diff --git a/app/src/assets/localization/en/device_details.json b/app/src/assets/localization/en/device_details.json
index 71df492e080..31a9b06b78a 100644
--- a/app/src/assets/localization/en/device_details.json
+++ b/app/src/assets/localization/en/device_details.json
@@ -88,6 +88,7 @@
   "missing_module": "missing {{num}} module",
   "module_actions_unavailable": "Module actions unavailable while protocol is running",
   "module_calibration_required_no_pipette_attached": "Module calibration required. Attach a pipette before running module calibration.",
+  "module_calibration_required_no_pipette_calibrated": "Module calibration required. Calibrate pipette before running module calibration. ",
   "module_calibration_required_update_pipette_FW": "Update pipette firmware before proceeding with required module calibration.",
   "module_calibration_required": "Module calibration required.",
   "module_controls": "Module Controls",
diff --git a/app/src/molecules/UpdateBanner/__tests__/UpdateBanner.test.tsx b/app/src/molecules/UpdateBanner/__tests__/UpdateBanner.test.tsx
index c04943ca650..9cd38ce7eca 100644
--- a/app/src/molecules/UpdateBanner/__tests__/UpdateBanner.test.tsx
+++ b/app/src/molecules/UpdateBanner/__tests__/UpdateBanner.test.tsx
@@ -85,6 +85,14 @@ describe('Module Update Banner', () => {
     const { queryByText } = render(props)
     expect(queryByText('Calibrate now')).not.toBeInTheDocument()
   })
+  it('should not render a calibrate link if pipette calibration is required', () => {
+    props = {
+      ...props,
+      calibratePipetteRequired: true,
+    }
+    const { queryByText } = render(props)
+    expect(queryByText('Calibrate now')).not.toBeInTheDocument()
+  })
   it('should not render a calibrate link if pipette firmware update is required', () => {
     props = {
       ...props,
@@ -98,6 +106,7 @@ describe('Module Update Banner', () => {
       ...props,
       updateType: 'firmware',
       attachPipetteRequired: true,
+      calibratePipetteRequired: true,
       updatePipetteFWRequired: true,
     }
     const { queryByText } = render(props)
diff --git a/app/src/molecules/UpdateBanner/index.tsx b/app/src/molecules/UpdateBanner/index.tsx
index 14e3b1485de..23455d46c4e 100644
--- a/app/src/molecules/UpdateBanner/index.tsx
+++ b/app/src/molecules/UpdateBanner/index.tsx
@@ -23,6 +23,7 @@ interface UpdateBannerProps {
   serialNumber: string
   isTooHot?: boolean
   attachPipetteRequired?: boolean
+  calibratePipetteRequired?: boolean
   updatePipetteFWRequired?: boolean
 }
 
@@ -33,6 +34,7 @@ export const UpdateBanner = ({
   setShowBanner,
   handleUpdateClick,
   attachPipetteRequired,
+  calibratePipetteRequired,
   updatePipetteFWRequired,
   isTooHot,
 }: UpdateBannerProps): JSX.Element | null => {
@@ -48,11 +50,16 @@ export const UpdateBanner = ({
     closeButtonRendered = false
     if (attachPipetteRequired)
       bannerMessage = t('module_calibration_required_no_pipette_attached')
+    else if (calibratePipetteRequired)
+      bannerMessage = t('module_calibration_required_no_pipette_calibrated')
     else if (updatePipetteFWRequired)
       bannerMessage = t('module_calibration_required_update_pipette_FW')
     else bannerMessage = t('module_calibration_required')
     hyperlinkText =
-      !attachPipetteRequired && !updatePipetteFWRequired && !isTooHot
+      !attachPipetteRequired &&
+      !updatePipetteFWRequired &&
+      !isTooHot &&
+      !calibratePipetteRequired
         ? t('calibrate_now')
         : ''
   } else {
diff --git a/app/src/organisms/Devices/InstrumentsAndModules.tsx b/app/src/organisms/Devices/InstrumentsAndModules.tsx
index ef6cb2a7f60..25007ca3d87 100644
--- a/app/src/organisms/Devices/InstrumentsAndModules.tsx
+++ b/app/src/organisms/Devices/InstrumentsAndModules.tsx
@@ -105,6 +105,8 @@ export function InstrumentsAndModules({
     attachedPipettes?.left ?? null
   )
   const attachPipetteRequired =
+    attachedLeftPipette == null && attachedRightPipette == null
+  const calibratePipetteRequired =
     attachedLeftPipette?.data?.calibratedOffset?.last_modified == null &&
     attachedRightPipette?.data?.calibratedOffset?.last_modified == null
   const updatePipetteFWRequired =
@@ -240,6 +242,7 @@ export function InstrumentsAndModules({
                   module={module}
                   isLoadedInRun={false}
                   attachPipetteRequired={attachPipetteRequired}
+                  calibratePipetteRequired={calibratePipetteRequired}
                   updatePipetteFWRequired={updatePipetteFWRequired}
                 />
               ))}
@@ -281,6 +284,7 @@ export function InstrumentsAndModules({
                   module={module}
                   isLoadedInRun={false}
                   attachPipetteRequired={attachPipetteRequired}
+                  calibratePipetteRequired={calibratePipetteRequired}
                   updatePipetteFWRequired={updatePipetteFWRequired}
                 />
               ))}
diff --git a/app/src/organisms/Devices/ProtocolRun/ProtocolRunModuleControls.tsx b/app/src/organisms/Devices/ProtocolRun/ProtocolRunModuleControls.tsx
index f8dcee3d93b..107db017315 100644
--- a/app/src/organisms/Devices/ProtocolRun/ProtocolRunModuleControls.tsx
+++ b/app/src/organisms/Devices/ProtocolRun/ProtocolRunModuleControls.tsx
@@ -15,6 +15,7 @@ import type { BadPipette, PipetteData } from '@opentrons/api-client'
 
 interface PipetteStatus {
   attachPipetteRequired: boolean
+  calibratePipetteRequired: boolean
   updatePipetteFWRequired: boolean
 }
 
@@ -51,9 +52,16 @@ const usePipetteIsReady = (): PipetteStatus => {
 
   const attachPipetteRequired =
     attachedLeftPipette == null && attachedRightPipette == null
+  const calibratePipetteRequired =
+    attachedLeftPipette?.data.calibratedOffset?.last_modified == null &&
+    attachedRightPipette?.data.calibratedOffset?.last_modified == null
   const updatePipetteFWRequired =
     leftPipetteRequiresFWUpdate != null || rightPipetteFWRequired != null
-  return { attachPipetteRequired, updatePipetteFWRequired }
+  return {
+    attachPipetteRequired,
+    calibratePipetteRequired,
+    updatePipetteFWRequired,
+  }
 }
 
 interface ProtocolRunModuleControlsProps {
@@ -67,7 +75,11 @@ export const ProtocolRunModuleControls = ({
 }: ProtocolRunModuleControlsProps): JSX.Element => {
   const { t } = useTranslation('protocol_details')
 
-  const { attachPipetteRequired, updatePipetteFWRequired } = usePipetteIsReady()
+  const {
+    attachPipetteRequired,
+    calibratePipetteRequired,
+    updatePipetteFWRequired,
+  } = usePipetteIsReady()
 
   const moduleRenderInfoForProtocolById = useModuleRenderInfoForProtocolById(
     runId
@@ -115,6 +127,7 @@ export const ProtocolRunModuleControls = ({
               slotName={module.slotName}
               isLoadedInRun={true}
               attachPipetteRequired={attachPipetteRequired}
+              calibratePipetteRequired={calibratePipetteRequired}
               updatePipetteFWRequired={updatePipetteFWRequired}
             />
           ) : null
@@ -135,6 +148,7 @@ export const ProtocolRunModuleControls = ({
               slotName={module.slotName}
               isLoadedInRun={true}
               attachPipetteRequired={attachPipetteRequired}
+              calibratePipetteRequired={calibratePipetteRequired}
               updatePipetteFWRequired={updatePipetteFWRequired}
             />
           ) : null
diff --git a/app/src/organisms/ModuleCard/__tests__/ModuleCard.test.tsx b/app/src/organisms/ModuleCard/__tests__/ModuleCard.test.tsx
index 599732ad763..31e0f92cd31 100644
--- a/app/src/organisms/ModuleCard/__tests__/ModuleCard.test.tsx
+++ b/app/src/organisms/ModuleCard/__tests__/ModuleCard.test.tsx
@@ -227,6 +227,7 @@ describe('ModuleCard', () => {
       robotName: mockRobot.name,
       isLoadedInRun: false,
       attachPipetteRequired: false,
+      calibratePipetteRequired: false,
       updatePipetteFWRequired: false,
     }
 
diff --git a/app/src/organisms/ModuleCard/index.tsx b/app/src/organisms/ModuleCard/index.tsx
index eb42bf67f39..2d76c99c97f 100644
--- a/app/src/organisms/ModuleCard/index.tsx
+++ b/app/src/organisms/ModuleCard/index.tsx
@@ -79,6 +79,7 @@ interface ModuleCardProps {
   robotName: string
   isLoadedInRun: boolean
   attachPipetteRequired: boolean
+  calibratePipetteRequired: boolean
   updatePipetteFWRequired: boolean
   runId?: string
   slotName?: string
@@ -93,6 +94,7 @@ export const ModuleCard = (props: ModuleCardProps): JSX.Element | null => {
     runId,
     slotName,
     attachPipetteRequired,
+    calibratePipetteRequired,
     updatePipetteFWRequired,
   } = props
   const dispatch = useDispatch<Dispatch>()
@@ -125,7 +127,9 @@ export const ModuleCard = (props: ModuleCardProps): JSX.Element | null => {
   })
   const requireModuleCalibration = module.moduleOffset?.last_modified == null
   const isPipetteReady =
-    (!attachPipetteRequired ?? false) && (!updatePipetteFWRequired ?? false)
+    (!attachPipetteRequired ?? false) &&
+    (!calibratePipetteRequired ?? false) &&
+    (!updatePipetteFWRequired ?? false)
   const latestRequestId = last(requestIds)
   const latestRequest = useSelector<State, RequestState | null>(state =>
     latestRequestId ? getRequestById(state, latestRequestId) : null
@@ -303,6 +307,7 @@ export const ModuleCard = (props: ModuleCardProps): JSX.Element | null => {
               />
             )}
             {attachPipetteRequired != null &&
+            calibratePipetteRequired != null &&
             updatePipetteFWRequired != null &&
             requireModuleCalibration &&
             !isPending ? (
@@ -313,6 +318,7 @@ export const ModuleCard = (props: ModuleCardProps): JSX.Element | null => {
                 setShowBanner={() => null}
                 handleUpdateClick={handleCalibrateClick}
                 attachPipetteRequired={attachPipetteRequired}
+                calibratePipetteRequired={calibratePipetteRequired}
                 updatePipetteFWRequired={updatePipetteFWRequired}
                 isTooHot={isTooHot}
               />