Text>
    <Focus start="15" len="31" />
    <Question id="T3" start="62" len="55">
      <SubQuestion qt="Prognosis">Will it spread to other parts of the body by the lymph?</SubQuestion>
    </Question>
    <Question id="T4" start="119" len="37">
      <SubQuestion qt="Manifestation">If it spreads, what are the symptoms?</SubQuestion>
    </Question>
    <Question id="T5" start="158" len="84">
      <SubQuestion qt="Anatomy">Can dermatofibrosarcoma affect heart?</SubQuestion>
      <SubQuestion qt="Anatomy">Can dermatofibrosarcoma affect lungs?</SubQuestion>
      <SubQuestion qt="Anatomy">Can dermatofibrosarcoma affect liver?</SubQuestion>
      <SubQuestion qt="Anatomy">Can dermatofibrosarcoma affect kidney?</SubQuestion>
      <SubQuestion qt="Anatomy">Can dermatofibrosarcoma affect other internal organs?</SubQuestion>
    </Question>
    <Question id="T7" start="244" len="29">
      <SubQuestion qt="Manifestation">If so, what are the symptoms?</SubQuestion>
    </Question>
    <Question id="T8" start="275" len="75">
      <SubQuestion qt="Diagnosis">Can any symptoms be found during a complete body checkup before it spreads?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1048">
    <Text>My husband had Lambert Eaton myasthenic syndrome. Are our two children at risk to develop this condition?</Text>
    <Focus start="15" len="33" />
    <Question id="T3" start="50" len="55">
      <SubQuestion qt="Susceptibility">Are our two children at risk to develop this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1049">
    <Text>My husband had surgery for a hemangioblastoma, but his doctors are clueless about what to do next. Should he have genetic testing?</Text>
    <Focus start="29" len="16" />
    <Question id="T3" start="99" len="31">
      <SubQuestion qt="Diagnosis">Should he have genetic testing?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1050">
    <Text>My husband has a family history of oculopharyngeal muscular dystrophy. I am worried that he may be affected. Can the symptoms of this condition occur at earlier ages in susequent generations? Could this condition affect sperm mobility? What are the chances that a child we have together could be affected?</Text>
    <Focus start="35" len="34" />
    <Question id="T4" start="109" len="82">
      <SubQuestion qt="Manifestation">Can the symptoms of this condition occur at earlier ages in susequent generations?</SubQuestion>
    </Question>
    <Question id="T5" start="192" len="43">
      <SubQuestion qt="OtherEffect">Could this condition affect sperm mobility?</SubQuestion>
    </Question>
    <Question id="T6" start="236" len="69">
      <SubQuestion qt="Susceptibility">What are the chances that a child we have together could be affected?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1051">
    <Text>My husband has a ganglioglioma, which he has battled for five years.  It seems like all the drugs or surgeries make it grow.  Is there anything you can tell me, such as what caused it or why is it growing so quickly?  I know a lot of people don't have it, but there have to be some answers.  Is any research being done on this condition?</Text>
    <Focus start="17" len="13" />
    <Question id="T4" start="126" len="90">
      <SubQuestion qt="Information">Is there anything you can tell me?</SubQuestion>
      <SubQuestion qt="Cause">Is there anything you can tell me, such as what caused it?</SubQuestion>
      <SubQuestion qt="OtherEffect">Is there anything you can tell me, such as why is it growing so quickly?</SubQuestion>
    </Question>
    <Question id="T8" start="292" len="45">
      <SubQuestion qt="Information" attrs="Research">Is any research being done on this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1052">
    <Text>My husband has Alagille syndrome which affects his liver, kidneys, back and blood pressure. He recently developed joint problems in both knees. Is this related to Alagille syndrome? What is the outlook for people with Allagille syndrome?</Text>
    <Focus start="15" len="17" />
    <Question id="T4" start="144" len="37">
      <SubQuestion qt="OtherEffect">Is this related to Alagille syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="182" len="55">
      <SubQuestion qt="Prognosis">What is the outlook for people with Allagille syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1053">
    <Text>My husband has been diagnosed with acute posterior multifocal placoid pigment epitheliopathy. Is the vision loss associated with this condition permanent?</Text>
    <Focus start="35" len="57" />
    <Question id="T3" start="94" len="60">
      <SubQuestion qt="Prognosis">Is the vision loss associated with this condition permanent?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1054">
    <Text>My husband has been diagnosed with gray zone lymphoma.  What are the treatment options for this condition?</Text>
    <Focus start="35" len="18" />
    <Question id="T3" start="56" len="50">
      <SubQuestion qt="Management">What are the treatment options for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1055">
    <Text>My husband has been diagnosed with type 2 myotonic dystrophy. We have two daughters who will be tested. Where can we learn more about this condition?</Text>
    <Focus start="35" len="25" />
    <Question id="T4" start="104" len="45">
      <SubQuestion qt="Information">Where can we learn more about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1056">
    <Text>My husband has been diagnosed with Wegener's granulomatosis. How might this condition be treated? How can I learn about research involving this condition?</Text>
    <Focus start="35" len="24" />
    <Question id="T3" start="61" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
    <Question id="T4" start="98" len="56">
      <SubQuestion qt="Information" attrs="Research">How can I learn about research involving this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1057">
    <Text>My husband has Ehlers Danlos syndrome hypermobility type. He has severe syncope and very low blood pressure. What heart conditions are associated with Ehlers Danlos syndrome hypermobility type? Do people with Ehlers Danlos syndrome hypermobility type have a shortened life expectancy?</Text>
    <Focus start="15" len="41" />
    <Question id="T4" start="109" len="84">
      <SubQuestion qt="OtherEffect">What heart conditions are associated with Ehlers Danlos syndrome hypermobility type?</SubQuestion>
    </Question>
    <Question id="T5" start="194" len="90">
      <SubQuestion qt="Prognosis">Do people with Ehlers Danlos syndrome hypermobility type have a shortened life expectancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1058">
    <Text>My husband has factor V Leiden. How could he have this when nobody else in his family has it including his parents? Is this disorder always passed down or can it skip a generation? What is the chance that our kids will have it?</Text>
    <Focus start="15" len="15" />
    <Question id="T3" start="32" len="83">
      <SubQuestion qt="Cause">How could he have this when nobody else in his family has it including his parents?</SubQuestion>
    </Question>
    <Question id="T4" start="116" len="64">
      <SubQuestion qt="Susceptibility">Is this disorder always passed down or can it skip a generation?</SubQuestion>
    </Question>
    <Question id="T5" start="181" len="46">
      <SubQuestion qt="Susceptibility">What is the chance that our kids will have it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1059">
    <Text>My husband has had osteochondritis dissecans for a number of years and has undergone multiple surgeries.  His condition is causing him more pain and disability than ever. He can hardly walk without assistance. He's been recommended knee replacements, but our insurance won't cover this surgery. Is there any advice that you can give me?  I'm not sure how I can help him.</Text>
    <Focus start="19" len="25" />
    <Question id="T6" start="295" len="41">
      <SubQuestion qt="Other">Is there any advice that you can give me?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1060">
    <Text>My husband has Klinefelter syndrome. I have read a lot of things about this syndrome, but I want to know more about the future. He is 33-years-old, and he didn't take any medication for Klinefelter syndrome in the past. What is the chance of him becoming a father?</Text>
    <Focus start="15" len="20" />
    <Question id="T3" start="37" len="90">
      <SubQuestion qt="Prognosis">I have read a lot of things about this syndrome, but I want to know more about the future.</SubQuestion>
    </Question>
    <Question id="T5" start="220" len="44">
      <SubQuestion qt="OtherEffect">What is the chance of him becoming a father?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1061">
    <Text>My husband has Lambert-Eaton myasthenic syndrome.  We read somewhere that this condition may be caused by an anesthetic.  I'm now unable to locate that information.  Is that true?  If so, what anesthetic?</Text>
    <Focus start="15" len="33" />
    <Question id="T5" start="166" len="13">
      <SubQuestion qt="Cause">Is that true?</SubQuestion>
    </Question>
    <Question id="T6" start="181" len="23">
      <SubQuestion qt="Cause">If so, what anesthetic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1062">
    <Text>My husband has prurigo nodularis (PN). No one knows how to treat the condition. Is there treatment for this skin disease? Is research being conducted to learn more about possible treatment options for prurigo nodularis?</Text>
    <Focus start="15" len="22" />
    <Question id="T4" start="80" len="41">
      <SubQuestion qt="Management">Is there treatment for this skin disease?</SubQuestion>
    </Question>
    <Question id="T5" start="122" len="97">
      <SubQuestion qt="Management" attrs="Research">Is research being conducted to learn more about possible treatment options for prurigo nodularis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1063">
    <Text>My husband has sclerosing mesenteritis. Is this disease dangerous?</Text>
    <Focus start="15" len="23" />
    <Question id="T3" start="40" len="26">
      <SubQuestion qt="Prognosis">Is this disease dangerous?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1064">
    <Text>My husband has situs inversus. Is the brain turned around or otherwise affected in individuals with this condition?</Text>
    <Focus start="15" len="14" />
    <Question id="T3" start="31" len="84">
      <SubQuestion qt="OtherEffect">Is the brain turned around in individuals with this condition?</SubQuestion>
      <SubQuestion qt="OtherEffect">Is the brain otherwise affected in individuals with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1065">
    <Text>My husband is 38-years-old, and we just found out he has fibromuscular dysplasia (FMD). He had a stroke 6 months ago. My question is, how long before he has another stroke? Can this take his life?</Text>
    <Focus start="57" len="29" />
    <Question id="T4" start="118" len="54">
      <SubQuestion qt="Prognosis">My question is, how long before he has another stroke?</SubQuestion>
    </Question>
    <Question id="T5" start="173" len="23">
      <SubQuestion qt="Prognosis">Can this take his life?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1066">
    <Text>My husband is a carrier of glutamic acidemia type I. I am not a carrier. Are our children at risk to develop this condition? Are all individuals with glutaric acidemia identified in infancy? Where can I access genetic testing for glutaminc acidemia type I?</Text>
    <Focus start="27" len="24" />
    <Question id="T4" start="73" len="51">
      <SubQuestion qt="Susceptibility">Are our children at risk to develop this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="125" len="65">
      <SubQuestion qt="Diagnosis">Are all individuals with glutaric acidemia identified in infancy?</SubQuestion>
    </Question>
    <Question id="T6" start="191" len="65">
      <SubQuestion qt="PersonOrg">Where can I access genetic testing for glutaminc acidemia type I?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1067">
    <Text>My husband, now 44 years of age, was diagnosed with alkaptonuria 10 years ago. Until recently, he experienced discoloration of the urine, occasional stiff joints, and rupture of tendons. Now he is having breathing problems and stomach issues. Are these symptoms related to alkaptonuria? Are there any treatments for this condition? Are there dietary guidelines for individuals with alkaptonuria?</Text>
    <Focus start="52" len="12" />
    <Question id="T5" start="243" len="43">
      <SubQuestion qt="Manifestation">Are these symptoms related to alkaptonuria?</SubQuestion>
    </Question>
    <Question id="T6" start="287" len="44">
      <SubQuestion qt="Management">Are there any treatments for this condition?</SubQuestion>
    </Question>
    <Question id="T7" start="332" len="63">
      <SubQuestion qt="Management">Are there dietary guidelines for individuals with alkaptonuria?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1068">
    <Text>My husband passed away rather suddenly from APL in 2009. I was reading that the translocation occurs after conception. I have two young boys and although I know it is not inherited, I would like to know if there is a way to test if the translocation has occurred.</Text>
    <Focus start="44" len="3" />
    <Question id="T4" start="119" len="144">
      <SubQuestion qt="Diagnosis">I have two young boys and although I know it is not inherited, I would like to know if there is a way to test if the translocation has occurred.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1069">
    <Text>My husband's brother just found out he has ARVC. My husband plans to have genetic testing. If my husband does not carry the gene, are my children still at risk for developing this condition? Also, if you have the gene will it be manifested as ARVC or do you just have the possibility of it developing?</Text>
    <Focus start="43" len="4" />
    <Question id="T4" start="91" len="99">
      <SubQuestion qt="Susceptibility">If my husband does not carry the gene, are my children still at risk for developing this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="191" len="110">
      <SubQuestion qt="Susceptibility">If you have the gene will it be manifested as ARVC or do you just have the possibility of it developing?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1070">
    <Text>My husband's grandmother had three children. Two of her sons with Wiskott Aldrich syndrome (WAS) died at ages 7 and 3. My husband's father did not have it, and he had 3 boys. My husband and I are expecting. Is there a chance our child will have WAS?</Text>
    <Focus start="66" len="30" />
    <Question id="T6" start="207" len="42">
      <SubQuestion qt="Susceptibility">Is there a chance our child will have WAS?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1071">
    <Text>My husband's sister's son has a form of ectodermal dysplasia (problems with the skin, hair, sweat glands and teeth). No one else in my husband's family is affected. My husband and I don't have children yet. Is it possible that my husband is a carrier or that my future children could have the condition or be carriers? I'm very confused and worried.</Text>
    <Focus start="40" len="20" />
    <Question id="T5" start="207" len="111">
      <SubQuestion qt="Susceptibility">Is it possible that my husband is a carrier?</SubQuestion>
      <SubQuestion qt="Susceptibility">Is it possible that my future children could have the condition?</SubQuestion>
      <SubQuestion qt="Susceptibility">Is it possible that my future children could be carriers?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1072">
    <Text>My husband was diagnosed in 1998 with VIPoma. He uses octreotide to help control the symptoms. Is there any other known treatment (other than surgery) for this rare cancer?</Text>
    <Focus start="38" len="6" />
    <Question id="T4" start="95" len="77">
      <SubQuestion qt="Management">Is there any other known treatment (other than surgery) for this rare cancer?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1073">
    <Text>My husband was diagnosed with Felty's syndrome and died a few months later. Is Felty's syndrome inherited? I am concerned that my son is at risk for having the condition.</Text>
    <Focus start="30" len="16" />
    <Question id="T2" start="76" len="30">
      <SubQuestion qt="Susceptibility">Is Felty's syndrome inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1074">
    <Text>My husband was diagnosed with multiple sclerosis (MS) in 1999, and now with a second opinion he was diagnosed with possible primary lateral sclerosis (PLS). How does MS differ from PLS? How are MS and PLS diagnosed?</Text>
    <Focus start="30" len="23" />
    <Focus start="124" len="31" />
    <Question id="T4" start="157" len="28">
      <SubQuestion qt="Other">How does MS differ from PLS?</SubQuestion>
    </Question>
    <Question id="T5" start="186" len="29">
      <SubQuestion qt="Diagnosis" attrs="Error">How are MS and PLS diagnosed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1075">
    <Text>My husband was diagnosed with sinonasal undifferentiated carcinoma (SNUC).  We know very little about it. The cancer has metastasized to his lymph nodes and liver.  It started with a very large tumor that grew up from the sinuses and pressed against his frontal lobe. He has had surgery and is now receiving chemotherapy.  Any information you have about this cancer, any current therapies, or research trials could be helpful.</Text>
    <Focus start="30" len="43" />
    <Question id="T7" start="323" len="103">
      <SubQuestion qt="Information">Any information you have about this cancer could be helpful.</SubQuestion>
      <SubQuestion qt="Management">Any information you have about any current therapies could be helpful.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Any information you have about research trials could be helpful.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1076">
    <Text>My identical twin sister has been diagnosed with progressive supranuclear palsy (PSP).  As it seems this disease may have a genetic cause, what is the chance that I would also develop PSP?  And within what timeframe?</Text>
    <Focus start="49" len="36" />
    <Question id="T3" start="88" len="100">
      <SubQuestion qt="Susceptibility">As it seems this disease may have a genetic cause, what is the chance that I would also develop PSP?</SubQuestion>
    </Question>
    <Question id="T4" start="190" len="26">
      <SubQuestion qt="Prognosis">Within what timeframe?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1077">
    <Text>My infant daughter passed away in the 1980s due to complications associated with autosomal recessive polycystic kidney disease.  Is there a cure for the disease?  What treatment options are available?</Text>
    <Focus start="81" len="45" />
    <Question id="T3" start="129" len="32">
      <SubQuestion qt="Management">Is there a cure for the disease?</SubQuestion>
    </Question>
    <Question id="T4" start="163" len="37">
      <SubQuestion qt="Management">What treatment options are available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1078">
    <Text>My infant nephew has been diagnosed with epidermolysis bullosa simplex, Koebner type. We were told that this is a genetic condition, even though no other members of our family are affected. We live in Spain and have not received much information. How is epidermolysis bullosa inherited? Can it be treated? How can we learn about research that may be occurring throughout the world?</Text>
    <Focus start="41" len="43" />
    <Question id="T5" start="247" len="39">
      <SubQuestion qt="Susceptibility">How is epidermolysis bullosa inherited?</SubQuestion>
    </Question>
    <Question id="T6" start="287" len="18">
      <SubQuestion qt="Management">Can it be treated?</SubQuestion>
    </Question>
    <Question id="T7" start="306" len="75">
      <SubQuestion qt="Information" attrs="Research">How can we learn about research that may be occurring throughout the world?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1079">
    <Text>My infant son has 5 cafe au lait spots on his trunk and left leg. He was adopted, so I don't know about family history. Is there a genetic test which can help to rule-out neurofibromatosis?</Text>
    <Focus start="171" len="17" />
    <Question id="T3" start="120" len="69">
      <SubQuestion qt="Diagnosis">Is there a genetic test which can help to rule-out neurofibromatosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1080">
    <Text>My little baby has Krabbe leukodystrophy. Here in Italy, doctors give us no chance. Can you help us?</Text>
    <Focus start="19" len="21" />
    <Question id="T4" start="84" len="16">
      <SubQuestion qt="Prognosis">Can you help us?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1081">
    <Text>My mom has been diagnosed with a Klatskin tumor. They tried to remove it but were unable to do so. What symptoms might develop as her condition progresses? Her eyesight has become blurred. Could this be related to her condition?</Text>
    <Focus start="33" len="14" />
    <Question id="T4" start="99" len="56">
      <SubQuestion qt="Manifestation">What symptoms might develop as her condition progresses?</SubQuestion>
    </Question>
    <Question id="T6" start="189" len="39">
      <SubQuestion qt="OtherEffect">Could this be related to her condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1082">
    <Text>My mom has had cerebellar degeneration for several years, yet I still know very little about it. Can you provide me with some information?</Text>
    <Focus start="15" len="23" />
    <Question id="T3" start="97" len="41">
      <SubQuestion qt="Information">Can you provide me with some information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1083">
    <Text>My mom is dying from this very painful and agonizing disease. She lost both of her legs 4 years ago due to the disease and it has now progressed to her hands, and it's looking as though it's now going to take her hands from her. The pain she bears is very difficult to endure. Is there anything that could help her?</Text>
    <Focus start="21" len="39" />
    <Question id="T5" start="277" len="38">
      <SubQuestion qt="Management">Is there anything that could help her?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1084">
    <Text>My mom passed away with MMT Uterine Cancer. The doctors tell me its very rare. I'm still unsure and wanted to know more about this cancer and if it is genetic.</Text>
    <Focus start="24" len="18" />
    <Question id="T4" start="79" len="80">
      <SubQuestion qt="Information">I'm still unsure and wanted to know more about this cancer.</SubQuestion>
      <SubQuestion qt="Cause">I'm still unsure and wanted to know if it is genetic.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1085">
    <Text>My mother and her identical twin sister have CADASIL. While some of my cousins have the condition, I do not. Am I at risk to inherit this condition?</Text>
    <Focus start="45" len="7" />
    <Question id="T4" start="109" len="39">
      <SubQuestion qt="Susceptibility">Am I at risk to inherit this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1086">
    <Text>My mother had a baby with anencephaly. Does this increase the chances for me to have a baby with this condition?</Text>
    <Focus start="26" len="11" />
    <Question id="T3" start="39" len="73">
      <SubQuestion qt="Susceptibility">Does this increase the chances for me to have a baby with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1087">
    <Text>My mother had a tumor removed from her back. They diagnosed the tumor as a dermatofibrosarcoma protuberans. They don't think they got it all. How quickly will this tumor regrow. Will my mother have to have another surgery. She is in her 80's and does not want to undergo a second surgery.</Text>
    <Focus start="75" len="31" />
    <Question id="T5" start="142" len="35">
      <SubQuestion qt="Prognosis">How quickly will this tumor regrow.</SubQuestion>
    </Question>
    <Question id="T6" start="178" len="44">
      <SubQuestion qt="Management">Will my mother have to have another surgery.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1088">
    <Text>My mother had HELLP syndrome. Is this condition genetic? Am I at high risk of getting HELLP syndrome when I get pregnant?</Text>
    <Focus start="14" len="14" />
    <Question id="T3" start="30" len="26">
      <SubQuestion qt="Susceptibility">Is this condition genetic?</SubQuestion>
    </Question>
    <Question id="T4" start="57" len="64">
      <SubQuestion qt="Susceptibility">Am I at high risk of getting HELLP syndrome when I get pregnant?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1089">
    <Text>My mother has been diagnosed with dermatomyositis. She has not responded to the treatments she has received. Can you provide information about the symptoms, treatment, and prognosis for this condition?</Text>
    <Focus start="34" len="15" />
    <Question id="T4" start="109" len="92">
      <SubQuestion qt="Manifestation">Can you provide information about the symptoms for this condition?</SubQuestion>
      <SubQuestion qt="Management">Can you provide information about the treatment for this condition?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you provide information about the prognosis for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1090">
    <Text>My mother has been diagnosed with gamma heavy chain disease. How can this disease be treated? Several members of my family have autoimmune diseases like those that may be associated with gamma heavy chain disease. Can this condition be prevented?</Text>
    <Focus start="34" len="25" />
    <Question id="T3" start="61" len="32">
      <SubQuestion qt="Management">How can this disease be treated?</SubQuestion>
    </Question>
    <Question id="T5" start="214" len="32">
      <SubQuestion qt="Management">Can this condition be prevented?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1091">
    <Text>My mother has had 2 to 3 episodes of transient global amnesia (TGA) in the last 8 months. How often does a person have repeated episodes of TGA? What can we do to make them stop?</Text>
    <Focus start="37" len="30" />
    <Question id="T3" start="90" len="54">
      <SubQuestion qt="Prognosis">How often does a person have repeated episodes of TGA?</SubQuestion>
    </Question>
    <Question id="T4" start="145" len="33">
      <SubQuestion qt="Management">What can we do to make them stop?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1092">
    <Text>My mother has had epidermolysis bullosa for many years. She recently underwent total knee replacement surgery and another surgery to flush out a staph infection and has had wound healing problems, including pus, redness and fever. We are concerned about complications from infection and wanted to know if there is any research related to wound healing in patients with epidermolysis bullosa. Where can we read more information about treatment? How can we find a physician who is knowledgeable about this condition?</Text>
    <Focus start="18" len="21" />
    <Question id="T4" start="231" len="160">
      <SubQuestion qt="Complication" attrs="Research">We are concerned about complications from infection and wanted to know if there is any research related to wound healing in patients with epidermolysis bullosa.</SubQuestion>
    </Question>
    <Question id="T5" start="392" len="51">
      <SubQuestion qt="Management">Where can we read more information about treatment?</SubQuestion>
    </Question>
    <Question id="T6" start="444" len="70">
      <SubQuestion qt="PersonOrg">How can we find a physician who is knowledgeable about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1093">
    <Text>My mother has polymyositis. How might this condition be treated?</Text>
    <Focus start="14" len="12" />
    <Question id="T3" start="28" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1094">
    <Text>My mother has recently been diagnosed with Carney Complex/Cushings syndrome. Where can we find more information and a place where she can receive emotional support?  A lot of the physicians involved in her care are unfamiliar with this condition.</Text>
    <Focus start="43" len="32" />
    <Question id="T3" start="77" len="87">
      <SubQuestion qt="Information">Where can we find more information?</SubQuestion>
      <SubQuestion qt="PersonOrg">Where can we find a place where she can receive emotional support?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1095">
    <Text>My mother has recently been diagnosed with this disease. Her first symptoms became apparent about 2.5 years ago when she developed weakness in one foot. She currently has little movement in her legs, and her hands, arms, speech and breathing are affected. What is the prognosis and life expectancy for this condition and what can we expect from here?</Text>
    <Focus start="43" len="12" />
    <Question id="T5" start="256" len="60">
      <SubQuestion qt="Prognosis">What is the prognosis for this condition?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the life expectancy for this condition?</SubQuestion>
    </Question>
    <Question id="T7" start="317" len="33">
      <SubQuestion qt="Prognosis">What can we expect from here?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1096">
    <Text>My mother has spasmodic dysphonia and I believe that I may have it too. How is this condition diagnosed? Is genetic testing available for this condition?</Text>
    <Focus start="14" len="19" />
    <Question id="T3" start="72" len="32">
      <SubQuestion qt="Diagnosis">How is this condition diagnosed?</SubQuestion>
    </Question>
    <Question id="T4" start="105" len="48">
      <SubQuestion qt="Diagnosis">Is genetic testing available for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1097">
    <Text>My mother has spastic paraplegia. She was diagnosed about five years ago at the Mayo Clinic. She has the complicated form of the disorder because she is confined to a wheelchair and her mind has slowed down. Also, her brother also had this disorder. I know that I have a 50% chance of inheriting this disorder. Since my family members' cases are so severe, does this mean mine probably would be as well? Also, what research is being done to work towards a cure for this?</Text>
    <Focus start="14" len="18" />
    <Question id="T7" start="311" len="92">
      <SubQuestion qt="Susceptibility">Since my family members' cases are so severe, does this mean mine probably would be as well?</SubQuestion>
    </Question>
    <Question id="T8" start="404" len="66">
      <SubQuestion qt="Management" attrs="Research">What research is being done to work towards a cure for this?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1098">
    <Text>My mother-in-law died from Goodpasture syndrome. Is my husband at an increased risk for developing this syndrome in the future?</Text>
    <Focus start="27" len="20" />
    <Question id="T3" start="49" len="78">
      <SubQuestion qt="Susceptibility">Is my husband at an increased risk for developing this syndrome in the future?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1099">
    <Text>My mother-in-law has been diagnosed with Gardner syndrome. How is this syndrome inherited? Is there a genetic test to find out if my wife, and eventually our children, are affected with Gardner syndrome?</Text>
    <Focus start="41" len="16" />
    <Question id="T3" start="59" len="31">
      <SubQuestion qt="Susceptibility">How is this syndrome inherited?</SubQuestion>
    </Question>
    <Question id="T4" start="91" len="112">
      <SubQuestion qt="Diagnosis">Is there a genetic test to find out if my wife are affected with Gardner syndrome?</SubQuestion>
      <SubQuestion qt="Diagnosis">Is there a genetic test to find out if eventually our children are affected with Gardner syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1100">
    <Text>My mother-in-law was recently diagnosed with Camurati-Engelmann disease. Can you provide me with information about this condition?</Text>
    <Focus start="45" len="26" />
    <Question id="T3" start="73" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1101">
    <Text>My mother is almost blind. Her diagnosis is Bardet-Biedl syndrome. She has no other symptoms besides being almost blind. Is there any cure or treatment for Bardet-Biedl syndrome anywhere in the world? Thank you very much.</Text>
    <Focus start="44" len="21" />
    <Question id="T5" start="121" len="79">
      <SubQuestion qt="Management">Is there any cure for Bardet-Biedl syndrome anywhere in the world?</SubQuestion>
      <SubQuestion qt="Management">Is there any treatment for Bardet-Biedl syndrome anywhere in the world?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1102">
    <Text>My mother is Brazilian and she has Chagas Disease. I would like to know if it is genetic and the chance that I or my children may have it.</Text>
    <Focus start="35" len="14" />
    <Question id="T3" start="51" len="87">
      <SubQuestion qt="Susceptibility">I would like to know if it is genetic.</SubQuestion>
      <SubQuestion qt="Susceptibility">I would like to know the chance that I may have it.</SubQuestion>
      <SubQuestion qt="Susceptibility">I would like to know the chance that my children may have it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1103">
    <Text>My mother is suffering from systemic mastocytosis. What types of treatment are available for this condition?</Text>
    <Focus start="28" len="21" />
    <Question id="T3" start="51" len="57">
      <SubQuestion qt="Management">What types of treatment are available for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1104">
    <Text>My mother, sister, and niece have been diagnosed with HNPCC, and I am told it is very likely that I also have HNPCC. I can not find a lot of information on this condition, can you help? What kind of doctor do I need to see? What kind of screening for cancer should I have done?</Text>
    <Focus start="54" len="5" />
    <Question id="T3" start="117" len="68">
      <SubQuestion qt="Information">I can not find a lot of information on this condition, can you help?</SubQuestion>
    </Question>
    <Question id="T4" start="186" len="37">
      <SubQuestion qt="PersonOrg">What kind of doctor do I need to see?</SubQuestion>
    </Question>
    <Question id="T5" start="224" len="53">
      <SubQuestion qt="Diagnosis">What kind of screening for cancer should I have done?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1105">
    <Text>My mother was diagnosed with Guillain-Barre syndrome after having a flu shot in 2001.  Does this make me more at risk of developing Guillain-Barre syndrome if I have a flu shot?</Text>
    <Focus start="29" len="23" />
    <Question id="T3" start="87" len="90">
      <SubQuestion qt="Cause">Does this make me more at risk of developing Guillain-Barre syndrome if I have a flu shot?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1106">
    <Text>My mother was diagnosed with pseudoxanthoma elasticum, but no one in the previous three generations of my father's family have been diagnosed with this condition.  Now I have a baby who seems to have lumps which look like pseudoxanthoma elasticum on his neck, but no one in the previous three generations of my husband's family have been diagnosed with this condition.  My questions are:1. How can I know whether or not my husband or I are unaffected carriers?  What type of blood test do I need to have?2. Several websites say that pseudoxanthoma elasticum is untreatable.  Is that true? Can the progression of this condition be slowed down or managed?3.  My baby was only 3-4 months old when I saw the yellow lumps on his neck, but I read that the average age for the onset of symptoms is in the teens.  Is it possible for a baby to show symptoms?</Text>
    <Focus start="29" len="24" />
    <Question id="T5" start="390" len="70">
      <SubQuestion qt="Diagnosis" attrs="Error">How can I know whether or not my husband are unaffected carriers?</SubQuestion>
      <SubQuestion qt="Diagnosis" attrs="Error">How can I know whether or not I are unaffected carriers?</SubQuestion>
    </Question>
    <Question id="T6" start="462" len="42">
      <SubQuestion qt="Diagnosis">What type of blood test do I need to have?</SubQuestion>
    </Question>
    <Question id="T10" start="575" len="13">
      <SubQuestion qt="Management">Is that true?</SubQuestion>
    </Question>
    <Question id="T11" start="589" len="64">
      <SubQuestion qt="Management">Can the progression of this condition be slowed down?</SubQuestion>
      <SubQuestion qt="Management">Can the progression of this condition be managed?</SubQuestion>
    </Question>
    <Question id="T15" start="806" len="43">
      <SubQuestion qt="Manifestation">Is it possible for a baby to show symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1107">
    <Text>My nephew and niece, ages 4 and 1, have been diagnosed with Bloom syndrome very recently. We, as a family, are passing through a lot of stress and would be highly obliged if you could let us know if there is any treatment or gene therapy which can be offered now or in the near future. Any help or leads would be highly appreciated.</Text>
    <Focus start="60" len="14" />
    <Question id="T3" start="90" len="195">
      <SubQuestion qt="Management">We, as a family, are passing through a lot of stress and would be highly obliged if you could let us know if there is any treatment which can be offered now.</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">We, as a family, are passing through a lot of stress and would be highly obliged if you could let us know if there is any treatment which can be offered in the near future.</SubQuestion>
      <SubQuestion qt="Management">We, as a family, are passing through a lot of stress and would be highly obliged if you could let us know if there is any gene therapy which can be offered now.</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">We, as a family, are passing through a lot of stress and would be highly obliged if you could let us know if there is any gene therapy which can be offered in the near future.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1108">
    <Text>My nephew has been diagnosed with Beals syndrome (also known as congenital contractural arachnodactyly). Can you provide me with information?</Text>
    <Focus start="34" len="14" />
    <Question id="T3" start="105" len="36">
      <SubQuestion qt="Information">Can you provide me with information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1109">
    <Text>My nephew has been diagnosed with Budd-Chiari syndrome. What is the treatment for this condition?</Text>
    <Focus start="34" len="20" />
    <Question id="T3" start="56" len="41">
      <SubQuestion qt="Management">What is the treatment for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1110">
    <Text>My nephew has been diagnosed with Jarcho-Levin syndrome. Do you have information on this condition that I could share with my family?</Text>
    <Focus start="34" len="21" />
    <Question id="T3" start="57" len="76">
      <SubQuestion qt="Information">Do you have information on this condition that I could share with my family?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1111">
    <Text>My nephew has been diagnosed with septo-optic dysplasia. My family is looking for information. Can this condition be cured? Are there any foundations that give support to families that are dealing with this illness. Are there any clinical studies being conducted for septo-optic dysplasia?</Text>
    <Focus start="34" len="21" />
    <Question id="T4" start="95" len="28">
      <SubQuestion qt="Management">Can this condition be cured?</SubQuestion>
    </Question>
    <Question id="T5" start="124" len="91">
      <SubQuestion qt="PersonOrg">Are there any foundations that give support to families that are dealing with this illness.</SubQuestion>
    </Question>
    <Question id="T6" start="216" len="73">
      <SubQuestion qt="Information" attrs="Research">Are there any clinical studies being conducted for septo-optic dysplasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1112">
    <Text>My nephew has just been diagnosed with Alpers syndrome. The family is devastated. Is there a treatment or cure?</Text>
    <Focus start="39" len="15" />
    <Question id="T4" start="82" len="29">
      <SubQuestion qt="Management">Is there a treatment?</SubQuestion>
      <SubQuestion qt="Management">Is there a cure?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1113">
    <Text>My nephew was born with a cleft lip and lip pits but tested negative for van der Woude syndrome. Neither parent has cleft lip, lip pits, or a family history of either. Is it possible that this genetic test is incorrect?</Text>
    <Focus start="73" len="22" />
    <Question id="T4" start="168" len="51">
      <SubQuestion qt="Diagnosis">Is it possible that this genetic test is incorrect?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1114">
    <Text>My nephew was diagnosed with hypophosphatemic rickets. He is on calcitriol but is not responding. What causes this, and is there any treatment?</Text>
    <Focus start="29" len="24" />
    <Question id="T4" start="98" len="17">
      <SubQuestion qt="Cause">What causes this?</SubQuestion>
    </Question>
    <Question id="T5" start="116" len="27">
      <SubQuestion qt="Management">Is there any treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1115">
    <Text>My nephew was diagnosed with Nance-Horan syndrome. He was born with cataracts, supernumerary teeth, and facial dysmorphism. He doesn't have intellectual disabilities. My sister is the carrier and she has some of the characteristics; but much less severe than her son. No other family members have features of the syndrome. Is it possible that the genetic defect started with her? And what are the chances of my sister having a child without the defect? Is it possible to be a carrier and not show any outward signs of the syndrome?</Text>
    <Focus start="29" len="20" />
    <Question id="T7" start="323" len="56">
      <SubQuestion qt="Susceptibility">Is it possible that the genetic defect started with her?</SubQuestion>
    </Question>
    <Question id="T8" start="380" len="72">
      <SubQuestion qt="Susceptibility">What are the chances of my sister having a child without the defect?</SubQuestion>
    </Question>
    <Question id="T9" start="453" len="78">
      <SubQuestion qt="Manifestation">Is it possible to be a carrier and not show any outward signs of the syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1116">
    <Text>My nephew was diagnosed with windblown hand. How is this condition treated? How can I find general information?</Text>
    <Focus start="29" len="14" />
    <Question id="T3" start="45" len="30">
      <SubQuestion qt="Management">How is this condition treated?</SubQuestion>
    </Question>
    <Question id="T4" start="76" len="35">
      <SubQuestion qt="Information">How can I find general information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1117">
    <Text>My newborn baby was diagnosed with galactosemia. Please tell me what I should do.</Text>
    <Focus start="35" len="12" />
    <Question id="T3" start="49" len="32">
      <SubQuestion qt="Management">Please tell me what I should do.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1118">
    <Text>My niece has 2q37 deletion syndrome. I was wondering what causes it and if it can be a hidden trait.</Text>
    <Focus start="13" len="22" />
    <Question id="T3" start="37" len="63">
      <SubQuestion qt="Cause">I was wondering what causes it.</SubQuestion>
      <SubQuestion qt="OtherEffect">I was wondering if it can be a hidden trait.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1119">
    <Text>My niece has been diagnosed with autosomal dominant craniometaphyseal dysplasia. Can you provide information regarding treatment and research ?</Text>
    <Focus start="33" len="46" />
    <Question id="T3" start="81" len="62">
      <SubQuestion qt="Management">Can you provide information regarding treatment?</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Can you provide information regarding research?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1120">
    <Text>My niece has been diagnosed with Wiedemann-Rautenstrauch syndrome and I was wondering what is known about the syndrome.</Text>
    <Focus start="33" len="32" />
    <Question id="T1" start="0" len="119">
      <SubQuestion qt="Information">My niece has been diagnosed with Wiedemann-Rautenstrauch syndrome and I was wondering what is known about the syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1121">
    <Text>My niece was diagnosed with this syndrome. Could you put me in touch with other families who have experience with this syndrome? From the information we found online, I believe that those children are mentally disabled. Could you please confirm that this is true and that ALL the kids with this syndrome will be mentally disabled?</Text>
    <Focus start="28" len="13" />
    <Question id="T3" start="43" len="85">
      <SubQuestion qt="PersonOrg">Could you put me in touch with other families who have experience with this syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="220" len="110">
      <SubQuestion qt="OtherEffect">Could you please confirm that this is true?</SubQuestion>
      <SubQuestion qt="OtherEffect">Could you please confirm that ALL the kids with this syndrome will be mentally disabled?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1122">
    <Text>My one year old daughter has been diagnosed with fibrous dysplasia (FD). FD has been found on her left leg in both her tibia and fibula bones. Is there any cure for this condition?</Text>
    <Focus start="49" len="22" />
    <Question id="T4" start="143" len="37">
      <SubQuestion qt="Management">Is there any cure for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1123">
    <Text>My one year-old daughter was admitted in the hospital because of breathing problems. Her ph level was 6.7 and she was unconscious for eight days. During those days there were many problems. Her doctor said that she had SCOT deficiency OR carnitine palmitoyl transferase 1 deficiency. Now she is normal. Will this happen again?</Text>
    <Focus start="219" len="15" />
    <Focus start="238" len="44" />
    <Question id="T8" start="303" len="23">
      <SubQuestion qt="Prognosis">Will this happen again?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1124">
    <Text>My parter and I are both AS (sickle cell carriers) and we intend to get married. How can we avert giving birth to a SS child? How early can the amniocentesis test be conducted during pregnancy? With the IVF method can the genotype be detected before the woman gets pregnant?</Text>
    <Focus start="25" len="25" />
    <Question id="T3" start="81" len="44">
      <SubQuestion qt="Management">How can we avert giving birth to a SS child?</SubQuestion>
    </Question>
    <Question id="T4" start="126" len="67">
      <SubQuestion qt="Diagnosis">How early can the amniocentesis test be conducted during pregnancy?</SubQuestion>
    </Question>
    <Question id="T5" start="194" len="80">
      <SubQuestion qt="Diagnosis">With the IVF method can the genotype be detected before the woman gets pregnant?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1125">
    <Text>My partner and I both have sickle cell trait and are planning to have a baby. During the pregnancy, are there any tests that could tell us whether the baby will have sickle cell anemia?  Is there a way to make sure that we do not have a child with the condition?</Text>
    <Focus start="27" len="17" />
    <Question id="T3" start="78" len="107">
      <SubQuestion qt="Diagnosis">During the pregnancy, are there any tests that could tell us whether the baby will have sickle cell anemia?</SubQuestion>
    </Question>
    <Question id="T4" start="187" len="75">
      <SubQuestion qt="Management">Is there a way to make sure that we do not have a child with the condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1126">
    <Text>My partner and I have both been diagnosed with beta-thalassemia minor. What is the likelihood of having a child without beta-thalassemia?</Text>
    <Focus start="47" len="22" />
    <Question id="T3" start="71" len="66">
      <SubQuestion qt="Susceptibility">What is the likelihood of having a child without beta-thalassemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1127">
    <Text>My partner has been diagnosed with Eales disease. How might this condition be treated?</Text>
    <Focus start="35" len="13" />
    <Question id="T3" start="50" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1128">
    <Text>My partner is a carrier for Simpson-Golabi-Behmel syndrome and her son was diagnosed with this rare condition. Is there information regarding prognosis or life expectancy for individuals with this syndrome? What are the potential long term effects on cardiac function? Could any heart abnormalities be corrected? How does the genetic mutation cause this condition, and should we expect other body areas to be affected? Also, my partner gets supraventricular tachycardia including atrial fibrillation. Can carriers of SGBS manifest some signs or symptoms of the condition? Can any type of procedure or intervention help my partner's heart issues?</Text>
    <Focus start="28" len="30" />
    <Question id="T3" start="111" len="95">
      <SubQuestion qt="Prognosis">Is there information regarding prognosis for individuals with this syndrome?</SubQuestion>
      <SubQuestion qt="Prognosis">Is there information regarding life expectancy for individuals with this syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="207" len="61">
      <SubQuestion qt="Prognosis">What are the potential long term effects on cardiac function?</SubQuestion>
    </Question>
    <Question id="T6" start="269" len="43">
      <SubQuestion qt="Management">Could any heart abnormalities be corrected?</SubQuestion>
    </Question>
    <Question id="T7" start="313" len="51">
      <SubQuestion qt="Cause">How does the genetic mutation cause this condition?</SubQuestion>
    </Question>
    <Question id="T8" start="365" len="53">
      <SubQuestion qt="Prognosis">Should we expect other body areas to be affected?</SubQuestion>
    </Question>
    <Question id="T10" start="501" len="70">
      <SubQuestion qt="Manifestation">Can carriers of SGBS manifest some signs of the condition?</SubQuestion>
      <SubQuestion qt="Manifestation">Can carriers of SGBS manifest some symptoms of the condition?</SubQuestion>
    </Question>
    <Question id="T12" start="572" len="73">
      <SubQuestion qt="Management">Can any type of procedure help my partner's heart issues?</SubQuestion>
      <SubQuestion qt="Management">Can any type of intervention help my partner's heart issues?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1129">
    <Text>My physician believes that I may have fibromyalgia. Can you provide me with information about this condition?</Text>
    <Focus start="38" len="12" />
    <Question id="T3" start="52" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1130">
    <Text>My physician recently mentioned that I may be at risk for Cowden syndrome. What can you tell me about this condition?</Text>
    <Focus start="58" len="15" />
    <Question id="T3" start="75" len="42">
      <SubQuestion qt="Information">What can you tell me about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1131">
    <Text>My question is in regards to a student who was diagnosed with this condition who is experiencing behavior problems. Is this common for this syndrome, and what recommendations do you suggest if behavioral problems do persist?</Text>
    <Focus start="62" len="14" />
    <Question id="T3" start="116" len="33">
      <SubQuestion qt="OtherEffect">Is this common for this syndrome?</SubQuestion>
    </Question>
    <Question id="T4" start="150" len="74">
      <SubQuestion qt="Management">What recommendations do you suggest if behavioral problems do persist?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1132">
    <Text>My second daughter, age one year, is affected by Trisomy 21 (Down syndrome). The doctors here say that there is no cure for Down syndrome. Can't the extra chromosome be delinked from other cells? Can't the extra chromosome be deactivated? Please help us, if there is any cure for Down syndrome.</Text>
    <Focus start="49" len="26" />
    <Question id="T4" start="139" len="56">
      <SubQuestion qt="Management">Can't the extra chromosome be delinked from other cells?</SubQuestion>
    </Question>
    <Question id="T5" start="196" len="42">
      <SubQuestion qt="Management">Can't the extra chromosome be deactivated?</SubQuestion>
    </Question>
    <Question id="T6" start="239" len="55">
      <SubQuestion qt="Management">Please help us, if there is any cure for Down syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1133">
    <Text>My sister and I have neurofibromas and dermal eccrine cylindromas. Do you have ANY information on these tumors or know where I can get more information?</Text>
    <Focus start="21" len="13" />
    <Focus start="39" len="26" />
    <Question id="T4" start="67" len="85">
      <SubQuestion qt="Information">Do you have ANY information on these tumors?</SubQuestion>
      <SubQuestion qt="Information">Do you know where I can get more information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1134">
    <Text>My sister died of a massive stroke caused by an AVM in her early 60's. Since we had the same parents, what are the chances that I may have this condition?  I am experiencing numbness in both arms at night. The numbness wakes me several times a night. Are there any possible connections?</Text>
    <Focus start="48" len="3" />
    <Question id="T3" start="71" len="83">
      <SubQuestion qt="Susceptibility">Since we had the same parents, what are the chances that I may have this condition?</SubQuestion>
    </Question>
    <Question id="T6" start="251" len="35">
      <SubQuestion qt="OtherEffect">Are there any possible connections?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1135">
    <Text>My sister has achondroplasia. There are no other cases in the family. My husband's family does not have a history of achondroplasia.  What are the chances of my future children having achondroplasia?</Text>
    <Focus start="14" len="14" />
    <Question id="T5" start="134" len="65">
      <SubQuestion qt="Susceptibility">What are the chances of my future children having achondroplasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1136">
    <Text>My sister has Arnold Chiari malformation (ACM) and I feel like that might be what's going on with me!  Is ACM so rare two sisters couldn't possible have the same conditions?</Text>
    <Focus start="14" len="32" />
    <Question id="T3" start="103" len="70">
      <SubQuestion qt="Susceptibility">Is ACM so rare two sisters couldn't possible have the same conditions?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1137">
    <Text>My sister has been diagnosed with acanthocytosis.  What is this condition?</Text>
    <Focus start="34" len="14" />
    <Question id="T3" start="51" len="23">
      <SubQuestion qt="Information">What is this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1138">
    <Text>My sister has been diagnosed with myotonic dystrophy and suffers from severe muscle weakness, heart disorders and cataracts. What treatment is available for this condition? Is there research being conducted?</Text>
    <Focus start="34" len="18" />
    <Question id="T3" start="125" len="47">
      <SubQuestion qt="Management">What treatment is available for this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="173" len="34">
      <SubQuestion qt="Management" attrs="Research">Is there research being conducted?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1139">
    <Text>My sister has Darier disease. Is this condition genetic? Are my children at risk to develop this condition? If so, what can be done to help prevent a flare-up?</Text>
    <Focus start="14" len="14" />
    <Question id="T3" start="30" len="26">
      <SubQuestion qt="Susceptibility">Is this condition genetic?</SubQuestion>
    </Question>
    <Question id="T4" start="57" len="50">
      <SubQuestion qt="Susceptibility">Are my children at risk to develop this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="108" len="51">
      <SubQuestion qt="Management">If so, what can be done to help prevent a flare-up?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1140">
    <Text>My sister has Friedreich's ataxia.  I am looking for ways to make her life easier. Can you tell me where I can find out about wheelchairs, exercises, and bathroom accomodations? I would also like to connect with people who can help me.</Text>
    <Focus start="14" len="19" />
    <Question id="T3" start="36" len="46">
      <SubQuestion qt="Management">I am looking for ways to make her life easier.</SubQuestion>
    </Question>
    <Question id="T4" start="83" len="94">
      <SubQuestion qt="Management">Can you tell me where I can find out about wheelchairs?</SubQuestion>
      <SubQuestion qt="Management">Can you tell me where I can find out about exercises?</SubQuestion>
      <SubQuestion qt="Management">Can you tell me where I can find out about bathroom accomodations?</SubQuestion>
    </Question>
    <Question id="T6" start="178" len="57">
      <SubQuestion qt="PersonOrg">I would also like to connect with people who can help me.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1141">
    <Text>My sister has had vulvar leukoplakia for 12 years. The problem remains stable. The infection area does not expand and is difficult to recognize, as it is only 1 cm. Sometimes the area is itching. Could you let us know about treatment methods for this disease? Is surgery needed? Is the disease getting serious?</Text>
    <Focus start="18" len="18" />
    <Question id="T6" start="196" len="63">
      <SubQuestion qt="Management">Could you let us know about treatment methods for this disease?</SubQuestion>
    </Question>
    <Question id="T7" start="260" len="18">
      <SubQuestion qt="Management">Is surgery needed?</SubQuestion>
    </Question>
    <Question id="T8" start="279" len="31">
      <SubQuestion qt="Prognosis">Is the disease getting serious?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1142">
    <Text>My sister has retinitis pigmentosa. Can this condition be cured?</Text>
    <Focus start="14" len="20" />
    <Question id="T3" start="36" len="28">
      <SubQuestion qt="Management">Can this condition be cured?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1143">
    <Text>My sister has two children that have been diagnosed with Wolf-Hirschhorn Syndrome. How common is it for a person to have more than one child with the syndrome? I am interested in getting a genetic test to see if I am a carrier. Will the test be covered by my insurance?  How much do they generally cost?</Text>
    <Focus start="57" len="24" />
    <Question id="T3" start="83" len="76">
      <SubQuestion qt="Susceptibility">How common is it for a person to have more than one child with the syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="228" len="41">
      <SubQuestion qt="Other">Will the test be covered by my insurance?</SubQuestion>
    </Question>
    <Question id="T6" start="271" len="32">
      <SubQuestion qt="Other">How much do they generally cost?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1144">
    <Text>My sister has Williams syndrome and I am concerned about my chances to have a child with this condition. Is Williams syndrome inherited? Are there any ways to prevent Williams syndrome?</Text>
    <Focus start="14" len="17" />
    <Question id="T3" start="105" len="31">
      <SubQuestion qt="Susceptibility">Is Williams syndrome inherited?</SubQuestion>
    </Question>
    <Question id="T4" start="137" len="48">
      <SubQuestion qt="Management">Are there any ways to prevent Williams syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1145">
    <Text>My sister-in-law was diagnosed with Susac syndrome last year.  She is currently receiving chemotherapy and IVIG treatments.  Are there any other forms of treatment available?</Text>
    <Focus start="36" len="14" />
    <Question id="T4" start="125" len="49">
      <SubQuestion qt="Management">Are there any other forms of treatment available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1146">
    <Text>My sister passed away several years ago from complications of Gaucher disease.  She was petite in build and darker skinned than any of her siblings who had much lighter complexions and stockier builds.  Would these differences have been due to Gaucher disease?</Text>
    <Focus start="62" len="15" />
    <Question id="T4" start="203" len="57">
      <SubQuestion qt="OtherEffect">Would these differences have been due to Gaucher disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1147">
    <Text>My sister recently passed away from Waterhouse–Friderichsen syndrome. Can you help me find information about this condition?</Text>
    <Focus start="36" len="32" />
    <Question id="T3" start="70" len="54">
      <SubQuestion qt="Information">Can you help me find information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1148">
    <Text>My sister's daughter (my niece) recently had a baby and he was diagnosed with medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency. If this condition is traced back to my sister, is it important for me and/or my children (ages 8 and 11) to be tested?</Text>
    <Focus start="78" len="60" />
    <Question id="T3" start="140" len="118">
      <SubQuestion qt="Susceptibility">If this condition is traced back to my sister, is it important for me to be tested?</SubQuestion>
      <SubQuestion qt="Susceptibility" attrs="Error">If this condition is traced back to my sister, is it important for my children (ages 8 to be tested?</SubQuestion>
      <SubQuestion qt="Susceptibility" attrs="Error">If this condition is traced back to my sister, is it important for 11) to be tested?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1149">
    <Text>My sister's son has been diagnosed with juvenile retinoschisis, and she has been told she is a carrier.  What is the risk that I am a carrier and that my son has this condition?</Text>
    <Focus start="40" len="22" />
    <Question id="T3" start="105" len="72">
      <SubQuestion qt="Susceptibility">What is the risk that I am a carrier?</SubQuestion>
      <SubQuestion qt="Susceptibility">What is the risk that my son has this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1150">
    <Text>My sister was recently diagnosed with Horner syndrome. Last year I was diagnosed with cluster headaches. Are these two condition related?</Text>
    <Focus start="38" len="15" />
    <Focus start="86" len="17" />
    <Question id="T5" start="105" len="32">
      <SubQuestion qt="OtherEffect">Are these two condition related?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1151">
    <Text>My son, 9 years old, has been diagnosed with this condition and I am looking for general information on incidence, prognosis and treatment. Thank you.</Text>
    <Focus start="45" len="14" />
    <Question id="T1" start="0" len="139">
      <SubQuestion qt="Susceptibility">My son, 9 years old, has been diagnosed with this condition and I am looking for general information on incidence.</SubQuestion>
      <SubQuestion qt="Prognosis">My son, 9 years old, has been diagnosed with this condition and I am looking for general information on prognosis.</SubQuestion>
      <SubQuestion qt="Management">My son, 9 years old, has been diagnosed with this condition and I am looking for general information on treatment.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1152">
    <Text>My son and daughter-in-law recently lost a baby boy to ornithine transcarbamylase (OTC) deficiency. My daughter-in-law has been identified as a carrier. Is it possible for carrier females to have a healthy baby?</Text>
    <Focus start="55" len="43" />
    <Question id="T4" start="153" len="58">
      <SubQuestion qt="Susceptibility">Is it possible for carrier females to have a healthy baby?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1153">
    <Text>My son developed dark spots when he was one and half years old. Lichen planus pigmentosa was confimed by biopsy. I am not treating his condition with medication. Is it possible for him to overcome this condition by himself? How long will it take?</Text>
    <Focus start="64" len="24" />
    <Question id="T5" start="162" len="61">
      <SubQuestion qt="Management">Is it possible for him to overcome this condition by himself?</SubQuestion>
    </Question>
    <Question id="T6" start="224" len="22">
      <SubQuestion qt="Prognosis">How long will it take?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1154">
    <Text>My son had limb body-wall complex. I gave birth over 2.5 years ago.There is not a lot of information on the condition. Could you please send me some information?</Text>
    <Focus start="11" len="22" />
    <Question id="T5" start="119" len="42">
      <SubQuestion qt="Information">Could you please send me some information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1155">
    <Text>My son has 22q11.2 deletion syndrome (velocardiofacial syndrome) and was recently diagnosed with thyroid problems. He was treated with calcium. Why? Since he started his calcium he has been having seizures that seem to be triggered by intense emotion. Why? Does his condition affect his central nervous system? How can we treat his seizures? Now that he has seizures could he be classified as having a condition other than 22q11.2 syndrome, such as hypoparathyroidism retardation dysmorpha syndrome? What is this syndrome?</Text>
    <Focus start="11" len="53" />
    <Question id="T4" start="144" len="4">
      <SubQuestion qt="OtherEffect">Why?</SubQuestion>
    </Question>
    <Question id="T6" start="252" len="4">
      <SubQuestion qt="OtherEffect">Why?</SubQuestion>
    </Question>
    <Question id="T7" start="257" len="53">
      <SubQuestion qt="OtherEffect">Does his condition affect his central nervous system?</SubQuestion>
    </Question>
    <Question id="T8" start="311" len="30">
      <SubQuestion qt="Management">How can we treat his seizures?</SubQuestion>
    </Question>
    <Question id="T9" start="342" len="157">
      <SubQuestion qt="Diagnosis">Now that he has seizures could he be classified as having a condition other than 22q11.2 syndrome?</SubQuestion>
      <SubQuestion qt="Diagnosis">Now that he has seizures could he be classified as having a condition other than 22q11.2 syndrome, such as hypoparathyroidism retardation dysmorpha syndrome?</SubQuestion>
    </Question>
    <Question id="T11" start="500" len="22">
      <SubQuestion qt="Information">What is this syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1156">
    <Text>My son has achondroplasia. He can sit up without support, but he does not walk, talk, or interact much with his surrounding environment. I have seen many specialists in my country. I am worried about his delays. Most doctors have recommended that I watch and wait. I would like to learn more about langauge and motor development in children with achondroplasia. How are infants and children with achondroplasia treated?</Text>
    <Focus start="11" len="14" />
    <Question id="T7" start="265" len="96">
      <SubQuestion qt="OtherEffect">I would like to learn more about langauge development in children with achondroplasia.</SubQuestion>
      <SubQuestion qt="OtherEffect">I would like to learn more about motor development in children with achondroplasia.</SubQuestion>
    </Question>
    <Question id="T9" start="362" len="57">
      <SubQuestion qt="Management">How are infants with achondroplasia treated?</SubQuestion>
      <SubQuestion qt="Management">How are children with achondroplasia treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1157">
    <Text>My son has amelogenesis imperfecta. Our insurance company has requested proof that this is a medical condition. Can you provide me with information on this topic?</Text>
    <Focus start="11" len="23" />
    <Question id="T4" start="112" len="50">
      <SubQuestion qt="Information">Can you provide me with information on this topic?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1158">
    <Text>My son has been diagnosed with a desmoplastic infantile ganglioma?  Could you tell me more about this tumor.</Text>
    <Focus start="33" len="32" />
    <Question id="T3" start="68" len="40">
      <SubQuestion qt="Information">Could you tell me more about this tumor.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1159">
    <Text>My son has been diagnosed with Adie syndrome. Can this condition be cured? How might it be treated?</Text>
    <Focus start="31" len="13" />
    <Question id="T3" start="46" len="28">
      <SubQuestion qt="Management">Can this condition be cured?</SubQuestion>
    </Question>
    <Question id="T4" start="75" len="24">
      <SubQuestion qt="Management">How might it be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1160">
    <Text>My son has been diagnosed with Freiberg's disease. Is this condition easy to diagnose? Can an individual with this condition continue to play sports and participate in physical activities? How is it treated?</Text>
    <Focus start="31" len="18" />
    <Question id="T3" start="51" len="35">
      <SubQuestion qt="Diagnosis">Is this condition easy to diagnose?</SubQuestion>
    </Question>
    <Question id="T4" start="87" len="101">
      <SubQuestion qt="Prognosis">Can an individual with this condition continue to play sports?</SubQuestion>
      <SubQuestion qt="Prognosis">Can an individual with this condition continue to participate in physical activities?</SubQuestion>
    </Question>
    <Question id="T6" start="189" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1161">
    <Text>My son has been diagnosed with GM1 gangliosidosis. Please tell me more about this condition.</Text>
    <Focus start="31" len="18" />
    <Question id="T3" start="51" len="41">
      <SubQuestion qt="Information">Please tell me more about this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1162">
    <Text>My son has been diagnosed with GSD type 3 based on liver biopsy. Is there another test to confirm this diagnosis? Are there any treatments available?</Text>
    <Focus start="31" len="10" />
    <Question id="T3" start="65" len="48">
      <SubQuestion qt="Diagnosis">Is there another test to confirm this diagnosis?</SubQuestion>
    </Question>
    <Question id="T4" start="114" len="35">
      <SubQuestion qt="Management">Are there any treatments available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1163">
    <Text>My son has been diagnosed with Jarcho-Levin syndrome. How can I ensure a long, healthy life for him?</Text>
    <Focus start="31" len="21" />
    <Question id="T3" start="54" len="46">
      <SubQuestion qt="Management">How can I ensure a long life for him?</SubQuestion>
      <SubQuestion qt="Management">How can I ensure a healthy life for him?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1164">
    <Text>My son has been diagnosed with MECP2 duplication syndrome. What are the symptoms of this condition? Is there treatment? What is the prognosis for individuals with this condition?</Text>
    <Focus start="31" len="26" />
    <Question id="T3" start="59" len="40">
      <SubQuestion qt="Manifestation">What are the symptoms of this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="100" len="19">
      <SubQuestion qt="Management">Is there treatment?</SubQuestion>
    </Question>
    <Question id="T5" start="120" len="58">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1165">
    <Text>My son has been diagnosed with phacomatosis pigmentovascularis. Can you provide me with further information on this condition?</Text>
    <Focus start="31" len="31" />
    <Question id="T3" start="64" len="62">
      <SubQuestion qt="Information">Can you provide me with further information on this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1166">
    <Text>My son has been diagnosed with this. He has failure to thrive. Are people with this disorder smaller and below their expected percentile?</Text>
    <Focus start="31" len="4" />
    <Question id="T4" start="63" len="74">
      <SubQuestion qt="OtherEffect">Are people with this disorder smaller?</SubQuestion>
      <SubQuestion qt="OtherEffect">Are people with this disorder below their expected percentile?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1167">
    <Text>My son has been diagnosed with Wolff Parkinson White syndrome. Should other members of my family be tested for this condition?</Text>
    <Focus start="31" len="30" />
    <Question id="T3" start="63" len="63">
      <SubQuestion qt="Susceptibility">Should other members of my family be tested for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1168">
    <Text>My son has been diagnose with acute pancreatitis. Please help me find more information, treatment, and medication.</Text>
    <Focus start="30" len="18" />
    <Question id="T3" start="50" len="64">
      <SubQuestion qt="Information">Please help me find more information.</SubQuestion>
      <SubQuestion qt="Management">Please help me find more treatment.</SubQuestion>
      <SubQuestion qt="Management">Please help me find more medication.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1169">
    <Text>My son has been found to carry a single familial Mediterranean fever (FMF) gene mutation. Could he still have FMF?</Text>
    <Focus start="40" len="48" />
    <Question id="T3" start="90" len="24">
      <SubQuestion qt="Susceptibility">Could he still have FMF?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1170">
    <Text>My son has frequent ketosis and occasional ketoacidosis. He has a diagnosis of ketotic hypoglycemia, but seems to have a lot of non-fasting ketotic vomiting episodes. I believe that he may have SCOT deficiency. Would SCOT deficiency cause abnormal amino acid, organic acid or carnitine results? If not, what type of lab work would support a diagnosis of this deficiency? How is the diagnosis of SCOT deficiency confirmed? What kind of lab results would you expect from a patient with SCOT deficiency while they are in crisis? How common is SCOT deficiency? How can I find a doctor or clinic that is familiar with this deficiency?</Text>
    <Focus start="194" len="15" />
    <Question id="T5" start="211" len="83">
      <SubQuestion qt="OtherEffect">Would SCOT deficiency cause abnormal amino acid?</SubQuestion>
      <SubQuestion qt="OtherEffect">Would SCOT deficiency cause abnormal organic acid?</SubQuestion>
      <SubQuestion qt="OtherEffect">Would SCOT deficiency cause abnormal carnitine results?</SubQuestion>
    </Question>
    <Question id="T7" start="295" len="75">
      <SubQuestion qt="Diagnosis">If not, what type of lab work would support a diagnosis of this deficiency?</SubQuestion>
    </Question>
    <Question id="T8" start="371" len="50">
      <SubQuestion qt="Diagnosis">How is the diagnosis of SCOT deficiency confirmed?</SubQuestion>
    </Question>
    <Question id="T9" start="422" len="103">
      <SubQuestion qt="Diagnosis">What kind of lab results would you expect from a patient with SCOT deficiency while they are in crisis?</SubQuestion>
    </Question>
    <Question id="T10" start="526" len="30">
      <SubQuestion qt="Susceptibility">How common is SCOT deficiency?</SubQuestion>
    </Question>
    <Question id="T11" start="557" len="72">
      <SubQuestion qt="PersonOrg">How can I find a doctor that is familiar with this deficiency?</SubQuestion>
      <SubQuestion qt="PersonOrg">How can I find a clinic that is familiar with this deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1171">
    <Text>My son has hypophosphatemic rickets and frequently develops abscesses in his mouth. Our doctor believes this is due to the weakened bones caused by this condition. Can you give me more information on this?</Text>
    <Focus start="11" len="24" />
    <Question id="T4" start="164" len="41">
      <SubQuestion qt="OtherEffect">Can you give me more information on this?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1172">
    <Text>My son has Kartagener syndrome and is having several medical problems. I need to know as much as possible about this condition.</Text>
    <Focus start="11" len="19" />
    <Question id="T3" start="71" len="56">
      <SubQuestion qt="Information">I need to know as much as possible about this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1173">
    <Text>My son has Klinefelter syndrome. I am aware that he may need testosterone replacement therapy (TRT) when he reaches puberty. For how long is TRT usually done?</Text>
    <Focus start="11" len="20" />
    <Question id="T4" start="125" len="33">
      <SubQuestion qt="Management">For how long is TRT usually done?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1174">
    <Text>My son has Marshall syndrome.  Years ago, they stated that life expectency was late teens to early twenties, but now I can't seem to find any such information.  Could you possibly clarify this?</Text>
    <Focus start="11" len="17" />
    <Question id="T4" start="161" len="32">
      <SubQuestion qt="Prognosis">Could you possibly clarify this?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1175">
    <Text>My son has MPS IIIB, and I would like to know if there is any current research or clinical trials for this condition. This seems to be a rare disease that is also ‘rare’ in research and so it has been very difficult to obtain any treatment for my son. Are you able to help?</Text>
    <Focus start="11" len="8" />
    <Question id="T1" start="0" len="117">
      <SubQuestion qt="Information" attrs="Research">My son has MPS IIIB, and I would like to know if there is any current research for this condition.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">My son has MPS IIIB, and I would like to know if there is any clinical trials for this condition.</SubQuestion>
    </Question>
    <Question id="T5" start="252" len="21">
      <SubQuestion qt="Management">Are you able to help?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1176">
    <Text>My son has nephrocalcinosis. Could you please tell me about it? Is it genetic? How might it be treated?</Text>
    <Focus start="11" len="16" />
    <Question id="T3" start="29" len="34">
      <SubQuestion qt="Information">Could you please tell me about it?</SubQuestion>
    </Question>
    <Question id="T4" start="64" len="14">
      <SubQuestion qt="Susceptibility">Is it genetic?</SubQuestion>
    </Question>
    <Question id="T5" start="79" len="24">
      <SubQuestion qt="Management">How might it be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1177">
    <Text>My son has NKH and is my first born child. What is the chance my next child will have NKH if he has a different father?</Text>
    <Focus start="11" len="3" />
    <Question id="T3" start="43" len="76">
      <SubQuestion qt="Susceptibility">What is the chance my next child will have NKH if he has a different father?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1178">
    <Text>My son has suffered meconium aspiration syndrome. What causes this condition?</Text>
    <Focus start="20" len="28" />
    <Question id="T3" start="50" len="27">
      <SubQuestion qt="Cause">What causes this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1179">
    <Text>My son has Tourette syndrome and in my country, Peru, there is little information about treatment. Could you please provide some information?</Text>
    <Focus start="11" len="17" />
    <Question id="T3" start="99" len="42">
      <SubQuestion qt="Management">Could you please provide some information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1180">
    <Text>My son has type 1 plasminogen deficiency and currently has been diagnosed with ligneous conjunctivitis. Please provide any and all information that you have with respect to this disease.</Text>
    <Focus start="79" len="23" />
    <Question id="T3" start="104" len="82">
      <SubQuestion qt="Information">Please provide any information that you have with respect to this disease.</SubQuestion>
      <SubQuestion qt="Information">Please provide all information that you have with respect to this disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1181">
    <Text>My son has what the doctor is calling fibromas on his legs that have been growing for about 2 years. Both legs have huge tumors on them and growing all the time. My son has been diagnosed with neurofibromatosis.  My understanding is that there is no cure?</Text>
    <Focus start="193" len="17" />
    <Question id="T5" start="213" len="42">
      <SubQuestion qt="Management">My understanding is that there is no cure?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1182">
    <Text>My son is 18 days old and has been diagnosed with tyrosinemia type 1. Is there any hope of curing my son's illness?</Text>
    <Focus start="50" len="18" />
    <Question id="T3" start="70" len="45">
      <SubQuestion qt="Management">Is there any hope of curing my son's illness?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1183">
    <Text>My son is 5 years old and has triple A syndrome. He has Addison's and alacrima, and we want to know if it is likely he will develop achalasia. What are the neurological effects of triple A syndrome and when could they affect him?</Text>
    <Focus start="30" len="17" />
    <Question id="T3" start="49" len="93">
      <SubQuestion qt="OtherEffect">He has Addison's and alacrima, and we want to know if it is likely he will develop achalasia.</SubQuestion>
    </Question>
    <Question id="T4" start="143" len="54">
      <SubQuestion qt="OtherEffect">What are the neurological effects of triple A syndrome?</SubQuestion>
    </Question>
    <Question id="T5" start="198" len="31">
      <SubQuestion qt="OtherEffect">When could they affect him?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1184">
    <Text>My son may have carnitine-acylcarnitine translocase deficiency. Can you provide me with information about this condition?</Text>
    <Focus start="16" len="46" />
    <Question id="T3" start="64" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1185">
    <Text>My son presented with a sudden onset of partial complex seizures and a friend provided us with information about neurocysticercosis. My son has not yet been tested, but I would like to know if this disease has an affect on a person's appetite or weight?</Text>
    <Focus start="113" len="18" />
    <Question id="T3" start="133" len="120">
      <SubQuestion qt="OtherEffect">My son has not yet been tested, but I would like to know if this disease has an affect on a person's appetite?</SubQuestion>
      <SubQuestion qt="OtherEffect">My son has not yet been tested, but I would like to know if this disease has an affect on a person's weight?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1186">
    <Text>My son suffers from recurrent aphthous stomatitis or Sutton disease 2. It took us 20 months to be given this diagnosis. I searched for diagnosis on the web site but did not find any information. Is there any information about Sutton disease 2 that I am somehow missing I am trying to become educated about his disease.</Text>
    <Focus start="20" len="49" />
    <Question id="T5" start="195" len="123">
      <SubQuestion qt="Information">Is there any information about Sutton disease 2 that I am somehow missing I am trying to become educated about his disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1187">
    <Text>My son suffers from Rubinstein-Taybi syndrome. Over the past year he has developed tremors affecting both upper extremities.  I am wondering if there is a known cause associated with the disorder.  My research seems to indicate there may be but I cannot find anything definitive.</Text>
    <Focus start="20" len="25" />
    <Question id="T4" start="126" len="70">
      <SubQuestion qt="Cause">I am wondering if there is a known cause associated with the disorder.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1188">
    <Text>My son was born with aplasia cutis congenita. He is now one year old and the spot on his head is about 4 inches long and 1/2 inch wide. As his head grows, the lesion continues to get bigger. His dermatologist has prescribed a skin cream to keep it moist, but my son continues to scratch it open daily. My son's doctor says that there is nothing that can be done until he is a teenager when a portion of the membrane can be removed and his scalp can be stitched together. I can't see waiting that long without a better recommendation. What treatment options are available?</Text>
    <Focus start="21" len="23" />
    <Question id="T8" start="534" len="37">
      <SubQuestion qt="Management">What treatment options are available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1189">
    <Text>My son was born with a vascular lesion in the right groin area.  A biopsy of the lesion suggested it is likely to be a non-involuting congenital hemangioma (NICH), but there is a possibility it is a kaposiform hemangioendothelioma.  I would like to know why it has not been possible to determine which of the two it actually is and why surgical excision will be necessary in the future.</Text>
    <Focus start="119" len="43" />
    <Focus start="199" len="31" />
    <Question id="T5" start="233" len="153">
      <SubQuestion qt="Diagnosis">I would like to know why it has not been possible to determine which of the two it actually is.</SubQuestion>
      <SubQuestion qt="Management">I would like to know why surgical excision will be necessary in the future.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1190">
    <Text>My son was born with clefts in both of his feet.  Is there any surgical solution to his condition?</Text>
    <Focus start="21" len="6" />
    <Question id="T3" start="50" len="48">
      <SubQuestion qt="Management">Is there any surgical solution to his condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1191">
    <Text>My son was born with cutis aplasia congenita.  He had two midline spots on his scalp, one spot was 11mm in diameter and the other spot was 13 mm. They have finally healed now and it took about 2 months. I was wondering if there is any research out there for a cause or if it is known what causes it.  I have taken him to four different doctors who have never seen it before and don't have a lot of information on it. He did have genetic testing done at birth which all came back normal.</Text>
    <Focus start="21" len="23" />
    <Question id="T5" start="203" len="96">
      <SubQuestion qt="Cause" attrs="Research">I was wondering if there is any research out there for a cause.</SubQuestion>
      <SubQuestion qt="Cause">I was wondering if it is known what causes it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1192">
    <Text>My son was diagnosed with a laryngeal cleft 4 months ago and I can't find much information about this condition. Everything I read is from a medical journal. I'm just looking for more information about laryngeal cleft.</Text>
    <Focus start="28" len="15" />
    <Question id="T3" start="158" len="60">
      <SubQuestion qt="Information">I'm just looking for more information about laryngeal cleft.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1193">
    <Text>My son was diagnosed with alpha-thalassemia x-linked intellectual disability syndrome. The questions I have relate to other members of the family. I have a sister who has children. I understand that if my sister has the mutation, there is a chance that she passed it to her daughter, who would then be a carrier. But the literature I have read isn't completely clear regarding boys.  If my sister carries the mutation, could she have passed it to her son and could her son be an unaffected carrier of the mutation?</Text>
    <Focus start="26" len="59" />
    <Question id="T7" start="384" len="130">
      <SubQuestion qt="Susceptibility">If my sister carries the mutation, could she have passed it to her son?</SubQuestion>
      <SubQuestion qt="Susceptibility">If my sister carries the mutation, could her son be an unaffected carrier of the mutation?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1194">
    <Text>My son was diagnosed with Beckwidth Weidemann syndrome. I would like to know if hemihypertrophy always happens? If not, what percentage of patients does it affect? What urological symptoms are associated with Beckwidth Weidemann syndrome? Does having urinary obstruction increase a person with this syndrome's risk for developing Wilms' tumor?  What is the risk for Wilms tumor and what kind of surveillance is needed?</Text>
    <Focus start="26" len="28" />
    <Question id="T3" start="56" len="55">
      <SubQuestion qt="OtherEffect">I would like to know if hemihypertrophy always happens?</SubQuestion>
    </Question>
    <Question id="T4" start="112" len="51">
      <SubQuestion qt="OtherEffect">If not, what percentage of patients does it affect?</SubQuestion>
    </Question>
    <Question id="T5" start="164" len="74">
      <SubQuestion qt="Manifestation">What urological symptoms are associated with Beckwidth Weidemann syndrome?</SubQuestion>
    </Question>
    <Question id="T6" start="239" len="104">
      <SubQuestion qt="Complication">Does having urinary obstruction increase a person with this syndrome's risk for developing Wilms' tumor?</SubQuestion>
    </Question>
    <Question id="T7" start="345" len="32">
      <SubQuestion qt="Susceptibility">What is the risk for Wilms tumor?</SubQuestion>
    </Question>
    <Question id="T8" start="378" len="40">
      <SubQuestion qt="Management">What kind of surveillance is needed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1195">
    <Text>My son was diagnosed with cheilitis glandularis. Is this curable, or are the symptoms curable? How close is this to angular cheilitis? Is there any other condition that this could be mistaken for?</Text>
    <Focus start="26" len="21" />
    <Question id="T3" start="49" len="16">
      <SubQuestion qt="Management">Is this curable?</SubQuestion>
    </Question>
    <Question id="T4" start="66" len="28">
      <SubQuestion qt="Management">Are the symptoms curable?</SubQuestion>
    </Question>
    <Question id="T5" start="95" len="39">
      <SubQuestion qt="Information">How close is this to angular cheilitis?</SubQuestion>
    </Question>
    <Question id="T6" start="135" len="61">
      <SubQuestion qt="Diagnosis">Is there any other condition that this could be mistaken for?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1196">
    <Text>My son was diagnosed with isobutyryl-CoA dehydrogenase deficiency (IBD deficiency) at birth. He is 7 months old and very healthy with no signs or symptoms. He is being followed by a specialist, gets regular blood tests, and follows a special diet. Will this condition be with him for the rest of his life? Is there anything that we can do for him?</Text>
    <Focus start="26" len="56" />
    <Question id="T5" start="248" len="57">
      <SubQuestion qt="Prognosis">Will this condition be with him for the rest of his life?</SubQuestion>
    </Question>
    <Question id="T6" start="306" len="41">
      <SubQuestion qt="Management">Is there anything that we can do for him?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1197">
    <Text>My son was diagnosed with neonatal diabetes mellitus. He is 15 days old and we are not sure if this is permanent or transient. I want to know what the lifespan is of babies with this illness. Also how can we find out if this diabetes is transient or permanent?</Text>
    <Focus start="26" len="26" />
    <Question id="T4" start="127" len="64">
      <SubQuestion qt="Prognosis">I want to know what the lifespan is of babies with this illness.</SubQuestion>
    </Question>
    <Question id="T5" start="192" len="68">
      <SubQuestion qt="Information">How can we find out if this diabetes is transient or permanent?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1198">
    <Text>My son was diagnosed with NF1. At birth, doctors noticed his neck was shorter and his eyes and ears where tilted a bit. They ran some test and discovered that he is missing the whole gene instead of it just being mutated. His genetic doctor said he's never really seen this before and can't really tell me much about how it's going to affect my son. I was just wondering if you had any information on this gene being completely missing.</Text>
    <Focus start="26" len="3" />
    <Question id="T6" start="350" len="86">
      <SubQuestion qt="Information">I was just wondering if you had any information on this gene being completely missing.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1199">
    <Text>My son was diagnosed with Opitz G/BBB syndrome and I was wondering if you can provide any information about this syndrome. I would like to have a full understanding of my son and his condition.</Text>
    <Focus start="26" len="20" />
    <Question id="T1" start="0" len="122">
      <SubQuestion qt="Information">My son was diagnosed with Opitz G/BBB syndrome and I was wondering if you can provide any information about this syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1200">
    <Text>My son was diagnosed with osteogenesis imperfecta type 6 and I would like to know more information about this condition.</Text>
    <Focus start="26" len="30" />
    <Question id="T1" start="0" len="120">
      <SubQuestion qt="Information">My son was diagnosed with osteogenesis imperfecta type 6 and I would like to know more information about this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1201">
    <Text>My son was diagnosed with pyruvate kinase deficiency when he was a baby. My husband and I were tested and are negative for being carriers. Could you tell me what else could cause pyruvate kinase deficiency?</Text>
    <Focus start="26" len="26" />
    <Question id="T4" start="139" len="67">
      <SubQuestion qt="Cause">Could you tell me what else could cause pyruvate kinase deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1202">
    <Text>My son was diagnosed with this last year. He has had multiple vaccinations. What are the actual numbers of how many Americans have this? Is there any work being done on finding a cure? Are there any ongoing studies? I know a little girl who has the same thing and she has had problems with her urinary tract but my son only had problems with his ears, nose and throat. Are these differences common? Any information would be greatly appreciated. Its very frustrating having so many questions and not many answers.</Text>
    <Focus start="26" len="4" />
    <Question id="T4" start="76" len="60">
      <SubQuestion qt="Susceptibility">What are the actual numbers of how many Americans have this?</SubQuestion>
    </Question>
    <Question id="T5" start="137" len="47">
      <SubQuestion qt="Management" attrs="Research">Is there any work being done on finding a cure?</SubQuestion>
    </Question>
    <Question id="T6" start="185" len="30">
      <SubQuestion qt="Management" attrs="Research">Are there any ongoing studies?</SubQuestion>
    </Question>
    <Question id="T8" start="369" len="29">
      <SubQuestion qt="OtherEffect">Are these differences common?</SubQuestion>
    </Question>
    <Question id="T9" start="399" len="45">
      <SubQuestion qt="Information">Any information would be greatly appreciated.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1203">
    <Text>My son was recently diagnosed with Horner syndrome. Is it possible that he got this after having his neck and back aligned by a chiropractor? Also as a parent is there anything I should be concerned about? Do you recommend any restrictions to his playing high school sports?</Text>
    <Focus start="35" len="15" />
    <Question id="T3" start="52" len="89">
      <SubQuestion qt="Cause">Is it possible that he got this after having his neck and back aligned by a chiropractor?</SubQuestion>
    </Question>
    <Question id="T4" start="142" len="63">
      <SubQuestion qt="OtherEffect">As a parent is there anything I should be concerned about?</SubQuestion>
    </Question>
    <Question id="T5" start="206" len="68">
      <SubQuestion qt="Prognosis">Do you recommend any restrictions to his playing high school sports?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1204">
    <Text>My son was recently diagnosed with hyper IgM syndrome. What information can you provide about this condition?</Text>
    <Focus start="35" len="18" />
    <Question id="T3" start="55" len="54">
      <SubQuestion qt="Information">What information can you provide about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1205">
    <Text>My son was recently diagnosed with primary hyperoxaluria type 2. Is this something that he can eventually outgrow? Can his liver repair itself and begin producing the missing enzyme? If not, is there any chance of him leading a full life or will he develop end stage renal disease before he has a chance to get old and gray?</Text>
    <Focus start="35" len="28" />
    <Question id="T3" start="65" len="49">
      <SubQuestion qt="Prognosis">Is this something that he can eventually outgrow?</SubQuestion>
    </Question>
    <Question id="T4" start="115" len="67">
      <SubQuestion qt="Prognosis">Can his liver repair itself and begin producing the missing enzyme?</SubQuestion>
    </Question>
    <Question id="T5" start="183" len="141">
      <SubQuestion qt="Prognosis">If not, is there any chance of him leading a full life or will he develop end stage renal disease before he has a chance to get old and gray?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1206">
    <Text>My son, who will be 13 years old in July, has West syndrome.  I would like to find a doctor in my area who specializes in this condition.  Any help would be appreciated.  Thank you.</Text>
    <Focus start="46" len="13" />
    <Question id="T3" start="62" len="75">
      <SubQuestion qt="PersonOrg">I would like to find a doctor in my area who specializes in this condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1207">
    <Text>My stepdaughter has Turner syndrome. I was wondering if her mother or father carries the gene that causes this disease? Would a blood test from her father indicate if it came from his side of the family?</Text>
    <Focus start="20" len="15" />
    <Question id="T3" start="37" len="82">
      <SubQuestion qt="Susceptibility">I was wondering if her mother carries the gene that causes this disease?</SubQuestion>
      <SubQuestion qt="Susceptibility">I was wondering if her father carries the gene that causes this disease?</SubQuestion>
    </Question>
    <Question id="T5" start="120" len="83">
      <SubQuestion qt="Diagnosis">Would a blood test from her father indicate if it came from his side of the family?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1208">
    <Text>My step-daughter was diagnosed with Alexander Disease less than a year ago. She is 2 years old. We were recently told that the disease is spreading to her pituitary gland. What impact will this have on the progression of the disease?</Text>
    <Focus start="36" len="17" />
    <Question id="T5" start="172" len="61">
      <SubQuestion qt="Prognosis">What impact will this have on the progression of the disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1209">
    <Text>My teenage daughter has Waardenburg syndrome. Recently she has developed body hair on her chest and upper lip. Her eyebrows are also growing together. Is this due to Waardenburg syndrome?</Text>
    <Focus start="24" len="20" />
    <Question id="T5" start="151" len="36">
      <SubQuestion qt="OtherEffect">Is this due to Waardenburg syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1210">
    <Text>My teenage son has been diagnosed with Lubs X-linked mental retardation.  What can you tell me about this condition?</Text>
    <Focus start="39" len="32" />
    <Question id="T3" start="74" len="42">
      <SubQuestion qt="Information">What can you tell me about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1211">
    <Text>My toddler daughter has been diagnosed with Langerhans cell histiocytosis. I'd like to learn as much as possible about the condition.</Text>
    <Focus start="44" len="29" />
    <Question id="T3" start="75" len="58">
      <SubQuestion qt="Information">I'd like to learn as much as possible about the condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1212">
    <Text>My two girls have WHIMS and I need to know what kind of treatment they can get. We're willing to travel to seek treatment. Their WBC counts are 100-300. One has warts on her foot and the other has about 100 warts on each hand.</Text>
    <Focus start="18" len="5" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Management">My two girls have WHIMS and I need to know what kind of treatment they can get.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1213">
    <Text>My two year-old daughter has the symptoms of Cohen syndrome. Could you please provide me with information about how this condition might be treated and what the prognosis is for individuals with it?</Text>
    <Focus start="45" len="14" />
    <Question id="T3" start="61" len="137">
      <SubQuestion qt="Management">Could you please provide me with information about how this condition might be treated?</SubQuestion>
      <SubQuestion qt="Prognosis">Could you please provide me with information about what the prognosis is for individuals with it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1214">
    <Text>My uncle has had pure red cell aplasia for almost three years. About two years ago the hospital in my home town would not treat him anymore because they thought it was impossible to cure him. My mother transferred him to a bigger hospital in another city. Now he is taking medications for a very long time but his hemoglobin never goes up. The hospital said there is nothing to do if those medications don't work. My whole family is hopeless again now. Could you please help my uncle? He is only forty years old.</Text>
    <Focus start="17" len="21" />
    <Question id="T8" start="453" len="31">
      <SubQuestion qt="Information">Could you please help my uncle?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1215">
    <Text>My uncle, my brother, and one of my brother's sons have testotoxicosis. My son is also affected. I took my son to an endocrinologist and he treated my son with ketoconazole. Treatment was stopped when my son was 11 years old. He continued to grow until the age of 13. Now he is 14 and is 5'7".  We are in the process of going back to the doctor that treated my son to get an x-ray of his hand to see if the growth plates have grown together. Has ketoconazole been proven to work successfully in boys with testotoxicosis?</Text>
    <Focus start="56" len="14" />
    <Question id="T9" start="442" len="78">
      <SubQuestion qt="Management">Has ketoconazole been proven to work successfully in boys with testotoxicosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1216">
    <Text>My wife and I had a child born with trisomy 17 mosaicism. Since then, we have had two healthy children. What is known about this chromosomal abnormality? I can't seem to find any information that is easy to read or find. When our child was born about 20 years ago, we where told that there had only been 7 live births and none had lived past 4 years of age.</Text>
    <Focus start="36" len="20" />
    <Question id="T4" start="104" len="49">
      <SubQuestion qt="Information">What is known about this chromosomal abnormality?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1217">
    <Text>My wife had a breast reduction to cure gigantomastia. But after a year, the ailment recurred.  What treatment options might be available for her now?</Text>
    <Focus start="39" len="13" />
    <Question id="T4" start="95" len="54">
      <SubQuestion qt="Management">What treatment options might be available for her now?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1218">
    <Text>My wife has been diagnosed with goblet cell carcinoma of the appendix. I am very concerned and can't find much information. Can you help? How can I find a specialist?</Text>
    <Focus start="32" len="37" />
    <Question id="T4" start="124" len="13">
      <SubQuestion qt="Information">Can you help?</SubQuestion>
    </Question>
    <Question id="T5" start="138" len="28">
      <SubQuestion qt="PersonOrg">How can I find a specialist?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1219">
    <Text>My wife has been diagnosed with MBL deficiency. Can you provide us with information on this condition?</Text>
    <Focus start="32" len="14" />
    <Question id="T3" start="48" len="54">
      <SubQuestion qt="Information">Can you provide us with information on this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1220">
    <Text>My wife has Charcot-Marie-Tooth disease type 2C. What is the prognosis for individuals with this condition?</Text>
    <Focus start="12" len="35" />
    <Question id="T3" start="49" len="58">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1221">
    <Text>My wife is showing many symptoms of this disease and is a confirmed carrier. Is it possible that she has it?</Text>
    <Focus start="36" len="12" />
    <Question id="T2" start="77" len="31">
      <SubQuestion qt="Diagnosis">Is it possible that she has it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1222">
    <Text>My wife was diagnosed by MRI with probable myxopapillary ependymoma. The specialist is recommending surgery; are there any other treatment options?</Text>
    <Focus start="43" len="24" />
    <Question id="T3" start="69" len="78">
      <SubQuestion qt="Management">The specialist is recommending surgery; are there any other treatment options?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1223">
    <Text>My wife was diagnosed with a cyst on her pineal gland. We have been researching information and have seen both good and bad things. She's had two MRIs and bloodwork done, and the doctors believe it's benign. What else can we do?</Text>
    <Focus start="29" len="24" />
    <Question id="T5" start="208" len="20">
      <SubQuestion qt="Management">What else can we do?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1224">
    <Text>My wife was diagnosed with relapsing polychondritis over 6 years ago. Her ear flares up about 2-3 times a year. In the beginning it went away on its own; now she takes prednisone but only during the flare. Our doctor says the next step would be methotrexate but before that she'd be on daily prednisone. The disease doesn't seem to be progressing and CT and PET scans indicate no other damage. Is there something more we should be doing such as diet supplements or other medications? Are there other things we should be watching for?</Text>
    <Focus start="27" len="24" />
    <Question id="T7" start="394" len="89">
      <SubQuestion qt="Management">Is there something more we should be doing?</SubQuestion>
      <SubQuestion qt="Management">Is there something more we should be doing such as diet supplements?</SubQuestion>
      <SubQuestion qt="Management">Is there something more we should be doing such as other medications?</SubQuestion>
    </Question>
    <Question id="T10" start="484" len="49">
      <SubQuestion qt="OtherEffect">Are there other things we should be watching for?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1225">
    <Text>My wife was recently diagnosed with idiopathic pulmonary fibrosis. She is being treated with N-Acetylcysteine, an anti-oxidant supplement.  Is there a newer therapy or treatment for this condition?</Text>
    <Focus start="36" len="29" />
    <Question id="T4" start="140" len="57">
      <SubQuestion qt="Management">Is there a newer therapy for this condition?</SubQuestion>
      <SubQuestion qt="Management">Is there a newer treatment for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1226">
    <Text>My young daughter has a rare genetic condition called diploid-triploid mosaicism. I am looking for any and all available information about this disorder. It is very rare and therefore it is very hard to find information that is of much use. Anything will help at this point.</Text>
    <Focus start="54" len="26" />
    <Question id="T3" start="82" len="71">
      <SubQuestion qt="Information">I am looking for any available information about this disorder.</SubQuestion>
      <SubQuestion qt="Information">I am looking for all available information about this disorder.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1227">
    <Text>My younger brother was recently diagnosed with hypereosinophilic (HES) syndrome.  I would like to know if this condition has a genetic element.</Text>
    <Focus start="47" len="32" />
    <Question id="T3" start="82" len="61">
      <SubQuestion qt="Susceptibility">I would like to know if this condition has a genetic element.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1228">
    <Text>My younger son has Johanson Blizzard syndrome. He has arrested growth, hearing loss, some teeth disappearance and pancreatic insufficiency. He was also diagnosed with pure red cell aplasia. How can we help pancreatic insufficiency, which helps with growth? Is there any help for hearing impairment?</Text>
    <Focus start="19" len="26" />
    <Question id="T5" start="190" len="66">
      <SubQuestion qt="Management">How can we help pancreatic insufficiency, which helps with growth?</SubQuestion>
    </Question>
    <Question id="T6" start="257" len="41">
      <SubQuestion qt="Management">Is there any help for hearing impairment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1229">
    <Text>Once an individual with pars planitis loses vision, can they get it back?  And what are the different surgeries that can treat pars planitis?</Text>
    <Focus start="24" len="13" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Prognosis">Once an individual with pars planitis loses vision, can they get it back?</SubQuestion>
    </Question>
    <Question id="T3" start="75" len="66">
      <SubQuestion qt="Management">What are the different surgeries that can treat pars planitis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1230">
    <Text>Once someone has this condition, is there anything that can be done to correct the problems caused by the genetic mutation?</Text>
    <Focus start="17" len="14" />
    <Question id="T1" start="0" len="123">
      <SubQuestion qt="Management">Once someone has this condition, is there anything that can be done to correct the problems caused by the genetic mutation?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1231">
    <Text>One of my infant twins has been diagnosed with citrullinemia. Her ammonia level was very high. Do children with this condition recover from the high levels of ammonia? How is this condition treated?</Text>
    <Focus start="47" len="13" />
    <Question id="T4" start="95" len="72">
      <SubQuestion qt="Prognosis">Do children with this condition recover from the high levels of ammonia?</SubQuestion>
    </Question>
    <Question id="T5" start="168" len="30">
      <SubQuestion qt="Management">How is this condition treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1232">
    <Text>One of my relatives was diagnosed with acute disseminated encephalomyelitis in 1997. Due to poor medical care, he has not received consistent treatment and his health has deteriorated over the years. He is now completely paralyzed. Is it too late for treatment to be effective? What is the prognosis for an individual who has not been treated promptly?</Text>
    <Focus start="39" len="36" />
    <Question id="T5" start="232" len="45">
      <SubQuestion qt="Management">Is it too late for treatment to be effective?</SubQuestion>
    </Question>
    <Question id="T6" start="278" len="74">
      <SubQuestion qt="Prognosis">What is the prognosis for an individual who has not been treated promptly?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1233">
    <Text>Our 34-year-old son was diagnosed with congenital bilateral absence of the vas deferens (CBAVD) resulting from the CFTR mutation. We also have another 31-year-old son and are concerned that he might be affected as well. Is either myself or my husband a carrier? Should we seek medical advice regarding these possibilities?</Text>
    <Focus start="39" len="56" />
    <Question id="T4" start="220" len="41">
      <SubQuestion qt="Diagnosis">Is myself a carrier?</SubQuestion>
      <SubQuestion qt="Diagnosis">Is my husband a carrier?</SubQuestion>
    </Question>
    <Question id="T6" start="262" len="60">
      <SubQuestion qt="PersonOrg">Should we seek medical advice regarding these possibilities?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1234">
    <Text>Our 7 year old is having bulbar symptoms. Can you provide us with information about Fazio Londe syndrome?</Text>
    <Focus start="84" len="20" />
    <Question id="T2" start="42" len="63">
      <SubQuestion qt="Information">Can you provide us with information about Fazio Londe syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1235">
    <Text>Our daughter-in-law has Castleman's and our granddaughter is now hospitalized with symptoms that are consistent with what we have read about Castleman's. I am asking if it is a hereditary disease.</Text>
    <Focus start="24" len="11" />
    <Question id="T3" start="154" len="42">
      <SubQuestion qt="Susceptibility">I am asking if it is a hereditary disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1236">
    <Text>Our daughter was recently diagnosed with mosaic trisomy 2.  Since birth she has always had an undiagnosed syndrome.  We felt relieved that we finally knew what she was born with but we have not been able to find any information about it. What can you provide us?</Text>
    <Focus start="41" len="16" />
    <Question id="T4" start="238" len="24">
      <SubQuestion qt="Information">What can you provide us?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1237">
    <Text>Our first born child had jejunal artresia. What are the chances of any further children we may have suffering from the same condition?</Text>
    <Focus start="25" len="16" />
    <Question id="T2" start="43" len="91">
      <SubQuestion qt="Susceptibility">What are the chances of any further children we may have suffering from the same condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1238">
    <Text>Our grandson was diagnosed recently with this disease and I am wondering if you could send me information on it. As his grandmother, I would like to know what are the health risks down the road for him and how we can help him live with this disease.</Text>
    <Focus start="41" len="12" />
    <Question id="T1" start="0" len="112">
      <SubQuestion qt="Information">Our grandson was diagnosed recently with this disease and I am wondering if you could send me information on it.</SubQuestion>
    </Question>
    <Question id="T3" start="113" len="136">
      <SubQuestion qt="Complication">As his grandmother, I would like to know what are the health risks down the road for him.</SubQuestion>
      <SubQuestion qt="Management">As his grandmother, I would like to know how we can help him live with this disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1239">
    <Text>Our son has had surgery and a tumor was found on the right colon. It was removed and first thought to be a gastrointestinal stromal tumor (GIST), but because of CD117 and CD34 testing we were told it was leiomyosarcoma. We have been to 2 oncologists, one says chemo and the other says chemo is not effective for this type. We are totally confused.</Text>
    <Focus start="204" len="14" />
    <Question id="T4" start="323" len="24">
      <SubQuestion qt="Other">We are totally confused.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1240">
    <Text>Please could you send me any information you have on Filippi syndrome or let me know where I can obtain information on it? Are there any support groups for people with this condition?</Text>
    <Focus start="53" len="16" />
    <Question id="T1" start="0" len="122">
      <SubQuestion qt="Information">Please could you send me any information you have on Filippi syndrome?</SubQuestion>
      <SubQuestion qt="Information">Please could you let me know where I can obtain information on it?</SubQuestion>
    </Question>
    <Question id="T4" start="123" len="60">
      <SubQuestion qt="PersonOrg">Are there any support groups for people with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1241">
    <Text>Please help me understand fetal and neonatal alloimmune thrombocytopenia and what might happen in future pregnancies.</Text>
    <Focus start="26" len="46" />
    <Question id="T1" start="0" len="117">
      <SubQuestion qt="Information" attrs="Error">Please help me understand fetal.</SubQuestion>
      <SubQuestion qt="Information">Please help me understand neonatal alloimmune thrombocytopenia.</SubQuestion>
      <SubQuestion qt="Prognosis">Please help me understand what might happen in future pregnancies.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1242">
    <Text>Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome), including symptoms, causes, treatment and prognosis.</Text>
    <Focus start="33" len="64" />
    <Question id="T1" start="0" len="151">
      <SubQuestion qt="Information">Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome).</SubQuestion>
      <SubQuestion qt="Manifestation">Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome), including symptoms.</SubQuestion>
      <SubQuestion qt="Cause">Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome), including causes.</SubQuestion>
      <SubQuestion qt="Management">Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome), including treatment.</SubQuestion>
      <SubQuestion qt="Prognosis">Please provide information about deafness, progressive with stapes fixation (Thies Reis syndrome), including prognosis.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1243">
    <Text>Please provide me with information and supportive resources for HERNS. I have loved ones with this condition and need help finding information and support.</Text>
    <Focus start="64" len="5" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="Information">Please provide me with information for HERNS.</SubQuestion>
      <SubQuestion qt="PersonOrg">Please provide me with supportive resources for HERNS.</SubQuestion>
    </Question>
    <Question id="T3" start="71" len="84">
      <SubQuestion qt="Information">I have loved ones with this condition and need help finding information.</SubQuestion>
      <SubQuestion qt="PersonOrg">I have loved ones with this condition and need help finding support.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1244">
    <Text>Please send me any information regarding treatment and/or clinical trials for this rare disease.</Text>
    <Focus start="78" len="17" />
    <Question id="T1" start="0" len="96">
      <SubQuestion qt="Management">Please send me any information regarding treatment for this rare disease.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">Please send me any information regarding clinical trials for this rare disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1245">
    <Text>Please send me any information you have regarding lipodermatosclerosis. The physicians in my area do not know how to treat my condition. The pain is getting unbearable at times and I am looking for any kind of treatments that may help my condition.</Text>
    <Focus start="50" len="20" />
    <Question id="T1" start="0" len="71">
      <SubQuestion qt="Information">Please send me any information you have regarding lipodermatosclerosis.</SubQuestion>
    </Question>
    <Question id="T4" start="137" len="111">
      <SubQuestion qt="Management">The pain is getting unbearable at times and I am looking for any kind of treatments that may help my condition.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1246">
    <Text>Please send me information on Von Hippel Lindau disease. I have high blood pressure, severe headaches, dizziness, and quick to anger.  After reading information on the Internet, I believe my symptoms might be explainded by VHL disease.</Text>
    <Focus start="30" len="25" />
    <Question id="T1" start="0" len="56">
      <SubQuestion qt="Information">Please send me information on Von Hippel Lindau disease.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1247">
    <Text>Please send us literature regarding SHORT syndrome. I am writing on behalf of a neighbor whose three children might have the syndrome. They are undergoing tests right now. She is at a loss and having a hard time coping.</Text>
    <Focus start="36" len="14" />
    <Question id="T1" start="0" len="51">
      <SubQuestion qt="Information" attrs="Research">Please send us literature regarding SHORT syndrome.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1248">
    <Text>Please tell me something about this. Is it life threatening? My nephew has been diagnosed with this. He works in a nursing home. Had 2 ear infections, pus in his eyes, a cough, orange urine, and fatigue.</Text>
    <Focus start="31" len="4" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Information">Please tell me something about this.</SubQuestion>
    </Question>
    <Question id="T2" start="37" len="23">
      <SubQuestion qt="Prognosis">Is it life threatening?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1249">
    <Text>Please tell me what you know about Marchiafava Bignami disease. I was diagnosed with this disease after presenting not with alcoholism, but with malnutrition (thiamine deficiency), dementia and memory loss. Where can I find information and answers regarding this disease and its occurrence with a similar presentation?</Text>
    <Focus start="35" len="27" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Information">Please tell me what you know about Marchiafava Bignami disease.</SubQuestion>
    </Question>
    <Question id="T4" start="207" len="111">
      <SubQuestion qt="Information">Where can I find information regarding this disease?</SubQuestion>
      <SubQuestion qt="Information">Where can I find information regarding its occurrence with a similar presentation?</SubQuestion>
      <SubQuestion qt="Information">Where can I find answers regarding this disease?</SubQuestion>
      <SubQuestion qt="Information">Where can I find answers regarding its occurrence with a similar presentation?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1250">
    <Text>Several members of my husband's family are carriers of Duchenne and Becker muscular dystrophy. My husband does not have the disease. What are the chances of passing on this condition to any children we may have?</Text>
    <Focus start="55" len="38" />
    <Question id="T4" start="133" len="78">
      <SubQuestion qt="Susceptibility">What are the chances of passing on this condition to any children we may have?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1251">
    <Text>Since my daughter passed from HEM, I have checked the leading publications for news of Greenburg's dysplasia. I am both happy and perplexed at the lack of mention. Are there truly only a handful of cases? Has this horrible condition not captured the eye of the research community? I was told that my daughter's death (after three weeks in the NICU) was due to this extraordinary mutation, and that her survival (although short) was beyond expectation. I am desperately looking for more information. Both my husband and I are carriers for the mutation and have many siblings. Our siblings have concerns over the prevalence of this mutation. I am not a medical professional. I would appreciate any response in "layman's terms" please.</Text>
    <Focus start="87" len="21" />
    <Question id="T4" start="164" len="40">
      <SubQuestion qt="Susceptibility">Are there truly only a handful of cases?</SubQuestion>
    </Question>
    <Question id="T5" start="205" len="75">
      <SubQuestion qt="Information" attrs="Research">Has this horrible condition not captured the eye of the research community?</SubQuestion>
    </Question>
    <Question id="T7" start="452" len="46">
      <SubQuestion qt="Information">I am desperately looking for more information.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1252">
    <Text>Since Usher syndrome is a ciliopathy, will my daughter who has it exhibit symptoms of other ciliopathies?  She has many chronic health problems including irregular menstrual cycles, migraine headaches, and obesity.</Text>
    <Focus start="6" len="14" />
    <Question id="T1" start="0" len="105">
      <SubQuestion qt="Manifestation">Since Usher syndrome is a ciliopathy, will my daughter who has it exhibit symptoms of other ciliopathies?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1253">
    <Text>The child of a good friend has been diagnosed with glutaric acidemia type II. Can this condition be cured at present? If not, what kind of measures should we take to keep the child in good health?</Text>
    <Focus start="51" len="25" />
    <Question id="T2" start="78" len="39">
      <SubQuestion qt="Management">Can this condition be cured at present?</SubQuestion>
    </Question>
    <Question id="T3" start="118" len="78">
      <SubQuestion qt="Management">If not, what kind of measures should we take to keep the child in good health?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1254">
    <Text>The doctor told me I have SIADH or syndrome of inappropriate antidiuretic hormone. I would like to know more about it.</Text>
    <Focus start="26" len="55" />
    <Question id="T3" start="83" len="35">
      <SubQuestion qt="Information">I would like to know more about it.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1255">
    <Text>The father of my children has been diagnosed with Fahr's disease.  I am concerned for him and my children.  I would like to learn more about this condition and how we might be able to help him.</Text>
    <Focus start="50" len="14" />
    <Question id="T4" start="108" len="85">
      <SubQuestion qt="Information">I would like to learn more about this condition.</SubQuestion>
      <SubQuestion qt="Management">I would like to learn more about how we might be able to help him.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1256">
    <Text>The father of my children lost his life after a short battle with colon cancer. Several members of his family had various other types of cancer. I would like to help my children prevent the development of cancer. What are the symptoms of familial adenomatoous polyposis (FAP)? What steps can we take to be better prepared for this disease? Who can help us with this endeavor?</Text>
    <Focus start="238" len="37" />
    <Question id="T4" start="213" len="63">
      <SubQuestion qt="Manifestation">What are the symptoms of familial adenomatoous polyposis (FAP)?</SubQuestion>
    </Question>
    <Question id="T6" start="277" len="62">
      <SubQuestion qt="Management">What steps can we take to be better prepared for this disease?</SubQuestion>
    </Question>
    <Question id="T7" start="340" len="35">
      <SubQuestion qt="PersonOrg">Who can help us with this endeavor?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1257">
    <Text>The information I have read said that most infections occur in younger people. I have not had any major problems until now at 56 years of age. Should I be under a doctors care regularly? Am I a candidate for disability?</Text>
    <Focus start="43" len="10" />
    <Question id="T3" start="143" len="43">
      <SubQuestion qt="Management">Should I be under a doctors care regularly?</SubQuestion>
    </Question>
    <Question id="T4" start="187" len="32">
      <SubQuestion qt="Other">Am I a candidate for disability?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1258">
    <Text>There is a history of Pelizaeus-Merzbacher disease in my family. I would like to learn more about this condition, including it's causes, symptoms, treatment and prognosis.</Text>
    <Focus start="22" len="28" />
    <Question id="T3" start="65" len="106">
      <SubQuestion qt="Information">I would like to learn more about this condition.</SubQuestion>
      <SubQuestion qt="Cause">I would like to learn more about this condition, including it's causes.</SubQuestion>
      <SubQuestion qt="Manifestation">I would like to learn more about this condition, including it's symptoms.</SubQuestion>
      <SubQuestion qt="Management">I would like to learn more about this condition, including it's treatment.</SubQuestion>
      <SubQuestion qt="Prognosis">I would like to learn more about this condition, including it's prognosis.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1259">
    <Text>There is limited information and resources on myelomeningocele where we live. I am concerned that my daughter isn't receiving the appropriate care. How is this condition usually treated?</Text>
    <Focus start="46" len="16" />
    <Question id="T4" start="148" len="38">
      <SubQuestion qt="Management">How is this condition usually treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1260">
    <Text>There seems to be limited material available pertaining to FACES syndrome.  Could you please provide me some information? Thank you.</Text>
    <Focus start="59" len="14" />
    <Question id="T3" start="76" len="45">
      <SubQuestion qt="Information">Could you please provide me some information?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1261">
    <Text>The woman I would like to marry has a family history of Parkinson disease. How is this condition inherited? How is it diagnosed? Is genetic testing available?</Text>
    <Focus start="56" len="17" />
    <Question id="T2" start="75" len="32">
      <SubQuestion qt="Susceptibility">How is this condition inherited?</SubQuestion>
    </Question>
    <Question id="T3" start="108" len="20">
      <SubQuestion qt="Diagnosis">How is it diagnosed?</SubQuestion>
    </Question>
    <Question id="T4" start="129" len="29">
      <SubQuestion qt="Diagnosis">Is genetic testing available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1262">
    <Text>They have diagnosed my niece with Salla disease. I understand that this is a very rare disease and that its main origin is Finland. Can you please let me know the life expectancy and quality of life we can expect? My niece is 7 years old. It has taken them 6 years to finally come up with this diagnosis.</Text>
    <Focus start="34" len="13" />
    <Question id="T3" start="132" len="81">
      <SubQuestion qt="Prognosis">Can you please let me know the life expectancy we can expect?</SubQuestion>
      <SubQuestion qt="Prognosis">Can you please let me know the quality of life we can expect?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1263">
    <Text>Three of my children have been diagnosed with Weill-Marchesani syndrome. Can you please provide me with information about this rare disease?</Text>
    <Focus start="46" len="25" />
    <Question id="T3" start="73" len="67">
      <SubQuestion qt="Information">Can you please provide me with information about this rare disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1264">
    <Text>Three siblings were admitted to the hospital because of cirrhosis, mental retardation, and retinal malformations.  Do these individuals have COACH syndrome?</Text>
    <Focus start="141" len="14" />
    <Question id="T2" start="115" len="41">
      <SubQuestion qt="Diagnosis">Do these individuals have COACH syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1265">
    <Text>Three years ago, I was diagnosed with "Clivus of Chordoma."  Since then, I have had four surgeries to remove as much of the tumor as possible, and I also went through a rigorous radiation therapy treatment program to shrink what was left of the tumor after the surgeries.  I would like any information you might have on this type of tumor.</Text>
    <Focus start="49" len="8" />
    <Question id="T4" start="273" len="66">
      <SubQuestion qt="Information">I would like any information you might have on this type of tumor.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1266">
    <Text>Two members of my immediate family died at birth as a result of arthrogryposis. Is this condition inherited? Can I have genetic testing done to determine my risk to have children with this condition?</Text>
    <Focus start="64" len="14" />
    <Question id="T3" start="80" len="28">
      <SubQuestion qt="Susceptibility">Is this condition inherited?</SubQuestion>
    </Question>
    <Question id="T4" start="109" len="90">
      <SubQuestion qt="Diagnosis">Can I have genetic testing done to determine my risk to have children with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1267">
    <Text>Two questions if I may: Is there any know medications or treatment that can be used for this condition? What can the life expectancy be?</Text>
    <Focus start="88" len="14" />
    <Question id="T1" start="0" len="103">
      <SubQuestion qt="Management">Two questions if I may: Is there any know medications that can be used for this condition?</SubQuestion>
      <SubQuestion qt="Management">Two questions if I may: Is there any know treatment that can be used for this condition?</SubQuestion>
    </Question>
    <Question id="T3" start="104" len="32">
      <SubQuestion qt="Prognosis">What can the life expectancy be?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1268">
    <Text>Two years ago I was diagnosed with X-linked myopathy with excessive autophagy. My concern is ensuring that this disease is not going to effect my heart or lungs. There is also no information on how to deal with this disease. I have always been active in sports and weight lifting all my life. Going up stairs and getting out of chairs continues to be more difficult. I read articles about what the problems will be - but I read nothing as to what I can do to make my life and pain more manageable. Has anyone with this condition ever had heart issues?</Text>
    <Focus start="35" len="42" />
    <Question id="T8" start="498" len="53">
      <SubQuestion qt="OtherEffect">Has anyone with this condition ever had heart issues?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1269">
    <Text>Unknowingly I contracted histoplasmosis related fibrosing mediastinitis in my youth. The calcium scarring has asymptomatically over-grown my superior vena cava completely occluding it. Can I become re-infected by another encounter with H. capsulatum fungus? Are my prodigy at higher risk of contracting fibrosing mediastinitis? Is there a genetic component?</Text>
    <Focus start="25" len="46" />
    <Question id="T3" start="185" len="72">
      <SubQuestion qt="Susceptibility">Can I become re-infected by another encounter with H. capsulatum fungus?</SubQuestion>
    </Question>
    <Question id="T4" start="258" len="69">
      <SubQuestion qt="Susceptibility">Are my prodigy at higher risk of contracting fibrosing mediastinitis?</SubQuestion>
    </Question>
    <Question id="T5" start="328" len="29">
      <SubQuestion qt="Susceptibility">Is there a genetic component?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1270">
    <Text>We found out my cousin has metachromatic leukodystrophy about 8 months ago. He has the adult form. He was having some problems about a year before we found out. I was wondering how long he might have to live and how bad the disease will get over time.</Text>
    <Focus start="27" len="28" />
    <Question id="T5" start="161" len="90">
      <SubQuestion qt="Prognosis">I was wondering how long he might have to live.</SubQuestion>
      <SubQuestion qt="Prognosis">I was wondering how bad the disease will get over time.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1271">
    <Text>We have a 2-year-old son who was diagnosed with Angelman syndrome. He has a deletion of the mother's part on chromosome 15. What are the chances of this syndrome occurring in our next baby? We have another 6-year-old son who is normal.</Text>
    <Focus start="48" len="17" />
    <Question id="T4" start="124" len="65">
      <SubQuestion qt="Susceptibility">What are the chances of this syndrome occurring in our next baby?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1272">
    <Text>We have been told that my newborn grandson has been classified as a carrier for cystic fibrosis.  I know that if both parents have the defective gene, the child has a 25 percent chance of actually getting CF, and a 50 percent chance of being a carrier.  My question is, can the child be a carrier if only one parent has the defective gene?  Thank you.</Text>
    <Focus start="80" len="15" />
    <Question id="T4" start="254" len="85">
      <SubQuestion qt="Susceptibility">My question is, can the child be a carrier if only one parent has the defective gene?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1273">
    <Text>We have just been told that our 2.5 year old grandson has Klinefelter syndrome.  We know very little about this condition and how it will affect him and his family in the future.  Where can we find additional information?  How can we find a health professional to discuss this in more detail?</Text>
    <Focus start="58" len="20" />
    <Question id="T4" start="180" len="41">
      <SubQuestion qt="Information">Where can we find additional information?</SubQuestion>
    </Question>
    <Question id="T5" start="223" len="69">
      <SubQuestion qt="PersonOrg">How can we find a health professional to discuss this in more detail?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1274">
    <Text>We have two children with Sjogren-Larsson syndrome. Is there treatment?</Text>
    <Focus start="26" len="24" />
    <Question id="T3" start="52" len="19">
      <SubQuestion qt="Management">Is there treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1275">
    <Text>We just found out that our grandson has 48,XXYY syndrome. We have an appointment with genetic doctors in a couple of weeks.  I was wondering if you could give us some information on what to expect and the prognosis for this and what we have to look forward to with him.</Text>
    <Focus start="40" len="16" />
    <Question id="T2" start="125" len="144">
      <SubQuestion qt="Prognosis">I was wondering if you could give us some information on what to expect.</SubQuestion>
      <SubQuestion qt="Prognosis">I was wondering if you could give us some information on the prognosis for this.</SubQuestion>
      <SubQuestion qt="Prognosis">I was wondering if you could give us some information on what we have to look forward to with him.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1276">
    <Text>We recently lost a colleague to Familial Mediterranean Fever. Are his siblings at risk to have inherited this condition? Is genetic testing available to individuals at risk?</Text>
    <Focus start="32" len="28" />
    <Question id="T3" start="62" len="58">
      <SubQuestion qt="Susceptibility">Are his siblings at risk to have inherited this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="121" len="52">
      <SubQuestion qt="Diagnosis">Is genetic testing available to individuals at risk?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1277">
    <Text>We work in Social Services and have recently had a child diagnosed with MOMO syndrome. Do you know if this is a life-limiting condition and if so, how?</Text>
    <Focus start="72" len="13" />
    <Question id="T3" start="87" len="48">
      <SubQuestion qt="Prognosis">Do you know if this is a life-limiting condition?</SubQuestion>
    </Question>
    <Question id="T4" start="136" len="15">
      <SubQuestion qt="Prognosis">If so, how?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1278">
    <Text>What about siblings of people with Bardet-Biedl syndrome?</Text>
    <Focus start="35" len="21" />
    <Question id="T1" start="0" len="57">
      <SubQuestion qt="Other">What about siblings of people with Bardet-Biedl syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1279">
    <Text>What are other issues that might come up as our son grows up with Leber congenital amaurosis?</Text>
    <Focus start="66" len="26" />
    <Question id="T1" start="0" len="93">
      <SubQuestion qt="Prognosis">What are other issues that might come up as our son grows up with Leber congenital amaurosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1280">
    <Text>What are risk factors for AL amyloidosis?</Text>
    <Focus start="26" len="14" />
    <Question id="T1" start="0" len="41">
      <SubQuestion qt="Complication">What are risk factors for AL amyloidosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1281">
    <Text>What are some of the signs or symptoms associated with trisomy 18p? What are some of the behavioural characteristics of this syndrome if any? What are some treatment options for an adolescent with this syndrome, ASD (autism spectrum disorder), and no intellectual disability displaying challenging behaviours?</Text>
    <Focus start="55" len="11" />
    <Question id="T1" start="0" len="67">
      <SubQuestion qt="Manifestation">What are some of the signs associated with trisomy 18p?</SubQuestion>
      <SubQuestion qt="Manifestation">What are some of the symptoms associated with trisomy 18p?</SubQuestion>
    </Question>
    <Question id="T2" start="68" len="73">
      <SubQuestion qt="Manifestation">What are some of the behavioural characteristics of this syndrome if any?</SubQuestion>
    </Question>
    <Question id="T3" start="142" len="167">
      <SubQuestion qt="Management">What are some treatment options for an adolescent with this syndrome, ASD (autism spectrum disorder), and no intellectual disability displaying challenging behaviours?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1282">
    <Text>What are the chances of having alpha 1-antitrypsin deficiency and panniculitis?</Text>
    <Focus start="31" len="30" />
    <Focus start="66" len="12" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Susceptibility">What are the chances of having alpha 1-antitrypsin deficiency and panniculitis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1283">
    <Text>What are the chances of having a normal baby after having a baby diagnosed with Fryns syndrome?</Text>
    <Focus start="80" len="14" />
    <Question id="T1" start="0" len="95">
      <SubQuestion qt="Susceptibility">What are the chances of having a normal baby after having a baby diagnosed with Fryns syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1284">
    <Text>What are the chances of passing osteogenesis imperfecta on to a child while pregnant? Can a vaginal delivery be perfomed or will a C-section be necessary?</Text>
    <Focus start="32" len="23" />
    <Question id="T1" start="0" len="85">
      <SubQuestion qt="Susceptibility">What are the chances of passing osteogenesis imperfecta on to a child while pregnant?</SubQuestion>
    </Question>
    <Question id="T3" start="86" len="68">
      <SubQuestion qt="Management">Can a vaginal delivery be perfomed or will a C-section be necessary?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1285">
    <Text>What are the common symptoms of complex regional pain syndrome?</Text>
    <Focus start="32" len="30" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Manifestation">What are the common symptoms of complex regional pain syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1286">
    <Text>What are the current genetic tests for cystic fibrosis? How much do they cost?</Text>
    <Focus start="39" len="15" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Diagnosis">What are the current genetic tests for cystic fibrosis?</SubQuestion>
    </Question>
    <Question id="T3" start="56" len="22">
      <SubQuestion qt="Other">How much do they cost?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1287">
    <Text>What are the dietary recommendations for individuals with Barrett syndrome?</Text>
    <Focus start="58" len="16" />
    <Question id="T1" start="0" len="75">
      <SubQuestion qt="Management">What are the dietary recommendations for individuals with Barrett syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1288">
    <Text>What are the early signs of cancer of the vulva if my sister has had leukoplakia there for 12 years?  Is biopsy necessary? Is there any medication for treatment of non-cancerous vulvar leukoplakia?</Text>
    <Focus start="69" len="11" />
    <Question id="T1" start="0" len="100">
      <SubQuestion qt="Manifestation">What are the early signs of cancer of the vulva if my sister has had leukoplakia there for 12 years?</SubQuestion>
    </Question>
    <Question id="T3" start="102" len="20">
      <SubQuestion qt="Diagnosis">Is biopsy necessary?</SubQuestion>
    </Question>
    <Question id="T4" start="123" len="74">
      <SubQuestion qt="Management">Is there any medication for treatment of non-cancerous vulvar leukoplakia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1289">
    <Text>What are the long term effects of being on Imuran? Is it feasible that polymyositis patients can eventually be medication free for this particular autoimmune disease? What is the long term prognosis of an individual who has been diagnosed with polymyositis? I recognize that this does vary with each individual. Lastly, the anti-Jo-1 antibody blood lab ranges were modified a few years ago. How does the new system range compare to the former process?</Text>
    <Focus start="71" len="12" />
    <Question id="T1" start="0" len="50">
      <SubQuestion qt="NotDisease">What are the long term effects of being on Imuran?</SubQuestion>
    </Question>
    <Question id="T2" start="51" len="115">
      <SubQuestion qt="Management">Is it feasible that polymyositis patients can eventually be medication free for this particular autoimmune disease?</SubQuestion>
    </Question>
    <Question id="T3" start="167" len="90">
      <SubQuestion qt="Prognosis">What is the long term prognosis of an individual who has been diagnosed with polymyositis?</SubQuestion>
    </Question>
    <Question id="T6" start="391" len="60">
      <SubQuestion qt="NotDisease">How does the new system range compare to the former process?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1290">
    <Text>What are the new or experimental treatments options for cri du chat syndome?</Text>
    <Focus start="56" len="19" />
    <Question id="T1" start="0" len="76">
      <SubQuestion qt="Management">What are the new treatments options for cri du chat syndome?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">What are the experimental treatments options for cri du chat syndome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1291">
    <Text>What are the presenting complaints of central post-stroke pain?</Text>
    <Focus start="38" len="24" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Manifestation">What are the presenting complaints of central post-stroke pain?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1292">
    <Text>What are the presenting features of Potter syndrome type 1? How is this condition inherited? What are the associated anomalies?</Text>
    <Focus start="36" len="22" />
    <Question id="T1" start="0" len="59">
      <SubQuestion qt="Manifestation">What are the presenting features of Potter syndrome type 1?</SubQuestion>
    </Question>
    <Question id="T3" start="60" len="32">
      <SubQuestion qt="Susceptibility">How is this condition inherited?</SubQuestion>
    </Question>
    <Question id="T4" start="93" len="34">
      <SubQuestion qt="OtherEffect">What are the associated anomalies?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1293">
    <Text>What are the recommendations for palliative care for myalgic encephalomyelitis?  What are the staging levels for this illness?</Text>
    <Focus start="53" len="25" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Management">What are the recommendations for palliative care for myalgic encephalomyelitis?</SubQuestion>
    </Question>
    <Question id="T3" start="81" len="45">
      <SubQuestion qt="Information">What are the staging levels for this illness?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1294">
    <Text>What are the signs and symptoms of familial hypercholesterolemia? What genes cause this condition?</Text>
    <Focus start="35" len="29" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Manifestation">What are the signs of familial hypercholesterolemia?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms of familial hypercholesterolemia?</SubQuestion>
    </Question>
    <Question id="T4" start="66" len="32">
      <SubQuestion qt="Cause">What genes cause this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1295">
    <Text>What are the signs and symptoms of systemic lupus erythematosus (SLE)?</Text>
    <Focus start="35" len="34" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="Manifestation">What are the signs of systemic lupus erythematosus (SLE)?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms of systemic lupus erythematosus (SLE)?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1296">
    <Text>What are the signs, symptoms, treatment, and prognosis for hypoplastic anemia?</Text>
    <Focus start="59" len="18" />
    <Question id="T1" start="0" len="78">
      <SubQuestion qt="Manifestation">What are the signs for hypoplastic anemia?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms for hypoplastic anemia?</SubQuestion>
      <SubQuestion qt="Management">What are the treatment for hypoplastic anemia?</SubQuestion>
      <SubQuestion qt="Prognosis">What are the prognosis for hypoplastic anemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1297">
    <Text>What are the suggested treatments for Chandler's syndrome? Is it possible to treat this condition with existing laser technology? If the condition is not treated, can it spread to the other eye?</Text>
    <Focus start="38" len="19" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="Management">What are the suggested treatments for Chandler's syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="59" len="70">
      <SubQuestion qt="Management">Is it possible to treat this condition with existing laser technology?</SubQuestion>
    </Question>
    <Question id="T4" start="130" len="64">
      <SubQuestion qt="OtherEffect">If the condition is not treated, can it spread to the other eye?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1298">
    <Text>What are the symptoms and possible treatments for this disease? I have many of the symptoms of hypokalemic periodic paralysis and hyperkalemic periodic paralysis but what I have seems to me more extensive and more intense.</Text>
    <Focus start="50" len="12" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Manifestation">What are the symptoms for this disease?</SubQuestion>
      <SubQuestion qt="Management">What are the possible treatments for this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1299">
    <Text>What are the symptoms and prognosis for individuals with CDG Ix?  We are pending tests results from an institute in Belgium to obtain a more specific diagnosis for my 13-month-old son. He has had a liver transplant at 6 months due to liver failure, coagulopathy, ascites, protein losing enteropathy (?), failure to thrive, and hypoglycemia. CT and MRI do not show any brain abnormalities.  He does not yet crawl or stand on his own, possibly because he was hospitalized for four months. I am worried about his developmental delay. He does have minimal delay in speech.</Text>
    <Focus start="57" len="6" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="Manifestation">What are the symptoms for individuals with CDG Ix?</SubQuestion>
      <SubQuestion qt="Prognosis">What are the prognosis for individuals with CDG Ix?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1300">
    <Text>What are the symptoms of cat scratch disease?</Text>
    <Focus start="25" len="19" />
    <Question id="T1" start="0" len="45">
      <SubQuestion qt="Manifestation">What are the symptoms of cat scratch disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1301">
    <Text>What are the symptoms of Gilbert syndrome?</Text>
    <Focus start="25" len="16" />
    <Question id="T1" start="0" len="42">
      <SubQuestion qt="Manifestation">What are the symptoms of Gilbert syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1302">
    <Text>What are the symptoms of MASS syndrome? Is MASS syndrome related to Marfan syndrome?</Text>
    <Focus start="25" len="13" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Manifestation">What are the symptoms of MASS syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="40" len="44">
      <SubQuestion qt="OtherEffect">Is MASS syndrome related to Marfan syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1303">
    <Text>What are the symptoms of microcystic adnexal carcinoma?</Text>
    <Focus start="25" len="29" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Manifestation">What are the symptoms of microcystic adnexal carcinoma?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1304">
    <Text>What are the symptoms of orofaciodigital syndrome type 6? How does this syndrome affect adults? What symptoms can I anticipate for my teenage son as he enters adulthood?</Text>
    <Focus start="25" len="31" />
    <Question id="T1" start="0" len="57">
      <SubQuestion qt="Manifestation">What are the symptoms of orofaciodigital syndrome type 6?</SubQuestion>
    </Question>
    <Question id="T3" start="58" len="37">
      <SubQuestion qt="OtherEffect">How does this syndrome affect adults?</SubQuestion>
    </Question>
    <Question id="T4" start="96" len="73">
      <SubQuestion qt="Manifestation">What symptoms can I anticipate for my teenage son as he enters adulthood?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1305">
    <Text>What are the treatments for Fanconi Bickel syndrome?</Text>
    <Focus start="28" len="23" />
    <Question id="T1" start="0" len="52">
      <SubQuestion qt="Management">What are the treatments for Fanconi Bickel syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1306">
    <Text>What can cause a person to have such a condition and what can one do for this condition?</Text>
    <Focus start="39" len="9" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Cause">What can cause a person to have such a condition?</SubQuestion>
    </Question>
    <Question id="T2" start="49" len="39">
      <SubQuestion qt="Management">What can one do for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1307">
    <Text>What can you tell me about acute intermittent porphyria and Chester porphyria?</Text>
    <Focus start="27" len="28" />
    <Focus start="60" len="17" />
    <Question id="T1" start="0" len="78">
      <SubQuestion qt="Information">What can you tell me about acute intermittent porphyria?</SubQuestion>
      <SubQuestion qt="Information">What can you tell me about Chester porphyria?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1308">
    <Text>What causes Alport syndrome? Is it always inherited?</Text>
    <Focus start="12" len="15" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Cause">What causes Alport syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="29" len="23">
      <SubQuestion qt="Susceptibility">Is it always inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1309">
    <Text>What causes an infant to be born with this condition? My 9 month old baby boy had surgery to repair this after months of us being told he had allergies, although it was clear he had an obstruction in his nasal cavity and he was not able to breath well since birth. Also, is this a hereditary condition? How many infants are diagnosed with this? What are the long term affects even after repair?</Text>
    <Focus start="38" len="14" />
    <Question id="T1" start="0" len="53">
      <SubQuestion qt="Cause">What causes an infant to be born with this condition?</SubQuestion>
    </Question>
    <Question id="T3" start="265" len="37">
      <SubQuestion qt="Susceptibility">Is this a hereditary condition?</SubQuestion>
    </Question>
    <Question id="T4" start="303" len="41">
      <SubQuestion qt="Susceptibility">How many infants are diagnosed with this?</SubQuestion>
    </Question>
    <Question id="T5" start="345" len="49">
      <SubQuestion qt="Prognosis">What are the long term affects even after repair?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1310">
    <Text>What causes a pineoblastoma?  Are there any risk factors for this disease?  Can it be inherited?</Text>
    <Focus start="14" len="13" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Cause">What causes a pineoblastoma?</SubQuestion>
    </Question>
    <Question id="T3" start="30" len="44">
      <SubQuestion qt="Complication">Are there any risk factors for this disease?</SubQuestion>
    </Question>
    <Question id="T4" start="76" len="20">
      <SubQuestion qt="Susceptibility">Can it be inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1311">
    <Text>What causes autoimmune polyglandular syndrome type 2? Is it inherited?</Text>
    <Focus start="12" len="40" />
    <Question id="T1" start="0" len="53">
      <SubQuestion qt="Cause">What causes autoimmune polyglandular syndrome type 2?</SubQuestion>
    </Question>
    <Question id="T3" start="54" len="16">
      <SubQuestion qt="Susceptibility">Is it inherited?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1312">
    <Text>What causes Binswanger's disease? How is it diagnosed? Who is most commonly affected? What are the signs and symptoms? How is it treated? What is the prognosis?</Text>
    <Focus start="12" len="20" />
    <Question id="T1" start="0" len="33">
      <SubQuestion qt="Cause">What causes Binswanger's disease?</SubQuestion>
    </Question>
    <Question id="T3" start="34" len="20">
      <SubQuestion qt="Diagnosis">How is it diagnosed?</SubQuestion>
    </Question>
    <Question id="T4" start="55" len="30">
      <SubQuestion qt="Susceptibility">Who is most commonly affected?</SubQuestion>
    </Question>
    <Question id="T5" start="86" len="32">
      <SubQuestion qt="Manifestation">What are the signs?</SubQuestion>
      <SubQuestion qt="Manifestation">What are the symptoms?</SubQuestion>
    </Question>
    <Question id="T6" start="119" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
    <Question id="T7" start="138" len="22">
      <SubQuestion qt="Prognosis">What is the prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1313">
    <Text>What causes Brown-Vialetto-Van Laere syndrome? Is genetic testing for this syndrome available? How can I learn more about research?</Text>
    <Focus start="12" len="33" />
    <Question id="T1" start="0" len="46">
      <SubQuestion qt="Cause">What causes Brown-Vialetto-Van Laere syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="47" len="47">
      <SubQuestion qt="Diagnosis">Is genetic testing for this syndrome available?</SubQuestion>
    </Question>
    <Question id="T4" start="95" len="36">
      <SubQuestion qt="Information" attrs="Research">How can I learn more about research?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1314">
    <Text>What causes Chiari malformation type 1? How can I learn about research on this topic? In particular I'm interested in learning more about the role of genetics and possible links to radiation or drug exposure.</Text>
    <Focus start="12" len="26" />
    <Question id="T1" start="0" len="39">
      <SubQuestion qt="Cause">What causes Chiari malformation type 1?</SubQuestion>
    </Question>
    <Question id="T3" start="40" len="45">
      <SubQuestion qt="Information" attrs="Research">How can I learn about research on this topic?</SubQuestion>
    </Question>
    <Question id="T4" start="86" len="122">
      <SubQuestion qt="Susceptibility">In particular I'm interested in learning more about the role of genetics.</SubQuestion>
      <SubQuestion qt="Cause">In particular I'm interested in learning more about possible links to radiation exposure.</SubQuestion>
      <SubQuestion qt="Cause">In particular I'm interested in learning more about possible links to drug exposure.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1315">
    <Text>What causes Down syndrome?</Text>
    <Focus start="12" len="13" />
    <Question id="T1" start="0" len="26">
      <SubQuestion qt="Cause">What causes Down syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1316">
    <Text>What causes Ehlers-Danlos syndrome and what are the symptoms?</Text>
    <Focus start="12" len="22" />
    <Question id="T1" start="0" len="34">
      <SubQuestion qt="Cause">What causes Ehlers-Danlos syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="35" len="26">
      <SubQuestion qt="Manifestation">What are the symptoms?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1317">
    <Text>What causes Erdheim-Chester disease?</Text>
    <Focus start="12" len="23" />
    <Question id="T1" start="0" len="36">
      <SubQuestion qt="Cause">What causes Erdheim-Chester disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1318">
    <Text>What causes essential thrombocythemia? How long do you live with it? What was the oldest that live with the disorder?</Text>
    <Focus start="12" len="25" />
    <Question id="T1" start="0" len="38">
      <SubQuestion qt="Cause">What causes essential thrombocythemia?</SubQuestion>
    </Question>
    <Question id="T3" start="39" len="29">
      <SubQuestion qt="Prognosis">How long do you live with it?</SubQuestion>
    </Question>
    <Question id="T4" start="69" len="48">
      <SubQuestion qt="Prognosis">What was the oldest that live with the disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1319">
    <Text>What causes Ewing's sarcoma? Is it inherited? If a child is affected, are his or her siblings at risk to develop it as well?</Text>
    <Focus start="12" len="15" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Cause">What causes Ewing's sarcoma?</SubQuestion>
    </Question>
    <Question id="T2" start="29" len="16">
      <SubQuestion qt="Susceptibility">Is it inherited?</SubQuestion>
    </Question>
    <Question id="T3" start="46" len="78">
      <SubQuestion qt="Susceptibility">If a child is affected, is his siblings at risk to develop it as well?</SubQuestion>
      <SubQuestion qt="Susceptibility">If a child is affected, is her siblings at risk to develop it as well?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1320">
    <Text>What causes Hashimoto's encephalitis?</Text>
    <Focus start="12" len="24" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Cause">What causes Hashimoto's encephalitis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1321">
    <Text>What causes hepatocellular carcinoma in children? Was it environmental or genetic factors?</Text>
    <Focus start="12" len="24" />
    <Question id="T1" start="0" len="49">
      <SubQuestion qt="Cause">What causes hepatocellular carcinoma in children?</SubQuestion>
    </Question>
    <Question id="T2" start="50" len="40">
      <SubQuestion qt="Cause" attrs="Error">Was it environmental or genetic factors?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1322">
    <Text>What causes hereditary spherocytosis? How can I learn about research on this topic? In particular I'm interested in learning more about the role of genetics and possible links to radiation or drug exposure.</Text>
    <Focus start="12" len="24" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Cause">What causes hereditary spherocytosis?</SubQuestion>
    </Question>
    <Question id="T2" start="38" len="45">
      <SubQuestion qt="Information" attrs="Research">How can I learn about research on this topic?</SubQuestion>
    </Question>
    <Question id="T3" start="84" len="122">
      <SubQuestion qt="Susceptibility">In particular I'm interested in learning more about the role of genetics.</SubQuestion>
      <SubQuestion qt="Cause">In particular I'm interested in learning more about possible links to radiation exposure.</SubQuestion>
      <SubQuestion qt="Cause">In particular I'm interested in learning more about possible links to drug exposure.</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1323">
    <Text>What causes idiopathic juxtafoveal retinal telangiectasia?</Text>
    <Focus start="12" len="45" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="Cause">What causes idiopathic juxtafoveal retinal telangiectasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1324">
    <Text>What causes mixed connective tissue disease? Is it genetic? Is it due to environmental exposures?</Text>
    <Focus start="12" len="31" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Cause">What causes mixed connective tissue disease?</SubQuestion>
    </Question>
    <Question id="T3" start="45" len="14">
      <SubQuestion qt="Susceptibility">Is it genetic?</SubQuestion>
    </Question>
    <Question id="T4" start="60" len="37">
      <SubQuestion qt="Cause">Is it due to environmental exposures?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1325">
    <Text>What causes pilomatrixomas?</Text>
    <Focus start="12" len="14" />
    <Question id="T1" start="0" len="27">
      <SubQuestion qt="Cause">What causes pilomatrixomas?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1326">
    <Text>What causes scleromyxedema and how is it treated?</Text>
    <Focus start="12" len="14" />
    <Question id="T1" start="0" len="26">
      <SubQuestion qt="Cause">What causes scleromyxedema?</SubQuestion>
    </Question>
    <Question id="T2" start="27" len="22">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1327">
    <Text>What causes the disorder? What happens to a person suffering from Zellweger Syndrome? What may indicate a person has Zellweger syndrome? Is the disorder more commonly found in a particular population? If so, what ethnicity? What is the status of current research on the syndrome? What are some possible outcomes of Zellweger syndrome?</Text>
    <Focus start="66" len="18" />
    <Question id="T1" start="0" len="25">
      <SubQuestion qt="Cause">What causes the disorder?</SubQuestion>
    </Question>
    <Question id="T2" start="26" len="59">
      <SubQuestion qt="OtherEffect">What happens to a person suffering from Zellweger Syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="86" len="50">
      <SubQuestion qt="Diagnosis">What may indicate a person has Zellweger syndrome?</SubQuestion>
    </Question>
    <Question id="T4" start="137" len="63">
      <SubQuestion qt="Susceptibility">Is the disorder more commonly found in a particular population?</SubQuestion>
    </Question>
    <Question id="T5" start="201" len="22">
      <SubQuestion qt="Susceptibility">If so, what ethnicity?</SubQuestion>
    </Question>
    <Question id="T6" start="224" len="55">
      <SubQuestion qt="Information" attrs="Research">What is the status of current research on the syndrome?</SubQuestion>
    </Question>
    <Question id="T7" start="280" len="54">
      <SubQuestion qt="Prognosis">What are some possible outcomes of Zellweger syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1328">
    <Text>What causes this to happen?</Text>
    <Focus start="12" len="4" />
    <Question id="T1" start="0" len="27">
      <SubQuestion qt="Cause">What causes this to happen?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1329">
    <Text>What complications, if any, could happen if a person with polycystic kidney disease becomes pregnant? What are the risks to the mother and the baby?</Text>
    <Focus start="58" len="25" />
    <Question id="T1" start="0" len="101">
      <SubQuestion qt="Complication">What complications, if any, could happen if a person with polycystic kidney disease becomes pregnant?</SubQuestion>
    </Question>
    <Question id="T2" start="102" len="46">
      <SubQuestion qt="Complication">What are the risks to the mother?</SubQuestion>
      <SubQuestion qt="Complication">What are the risks to the baby?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1330">
    <Text>What distinguishes Lucey-Driscoll syndrome from other causes of jaundice?  Is this condition hereditary?</Text>
    <Focus start="19" len="23" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Diagnosis">What distinguishes Lucey-Driscoll syndrome from other causes of jaundice?</SubQuestion>
    </Question>
    <Question id="T3" start="75" len="29">
      <SubQuestion qt="Susceptibility">Is this condition hereditary?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1331">
    <Text>What does it mean to have a chromosome 1q42.4-qter duplication?</Text>
    <Focus start="28" len="34" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Information">What does it mean to have a chromosome 1q42.4-qter duplication?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1332">
    <Text>What does myasthenia gravis do to my body?</Text>
    <Focus start="10" len="17" />
    <Question id="T1" start="0" len="42">
      <SubQuestion qt="Manifestation">What does myasthenia gravis do to my body?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1333">
    <Text>What environmental factors can cause this? Could it be a toxin breathed in during pregnancy or something you ate or drank?</Text>
    <Focus start="37" len="4" />
    <Question id="T1" start="0" len="42">
      <SubQuestion qt="Cause">What environmental factors can cause this?</SubQuestion>
    </Question>
    <Question id="T2" start="43" len="79">
      <SubQuestion qt="Cause">Could it be a toxin breathed in during pregnancy?</SubQuestion>
      <SubQuestion qt="Cause">Could it be something you ate?</SubQuestion>
      <SubQuestion qt="Cause">Could it be something you drank?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1334">
    <Text>What have been the affects of TRPS in the later years in life? Does any of the other people that have it have a problem with excessive sweating? If so, is there any kind of treatment that can cure it?</Text>
    <Focus start="30" len="4" />
    <Question id="T1" start="0" len="62">
      <SubQuestion qt="Prognosis">What have been the affects of TRPS in the later years in life?</SubQuestion>
    </Question>
    <Question id="T2" start="63" len="81">
      <SubQuestion qt="OtherEffect">Does any of the other people that have it have a problem with excessive sweating?</SubQuestion>
    </Question>
    <Question id="T3" start="145" len="55">
      <SubQuestion qt="Management">If so, is there any kind of treatment that can cure it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1335">
    <Text>What information can you provide about Floating-Harbor syndrome?</Text>
    <Focus start="39" len="24" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="Information">What information can you provide about Floating-Harbor syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1336">
    <Text>What information do you have on acromicric dysplasia? What is the prevalence? Is HGH treatment used for people with this condition, and if so, what are the results? What is the average adult height? My daughter has been diagnosed with it based upon her skeletal bone X-ray but we are in the process of going through genetic testing for it to confirm.</Text>
    <Focus start="32" len="20" />
    <Question id="T1" start="0" len="53">
      <SubQuestion qt="Information">What information do you have on acromicric dysplasia?</SubQuestion>
    </Question>
    <Question id="T3" start="54" len="23">
      <SubQuestion qt="Susceptibility">What is the prevalence?</SubQuestion>
    </Question>
    <Question id="T4" start="78" len="53">
      <SubQuestion qt="Management">Is HGH treatment used for people with this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="132" len="32">
      <SubQuestion qt="Management">If so, what are the results?</SubQuestion>
    </Question>
    <Question id="T6" start="165" len="33">
      <SubQuestion qt="OtherEffect">What is the average adult height?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1337">
    <Text>What information is available for Eisenmenger syndrome?</Text>
    <Focus start="34" len="20" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Information">What information is available for Eisenmenger syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1338">
    <Text>What is acute myelomonocytic leukemia and how is it best treated?  Is there any research or new treatment currently in trials that is available to treat this disease?  My father has just been diagnosed with this condition.</Text>
    <Focus start="8" len="29" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Information">What is acute myelomonocytic leukemia?</SubQuestion>
    </Question>
    <Question id="T2" start="38" len="27">
      <SubQuestion qt="Management">How is it best treated?</SubQuestion>
    </Question>
    <Question id="T3" start="67" len="99">
      <SubQuestion qt="Information" attrs="Research">Is there any research?</SubQuestion>
      <SubQuestion qt="Management" attrs="Research">Is there any new treatment currently in trials that is available to treat this disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1339">
    <Text>What is adenoameloblastoma? What causes it and how might it be treated?</Text>
    <Focus start="8" len="18" />
    <Question id="T1" start="0" len="27">
      <SubQuestion qt="Information">What is adenoameloblastoma?</SubQuestion>
    </Question>
    <Question id="T3" start="28" len="14">
      <SubQuestion qt="Cause">What causes it?</SubQuestion>
    </Question>
    <Question id="T4" start="43" len="28">
      <SubQuestion qt="Management">How might it be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1340">
    <Text>What is a hemangioendothelioma?  How common is it?</Text>
    <Focus start="10" len="20" />
    <Question id="T1" start="0" len="31">
      <SubQuestion qt="Information">What is a hemangioendothelioma?</SubQuestion>
    </Question>
    <Question id="T3" start="33" len="17">
      <SubQuestion qt="Susceptibility">How common is it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1341">
    <Text>What is Askin's tumor? What causes it?</Text>
    <Focus start="8" len="13" />
    <Question id="T1" start="0" len="22">
      <SubQuestion qt="Information">What is Askin's tumor?</SubQuestion>
    </Question>
    <Question id="T2" start="23" len="15">
      <SubQuestion qt="Cause">What causes it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1342">
    <Text>What is bilateral frontoparietal polymicrogyria? What are its symptoms? How is it different from bilateral perisylvian polymicrogyria in how it presents and what symptoms we see?</Text>
    <Focus start="8" len="39" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Information">What is bilateral frontoparietal polymicrogyria?</SubQuestion>
    </Question>
    <Question id="T3" start="49" len="22">
      <SubQuestion qt="Manifestation">What are its symptoms?</SubQuestion>
    </Question>
    <Question id="T4" start="72" len="106">
      <SubQuestion qt="Diagnosis">How is it different from bilateral perisylvian polymicrogyria in how it presents?</SubQuestion>
      <SubQuestion qt="Diagnosis">How is it different from bilateral perisylvian polymicrogyria in what symptoms we see?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1343">
    <Text>What is branchiootorenal syndrome? How can I learn more about this condition? How can I find a specialist?</Text>
    <Focus start="8" len="25" />
    <Question id="T1" start="0" len="34">
      <SubQuestion qt="Information">What is branchiootorenal syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="35" len="42">
      <SubQuestion qt="Information">How can I learn more about this condition?</SubQuestion>
    </Question>
    <Question id="T3" start="78" len="28">
      <SubQuestion qt="PersonOrg">How can I find a specialist?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1344">
    <Text>What is Buerger disease? Are there products other than cigarette tobacco associated with Buerger disease?</Text>
    <Focus start="8" len="15" />
    <Question id="T1" start="0" len="24">
      <SubQuestion qt="Information">What is Buerger disease?</SubQuestion>
    </Question>
    <Question id="T2" start="25" len="80">
      <SubQuestion qt="Cause">Are there products other than cigarette tobacco associated with Buerger disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1345">
    <Text>What is Canavan disease? How does it happen? Can it be treated? What is the prognosis?</Text>
    <Focus start="8" len="15" />
    <Question id="T1" start="0" len="24">
      <SubQuestion qt="Information">What is Canavan disease?</SubQuestion>
    </Question>
    <Question id="T2" start="25" len="19">
      <SubQuestion qt="Cause">How does it happen?</SubQuestion>
    </Question>
    <Question id="T3" start="45" len="18">
      <SubQuestion qt="Management">Can it be treated?</SubQuestion>
    </Question>
    <Question id="T4" start="64" len="22">
      <SubQuestion qt="Prognosis">What is the prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1346">
    <Text>What is caudal regression syndrome? What kind of therapies can we get for a child with this condition?</Text>
    <Focus start="8" len="26" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Information">What is caudal regression syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="36" len="66">
      <SubQuestion qt="Management">What kind of therapies can we get for a child with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1347">
    <Text>What is cryoglobulinemia?  How is it diagnosed?  How might it be treated?  What are the expected outcomes for individuals with cryoglobulinemia?  How common is it?</Text>
    <Focus start="8" len="16" />
    <Question id="T1" start="0" len="25">
      <SubQuestion qt="Information">What is cryoglobulinemia?</SubQuestion>
    </Question>
    <Question id="T2" start="27" len="20">
      <SubQuestion qt="Diagnosis">How is it diagnosed?</SubQuestion>
    </Question>
    <Question id="T3" start="49" len="24">
      <SubQuestion qt="Management">How might it be treated?</SubQuestion>
    </Question>
    <Question id="T4" start="75" len="69">
      <SubQuestion qt="Prognosis">What are the expected outcomes for individuals with cryoglobulinemia?</SubQuestion>
    </Question>
    <Question id="T5" start="146" len="17">
      <SubQuestion qt="Susceptibility">How common is it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1348">
    <Text>What is currently known about Hallermann-Streiff syndrome? Is there a genetic test for this condition?</Text>
    <Focus start="30" len="27" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="Information">What is currently known about Hallermann-Streiff syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="59" len="43">
      <SubQuestion qt="Diagnosis">Is there a genetic test for this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1349">
    <Text>What is double inferior vena cava, and how does it affect your health? How is it treated, and what is the prognosis?</Text>
    <Focus start="8" len="25" />
    <Question id="T1" start="0" len="34">
      <SubQuestion qt="Information">What is double inferior vena cava?</SubQuestion>
    </Question>
    <Question id="T2" start="35" len="35">
      <SubQuestion qt="OtherEffect">How does it affect your health?</SubQuestion>
    </Question>
    <Question id="T3" start="71" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
    <Question id="T4" start="90" len="26">
      <SubQuestion qt="Prognosis">What is the prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1350">
    <Text>What is Ehlers-Danlos syndrome vascular type? What are the symptoms and how is it treated?</Text>
    <Focus start="8" len="36" />
    <Question id="T1" start="0" len="45">
      <SubQuestion qt="Information">What is Ehlers-Danlos syndrome vascular type?</SubQuestion>
    </Question>
    <Question id="T3" start="46" len="21">
      <SubQuestion qt="Manifestation">What are the symptoms?</SubQuestion>
    </Question>
    <Question id="T4" start="68" len="22">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1351">
    <Text>What is empty sella syndrome? What are the unusual facial features associated with the syndrome?</Text>
    <Focus start="8" len="20" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Information">What is empty sella syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="30" len="66">
      <SubQuestion qt="OtherEffect">What are the unusual facial features associated with the syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1352">
    <Text>What is epithelioid sarcoma?  Why is it difficult to diagnose?  What is the average length of time between the beginning of symptoms and diagnosis?  How rare is it?</Text>
    <Focus start="8" len="19" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Information">What is epithelioid sarcoma?</SubQuestion>
    </Question>
    <Question id="T2" start="30" len="32">
      <SubQuestion qt="Diagnosis">Why is it difficult to diagnose?</SubQuestion>
    </Question>
    <Question id="T3" start="64" len="83">
      <SubQuestion qt="Other">What is the average length of time between the beginning of symptoms and diagnosis?</SubQuestion>
    </Question>
    <Question id="T4" start="149" len="15">
      <SubQuestion qt="Susceptibility">How rare is it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1353">
    <Text>What is familial Mediterranean fever (FMF)? Is there any connection between fibromyalgia and FMF? Has any link been established between a family history of arthritis and FMF?</Text>
    <Focus start="8" len="34" />
    <Question id="T1" start="0" len="43">
      <SubQuestion qt="Information">What is familial Mediterranean fever (FMF)?</SubQuestion>
    </Question>
    <Question id="T2" start="44" len="53">
      <SubQuestion qt="OtherEffect">Is there any connection between fibromyalgia and FMF?</SubQuestion>
    </Question>
    <Question id="T3" start="98" len="76">
      <SubQuestion qt="OtherEffect">Has any link been established between a family history of arthritis and FMF?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1354">
    <Text>What is gray platelet syndrome? My daughter has low platelet counts and I am desperate for answers.</Text>
    <Focus start="8" len="22" />
    <Question id="T1" start="0" len="31">
      <SubQuestion qt="Information">What is gray platelet syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1355">
    <Text>What is HLH and what are the symptoms of this condition?</Text>
    <Focus start="8" len="3" />
    <Question id="T1" start="0" len="11">
      <SubQuestion qt="Information">What is HLH?</SubQuestion>
    </Question>
    <Question id="T2" start="12" len="44">
      <SubQuestion qt="Manifestation">What are the symptoms of this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1356">
    <Text>What is hypomelanosis of Ito?</Text>
    <Focus start="8" len="20" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Information">What is hypomelanosis of Ito?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1357">
    <Text>What is known about monilethrix?  I was told that there isn't a cure.  Is there any research being done to discover a cure?  What type of treatment is currently available?</Text>
    <Focus start="20" len="11" />
    <Question id="T1" start="0" len="32">
      <SubQuestion qt="Information">What is known about monilethrix?</SubQuestion>
    </Question>
    <Question id="T3" start="71" len="52">
      <SubQuestion qt="Management" attrs="Research">Is there any research being done to discover a cure?</SubQuestion>
    </Question>
    <Question id="T4" start="125" len="46">
      <SubQuestion qt="Management">What type of treatment is currently available?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1358">
    <Text>What is known about the inheritance of laryngomalacia?</Text>
    <Focus start="39" len="14" />
    <Question id="T1" start="0" len="54">
      <SubQuestion qt="Susceptibility">What is known about the inheritance of laryngomalacia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1359">
    <Text>What is Kohler disease? Also what's the difference between "osteochondrosis" and "osteonecrosis?"</Text>
    <Focus start="8" len="14" />
    <Question id="T1" start="0" len="23">
      <SubQuestion qt="Information">What is Kohler disease?</SubQuestion>
    </Question>
    <Question id="T2" start="24" len="73">
      <SubQuestion qt="Information">What's the difference between "osteochondrosis" and "osteonecrosis??</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1360">
    <Text>What is limbic encephalitis?  I am working with a patient with this condition.</Text>
    <Focus start="8" len="19" />
    <Question id="T1" start="0" len="28">
      <SubQuestion qt="Information">What is limbic encephalitis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1361">
    <Text>What is lipid storage myopathy?</Text>
    <Focus start="8" len="22" />
    <Question id="T1" start="0" len="31">
      <SubQuestion qt="Information">What is lipid storage myopathy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1362">
    <Text>What is Meesmann corneal dystrophy?</Text>
    <Focus start="8" len="26" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Information">What is Meesmann corneal dystrophy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1363">
    <Text>What is morphea and atrophoderma of Pierini and Pasini? How is atrophoderma of Pierini and Pasini treated?</Text>
    <Focus start="8" len="46" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Information">What is morphea and atrophoderma of Pierini and Pasini?</SubQuestion>
    </Question>
    <Question id="T2" start="56" len="50">
      <SubQuestion qt="Management">How is atrophoderma of Pierini and Pasini treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1364">
    <Text>What is most effective treatment and cure for lichen planopilaris?</Text>
    <Focus start="46" len="19" />
    <Question id="T1" start="0" len="66">
      <SubQuestion qt="Management">What is most effective treatment for lichen planopilaris?</SubQuestion>
      <SubQuestion qt="Management">What is most effective cure for lichen planopilaris?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1365">
    <Text>What is mucinous adenocarcinoma of the appendix?</Text>
    <Focus start="8" len="39" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Information">What is mucinous adenocarcinoma of the appendix?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1366">
    <Text>What is multiple familial trichoepithelioma? I was diagnosed with this condition, but no one else in my family has it. How can this be?</Text>
    <Focus start="8" len="35" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Information">What is multiple familial trichoepithelioma?</SubQuestion>
    </Question>
    <Question id="T4" start="119" len="16">
      <SubQuestion qt="Susceptibility">How can this be?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1367">
    <Text>What is PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome? What causes it? Are there any support groups? Are there any research studies?</Text>
    <Focus start="8" len="84" />
    <Question id="T1" start="0" len="93">
      <SubQuestion qt="Information">What is PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="94" len="15">
      <SubQuestion qt="Cause">What causes it?</SubQuestion>
    </Question>
    <Question id="T4" start="110" len="29">
      <SubQuestion qt="PersonOrg">Are there any support groups?</SubQuestion>
    </Question>
    <Question id="T5" start="140" len="31">
      <SubQuestion qt="Information" attrs="Research">Are there any research studies?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1368">
    <Text>What is Poland syndrome? Does this condition cause physiologic functional impairment?</Text>
    <Focus start="8" len="15" />
    <Question id="T1" start="0" len="24">
      <SubQuestion qt="Information">What is Poland syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="25" len="60">
      <SubQuestion qt="OtherEffect">Does this condition cause physiologic functional impairment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1369">
    <Text>What is porokeratosis of Mibelli?  Does it spread to other parts of the body?  Can it turn malignant?  How is it treated?  What is the disease course without treatment?  Can it be transmitted to others?  If so, how is it transmitted?</Text>
    <Focus start="8" len="24" />
    <Question id="T1" start="0" len="33">
      <SubQuestion qt="Information">What is porokeratosis of Mibelli?</SubQuestion>
    </Question>
    <Question id="T3" start="35" len="42">
      <SubQuestion qt="Anatomy">Does it spread to other parts of the body?</SubQuestion>
    </Question>
    <Question id="T4" start="79" len="22">
      <SubQuestion qt="Complication">Can it turn malignant?</SubQuestion>
    </Question>
    <Question id="T5" start="103" len="18">
      <SubQuestion qt="Management">How is it treated?</SubQuestion>
    </Question>
    <Question id="T6" start="123" len="45">
      <SubQuestion qt="Prognosis">What is the disease course without treatment?</SubQuestion>
    </Question>
    <Question id="T7" start="170" len="32">
      <SubQuestion qt="Susceptibility">Can it be transmitted to others?</SubQuestion>
    </Question>
    <Question id="T8" start="204" len="29">
      <SubQuestion qt="Susceptibility">If so, how is it transmitted?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1370">
    <Text>What is reflex sympathetic dystrophy?</Text>
    <Focus start="8" len="28" />
    <Question id="T1" start="0" len="37">
      <SubQuestion qt="Information">What is reflex sympathetic dystrophy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1371">
    <Text>What is Shwachman-Diamond syndrome and what causes it?</Text>
    <Focus start="8" len="26" />
    <Question id="T1" start="0" len="34">
      <SubQuestion qt="Information">What is Shwachman-Diamond syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="35" len="19">
      <SubQuestion qt="Cause">What causes it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1372">
    <Text>What is sialidosis type I? How might this condition be treated?</Text>
    <Focus start="8" len="17" />
    <Question id="T1" start="0" len="26">
      <SubQuestion qt="Information">What is sialidosis type I?</SubQuestion>
    </Question>
    <Question id="T2" start="27" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1373">
    <Text>What is Sommer Hines syndrome? How can I learn more about treatment?</Text>
    <Focus start="8" len="21" />
    <Question id="T1" start="0" len="30">
      <SubQuestion qt="Information">What is Sommer Hines syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="31" len="37">
      <SubQuestion qt="Management">How can I learn more about treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1374">
    <Text>What is the average life expectancy of an individual with methylmalonic aciduria? I understand it is a rare disease and that all cases are different. And how many cases of cobalamin C deficiency are there in the U.S.?</Text>
    <Focus start="58" len="22" />
    <Question id="T1" start="0" len="81">
      <SubQuestion qt="Prognosis">What is the average life expectancy of an individual with methylmalonic aciduria?</SubQuestion>
    </Question>
    <Question id="T3" start="150" len="67">
      <SubQuestion qt="Susceptibility">How many cases of cobalamin C deficiency are there in the U.S.?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1375">
    <Text>What is the best pain management regimen for a 50-year-old with hemoglobin sickle-beta thalassemia experiencing sickle cell crisis? Lately, the onset has become more frequent, about every three months. Is this normal?</Text>
    <Focus start="64" len="34" />
    <Question id="T1" start="0" len="131">
      <SubQuestion qt="Management">What is the best pain management regimen for a 50-year-old with hemoglobin sickle-beta thalassemia experiencing sickle cell crisis?</SubQuestion>
    </Question>
    <Question id="T3" start="202" len="15">
      <SubQuestion qt="Prognosis">Is this normal?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1376">
    <Text>What is the best treatment and are there any dietary changes I should make? Are there any trials?</Text>
    <Question id="T1" start="0" len="26">
      <SubQuestion qt="Management">What is the best treatment?</SubQuestion>
    </Question>
    <Question id="T2" start="27" len="48">
      <SubQuestion qt="Management">Are there any dietary changes I should make?</SubQuestion>
    </Question>
    <Question id="T3" start="76" len="21">
      <SubQuestion qt="Management" attrs="Research">Are there any trials?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1377">
    <Text>What is the best treatment for a 3 year old who has arginase deficiency?  And what is the prognosis?</Text>
    <Focus start="52" len="19" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Management">What is the best treatment for a 3 year old who has arginase deficiency?</SubQuestion>
    </Question>
    <Question id="T2" start="74" len="26">
      <SubQuestion qt="Prognosis">What is the prognosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1378">
    <Text>What is the best treatment for Rosai-Dorfman? A biopsy was done about 2 years ago. The doctor is considering radiation therapy. I have a lesion deep in my pelvic bone.</Text>
    <Focus start="31" len="13" />
    <Question id="T1" start="0" len="45">
      <SubQuestion qt="Management">What is the best treatment for Rosai-Dorfman?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1379">
    <Text>What is the cause of Vogt-Koyanagi-Harada syndrome?</Text>
    <Focus start="21" len="29" />
    <Question id="T1" start="0" len="51">
      <SubQuestion qt="Cause">What is the cause of Vogt-Koyanagi-Harada syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1380">
    <Text>What is the chance for children with Klumpke paralysis to recover arm and hand strength and mobility? How might Klumpke paralysis be treated? Will surgery benefit my child?</Text>
    <Focus start="37" len="17" />
    <Question id="T1" start="0" len="101">
      <SubQuestion qt="Prognosis">What is the chance for children with Klumpke paralysis to recover arm strength?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the chance for children with Klumpke paralysis to recover arm mobility?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the chance for children with Klumpke paralysis to recover hand strength?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the chance for children with Klumpke paralysis to recover hand mobility?</SubQuestion>
    </Question>
    <Question id="T5" start="102" len="39">
      <SubQuestion qt="Management">How might Klumpke paralysis be treated?</SubQuestion>
    </Question>
    <Question id="T6" start="142" len="30">
      <SubQuestion qt="Management">Will surgery benefit my child?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1381">
    <Text>What is the chance of having another child with Angelman syndrome if a mother has a translocation of chromosomes 15 and 7? Is there additional genetic testing that could be performed?</Text>
    <Focus start="48" len="17" />
    <Question id="T1" start="0" len="122">
      <SubQuestion qt="Susceptibility">What is the chance of having another child with Angelman syndrome if a mother has a translocation of chromosomes 15 and 7?</SubQuestion>
    </Question>
    <Question id="T3" start="123" len="60">
      <SubQuestion qt="Diagnosis">Is there additional genetic testing that could be performed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1382">
    <Text>What is the chance that a sibling of a child with Diamond-Blackfan anemia will also have the condition in a family with no prior history of Diamond-Blackfan anemia?</Text>
    <Focus start="50" len="23" />
    <Question id="T1" start="0" len="164">
      <SubQuestion qt="Susceptibility">What is the chance that a sibling of a child with Diamond-Blackfan anemia will also have the condition in a family with no prior history of Diamond-Blackfan anemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1383">
    <Text>What is the current understanding of the risk for developing multiple myeloma among first degree relatives of an affected person? For example, if a parent has been diagnosed with multiple myeloma, what is the risk to a child?</Text>
    <Focus start="61" len="16" />
    <Question id="T1" start="0" len="129">
      <SubQuestion qt="Susceptibility">What is the current understanding of the risk for developing multiple myeloma among first degree relatives of an affected person?</SubQuestion>
    </Question>
    <Question id="T3" start="130" len="95">
      <SubQuestion qt="Susceptibility">For example, if a parent has been diagnosed with multiple myeloma, what is the risk to a child?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1384">
    <Text>What is the difference between a epithelioid sarcoma and a lipoma or liposarcoma?</Text>
    <Focus start="33" len="19" />
    <Focus start="59" len="6" />
    <Focus start="69" len="11" />
    <Question id="T1" start="0" len="81">
      <SubQuestion qt="Diagnosis">What is the difference between a epithelioid sarcoma and a lipoma?</SubQuestion>
      <SubQuestion qt="Diagnosis">What is the difference between a epithelioid sarcoma and a liposarcoma?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1385">
    <Text>What is the difference between cryoglobulinemia and cold agglutinin disease?</Text>
    <Focus start="31" len="16" />
    <Focus start="52" len="23" />
    <Question id="T1" start="0" len="76">
      <SubQuestion qt="Diagnosis">What is the difference between cryoglobulinemia and cold agglutinin disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1386">
    <Text>What is the difference between Roberts syndrome and tetra-amelia syndrome? How can my condition be diagnosed?</Text>
    <Focus start="31" len="16" />
    <Focus start="52" len="21" />
    <Question id="T1" start="0" len="74">
      <SubQuestion qt="Diagnosis">What is the difference between Roberts syndrome and tetra-amelia syndrome?</SubQuestion>
    </Question>
    <Question id="T4" start="75" len="34">
      <SubQuestion qt="Diagnosis">How can my condition be diagnosed?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1387">
    <Text>What is the difference between uterine adenosarcoma and uterine adenocarcinoma?  Or are they the same thing?  I'm trying to research this diagnosis and keep seeing these phrases used interchangeably.</Text>
    <Focus start="31" len="20" />
    <Focus start="56" len="22" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Diagnosis">What is the difference between uterine adenosarcoma and uterine adenocarcinoma?</SubQuestion>
    </Question>
    <Question id="T2" start="81" len="27">
      <SubQuestion qt="Information">Are they the same thing?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1388">
    <Text>What is the expected life span of a person with this chromosome deletion? I am very concerned about my grandson who has this deletion and lately seems to be sick a lot. He has always had a lot of sickness, but now it seems to be more often. He is 20 years old.</Text>
    <Focus start="48" len="24" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Prognosis">What is the expected life span of a person with this chromosome deletion?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1389">
    <Text>What is the incidence of amniotic band syndrome? Where can I find information about clinical trials?</Text>
    <Focus start="25" len="22" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Susceptibility">What is the incidence of amniotic band syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="49" len="51">
      <SubQuestion qt="Information" attrs="Research">Where can I find information about clinical trials?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1390">
    <Text>What is the incidence of congenital fiber type disproportion? Is it considered a rare disease?</Text>
    <Focus start="25" len="35" />
    <Question id="T1" start="0" len="61">
      <SubQuestion qt="Susceptibility">What is the incidence of congenital fiber type disproportion?</SubQuestion>
    </Question>
    <Question id="T2" start="62" len="32">
      <SubQuestion qt="Susceptibility">Is it considered a rare disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1391">
    <Text>What is the incidence of Melkersson-Rosenthal syndrome? How many cases have been reported in India?</Text>
    <Focus start="25" len="29" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Susceptibility">What is the incidence of Melkersson-Rosenthal syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="56" len="43">
      <SubQuestion qt="Susceptibility">How many cases have been reported in India?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1392">
    <Text>What is the incidence of pityriasis lichenoides et varioliformis acuta (PLEVA) in the United States? How often does PLEVA turn into something more serious?</Text>
    <Focus start="25" len="53" />
    <Question id="T1" start="0" len="100">
      <SubQuestion qt="Susceptibility">What is the incidence of pityriasis lichenoides et varioliformis acuta (PLEVA) in the United States?</SubQuestion>
    </Question>
    <Question id="T3" start="101" len="54">
      <SubQuestion qt="Other">How often does PLEVA turn into something more serious?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1393">
    <Text>What is the life expectancy for 22q13.3 deletion syndrome?</Text>
    <Focus start="32" len="25" />
    <Question id="T1" start="0" len="58">
      <SubQuestion qt="Prognosis">What is the life expectancy for 22q13.3 deletion syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1394">
    <Text>What is the life expectancy for a baby with semi-lobar holoprosencephaly? What are the most common defects?</Text>
    <Focus start="44" len="28" />
    <Question id="T1" start="0" len="73">
      <SubQuestion qt="Prognosis">What is the life expectancy for a baby with semi-lobar holoprosencephaly?</SubQuestion>
    </Question>
    <Question id="T3" start="74" len="33">
      <SubQuestion qt="OtherEffect">What are the most common defects?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1395">
    <Text>What is the life expectancy for a child with Dravet syndrome? Other main characteristics?</Text>
    <Focus start="45" len="15" />
    <Question id="T1" start="0" len="61">
      <SubQuestion qt="Prognosis">What is the life expectancy for a child with Dravet syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="62" len="27">
      <SubQuestion qt="Manifestation">Other main characteristics?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1396">
    <Text>What is the life expectancy for FG syndrome?</Text>
    <Focus start="32" len="11" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Prognosis">What is the life expectancy for FG syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1397">
    <Text>What is the life expectancy for individuals with optic atrophy 1?</Text>
    <Focus start="49" len="15" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Prognosis">What is the life expectancy for individuals with optic atrophy 1?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1398">
    <Text>What is the life-expectancy for individuals with protein S deficiency?</Text>
    <Focus start="49" len="20" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="Prognosis">What is the life-expectancy for individuals with protein S deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1399">
    <Text>What is the life expectancy for infants diagnosed with Waldmann disease?</Text>
    <Focus start="55" len="16" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Prognosis">What is the life expectancy for infants diagnosed with Waldmann disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1400">
    <Text>What is the life expectancy for someone with purine nucleoside phosphorylase deficiency?</Text>
    <Focus start="45" len="42" />
    <Question id="T1" start="0" len="88">
      <SubQuestion qt="Prognosis">What is the life expectancy for someone with purine nucleoside phosphorylase deficiency?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1401">
    <Text>What is the life expectancy for someone with Wolf-Hirschhorn syndrome?</Text>
    <Focus start="45" len="24" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="Prognosis">What is the life expectancy for someone with Wolf-Hirschhorn syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1402">
    <Text>What is the life expectancy of a child with VLCAD deficiency? Who are the best doctors in the United States for this condition? I was told that my child has one mutated gene and one with significant variables. Does that mean she has the condition?</Text>
    <Focus start="44" len="16" />
    <Question id="T1" start="0" len="61">
      <SubQuestion qt="Prognosis">What is the life expectancy of a child with VLCAD deficiency?</SubQuestion>
    </Question>
    <Question id="T3" start="62" len="65">
      <SubQuestion qt="PersonOrg">Who are the best doctors in the United States for this condition?</SubQuestion>
    </Question>
    <Question id="T5" start="210" len="37">
      <SubQuestion qt="Diagnosis">Does that mean she has the condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1403">
    <Text>What is the life expectancy of an adult with Sturge-Weber syndrome?</Text>
    <Focus start="45" len="21" />
    <Question id="T1" start="0" len="67">
      <SubQuestion qt="Prognosis">What is the life expectancy of an adult with Sturge-Weber syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1404">
    <Text>What is the life expectancy of an individual with Costello syndrome?</Text>
    <Focus start="50" len="17" />
    <Question id="T1" start="0" len="68">
      <SubQuestion qt="Prognosis">What is the life expectancy of an individual with Costello syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1405">
    <Text>What is the life expectancy of individuals with Cornelia de Lange syndrome?</Text>
    <Focus start="48" len="26" />
    <Question id="T1" start="0" len="75">
      <SubQuestion qt="Prognosis">What is the life expectancy of individuals with Cornelia de Lange syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1406">
    <Text>What is the life expectancy of someone born with chondrodysplasia punctata 1, X-linked recessive (CDPX1)? What are the odds of getting CDPX1? What research is being done at present regarding CDPX1?</Text>
    <Focus start="49" len="55" />
    <Question id="T1" start="0" len="105">
      <SubQuestion qt="Prognosis">What is the life expectancy of someone born with chondrodysplasia punctata 1, X-linked recessive (CDPX1)?</SubQuestion>
    </Question>
    <Question id="T3" start="106" len="35">
      <SubQuestion qt="Susceptibility">What are the odds of getting CDPX1?</SubQuestion>
    </Question>
    <Question id="T4" start="142" len="55">
      <SubQuestion qt="Information" attrs="Research">What research is being done at present regarding CDPX1?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1407">
    <Text>What is the life expectancy of someone with POEMS syndrome?  I was diagnosed when I was in my 50s.  I am currently taking Revlamid.  I walk with a walker and I have had many skin sores.</Text>
    <Focus start="44" len="14" />
    <Question id="T1" start="0" len="59">
      <SubQuestion qt="Prognosis">What is the life expectancy of someone with POEMS syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1408">
    <Text>What is the long-term prognosis of tracheobronchomalacia?</Text>
    <Focus start="35" len="21" />
    <Question id="T1" start="0" len="57">
      <SubQuestion qt="Prognosis">What is the long-term prognosis of tracheobronchomalacia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1409">
    <Text>What is the name of the blood test used to diagnose Lynch syndrome?</Text>
    <Focus start="52" len="14" />
    <Question id="T1" start="0" len="67">
      <SubQuestion qt="Diagnosis">What is the name of the blood test used to diagnose Lynch syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1410">
    <Text>What is the name of the test that would be used to diagnose this condition? Is there more than one test? Most importantly, how accurate is this test for both positive and negative results?</Text>
    <Focus start="60" len="14" />
    <Question id="T1" start="0" len="75">
      <SubQuestion qt="Diagnosis">What is the name of the test that would be used to diagnose this condition?</SubQuestion>
    </Question>
    <Question id="T3" start="76" len="28">
      <SubQuestion qt="Diagnosis">Is there more than one test?</SubQuestion>
    </Question>
    <Question id="T4" start="105" len="83">
      <SubQuestion qt="Diagnosis" attrs="Error">Most importantly, how accurate is this test for both positive results?</SubQuestion>
      <SubQuestion qt="Diagnosis" attrs="Error">Most importantly, how accurate is this test for negative results?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1411">
    <Text>What is the oldest a person with this condition is known to live for?</Text>
    <Focus start="33" len="14" />
    <Question id="T1" start="0" len="69">
      <SubQuestion qt="Prognosis">What is the oldest a person with this condition is known to live for?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1412">
    <Text>What is the outlook for people with autoimmune hemolytic anemia?</Text>
    <Focus start="36" len="27" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="Prognosis">What is the outlook for people with autoimmune hemolytic anemia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1413">
    <Text>What is the prevalence of calciphylaxis in the United States of America?</Text>
    <Focus start="26" len="13" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Susceptibility">What is the prevalence of calciphylaxis in the United States of America?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1414">
    <Text>What is the prognosis for individuals affected by idiopathic pulmonary hemosiderosis? Will a cure become available? Can the disease become terminal?</Text>
    <Focus start="50" len="34" />
    <Question id="T1" start="0" len="85">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals affected by idiopathic pulmonary hemosiderosis?</SubQuestion>
    </Question>
    <Question id="T3" start="86" len="29">
      <SubQuestion qt="Management">Will a cure become available?</SubQuestion>
    </Question>
    <Question id="T4" start="116" len="32">
      <SubQuestion qt="Prognosis">Can the disease become terminal?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1415">
    <Text>What is the prognosis for individuals affected by sixth nerve palsy?</Text>
    <Focus start="50" len="17" />
    <Question id="T1" start="0" len="68">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals affected by sixth nerve palsy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1416">
    <Text>What is the prognosis for individuals diagnosed with Brugada syndrome?</Text>
    <Focus start="53" len="16" />
    <Question id="T1" start="0" len="70">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals diagnosed with Brugada syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1417">
    <Text>What is the prognosis for individuals with femoral facial syndrome, especially regarding mobility? What is the life expectancy for this condition? Can the condition be passed on to one's children?</Text>
    <Focus start="43" len="23" />
    <Question id="T1" start="0" len="98">
      <SubQuestion qt="Prognosis">What is the prognosis for individuals with femoral facial syndrome?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the prognosis for individuals with femoral facial syndrome, especially regarding mobility?</SubQuestion>
    </Question>
    <Question id="T3" start="99" len="47">
      <SubQuestion qt="Prognosis">What is the life expectancy for this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="147" len="49">
      <SubQuestion qt="Susceptibility">Can the condition be passed on to one's children?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1418">
    <Text>What is the prognosis for Pitt-Hopkins syndrome?</Text>
    <Focus start="26" len="21" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="Prognosis">What is the prognosis for Pitt-Hopkins syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1419">
    <Text>What is the prognosis or life expectancy for people diagnosed with melorheostosis?</Text>
    <Focus start="67" len="14" />
    <Question id="T1" start="0" len="82">
      <SubQuestion qt="Prognosis">What is the prognosis for people diagnosed with melorheostosis?</SubQuestion>
      <SubQuestion qt="Prognosis">What is the life expectancy for people diagnosed with melorheostosis?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1420">
    <Text>What is the recommended follow up or management of AFAP after the colon has been removed? The small intestine is connected to the rectum. I have had polyps in the rectum and also in the stomach since the colon was removed. How often do I need to do follow up tests to make sure nothing is growing in there?</Text>
    <Focus start="51" len="4" />
    <Question id="T1" start="0" len="89">
      <SubQuestion qt="Management">What is the recommended follow up of AFAP after the colon has been removed?</SubQuestion>
      <SubQuestion qt="Management">What is the recommended management of AFAP after the colon has been removed?</SubQuestion>
    </Question>
    <Question id="T4" start="223" len="83">
      <SubQuestion qt="Management">How often do I need to do follow up tests to make sure nothing is growing in there?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1421">
    <Text>What is the recurrence risk in another pregnancy?</Text>
    <Question id="T1" start="0" len="49">
      <SubQuestion qt="Prognosis">What is the recurrence risk in another pregnancy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1422">
    <Text>What is the right name for epidermolytic hyperkeratosis? Is anyone doing research on this disease? Is there a cure?</Text>
    <Focus start="27" len="28" />
    <Question id="T1" start="0" len="56">
      <SubQuestion qt="Information">What is the right name for epidermolytic hyperkeratosis?</SubQuestion>
    </Question>
    <Question id="T3" start="57" len="41">
      <SubQuestion qt="Information" attrs="Research">Is anyone doing research on this disease?</SubQuestion>
    </Question>
    <Question id="T4" start="99" len="16">
      <SubQuestion qt="Management">Is there a cure?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1423">
    <Text>What is the treatment for Jacobsen syndrome? Our 6 month old baby was diagnosed with this last week.</Text>
    <Focus start="26" len="17" />
    <Question id="T1" start="0" len="44">
      <SubQuestion qt="Management">What is the treatment for Jacobsen syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1424">
    <Text>What is the treatment? Is there a way to improve the bone growth?</Text>
    <Question id="T1" start="0" len="22">
      <SubQuestion qt="Management">What is the treatment?</SubQuestion>
    </Question>
    <Question id="T2" start="23" len="42">
      <SubQuestion qt="Management">Is there a way to improve the bone growth?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1425">
    <Text>What is the treatment or remedy of mixed connective tissue disorder?</Text>
    <Focus start="35" len="32" />
    <Question id="T1" start="0" len="68">
      <SubQuestion qt="Management">What is the treatment of mixed connective tissue disorder?</SubQuestion>
      <SubQuestion qt="Management">What is the remedy of mixed connective tissue disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1426">
    <Text>What is the treatment protocol for amelogenesis imperfecta? Is fluoride supplementation useful for "hardening" the enamel of the teeth of individuals affected by this condition?</Text>
    <Focus start="35" len="23" />
    <Question id="T1" start="0" len="59">
      <SubQuestion qt="Management">What is the treatment protocol for amelogenesis imperfecta?</SubQuestion>
    </Question>
    <Question id="T3" start="60" len="117">
      <SubQuestion qt="Management">Is fluoride supplementation useful for "hardening" the enamel of the teeth of individuals affected by this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1427">
    <Text>What is this exactly and how does it effect someone?</Text>
    <Focus start="8" len="4" />
    <Question id="T1" start="0" len="20">
      <SubQuestion qt="Information">What is this exactly?</SubQuestion>
    </Question>
    <Question id="T2" start="21" len="31">
      <SubQuestion qt="OtherEffect">How does it effect someone?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1428">
    <Text>What is this? Why do I have it? I just had a baby and found out I had it. My sister also just had a baby and has it too. Will we be okay?</Text>
    <Focus start="8" len="4" />
    <Question id="T1" start="0" len="13">
      <SubQuestion qt="Information">What is this?</SubQuestion>
    </Question>
    <Question id="T2" start="14" len="17">
      <SubQuestion qt="Cause">Why do I have it?</SubQuestion>
    </Question>
    <Question id="T5" start="121" len="16">
      <SubQuestion qt="Prognosis">Will we be okay?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1429">
    <Text>What is tubular aggregate myopathy?</Text>
    <Focus start="8" len="26" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Information">What is tubular aggregate myopathy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1430">
    <Text>What is Wiskott Aldrich syndrome and what does it do to the body?</Text>
    <Focus start="8" len="24" />
    <Question id="T1" start="0" len="32">
      <SubQuestion qt="Information">What is Wiskott Aldrich syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="33" len="32">
      <SubQuestion qt="OtherEffect">What does it do to the body?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1431">
    <Text>What kind of disease is this? What impact will it have on my life? Where did it come from? I don't understand how I got this 'rare' disease and don't know anything about it.  Could you please help me understand? I would like to be in a research study. How can I find one?</Text>
    <Focus start="24" len="4" />
    <Question id="T1" start="0" len="29">
      <SubQuestion qt="Information">What kind of disease is this?</SubQuestion>
    </Question>
    <Question id="T2" start="30" len="36">
      <SubQuestion qt="Prognosis">What impact will it have on my life?</SubQuestion>
    </Question>
    <Question id="T3" start="67" len="23">
      <SubQuestion qt="Susceptibility">Where did it come from?</SubQuestion>
    </Question>
    <Question id="T5" start="175" len="36">
      <SubQuestion qt="Information">Could you please help me understand?</SubQuestion>
    </Question>
    <Question id="T7" start="252" len="19">
      <SubQuestion qt="PersonOrg" attrs="Research">How can I find one?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1432">
    <Text>What kind of vision loss is associated with Charcot-Marie-Tooth disease?</Text>
    <Focus start="44" len="27" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="OtherEffect">What kind of vision loss is associated with Charcot-Marie-Tooth disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1433">
    <Text>What lung conditions are commonly associated with yellow nail syndrome? How are they treated?</Text>
    <Focus start="50" len="20" />
    <Question id="T1" start="0" len="71">
      <SubQuestion qt="OtherEffect">What lung conditions are commonly associated with yellow nail syndrome?</SubQuestion>
    </Question>
    <Question id="T3" start="72" len="21">
      <SubQuestion qt="Management">How are they treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1434">
    <Text>What medications and/or treatments can I use for this condition? The itching is driving me crazy. At the moment I take anti-histamines, would PUVA treatments help? Will this condition ever leave?</Text>
    <Focus start="49" len="14" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="Management">What medications can I use for this condition?</SubQuestion>
      <SubQuestion qt="Management">What treatments can I use for this condition?</SubQuestion>
    </Question>
    <Question id="T4" start="98" len="65">
      <SubQuestion qt="Management">At the moment I take anti-histamines, would PUVA treatments help?</SubQuestion>
    </Question>
    <Question id="T6" start="164" len="31">
      <SubQuestion qt="Prognosis">Will this condition ever leave?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1435">
    <Text>What medicines have been successfully used other than Cytoxan and Prednisone for primary angiitis of the central nervous system? I've been diagnosed since 2009 and these medicines have compromised my lung.</Text>
    <Focus start="81" len="46" />
    <Question id="T1" start="0" len="128">
      <SubQuestion qt="Management">What medicines have been successfully used other than Cytoxan and Prednisone for primary angiitis of the central nervous system?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1436">
    <Text>What methods have been used to successfully treat idiopathic hypersomnolence? Is modafinil still the preferred treatment?</Text>
    <Focus start="50" len="26" />
    <Question id="T1" start="0" len="77">
      <SubQuestion qt="Management">What methods have been used to successfully treat idiopathic hypersomnolence?</SubQuestion>
    </Question>
    <Question id="T3" start="78" len="43">
      <SubQuestion qt="Management">Is modafinil still the preferred treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1437">
    <Text>What percentage of patients with Alström syndrome become deaf? What is the average age of deafness?</Text>
    <Focus start="33" len="16" />
    <Question id="T1" start="0" len="62">
      <SubQuestion qt="Prognosis">What percentage of patients with Alström syndrome become deaf?</SubQuestion>
    </Question>
    <Question id="T2" start="63" len="36">
      <SubQuestion qt="Prognosis">What is the average age of deafness?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1438">
    <Text>What percentage of patients with Wolff Parkinson White syndrome have Ebstein's anomaly?</Text>
    <Focus start="33" len="30" />
    <Focus start="69" len="17" />
    <Question id="T1" start="0" len="87">
      <SubQuestion qt="Susceptibility">What percentage of patients with Wolff Parkinson White syndrome have Ebstein's anomaly?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1439">
    <Text>What percentage of people with thrombotic thrombocytopenic purpura (TTP) experience a relapse of symptoms following treatment?</Text>
    <Focus start="31" len="41" />
    <Question id="T1" start="0" len="126">
      <SubQuestion qt="Prognosis">What percentage of people with thrombotic thrombocytopenic purpura (TTP) experience a relapse of symptoms following treatment?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1440">
    <Text>What symptoms might I get from this condition and how does this affect my testosterone level?</Text>
    <Focus start="31" len="14" />
    <Question id="T1" start="0" len="45">
      <SubQuestion qt="Manifestation">What symptoms might I get from this condition?</SubQuestion>
    </Question>
    <Question id="T2" start="46" len="47">
      <SubQuestion qt="OtherEffect">How does this affect my testosterone level?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1441">
    <Text>What testing is available to distinguish between the different types of achondrogenesis? What is the chance of having another child with this condition?</Text>
    <Focus start="72" len="15" />
    <Question id="T1" start="0" len="88">
      <SubQuestion qt="Diagnosis">What testing is available to distinguish between the different types of achondrogenesis?</SubQuestion>
    </Question>
    <Question id="T3" start="89" len="63">
      <SubQuestion qt="Susceptibility">What is the chance of having another child with this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1442">
    <Text>What tests will my doctor order to confirm if I have Huntington disease?</Text>
    <Focus start="53" len="18" />
    <Question id="T1" start="0" len="72">
      <SubQuestion qt="Diagnosis">What tests will my doctor order to confirm if I have Huntington disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1443">
    <Text>What treatment options are available for myoepithelial carcinoma?  Is there a clinical trial for treatment of this cancer?</Text>
    <Focus start="41" len="23" />
    <Question id="T1" start="0" len="65">
      <SubQuestion qt="Management">What treatment options are available for myoepithelial carcinoma?</SubQuestion>
    </Question>
    <Question id="T3" start="67" len="55">
      <SubQuestion qt="Management" attrs="Research">Is there a clinical trial for treatment of this cancer?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1444">
    <Text>What treatments are available for hereditary neuropathy with liability to pressure palsy?</Text>
    <Focus start="34" len="54" />
    <Question id="T1" start="0" len="89">
      <SubQuestion qt="Management">What treatments are available for hereditary neuropathy with liability to pressure palsy?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1445">
    <Text>What treatments are available for ovarian small cell carcinoma? What specific drugs have been successfully used for chemotherapy? Are there any clinical trials?</Text>
    <Focus start="34" len="28" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Management">What treatments are available for ovarian small cell carcinoma?</SubQuestion>
    </Question>
    <Question id="T3" start="64" len="65">
      <SubQuestion qt="Management">What specific drugs have been successfully used for chemotherapy?</SubQuestion>
    </Question>
    <Question id="T4" start="130" len="30">
      <SubQuestion qt="Information" attrs="Research">Are there any clinical trials?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1446">
    <Text>What types of treatments are there for Cowden syndrome? Should treatment begin right after diagnosis or is there a waiting period?</Text>
    <Focus start="39" len="15" />
    <Question id="T1" start="0" len="55">
      <SubQuestion qt="Management">What types of treatments are there for Cowden syndrome?</SubQuestion>
    </Question>
    <Question id="T2" start="56" len="74">
      <SubQuestion qt="Management">Should treatment begin right after diagnosis or is there a waiting period?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1447">
    <Text>What would cause 2 children of the same family to have this disease, and how common is it?</Text>
    <Focus start="55" len="12" />
    <Question id="T1" start="0" len="68">
      <SubQuestion qt="Cause">What would cause 2 children of the same family to have this disease?</SubQuestion>
    </Question>
    <Question id="T2" start="69" len="21">
      <SubQuestion qt="Susceptibility">How common is it?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1448">
    <Text>When a person has an autosomal recessive condition like glycogen storage disease type VI, what is the likelihood that their child will have the disorder?</Text>
    <Focus start="21" len="29" />
    <Question id="T1" start="0" len="153">
      <SubQuestion qt="Susceptibility">When a person has an autosomal recessive condition like glycogen storage disease type VI, what is the likelihood that their child will have the disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1449">
    <Text>When I bend over and straighten up my spine feels like its ripping open. Is this part of the disorder?</Text>
    <Focus start="89" len="12" />
    <Question id="T2" start="73" len="29">
      <SubQuestion qt="OtherEffect">Is this part of the disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1450">
    <Text>When I was about 8-years-old, I was hospitalized due to encephalitis lethargica. I was extremely ill and it took me a long time to recover. Last May, I was diagnosed with a benign meningioma. Could my childhood illness be related to the development of my tumor? Are there any documented cases of meningioma in other survivors of encephalitis lethargica?</Text>
    <Focus start="56" len="23" />
    <Focus start="173" len="17" />
    <Question id="T5" start="192" len="69">
      <SubQuestion qt="OtherEffect">Could my childhood illness be related to the development of my tumor?</SubQuestion>
    </Question>
    <Question id="T7" start="262" len="91">
      <SubQuestion qt="OtherEffect">Are there any documented cases of meningioma in other survivors of encephalitis lethargica?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1451">
    <Text>When my second daughter was born last year, I noticed that she had a small bald patch the size of a coin. I am afraid that she might have aplasia cutis congenita. Can you provide me with information about this condition?</Text>
    <Focus start="138" len="23" />
    <Question id="T3" start="163" len="57">
      <SubQuestion qt="Information">Can you provide me with information about this condition?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1452">
    <Text>When staging Merkel cell carcinoma with sentinel lymph node biopsy, is the use of a tracer as effective as blue dye for identifying the sentinel lymph node?  What is the role of Mohs surgery for treating Merkel cell carcinoma?</Text>
    <Focus start="13" len="21" />
    <Question id="T1" start="0" len="156">
      <SubQuestion qt="Diagnosis">When staging Merkel cell carcinoma with sentinel lymph node biopsy, is the use of a tracer as effective as blue dye for identifying the sentinel lymph node?</SubQuestion>
    </Question>
    <Question id="T2" start="158" len="68">
      <SubQuestion qt="Management">What is the role of Mohs surgery for treating Merkel cell carcinoma?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1453">
    <Text>When was bilateral Goldenhar named? What case initiated this name? What is the correct percentage of people with Goldenhar and bilateral Goldenhar US and Worldwide?</Text>
    <Focus start="9" len="19" />
    <Question id="T1" start="0" len="35">
      <SubQuestion qt="Other">When was bilateral Goldenhar named?</SubQuestion>
    </Question>
    <Question id="T2" start="36" len="30">
      <SubQuestion qt="Other">What case initiated this name?</SubQuestion>
    </Question>
    <Question id="T3" start="67" len="97">
      <SubQuestion qt="Susceptibility">What is the correct percentage of people with Goldenhar US?</SubQuestion>
      <SubQuestion qt="Susceptibility">What is the correct percentage of people with Goldenhar Worldwide?</SubQuestion>
      <SubQuestion qt="Susceptibility">What is the correct percentage of people with bilateral Goldenhar US?</SubQuestion>
      <SubQuestion qt="Susceptibility">What is the correct percentage of people with bilateral Goldenhar Worldwide?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1454">
    <Text>Where and who do I turn to get the help that my daughter needs? What medications are used for this? How long before it will go into remission? How much can be expected of a person that has this and it is not in remission?</Text>
    <Focus start="94" len="4" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="PersonOrg">Where do I turn to get the help that my daughter needs?</SubQuestion>
      <SubQuestion qt="PersonOrg">Who do I turn to get the help that my daughter needs?</SubQuestion>
    </Question>
    <Question id="T3" start="64" len="35">
      <SubQuestion qt="Management">What medications are used for this?</SubQuestion>
    </Question>
    <Question id="T4" start="100" len="42">
      <SubQuestion qt="Prognosis">How long before it will go into remission?</SubQuestion>
    </Question>
    <Question id="T5" start="143" len="78">
      <SubQuestion qt="Prognosis">How much can be expected of a person that has this and it is not in remission?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1455">
    <Text>Where can confirmatory testing for Tangier disease be performed? How might this condition be treated?</Text>
    <Focus start="35" len="15" />
    <Question id="T1" start="0" len="64">
      <SubQuestion qt="PersonOrg">Where can confirmatory testing for Tangier disease be performed?</SubQuestion>
    </Question>
    <Question id="T2" start="65" len="36">
      <SubQuestion qt="Management">How might this condition be treated?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1456">
    <Text>Where can I find a doctor for tarsal carpal coalition syndrome in Mississippi or Alabama?</Text>
    <Focus start="30" len="32" />
    <Question id="T1" start="0" len="89">
      <SubQuestion qt="PersonOrg">Where can I find a doctor for tarsal carpal coalition syndrome in Mississippi?</SubQuestion>
      <SubQuestion qt="PersonOrg">Where can I find a doctor for tarsal carpal coalition syndrome in Alabama?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1457">
    <Text>Where can I find a good description of Wyburn Mason's syndrome?</Text>
    <Focus start="39" len="23" />
    <Question id="T1" start="0" len="63">
      <SubQuestion qt="Information">Where can I find a good description of Wyburn Mason's syndrome?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1458">
    <Text>Where can I find a recommended doctor to treat my nephew with Kyphomelic Dysplasia?</Text>
    <Focus start="62" len="20" />
    <Question id="T1" start="0" len="83">
      <SubQuestion qt="PersonOrg">Where can I find a recommended doctor to treat my nephew with Kyphomelic Dysplasia?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1459">
    <Text>Where can I find information about the symptoms of hereditary cerebral hemorrhage with amyloidosis - Dutch type?</Text>
    <Focus start="51" len="60" />
    <Question id="T1" start="0" len="112">
      <SubQuestion qt="Manifestation">Where can I find information about the symptoms of hereditary cerebral hemorrhage with amyloidosis - Dutch type?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1460">
    <Text>Where can I find information on National Institutes of Health (NIH) funding for rare diseases, specifically retinitis pigmentosa? I am also looking for information on the cost of having this condition and current research projects. How many people have retinitis pigmentosa in the United States?</Text>
    <Focus start="108" len="20" />
    <Question id="T1" start="0" len="129">
      <SubQuestion qt="Other" attrs="Research">Where can I find information on National Institutes of Health (NIH) funding for rare diseases?</SubQuestion>
      <SubQuestion qt="Other" attrs="Research">Where can I find information on National Institutes of Health (NIH) funding for rare diseases, specifically retinitis pigmentosa?</SubQuestion>
    </Question>
    <Question id="T4" start="130" len="101">
      <SubQuestion qt="Other">I am also looking for information on the cost of having this condition.</SubQuestion>
      <SubQuestion qt="Information" attrs="Research">I am also looking for information on current research projects.</SubQuestion>
    </Question>
    <Question id="T6" start="232" len="63">
      <SubQuestion qt="Susceptibility">How many people have retinitis pigmentosa in the United States?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1461">
    <Text>Where can I find the latest information about genetic testing for bipolar disorder?</Text>
    <Focus start="66" len="16" />
    <Question id="T1" start="0" len="83">
      <SubQuestion qt="Diagnosis">Where can I find the latest information about genetic testing for bipolar disorder?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1462">
    <Text>Where can I get a complete list of all genes that have been associated with Crohn's disease?</Text>
    <Focus start="76" len="15" />
    <Question id="T1" start="0" len="92">
      <SubQuestion qt="Cause">Where can I get a complete list of all genes that have been associated with Crohn's disease?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1463">
    <Text>Where can I get information on cystic fibrosis carrier screening and the official recommendations for pregnant women?</Text>
    <Focus start="31" len="15" />
    <Question id="T1" start="0" len="117">
      <SubQuestion qt="Diagnosis">Where can I get information on cystic fibrosis carrier screening?</SubQuestion>
      <SubQuestion qt="Management">Where can I get information on the official recommendations for pregnant women?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1464">
    <Text>Where is the gene responsible for Hutchinson-Gilford progeria syndrome located?</Text>
    <Focus start="34" len="36" />
    <Question id="T1" start="0" len="79">
      <SubQuestion qt="Anatomy">Where is the gene responsible for Hutchinson-Gilford progeria syndrome located?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1465">
    <Text>Why does it appear that hemolysis occurs mostly at night?</Text>
    <Focus start="24" len="9" />
    <Question id="T1" start="0" len="57">
      <SubQuestion qt="OtherEffect">Why does it appear that hemolysis occurs mostly at night?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1466">
    <Text>Will Fabry disease affect a transplanted kidney? Previous to the transplant the disease was being managed with an enzyme supplement. Will the enzyme supplement need to be continued? What are, if any, cautions or additional treatments required to manage the disease with a transplanted kidney?</Text>
    <Focus start="5" len="13" />
    <Question id="T1" start="0" len="48">
      <SubQuestion qt="OtherEffect">Will Fabry disease affect a transplanted kidney?</SubQuestion>
    </Question>
    <Question id="T4" start="133" len="48">
      <SubQuestion qt="Management">Will the enzyme supplement need to be continued?</SubQuestion>
    </Question>
    <Question id="T5" start="182" len="110">
      <SubQuestion qt="Management">What are, if any, cautions required to manage the disease with a transplanted kidney?</SubQuestion>
      <SubQuestion qt="Management">What are, if any, additional treatments required to manage the disease with a transplanted kidney?</SubQuestion>
    </Question>
  </Request>
  <Request docID="GARD_Q_1467">
    <Text>Would the toes being bent down and not wanting to come up be part of this disease? I also have one knee that is in constant pain and doesn't want to lay flat anymore. I was told a few years ago that this disease runs in my family. I haven't mentioned it yet to my family physician as I just remembered it and wanted to get some more info about this disease.</Text>
    <Focus start="69" len="12" />
    <Question id="T1" start="0" len="82">
      <SubQuestion qt="OtherEffect">Would the toes being bent down and not wanting to come up be part of this disease?</SubQuestion>
    </Question>
    <Question id="T4" start="231" len="126">
      <SubQuestion qt="Information">I haven't mentioned it yet to my family physician as I just remembered it and wanted to get some more info about this disease.</SubQuestion>
    </Question>
  </Request>
</QuestionAnnotationFile>