diff --git a/pkgs/development/python-modules/pylibdmtx/default.nix b/pkgs/development/python-modules/pylibdmtx/default.nix
new file mode 100644
index 0000000000000..2152ac54241d4
--- /dev/null
+++ b/pkgs/development/python-modules/pylibdmtx/default.nix
@@ -0,0 +1,47 @@
+{ fetchFromGitHub
+, buildPythonPackage
+, pillow
+, numpy
+, libdmtx
+, lib
+}:
+
+buildPythonPackage rec {
+  pname = "pylibdmtx";
+  version = "0.1.10";
+
+  src = fetchFromGitHub {
+    owner = "NaturalHistoryMuseum";
+    repo = pname;
+    rev = "v${version}";
+    hash = "sha256-vNWzhO4V0mj4eItZ0Z5UG9RBCqprIcgMGNyIe1+mXWY=";
+  };
+
+  # Change:
+  # def load():
+  #     """Loads the libdmtx shared library.
+  #
+  # To:
+  # def load():
+  #     return cdll.LoadLibrary("/nix/store/.../lib/libdmtx.so")
+  #     """Loads the libdmtx shared library.
+  postPatch = ''
+    sed -i '\#def load.*#a\    return cdll.LoadLibrary("${libdmtx}/lib/libdmtx.so")' \
+        pylibdmtx/dmtx_library.py
+
+    # Checks that the loader works in various scenarios, but we just
+    # forced it to only work one way.
+    rm pylibdmtx/tests/test_dmtx_library.py
+  '';
+
+  propagatedBuildInputs = [ pillow numpy ];
+
+  pythonImportsCheck = [ "pylibdmtx" ];
+
+  meta = with lib; {
+    description = "Read and write Data Matrix barcodes from Python 2 and 3 using the libdmtx library";
+    homepage = "https://github.com/NaturalHistoryMuseum/pylibdmtx/";
+    license = licenses.mit;
+    maintainers = with maintainers; [ grahamc ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 81a0dd25aba23..637f9640bd57d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -7868,6 +7868,8 @@ in {
 
   pylibconfig2 = callPackage ../development/python-modules/pylibconfig2 { };
 
+  pylibdmtx = callPackage ../development/python-modules/pylibdmtx { };
+
   pylibftdi = callPackage ../development/python-modules/pylibftdi {
     inherit (pkgs) libusb1;
   };