diff --git a/integration_tests/src/main/python/string_test.py b/integration_tests/src/main/python/string_test.py
index 5151484fcca..46fcba58074 100644
--- a/integration_tests/src/main/python/string_test.py
+++ b/integration_tests/src/main/python/string_test.py
@@ -771,6 +771,23 @@ def test_regexp_extract_idx_0():
                 'regexp_extract(a, "^([a-d]*)[0-9]*([a-d]*)\\z", 0)'),
         conf=_regexp_conf)
 
+def test_regexp_whitespace():
+    gen = mk_str_gen('\u001e[abcd]\t\n{1,3} [0-9]\n {1,3}\x0b\t[abcd]\r\f[0-9]{0,10}')
+    assert_gpu_and_cpu_are_equal_collect(
+            lambda spark: unary_op_df(spark, gen).selectExpr(
+                'rlike(a, "\\s{2}")',
+                'rlike(a, "\\s{3}")',
+                'rlike(a, "[abcd]+\\s+[0-9]+")',
+                'rlike(a, "\\S{3}")',
+                'rlike(a, "[abcd]+\\s+\\S{2,3}")',
+                'regexp_extract(a, "([a-d]+)([0-9\\s]+)([a-d]+)", 2)',
+                'regexp_extract(a, "([a-d]+)(\\S+)([0-9]+)", 2)',
+                'regexp_extract(a, "([a-d]+)(\\S+)([0-9]+)", 3)',
+                'regexp_replace(a, "(\\s+)", "@")',
+                'regexp_replace(a, "(\\S+)", "#")',
+            ),
+        conf=_regexp_conf)
+
 def test_rlike():
     gen = mk_str_gen('[abcd]{1,3}')
     assert_gpu_and_cpu_are_equal_collect(
diff --git a/spark2-sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala b/spark2-sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
index 705faa446a8..9025d7120e5 100644
--- a/spark2-sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
+++ b/spark2-sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
@@ -584,9 +584,6 @@ class CudfRegexTranspiler(mode: RegexMode) {
         case 'b' | 'B' =>
           // see https://github.com/NVIDIA/spark-rapids/issues/4517
           throw new RegexUnsupportedException("word boundaries are not supported")
-        case 's' | 'S' =>
-          // see https://github.com/NVIDIA/spark-rapids/issues/4528
-          throw new RegexUnsupportedException("whitespace classes are not supported")
         case 'A' if mode == RegexSplitMode =>
           throw new RegexUnsupportedException("string anchor \\A is not supported in split mode")
         case 'Z' if mode == RegexSplitMode =>
@@ -604,6 +601,11 @@ class CudfRegexTranspiler(mode: RegexMode) {
         case 'Z' =>
           // see https://github.com/NVIDIA/spark-rapids/issues/4532
           throw new RegexUnsupportedException("string anchor \\Z is not supported")
+        case 's' | 'S' =>
+          val chars: ListBuffer[RegexCharacterClassComponent] = ListBuffer(
+            RegexChar(' '), RegexChar('\u000b'))
+          chars ++= Seq('n', 't', 'r', 'f').map(RegexEscaped)
+          RegexCharacterClass(negated = ch.isUpper, characters = chars)
         case _ =>
           regex
       }
diff --git a/sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala b/sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
index 2589bf5c897..4cf88e2ae12 100644
--- a/sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
+++ b/sql-plugin/src/main/scala/com/nvidia/spark/rapids/RegexParser.scala
@@ -584,9 +584,6 @@ class CudfRegexTranspiler(mode: RegexMode) {
         case 'b' | 'B' =>
           // see https://github.com/NVIDIA/spark-rapids/issues/4517
           throw new RegexUnsupportedException("word boundaries are not supported")
-        case 's' | 'S' =>
-          // see https://github.com/NVIDIA/spark-rapids/issues/4528
-          throw new RegexUnsupportedException("whitespace classes are not supported")
         case 'A' if mode == RegexSplitMode =>
           throw new RegexUnsupportedException("string anchor \\A is not supported in split mode")
         case 'Z' if mode == RegexSplitMode =>
@@ -604,6 +601,11 @@ class CudfRegexTranspiler(mode: RegexMode) {
         case 'Z' =>
           // see https://github.com/NVIDIA/spark-rapids/issues/4532
           throw new RegexUnsupportedException("string anchor \\Z is not supported")
+        case 's' | 'S' =>
+          val chars: ListBuffer[RegexCharacterClassComponent] = ListBuffer(
+            RegexChar(' '), RegexChar('\u000b'))
+          chars ++= Seq('n', 't', 'r', 'f').map(RegexEscaped)
+          RegexCharacterClass(negated = ch.isUpper, characters = chars)
         case _ =>
           regex
       }
diff --git a/tests/src/test/scala/com/nvidia/spark/rapids/RegularExpressionTranspilerSuite.scala b/tests/src/test/scala/com/nvidia/spark/rapids/RegularExpressionTranspilerSuite.scala
index f1e2c0ca3ff..a0c26a1636c 100644
--- a/tests/src/test/scala/com/nvidia/spark/rapids/RegularExpressionTranspilerSuite.scala
+++ b/tests/src/test/scala/com/nvidia/spark/rapids/RegularExpressionTranspilerSuite.scala
@@ -221,6 +221,12 @@ class RegularExpressionTranspilerSuite extends FunSuite with Arm {
     }
   }
 
+  test("whitespace boundaries - replace") {
+    assertCpuGpuMatchesRegexpReplace(
+      Seq("\\s", "\\S"),
+      Seq("\u001eTEST"))
+  }
+
   test("match literal $ - find") {
     assertCpuGpuMatchesRegexpFind(
       Seq("\\$", "\\$[0-9]"),
@@ -292,7 +298,7 @@ class RegularExpressionTranspilerSuite extends FunSuite with Arm {
     assertCpuGpuMatchesRegexpFind(patterns, inputs)
   }
 
-  private val REGEXP_LIMITED_CHARS_COMMON = "|()[]{},.^$*+?abc123x\\ \t\r\nBsdwSDWzZ"
+  private val REGEXP_LIMITED_CHARS_COMMON = "|()[]{},.^$*+?abc123x\\ \t\r\n\f\u000bBsdwSDWzZ"
 
   private val REGEXP_LIMITED_CHARS_FIND = REGEXP_LIMITED_CHARS_COMMON