Potency results on the repeated biotransformation

[david1597]

The potency results are back for batch number two of the Pfizer biosynthesis compound:

Originally made last year, that batch showed a potency of 6 nM. The organic chemistry lab synthesis of this compound ("The OHOH") was completed a couple of months ago (#36); coming back at 660 nM (#54).

The result of the repeated biosynthesis has come back with a potency of 115 nM. Again, this aspect of Series 4 isn't making things easy! We still plan to send the sample made in Sydney for a retest next we send off samples. We should also decide, over the coming weeks, what further actions to take in terms of overall direction in regards to this sector of Series 4.

[MFernflower]

Random Q - Is it possible that our 6 nanomolar magic bullet was a para-hydroxy-phenyl OHOH compound? @david1597 @edwintse

[mattodd]

(Am back online - hello everyone. Will now catch up on everything OSM-related).
Thanks @david1597 . Do you have a link to the primary data, or were the data uploaded to ScienceCloud (in which case a screenshot can help)? Is 115 nM an average of runs?
Yes, we need to repeat the analysis of the Sydney-made compound. Can I check: the NMR data for the purified Sydney compound and the repeated Pfizer compound match, right? Do we have that NMR comparison anywhere (as we did for the original samples that did not match)? We'll need it for the S4 paper, on the assumption we include this. Obviously this would at the same time answer @MFernflower 's question above.