diff --git a/pkgs/development/python-modules/libnacl/default.nix b/pkgs/development/python-modules/libnacl/default.nix
index d07c08bc65b64..ec6d1e4425646 100644
--- a/pkgs/development/python-modules/libnacl/default.nix
+++ b/pkgs/development/python-modules/libnacl/default.nix
@@ -2,39 +2,37 @@
 , stdenv
 , buildPythonPackage
 , fetchFromGitHub
-, fetchpatch
+, poetry-core
 , libsodium
 , pytestCheckHook
 }:
 
 buildPythonPackage rec {
   pname = "libnacl";
-  version = "1.7.2";
+  version = "2.1.0";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "saltstack";
     repo = pname;
     rev = "v${version}";
-    hash = "sha256-nttR9PQimhqd2pByJ5IJzJ4RmSI4y7lcX7a7jcK+vqc=";
+    hash = "sha256-phECLGDcBfDi/r2y0eGtqgIX/hvirtBqO8UUvEJ66zo=";
   };
 
-  patches = [
-    # Fixes build on 32-bit platforms
-    (fetchpatch {
-      name = "fix-crypto_kdf_derive_from_key-32bit.patch";
-      url = "https://github.com/saltstack/libnacl/commit/e8a1f95ee1d4d0806fb6aee793dcf308b05d485d.patch";
-      hash = "sha256-z6TAVNfPcuWZ/hRgk6Aa8I1IGzne7/NYnUOOQ3TjGVU=";
-    })
-  ];
+  nativeBuildInputs = [ poetry-core ];
 
   buildInputs = [ libsodium ];
 
   postPatch =
     let soext = stdenv.hostPlatform.extensions.sharedLibrary; in
     ''
-      substituteInPlace "./libnacl/__init__.py" --replace \
-        "ctypes.cdll.LoadLibrary('libsodium${soext}')" \
-        "ctypes.cdll.LoadLibrary('${libsodium}/lib/libsodium${soext}')"
+      substituteInPlace "./libnacl/__init__.py" \
+        --replace \
+          "l_path = ctypes.util.find_library('sodium')" \
+          "l_path = None" \
+        --replace \
+          "ctypes.cdll.LoadLibrary('libsodium${soext}')" \
+          "ctypes.cdll.LoadLibrary('${libsodium}/lib/libsodium${soext}')"
     '';
 
   nativeCheckInputs = [ pytestCheckHook ];