diff --git a/Core/Config.cpp b/Core/Config.cpp
index dd0dcc4b2ffb..337e77b89a17 100644
--- a/Core/Config.cpp
+++ b/Core/Config.cpp
@@ -516,6 +516,7 @@ static ConfigSetting graphicsSettings[] = {
 	ConfigSetting("SoftwareRenderer", &g_Config.bSoftwareRendering, false, true, true),
 	ReportedConfigSetting("HardwareTransform", &g_Config.bHardwareTransform, true, true, true),
 	ReportedConfigSetting("SoftwareSkinning", &g_Config.bSoftwareSkinning, true, true, true),
+	ConfigSetting("ShaderDepal", &g_Config.bShaderDepal, false, true, true),
 	ReportedConfigSetting("TextureFiltering", &g_Config.iTexFiltering, 1, true, true),
 	ReportedConfigSetting("BufferFiltering", &g_Config.iBufFilter, 1, true, true),
 	ReportedConfigSetting("InternalResolution", &g_Config.iInternalResolution, &DefaultInternalResolution, true, true),
diff --git a/Core/Config.h b/Core/Config.h
index 66bfe22c0342..983df3ef4e7d 100644
--- a/Core/Config.h
+++ b/Core/Config.h
@@ -162,6 +162,7 @@ struct Config {
 	bool bSoftwareRendering;
 	bool bHardwareTransform; // only used in the GLES backend
 	bool bSoftwareSkinning;  // may speed up some games
+	bool bShaderDepal;
 
 	int iRenderingMode; // 0 = non-buffered rendering 1 = buffered rendering
 	int iTexFiltering; // 1 = off , 2 = nearest , 3 = linear , 4 = linear(CG)
diff --git a/GPU/GLES/TextureCacheGLES.cpp b/GPU/GLES/TextureCacheGLES.cpp
index 82589441931c..69e354017001 100644
--- a/GPU/GLES/TextureCacheGLES.cpp
+++ b/GPU/GLES/TextureCacheGLES.cpp
@@ -439,12 +439,10 @@ class TextureShaderApplier {
 void TextureCacheGLES::ApplyTextureFramebuffer(TexCacheEntry *entry, VirtualFramebuffer *framebuffer) {
 	DepalShader *depal = nullptr;
 	uint32_t clutMode = gstate.clutformat & 0xFFFFFF;
-
-#if 0
-	bool useShaderDepal = gstate_c.Supports(GPU_SUPPORTS_GLSL_ES_300);
-#else
 	bool useShaderDepal = false;
-#endif
+	if (g_Config.bShaderDepal) {
+		useShaderDepal = gstate_c.Supports(GPU_SUPPORTS_GLSL_ES_300);
+	}
 
 	if ((entry->status & TexCacheEntry::STATUS_DEPALETTIZE) && !g_Config.bDisableSlowFramebufEffects) {
 		if (useShaderDepal) {
diff --git a/UI/GameSettingsScreen.cpp b/UI/GameSettingsScreen.cpp
index 55894531d5cb..87ff7ffee65c 100644
--- a/UI/GameSettingsScreen.cpp
+++ b/UI/GameSettingsScreen.cpp
@@ -326,6 +326,11 @@ void GameSettingsScreen::CreateViews() {
 		});
 		swSkin->SetDisabledPtr(&g_Config.bSoftwareRendering);
 
+		if (g_Config.iGPUBackend == (int)GPUBackend::OPENGL) {
+			CheckBox *shaderDepal = graphicsSettings->Add(new CheckBox(&g_Config.bShaderDepal, gr->T("Shader Depal")));
+			shaderDepal->SetDisabledPtr(&g_Config.bSoftwareRendering);
+		}
+		
 		CheckBox *vtxCache = graphicsSettings->Add(new CheckBox(&g_Config.bVertexCache, gr->T("Vertex Cache")));
 		vtxCache->OnClick.Add([=](EventParams &e) {
 			settingInfo_->Show(gr->T("VertexCache Tip", "Faster, but may cause temporary flicker"), e.v);