diff --git a/app/src/organisms/Devices/ProtocolRun/ConfirmMissingStepsModal.tsx b/app/src/organisms/Devices/ProtocolRun/ConfirmMissingStepsModal.tsx
new file mode 100644
index 00000000000..af480cdbc65
--- /dev/null
+++ b/app/src/organisms/Devices/ProtocolRun/ConfirmMissingStepsModal.tsx
@@ -0,0 +1,67 @@
+import * as React from 'react'
+import { useTranslation } from 'react-i18next'
+import {
+  ALIGN_CENTER,
+  DIRECTION_COLUMN,
+  DIRECTION_ROW,
+  Flex,
+  JUSTIFY_FLEX_END,
+  Link,
+  PrimaryButton,
+  SecondaryButton,
+  SPACING,
+  LegacyStyledText,
+  TEXT_ALIGN_CENTER,
+  TYPOGRAPHY,
+} from '@opentrons/components'
+import { LegacyModal } from '../../../molecules/LegacyModal'
+
+interface ConfirmMissingStepsModalProps {
+  onCloseClick: () => void
+  onConfirmClick: () => void
+  missingSteps: string[]
+}
+export const ConfirmMissingStepsModal = (
+  props: ConfirmMissingStepsModalProps
+): JSX.Element | null => {
+  const { missingSteps, onCloseClick, onConfirmClick } = props
+  const { t, i18n } = useTranslation(['protocol_setup', 'shared'])
+
+  const confirmAttached = (): void => {
+    onConfirmClick()
+    onCloseClick()
+  }
+
+  return (
+    <LegacyModal
+      title={t('are_you_sure_you_want_to_proceed')}
+      type="warning"
+      onClose={onCloseClick}
+    >
+      <Flex flexDirection={DIRECTION_COLUMN} fontSize={TYPOGRAPHY.fontSizeP}>
+        <LegacyStyledText paddingBottom={SPACING.spacing4}>
+          {t('you_havent_confirmed', {
+            missingSteps: new Intl.ListFormat('en', {
+              style: 'short',
+              type: 'conjunction',
+            }).format(missingSteps.map(step => t(step))),
+          })}
+        </LegacyStyledText>
+      </Flex>
+      <Flex
+        flexDirection={DIRECTION_ROW}
+        paddingTop={SPACING.spacing32}
+        justifyContent={JUSTIFY_FLEX_END}
+        alignItems={ALIGN_CENTER}
+        gap={SPACING.spacing8}
+      >
+        <SecondaryButton onClick={onCloseClick}>
+          {i18n.format(t('shared:go_back'), 'capitalize')}
+        </SecondaryButton>
+        <PrimaryButton onClick={confirmAttached}>
+          {t('start_run')}
+        </PrimaryButton>
+      </Flex>
+    </LegacyModal>
+  )
+}
diff --git a/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx b/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
index 6a704c96699..5d9821cc5a6 100644
--- a/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/ProtocolRunHeader.tsx
@@ -77,6 +77,7 @@ import {
 } from '../../../organisms/RunTimeControl/hooks'
 import { useIsHeaterShakerInProtocol } from '../../ModuleCard/hooks'
 import { ConfirmAttachmentModal } from '../../ModuleCard/ConfirmAttachmentModal'
+import { ConfirmMissingStepsModal } from './ConfirmMissingStepsModal'
 import {
   useProtocolDetailsForRun,
   useProtocolAnalysisErrors,
@@ -132,6 +133,7 @@ interface ProtocolRunHeaderProps {
   robotName: string
   runId: string
   makeHandleJumpToStep: (index: number) => () => void
+  missingSetupSteps: string[]
 }
 
 export function ProtocolRunHeader({
@@ -139,6 +141,7 @@ export function ProtocolRunHeader({
   robotName,
   runId,
   makeHandleJumpToStep,
+  missingSetupSteps,
 }: ProtocolRunHeaderProps): JSX.Element | null {
   const { t } = useTranslation(['run_details', 'shared'])
   const navigate = useNavigate()
@@ -447,6 +450,7 @@ export function ProtocolRunHeader({
               isDoorOpen={isDoorOpen}
               isFixtureMismatch={isFixtureMismatch}
               isResetRunLoadingRef={isResetRunLoadingRef}
+              missingSetupSteps={missingSetupSteps}
             />
           </Flex>
         </Box>
@@ -591,6 +595,7 @@ interface ActionButtonProps {
   isDoorOpen: boolean
   isFixtureMismatch: boolean
   isResetRunLoadingRef: React.MutableRefObject<boolean>
+  missingSetupSteps: string[]
 }
 
 // TODO(jh, 04-22-2024): Refactor switch cases into separate factories to increase readability and testability.
@@ -603,6 +608,7 @@ function ActionButton(props: ActionButtonProps): JSX.Element {
     isDoorOpen,
     isFixtureMismatch,
     isResetRunLoadingRef,
+    missingSetupSteps,
   } = props
   const navigate = useNavigate()
   const { t } = useTranslation(['run_details', 'shared'])
@@ -682,12 +688,20 @@ function ActionButton(props: ActionButtonProps): JSX.Element {
   )
   const {
     confirm: confirmAttachment,
-    showConfirmation: showConfirmationModal,
-    cancel: cancelExit,
+    showConfirmation: showHSConfirmationModal,
+    cancel: cancelExitHSConfirmation,
   } = useConditionalConfirm(
     handleProceedToRunClick,
     !configBypassHeaterShakerAttachmentConfirmation
   )
+  const {
+    confirm: confirmMissingSteps,
+    showConfirmation: showMissingStepsConfirmationModal,
+    cancel: cancelExitMissingStepsConfirmation,
+  } = useConditionalConfirm(
+    handleProceedToRunClick,
+    missingSetupSteps.length !== 0
+  )
   const robotAnalyticsData = useRobotAnalyticsData(robotName)
 
   const isHeaterShakerInProtocol = useIsHeaterShakerInProtocol()
@@ -745,6 +759,11 @@ function ActionButton(props: ActionButtonProps): JSX.Element {
     handleButtonClick = () => {
       if (isHeaterShakerShaking && isHeaterShakerInProtocol) {
         setShowIsShakingModal(true)
+      } else if (
+        missingSetupSteps.length !== 0 &&
+        (runStatus === RUN_STATUS_IDLE || runStatus === RUN_STATUS_STOPPED)
+      ) {
+        confirmMissingSteps()
       } else if (
         isHeaterShakerInProtocol &&
         !isHeaterShakerShaking &&
@@ -825,13 +844,21 @@ function ActionButton(props: ActionButtonProps): JSX.Element {
             startRun={play}
           />
         )}
-      {showConfirmationModal && (
+      {showHSConfirmationModal && (
         <ConfirmAttachmentModal
-          onCloseClick={cancelExit}
+          onCloseClick={cancelExitHSConfirmation}
           isProceedToRunModal={true}
           onConfirmClick={handleProceedToRunClick}
         />
       )}
+      {showMissingStepsConfirmationModal && (
+        <ConfirmMissingStepsModal
+          onCloseClick={cancelExitMissingStepsConfirmation}
+          onConfirmClick={handleProceedToRunClick}
+          missingSteps={missingSetupSteps}
+        />
+      )}
+      {}
     </>
   )
 }
diff --git a/app/src/organisms/Devices/ProtocolRun/ProtocolRunSetup.tsx b/app/src/organisms/Devices/ProtocolRun/ProtocolRunSetup.tsx
index 78eae1454cc..d5c9e56585b 100644
--- a/app/src/organisms/Devices/ProtocolRun/ProtocolRunSetup.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/ProtocolRunSetup.tsx
@@ -62,16 +62,33 @@ export type StepKey =
   | typeof LABWARE_SETUP_KEY
   | typeof LIQUID_SETUP_KEY
 
+export type MissingStep =
+  | 'applied_labware_offsets'
+  | 'labware_placement'
+  | 'liquids'
+
+export type MissingSteps = MissingStep[]
+
+export const initialMissingSteps = (): MissingSteps => [
+  'applied_labware_offsets',
+  'labware_placement',
+  'liquids',
+]
+
 interface ProtocolRunSetupProps {
   protocolRunHeaderRef: React.RefObject<HTMLDivElement> | null
   robotName: string
   runId: string
+  setMissingSteps: (missingSteps: MissingSteps) => void
+  missingSteps: MissingSteps
 }
 
 export function ProtocolRunSetup({
   protocolRunHeaderRef,
   robotName,
   runId,
+  setMissingSteps,
+  missingSteps,
 }: ProtocolRunSetupProps): JSX.Element | null {
   const { t, i18n } = useTranslation('protocol_setup')
   const robotProtocolAnalysis = useMostRecentCompletedAnalysis(runId)
@@ -246,8 +263,13 @@ export function ProtocolRunSetup({
         <SetupLabwarePositionCheck
           {...{ runId, robotName }}
           setOffsetsConfirmed={confirmed => {
-            confirmed && setExpandedStepKey(LABWARE_SETUP_KEY)
             setLpcComplete(confirmed)
+            if (confirmed) {
+              setExpandedStepKey(LABWARE_SETUP_KEY)
+              setMissingSteps(
+                missingSteps.filter(step => step !== 'applied_labware_offsets')
+              )
+            }
           }}
           offsetsConfirmed={lpcComplete}
         />
@@ -270,6 +292,9 @@ export function ProtocolRunSetup({
           setLabwareConfirmed={(confirmed: boolean) => {
             setLabwareSetupComplete(confirmed)
             if (confirmed) {
+              setMissingSteps(
+                missingSteps.filter(step => step !== 'labware_placement')
+              )
               const nextStep =
                 targetStepKeyInOrder.findIndex(v => v === LABWARE_SETUP_KEY) ===
                 targetStepKeyInOrder.length - 1
@@ -298,6 +323,7 @@ export function ProtocolRunSetup({
           setLiquidSetupConfirmed={(confirmed: boolean) => {
             setLiquidSetupComplete(confirmed)
             if (confirmed) {
+              setMissingSteps(missingSteps.filter(step => step != 'liquids'))
               setExpandedStepKey(null)
             }
           }}
diff --git a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
index 70b16c61b55..872dff5771f 100644
--- a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunHeader.test.tsx
@@ -97,7 +97,9 @@ import {
   ProtocolDropTipModal,
   useProtocolDropTipModal,
 } from '../ProtocolDropTipModal'
+import { ConfirmMissingStepsModal } from '../ConfirmMissingStepsModal'
 
+import type { MissingSteps } from '../ProtocolRunSetup'
 import type { UseQueryResult } from 'react-query'
 import type { NavigateFunction } from 'react-router-dom'
 import type { Mock } from 'vitest'
@@ -153,6 +155,7 @@ vi.mock('../../../ProtocolUpload/hooks/useMostRecentRunId')
 vi.mock('../../../../resources/runs')
 vi.mock('../../../ErrorRecoveryFlows')
 vi.mock('../ProtocolDropTipModal')
+vi.mock('../ConfirmMissingStepsModal')
 
 const ROBOT_NAME = 'otie'
 const RUN_ID = '95e67900-bc9f-4fbf-92c6-cc4d7226a51b'
@@ -215,6 +218,7 @@ const mockDoorStatus = {
     doorRequiredClosedForProtocol: true,
   },
 }
+let mockMissingSteps: MissingSteps = []
 
 const render = () => {
   return renderWithProviders(
@@ -224,6 +228,7 @@ const render = () => {
         robotName={ROBOT_NAME}
         runId={RUN_ID}
         makeHandleJumpToStep={vi.fn(() => vi.fn())}
+        missingSetupSteps={mockMissingSteps}
       />
     </BrowserRouter>,
     { i18nInstance: i18n }
@@ -240,7 +245,7 @@ describe('ProtocolRunHeader', () => {
     mockTrackProtocolRunEvent = vi.fn(() => new Promise(resolve => resolve({})))
     mockCloseCurrentRun = vi.fn()
     mockDetermineTipStatus = vi.fn()
-
+    mockMissingSteps = []
     vi.mocked(useTrackEvent).mockReturnValue(mockTrackEvent)
     vi.mocked(ConfirmCancelModal).mockReturnValue(
       <div>Mock ConfirmCancelModal</div>
@@ -267,6 +272,9 @@ describe('ProtocolRunHeader', () => {
     vi.mocked(ConfirmAttachmentModal).mockReturnValue(
       <div>mock confirm attachment modal</div>
     )
+    vi.mocked(ConfirmMissingStepsModal).mockReturnValue(
+      <div>mock missing steps modal</div>
+    )
     when(vi.mocked(useProtocolAnalysisErrors)).calledWith(RUN_ID).thenReturn({
       analysisErrors: null,
     })
diff --git a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunSetup.test.tsx b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunSetup.test.tsx
index c64d00aa534..e4fbc00e234 100644
--- a/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunSetup.test.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/__tests__/ProtocolRunSetup.test.tsx
@@ -40,6 +40,7 @@ import { SetupLiquids } from '../SetupLiquids'
 import { SetupModuleAndDeck } from '../SetupModuleAndDeck'
 import { EmptySetupStep } from '../EmptySetupStep'
 import { ProtocolRunSetup } from '../ProtocolRunSetup'
+import type { MissingSteps } from '../ProtocolRunSetup'
 import { useNotifyRunQuery } from '../../../../resources/runs'
 
 import type * as SharedData from '@opentrons/shared-data'
@@ -68,12 +69,18 @@ vi.mock('@opentrons/shared-data', async importOriginal => {
 const ROBOT_NAME = 'otie'
 const RUN_ID = '1'
 const MOCK_PROTOCOL_LIQUID_KEY = { liquids: [] }
+let mockMissingSteps: MissingSteps = []
+const mockSetMissingSteps = vi.fn((missingSteps: MissingSteps) => {
+  mockMissingSteps = missingSteps
+})
 const render = () => {
   return renderWithProviders(
     <ProtocolRunSetup
       protocolRunHeaderRef={null}
       robotName={ROBOT_NAME}
       runId={RUN_ID}
+      missingSteps={mockMissingSteps}
+      setMissingSteps={mockSetMissingSteps}
     />,
     {
       i18nInstance: i18n,
@@ -83,6 +90,7 @@ const render = () => {
 
 describe('ProtocolRunSetup', () => {
   beforeEach(() => {
+    mockMissingSteps = []
     when(vi.mocked(useIsFlex)).calledWith(ROBOT_NAME).thenReturn(false)
     when(vi.mocked(useMostRecentCompletedAnalysis))
       .calledWith(RUN_ID)
diff --git a/app/src/pages/Devices/ProtocolRunDetails/index.tsx b/app/src/pages/Devices/ProtocolRunDetails/index.tsx
index 6e5501e6abd..82865237d8e 100644
--- a/app/src/pages/Devices/ProtocolRunDetails/index.tsx
+++ b/app/src/pages/Devices/ProtocolRunDetails/index.tsx
@@ -31,7 +31,10 @@ import {
 } from '../../../organisms/Devices/hooks'
 import { ProtocolRunHeader } from '../../../organisms/Devices/ProtocolRun/ProtocolRunHeader'
 import { RunPreview } from '../../../organisms/RunPreview'
-import { ProtocolRunSetup } from '../../../organisms/Devices/ProtocolRun/ProtocolRunSetup'
+import {
+  ProtocolRunSetup,
+  initialMissingSteps,
+} from '../../../organisms/Devices/ProtocolRun/ProtocolRunSetup'
 import { BackToTopButton } from '../../../organisms/Devices/ProtocolRun/BackToTopButton'
 import { ProtocolRunModuleControls } from '../../../organisms/Devices/ProtocolRun/ProtocolRunModuleControls'
 import { ProtocolRunRuntimeParameters } from '../../../organisms/Devices/ProtocolRun/ProtocolRunRunTimeParameters'
@@ -137,7 +140,6 @@ export function ProtocolRunDetails(): JSX.Element | null {
   React.useEffect(() => {
     dispatch(fetchProtocols())
   }, [dispatch])
-
   return robot != null ? (
     <ApiHostProvider
       key={robot.name}
@@ -188,6 +190,10 @@ function PageContents(props: PageContentsProps): JSX.Element {
     }
   }, [jumpedIndex])
 
+  const [missingSteps, setMissingSteps] = React.useState<
+    ReturnType<typeof initialMissingSteps>
+  >(initialMissingSteps())
+
   const makeHandleScrollToStep = (i: number) => () => {
     listRef.current?.scrollToIndex(i, true, -1 * JUMP_OFFSET_FROM_TOP_PX)
   }
@@ -207,6 +213,8 @@ function PageContents(props: PageContentsProps): JSX.Element {
           protocolRunHeaderRef={protocolRunHeaderRef}
           robotName={robotName}
           runId={runId}
+          setMissingSteps={setMissingSteps}
+          missingSteps={missingSteps}
         />
       ),
       backToTop: (
@@ -248,12 +256,16 @@ function PageContents(props: PageContentsProps): JSX.Element {
       backToTop: null,
     },
   }
-
-  const tabDetails = protocolRunDetailsContentByTab[protocolRunDetailsTab] ?? (
-    // default to the setup tab if no tab or nonexistent tab is passed as a param
-
-    <Navigate to={`/devices/${robotName}/protocol-runs/${runId}/setup`} />
-  )
+  console.log(`run details tab is ${protocolRunDetailsTab}`)
+  const tabDetails = protocolRunDetailsContentByTab[
+    protocolRunDetailsTab
+  ] ?? // default to the setup tab if no tab or nonexistent tab is passed as a param
+  {
+    content: (
+      <Navigate to={`/devices/${robotName}/protocol-runs/${runId}/setup`} />
+    ),
+    backToTop: null,
+  }
   const { content, backToTop } = tabDetails
 
   return (
@@ -263,6 +275,7 @@ function PageContents(props: PageContentsProps): JSX.Element {
         robotName={robotName}
         runId={runId}
         makeHandleJumpToStep={makeHandleJumpToStep}
+        missingSetupSteps={missingSteps}
       />
       <Flex gridGap={SPACING.spacing8} marginBottom={SPACING.spacing12}>
         <SetupTab